School of Life Sciences

  • United Kingdom

Research Output 1968 2020

Article
21 Citations (Scopus)

Amino acid neurotoxins in feathers of the Lesser Flamingo, Phoeniconaias minor

Metcalf, J. S., Banack, S. A., Kotut, K., Krienitz, L. & Codd, G. A., Jan 2013, In : Chemosphere. 90, 2, p. 835-839 5 p.

Research output: Contribution to journalArticle

Feathers
Neurotoxins
feather
Lakes
Amino acids
2 Citations (Scopus)
40 Downloads (Pure)
Open Access
File
Carbonates
Nanoparticles
Fungi
Minerals
Amino Acids
131 Citations (Scopus)

Amino acid sequence analysis of the annexin super-gene family of proteins

Barton, G. J., Newman, R. H., Freemont, P. S. & Crumpton, M. J., Jun 1991, In : European Journal of Biochemistry. 198, 3, p. 749-760 12 p.

Research output: Contribution to journalArticle

Annexins
Protein Sequence Analysis
Genes
Amino Acids
Uteroglobin
25 Citations (Scopus)

Amino acid sequence at the site on protein phosphatase inhibitor-2, phosphorylated by glycogen synthase kinase-3

Aitken, A., Holmes, C. F. B., Campbell, D. G., Resink, T. J., Cohen, P., Leung, C. T. W. & Williams, D. H., 9 Nov 1984, In : Biochimica et Biophysica Acta (BBA)/Protein Structure and Molecular. 790, 3, p. 288-291 4 p.

Research output: Contribution to journalArticle

Glycogen Synthase Kinase 3
Glycogen Synthase Kinases
Phosphorylation
Amino Acid Sequence
Hormones
20 Downloads (Pure)

Amino acid substitutions in the human homomeric β3 GABAA receptor that enable activation by GABA

Gottschald Chiodi, C., Baptista-Hon, D., Hunter, W. & Hales, T., 15 Feb 2019, In : Journal of Biological Chemistry. 294, 7, p. 2375-2385 11 p.

Research output: Contribution to journalArticle

Open Access
File
GABA-A Receptors
Amino Acid Substitution
gamma-Aminobutyric Acid
Substitution reactions
Chemical activation
221 Citations (Scopus)

Amino acid transporters: roles in amino acid sensing and signalling in animal cells

Hyde, R., Taylor, P. M. & Hundal, H. S., 2003, In : Biochemical Journal. 373, 1, p. 1-18 18 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Amino acid transporters: eminences grises of nutrient signalling mechanisms?

Taylor, P. M., Feb 2009, In : Biochemical Society Transactions. 37, p. 237-241 5 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)
83 Downloads (Pure)

A minor role of WNK3 in regulating phosphorylation of renal NKCC2 and NCC co-transporters in vivo

Oi, K., Sohara, E., Rai, T., Misawa, M., Chiga, M., Alessi, D. R., Sasaki, S. & Uchida, S., 15 Dec 2012, In : Open Biology. 1, 2, p. 120-127 8 p.

Research output: Contribution to journalArticle

Open Access
File
symporters
Symporters
Phosphorylation
Nutrition
Knockout Mice
1 Citation (Scopus)

A missense mutation in the catalytic domain of O-GlcNAc transferase links perturbations in protein O-GlcNAcylation to X-linked intellectual disability

Pravata, V. M., Gundogdu, M., Bartual, S. G., Ferenbach, A. T., Stavridis, M., Õunap, K., Pajusalu, S., Žordania, R., Wojcik, M. H. & van Aalten, D. M. F., 7 Nov 2019, In : FEBS Letters.

Research output: Contribution to journalArticle

Missense Mutation
Intellectual Disability
Catalytic Domain
X ray crystallography
Stem cells

Ammonium and methylamine transport by the ectomycorrhizal fungus Paxillus involutus and ectomycorrhizas

Javelle, A., Chalot, M., Söderström, B. & Botton, B., 1999, In : FEMS Microbiology Ecology. 30, 4, p. 355-366 12 p.

Research output: Contribution to journalArticle

Ammonium Compounds
Fungi
ammonium
fungus
kinetics
161 Citations (Scopus)

Ammonium sensing in Escherichia coli. role of the ammonium transporter AmtB and AmtB-GlnK complex formation

Javelle, A., Severi, E., Thornton, J. & Merrick, M., 2004, In : Journal of Biological Chemistry. 279, 10, p. 8530-8 9 p.

Research output: Contribution to journalArticle

Ammonium Compounds
Escherichia coli
Signal transduction
Signal Transduction
Proteins
63 Citations (Scopus)

A model for DNA replication showing how dormant origins safeguard against replication fork failure

Blow, J. J. & Ge, X. Q., Apr 2009, In : EMBO Reports. 10, 4, p. 406-412 7 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

A Model Sheet Mineral System to Study Fungal Bioweathering of Mica

Wei, Z., Kierans, M. & Gadd, G. M., 2012, In : Geomicrobiology Journal. 29, 4, p. 323-331 9 p.

Research output: Contribution to journalArticle

78 Citations (Scopus)

A molecular explanation for the recessive nature of parkin-linked Parkinson's disease

Spratt, D. E., Julio Martinez-Torres, R., Noh, Y. J., Mercier, P., Manczyk, N., Barber, K. R., Aguirre, J. D., Burchell, L., Purkiss, A., Walden, H. & Shaw, G. S., 1 Jan 2013, In : Nature Communications. 4, 12 p., 1983.

Research output: Contribution to journalArticle

Parkinson disease
mutations
Ubiquitin
Parkinson Disease
Parkinsonian Disorders
8 Citations (Scopus)
119 Downloads (Pure)

A Molecular Hybridization Approach for the Design of Potent, Highly Selective, and Brain-Penetrant N-Myristoyltransferase Inhibitors

Harrison, J. R., Brand, S., Smith, V., Robinson, D. A., Thompson, S., Smith, A., Davies, K., Mok, N., Torrie, L. S., Collie, I., Hallyburton, I., Norval, S., Simeons, F. R. C., Stojanovski, L., Frearson, J. A., Brenk, R., Wyatt, P. G., Gilbert, I. H. & Read, K. D., 12 Sep 2018, In : Journal of Medicinal Chemistry. 61, 18, p. 8374–8389 16 p.

Research output: Contribution to journalArticle

Open Access
File
African Trypanosomiasis
Trypanosoma brucei brucei
Crystallography
Central Nervous System Diseases
Peripheral Nervous System
47 Citations (Scopus)

A molecular method to assess Phytophthora diversity in environmental samples

Scibetta, S., Schena, L., Chimento, A., Cacciola, S. O. & Cooke, D. E. L., Mar 2012, In : Journal of Microbiological Methods. 88, 3, p. 356-368 13 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
53 Downloads (Pure)
Open Access
File
Ions
DNA
Enzymes
Substrate Specificity
Catalytic Domain
1468 Citations (Scopus)

AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy

Hardie, D. G., Oct 2007, In : Nature Reviews Molecular Cell Biology. 8, 10, p. 774-85 12 p.

Research output: Contribution to journalArticle

AMP-Activated Protein Kinases
Cell Polarity
Eukaryotic Cells
Catalytic Domain
Homeostasis
104 Citations (Scopus)
69 Downloads (Pure)

AMP-activated protein kinase: a cellular energy sensor that comes in twelve flavours

Ross, F. A., MacKintosh, C. & Hardie, D. G., 24 Mar 2016, In : FEBS Journal. 283, 16, p. 2987-3001 15 p.

Research output: Contribution to journalArticle

Open Access
File
AMP-Activated Protein Kinases
Flavors
Protein Isoforms
Tumors
Sensors
345 Citations (Scopus)

AMP-activated protein kinase: Greater AMP dependence, and preferential nuclear localization, of complexes containing the α2 isoform

Salt, I., Celler, J. W., Hawley, S. A., Prescott, A., Woods, A., Carling, D. & Hardie, D. G., 15 Aug 1998, In : Biochemical Journal. 334, 1, p. 177-187 11 p.

Research output: Contribution to journalArticle

AMP-Activated Protein Kinases
Adenosine Monophosphate
Protein Isoforms
Phosphotransferases
Adenosine Triphosphate
114 Citations (Scopus)
27 Citations (Scopus)

AMP-activated protein kinase and hypoxic pulmonary vasoconstriction

Robertson, T. P., Mustard, K. J. W., Lewis, T. H., Clark, J. H., Wyatt, C. N., Blanco, E. A., Peers, C., Hardie, D. G. & Evans, A. M., 24 Oct 2008, In : European Journal of Pharmacology. 595, 1-3, p. 39-43 5 p.

Research output: Contribution to journalArticle

324 Citations (Scopus)

AMP-activated protein kinase as a drug target

Hardie, D. G., Feb 2007, In : Annual Review of Pharmacology and Toxicology. 47, p. 185-210 26 p.

Research output: Contribution to journalArticle

AMP-Activated Protein Kinases
Pharmaceutical Preparations
Adenosine Triphosphate
Biguanides
Thiazolidinediones
11 Citations (Scopus)
95 Downloads (Pure)

AMP-activated protein kinase inhibits Kv1.5 channel currents of pulmonary arterial myocytes in response to hypoxia and inhibition of mitochondrial oxidative phosphorylation

Moral-Sanz, J., Mahmoud, A. D., Ross, F. A., Eldstrom, J., Fedida, D., Hardie, D. G. & Evans, A. M., 1 Sep 2016, In : Journal of Physiology. 594, 17, p. 4901-4915 15 p.

Research output: Contribution to journalArticle

Open Access
File
AMP-Activated Protein Kinases
Oxidative Phosphorylation
Muscle Cells
Lung
A 769662
906 Citations (Scopus)

AMP-activated protein kinase in metabolic control and insulin signaling

Towler, M. C. & Hardie, D. G., 16 Feb 2007, In : Circulation Research. 100, 3, p. 328-41 14 p.

Research output: Contribution to journalArticle

AMP-Activated Protein Kinases
Adenosine Triphosphate
Adenosine Monophosphate
Insulin
Physiological Stress
94 Citations (Scopus)
102 Citations (Scopus)

AMP-activated protein kinase mediates preconditioning in cardiomyocytes by regulating activity and trafficking of sarcolemmal ATP-sensitive K(+) channels

Sukhodub, A., Jovanović, S., Du, Q., Budas, G., Clelland, A. K., Shen, M., Sakamoto, K., Tian, R. & Jovanovic, A., Jan 2007, In : Journal of Cellular Physiology. 210, 1, p. 224-36 13 p.

Research output: Contribution to journalArticle

AMP-Activated Protein Kinases
Cardiac Myocytes
Adenosine Triphosphate
KATP Channels
Mitochondrial Membrane Potential
214 Citations (Scopus)
82 Downloads (Pure)

AMP Is a True Physiological Regulator of AMP-Activated Protein Kinase by Both Allosteric Activation and Enhancing Net Phosphorylation

Gowans, G. J., Hawley, S. A., Ross, F. A. & Hardie, D. G., 1 Oct 2013, In : Cell Metabolism. 18, 4, p. 556-566 11 p.

Research output: Contribution to journalArticle

Open Access
File
AMP-Activated Protein Kinases
Adenosine Monophosphate
Phosphorylation
Adenosine Diphosphate
Adenosine Triphosphate
215 Citations (Scopus)
76 Downloads (Pure)

AMPK: a target for drugs and natural products with effects on both diabetes and cancer

Hardie, D. G., Jul 2013, In : Diabetes. 62, 7, p. 2164-2172 9 p.

Research output: Contribution to journalArticle

Open Access
File
AMP-Activated Protein Kinases
Biological Products
Metformin
Pharmaceutical Preparations
Neoplasms
142 Citations (Scopus)
94 Downloads (Pure)

AMPK: regulating energy balance at the cellular and whole body levels

Hardie, D. G. & Ashford, M. L. J., Mar 2014, In : Physiology. 29, 2, p. 99-107 9 p.

Research output: Contribution to journalArticle

Open Access
File
AMP-Activated Protein Kinases
Adenine Nucleotides
Energy Intake
Eukaryota
Energy Metabolism
441 Citations (Scopus)

AMPK: a key regulator of energy balance in the single cell and the whole organism

Hardie, D. G., Sep 2008, In : International Journal of Obesity. 32, p. S7-S12 6 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

AMPK: opposing the metabolic changes in both tumour cells and inflammatory cells?

Dandapani, M. & Hardie, D. G., Apr 2013, In : Biochemical Society Transactions. 41, 2, p. 687-693 7 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

AMPK activators inhibit the proliferation of human melanomas bearing the activated MAPK pathway

Petti, C., Vegetti, C., Molla, A., Bersani, I., Cleris, L., Mustard, K. J., Formelli, F., Hardie, G. D., Sensi, M. & Anichini, A., 2012, In : Melanoma Research. 22, 5, p. 341-350 10 p.

Research output: Contribution to journalArticle

AMP-Activated Protein Kinases
Melanoma
Phenformin
Mitogen-Activated Protein Kinase Kinases
Phosphorylation
34 Citations (Scopus)

AMPK and SNF1: snuffing out stress

Hardie, D. G., 7 Nov 2007, In : Cell Metabolism. 6, 5, p. 339-40 2 p.

Research output: Contribution to journalArticle

AMP-Activated Protein Kinases
Adenosine Monophosphate
Glycogen
Homeostasis
Nucleotides
40 Citations (Scopus)

AMPK antagonizes hepatic glucagon-stimulated cyclic AMP signalling via phosphorylation-induced activation of cyclic nucleotide phosphodiesterase 4B

Johanns, M., Lai, Y. C., Hsu, M. F., Jacobs, R., Vertommen, D., Van Sande, J., Dumont, J. E., Woods, A., Carling, D., Hue, L., Viollet, B., Foretz, M. & Rider, M. H., 8 Mar 2016, In : Nature Communications. 7, 10856.

Research output: Contribution to journalArticle

Open Access
cyclic AMP
Type 4 Cyclic Nucleotide Phosphodiesterase
adenosine monophosphate
phosphorylation
Phosphorylation
25 Citations (Scopus)
245 Downloads (Pure)

AMPK Causes Cell Cycle Arrest in LKB1-deficient Cells via Activation of CAMKK2

Fogarty, S., Ross, F. A., Vara Ciruelos, D., Gray, A., Gowans, G. J. & Hardie, D. G., 1 Aug 2016, In : Molecular Cancer Research. 14, 8, p. 683-695 13 p.

Research output: Contribution to journalArticle

Open Access
File
AMP-Activated Protein Kinases
Cell Cycle Checkpoints
Null Lymphocytes
Phosphorylation
Calcimycin
23 Citations (Scopus)

AMPK dilates resistance arteries via activation of SERCA and BKCa channels in smooth muscle

Schneider, H., Schubert, K. M., Blodow, S., Kreutz, C-P., Erdogmus, S., Wiedenmann, M., Qiu, J., Fey, T., Ruth, P., Lubomirov, L. T., Pfitzer, G., Mederos y Schnitzler, M., Hardie, D. G., Gudermann, T. & Pohl, U., Jul 2015, In : Hypertension. 66, 1, p. 108-116 9 p.

Research output: Contribution to journalArticle

AMP-Activated Protein Kinases
Smooth Muscle
Arteries
Vascular Smooth Muscle
Smooth Muscle Myocytes
12 Citations (Scopus)

AMPK modulates glucose-sensing in insulin-secreting cells by altered phosphotransfer to KATP channels

Beall, C., Watterson, K. R., McCrimmon, R. J. & Ashford, M. L. J., Jun 2013, In : Journal of Bioenergetics and Biomembranes. 45, 3, p. 229-241 13 p.

Research output: Contribution to journalArticle

KATP Channels
AMP-Activated Protein Kinases
Insulin-Secreting Cells
Glucose
Adenylate Kinase
120 Citations (Scopus)

AMPK promotes p53 acetylation via phosphorylation and inactivation of SIRT1 in liver cancer cells

Lee, C-W., Wong, L. L-Y., Tse, E. Y-T., Liu, H-F., Leong, V. Y-L., Lee, J. M-F., Hardie, D. G., Ng, I. O-L. & Ching, Y-P., 2012, In : Cancer Research. 72, 17, p. 4394-4404 11 p.

Research output: Contribution to journalArticle

AMP-Activated Protein Kinases
Acetylation
Liver Neoplasms
Phosphorylation
Hepatocellular Carcinoma
249 Citations (Scopus)
91 Downloads (Pure)

AMPK-sensing energy while talking to other signaling pathways

Hardie, D. G., 2 Dec 2014, In : Cell Metabolism. 20, 6, p. 939-952 14 p.

Research output: Contribution to journalArticle

Open Access
File
AMP-Activated Protein Kinases
Food
Lysosomes
Eukaryota
Catalytic Domain
108 Citations (Scopus)

AMPKα1: a glucose sensor that controls CD8 T-cell memory

Rolf, J., Zarrouk, M., Finlay, D. K., Foretz, M., Viollet, B. & Cantrell, D. A., Apr 2013, In : European Journal of Immunology. 43, 4, p. 889-896 8 p.

Research output: Contribution to journalArticle

72 Citations (Scopus)

Amplified biochemical oscillations in cellular systems

McKane, A. J., Nagy, J. D., Newman, T. J. & Stefanini, M. O., Jul 2007, In : Journal of Statistical Physics. 128, 1-2, p. 165-191 27 p.

Research output: Contribution to journalArticle

Cellular Systems
Oscillation
oscillations
Amplification
Reaction Kinetics
1 Citation (Scopus)
128 Downloads (Pure)

A Multicellular Model of Intestinal Crypt Buckling and Fission

Almet, A. A., Hughes, B. D., Landman, K. A., Näthke, I. S. & Osborne, J. M., Feb 2018, In : Bulletin of Mathematical Biology. 80, 2, p. 335-359 25 p.

Research output: Contribution to journalArticle

Open Access
File
intestinal crypts
buckling
Buckling
Organoids
Tissue
72 Citations (Scopus)

A multidimensional strategy to detect polypharmacological targets in the absence of structural and sequence homology

Durrant, J. D., Amaro, R. E., Xie, L., Urbaniak, M. D., Ferguson, M. A. J., Haapalainen, A., Chen, Z., Di Guilmi, A. M., Wunder, F., Bourne, P. E. & McCammon, J. A., Jan 2010, In : PLoS Computational Biology. 6, 1, p. - 8 p., e1000648.

Research output: Contribution to journalArticle

2 Citations (Scopus)
92 Downloads (Pure)

A multifaceted approach to identify non-specific enzyme inhibition: Application to Mycobacterium tuberculosis shikimate kinase

Alturki, M. S., Fuanta, N. R., Jarrard, M. A., Hobrath, J. V., Goodwin, D. C., Rants'o, T. A. & Calderón, A. I., 15 Feb 2018, In : Bioorganic and Medicinal Chemistry Letters. 28, 4, p. 802-808 7 p.

Research output: Contribution to journalArticle

Open Access
File
shikimate kinase
Enzyme inhibition
Mycobacterium tuberculosis
Assays
Screening
15 Citations (Scopus)

A Multifunctional Protease Inhibitor To Regulate Endolysosomal Function

van Kasteren, S. I., Berlin, I., Colbert, J. D., Keane, D., Ovaa, H. & Watts, C., Nov 2011, In : ACS Chemical Biology. 6, 11, p. 1198-1204 7 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

A multiprotein binding interface in an intrinsically disordered region of the tumor suppressor protein interferon regulatory factor-1

Narayan, V., Halada, P., Hernychová, L., Chong, Y. P., Žáková, J., Hupp, T. R., Vojtesek, B. & Ball, K. L., 22 Apr 2011, In : Journal of Biological Chemistry. 286, 16, p. 14291-14303 13 p.

Research output: Contribution to journalArticle

Interferon Regulatory Factor-1
Tumor Suppressor Proteins
Peptide Aptamers
Carrier Proteins
Intrinsically Disordered Proteins
40 Citations (Scopus)

A multi-repeat adhesin of the phytopathogen, Pectobacterium atrosepticum, is secreted by a Type I pathway and is subject to complex regulation involving a non-canonical diguanylate cyclase

Perez-Mendoza, D., Coulthurst, S. J., Humphris, S., Campbell, E., Welch, M., Toth, I. K. & Salmond, G. P. C., Nov 2011, In : Molecular Microbiology. 82, 3, p. 719-733 15 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

A mutant O-GlcNAcase as a probe to reveal global dynamics of protein O-GlcNAcylation during Drosophila embryonic development

Mariappa, D., Selvan, N., Borodkin, V. S., Alonso, J., Ferenbach, A. T., Shepherd, C., Navratilova, I. H. & Van Aalten, D. M. F., Sep 2015, In : Biochemical Journal. 470, 2, p. 255-262 8 p.

Research output: Contribution to journalArticle

Drosophila
Embryonic Development
Glycosylation
Threonine
Serine
16 Citations (Scopus)
120 Downloads (Pure)

A mutant O-GlcNAcase enriches Drosophila developmental regulators

Selvan, N., Williamson, R., Mariappa, D., Campbell, D. G., Gourlay, R., Ferenbach, A. T., Aristotelous, T., Hopkins-Navratilova, I., Trost, M. & van Aalten, D. M. F., Aug 2017, In : Nature Chemical Biology. 13, 8, p. 882-887 8 p.

Research output: Contribution to journalArticle

Open Access
File
Drosophila
Embryonic Development
Proteins
Comb and Wattles
Homeobox Genes