School of Life Sciences

  • United Kingdom

Research Output 1968 2020

Article
1 Citation (Scopus)

Ancient barley landraces adapted to marginal soils demonstrate exceptional tolerance to manganese limitation

Schmidt, S. B., George, T. S., Brown, L. K., Booth, A., Wishart, J., Hedley, P. E., Martin, P., Russell, J. & Husted, S., 15 Dec 2018, In : Annals of Botany.

Research output: Contribution to journalArticle

landraces
manganese
barley
soil
grain yield
181 Citations (Scopus)

Ancient class of translocated oomycete effectors targets the host nucleus

Schornack, S., van Damme, M., Bozkurt, T. O., Cano, L. M., Smoker, M., Thines, M., Gaulin, E., Kamoun, S. & Huitema, E., 5 Oct 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 40, p. 17421-17426 6 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)
133 Downloads (Pure)

Ancient eukaryotic origin and evolutionary plasticity of nuclear lamina

Koreny, L. & Field, M. C., 1 Sep 2016, In : Genome Biology and Evolution. 8, 9, p. 2663-2671 9 p.

Research output: Contribution to journalArticle

Open Access
File
Nuclear Lamina
Lamins
nuclear membrane
plasticity
ancestry
248 Citations (Scopus)

Ancient hybridizations among the ancestral genomes of bread wheat

Marcussen, T., Sandve, S. R., Heier, L., Spannagl, M., Pfeifer, M., Jakobsen, K. S., Wulff, B. B. H., Steuernagel, B., Mayer, K. F. X. & Olsen, O-A., 18 Jul 2014, In : Science. 345, 6194, 4 p., 1250092.

Research output: Contribution to journalArticle

Bread
Triticum
Genome
Polyploidy
Diploidy
12 Citations (Scopus)

An effective assay for high cellular resolution time-lapse imaging of sensory placode formation and morphogenesis

Shiau, C. E., Das, R. M. & Storey, K. G., 9 May 2011, In : BMC Neuroscience. 12, p. - 11 p., 37.

Research output: Contribution to journalArticle

47 Citations (Scopus)
Sequence Deletion
Insertional Mutagenesis
Databases
30 Citations (Scopus)

An efficient synthesis of argifin: a natural product chitinase inhibitor with chemotherapeutic potential

Dixon, M. J., Andersen, O. A., van Aalten, D. M. F. & Eggleston, I. M., 1 Nov 2005, In : Bioorganic & Medicinal Chemistry Letters. 15, 21, p. 4717-4721 5 p.

Research output: Contribution to journalArticle

Chitinases
Biological Products
Aspergillus fumigatus
Aspergillus
X-Rays
38 Citations (Scopus)
Chromaffin Cells
GABA-A Receptors
gamma-Aminobutyric Acid
Action Potentials
Acetylcholine
48 Citations (Scopus)
Nodose Ganglion
Inhibitory Concentration 50
Rabbits
Neurons
Baths
75 Citations (Scopus)
HEK293 Cells
Inhibitory Concentration 50
Zinc
Pharmacology
Methysergide
6 Citations (Scopus)

An emerging molecular mechanism for the neural vs mesodermal cell fate decision

Li, R. A. & Storey, K. G., May 2011, In : Cell Research. 21, 5, p. 708-710 3 p.

Research output: Contribution to journalArticle

46 Citations (Scopus)

An endosomal tether undergoes an entropic collapse to bring vesicles together

Murray, D. H., Jahnel, M., Lauer, J., Avellaneda, M. J., Brouilly, N., Cezanne, A., Morales-Navarrete, H., Perini, E. D., Ferguson, C., Lupas, A. N., Kalaidzidis, Y., Parton, R. G., Grill, S. W. & Zerial, M., 24 Aug 2016, In : Nature. 537, 7618, p. 107-111 5 p.

Research output: Contribution to journalArticle

Membrane Fusion
Membranes
rab GTP-Binding Proteins
Optical Tweezers
SNARE Proteins
58 Citations (Scopus)

A neoproterozoic transition in the marine nitrogen cycle

Sánchez-Baracaldo, P., Ridgwell, A. & Raven, J. A., 17 Mar 2014, In : Current Biology. 24, 6, p. 652-657 6 p.

Research output: Contribution to journalArticle

Nitrogen Cycle
Oceans and Seas
nitrogen-fixing cyanobacteria
Nitrogen
oceans
56 Citations (Scopus)
70 Downloads (Pure)

An eQTL analysis of partial resistance to Puccinia hordei in barley

Chen, X., Hackett, C. A., Niks, R. E., Hedley, P. E., Booth, C., Druka, A., Marcel, T. C., Vels, A., Bayer, M., Milne, I., Morris, J., Ramsay, L., Marshall, D., Cardle, L. & Waugh, R., 6 Jan 2010, In : PLoS ONE. 5, 1, e8598.

Research output: Contribution to journalArticle

Open Access
File
Puccinia hordei
Quantitative Trait Loci
Hordeum
quantitative trait loci
Genes
315 Citations (Scopus)

An essential component of a novel bacterial protein export system with homologues in plastids and mitochondria

Bogsch, E. G., Sargent, F., Stanley, N. R., Berks, B. C., Robinson, C. & Palmer, T., 1998, In : Journal of Biological Chemistry. 273, 29, p. 18003-18006 4 p.

Research output: Contribution to journalArticle

Mitochondria
Plastids
Bacterial Proteins
Arginine
Thylakoid Membrane Proteins
15 Citations (Scopus)

An essential role for calmodulin in regulating human T cell aggregation

Fagerholm, S. C., Prescott, A., Cohen, P., Gahmberg, C. G. & Lehto, V-P. (ed.), 28 Feb 2001, In : FEBS Letters. 491, 1-2, p. 131-6 6 p.

Research output: Contribution to journalArticle

Cell Aggregation
T-cells
Calmodulin
Actins
Agglomeration
42 Citations (Scopus)

An essential role for hGle1 nucleocytoplasmic shuttling in mRNA export

Kendirgi, F., Barry, D. M., Griffis, E. R., Powers, M. A. & Wente, S. R., 2003, In : Journal of Cell Biology. 160, 7, p. 1029-40 12 p.

Research output: Contribution to journalArticle

Messenger RNA
HeLa Cells
Nuclear Envelope
Amino Acids
Protein Isoforms
40 Citations (Scopus)

An essential role for the DnaK molecular chaperone in stabilizing over-expressed substrate proteins of the bacterial twin-arginine translocation pathway

Perez-Rodriguez, R., Fisher, A. C., Perlmutter, J. D., Hicks, M. G., Chanal, A., Santini, C-L., Wu, L-F., Palmer, T. & DeLisa, M. P., 2007, In : Journal of Molecular Biology. 367, 3, p. 715-730 16 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

An essential role for the Saccharomyces cerevisiae DEAD-box helicase DHH1 in G1/S DNA-damage checkpoint recovery

Bergkessel, M. & Reese, J. C., 1 May 2004, In : Genetics. 167, 1, p. 21-33 13 p.

Research output: Contribution to journalArticle

DNA Damage
G1 Phase Cell Cycle Checkpoints
Saccharomyces cerevisiae
Cell Cycle
DEAD-box RNA Helicases
55 Citations (Scopus)

Anesthetic activity of novel water-soluble 2β-morpholinyl steroids and their modulatory effects at GABA(A) receptors

Anderson, A., Boyd, A. C., Byford, A., Campbell, A. C., Gemmell, D. K., Hamilton, N. M., Hill, D. R., Hill-Venning, C., Lambert, J. J., Maidment, M. S., May, V., Marshall, R. J., Peters, J. A., Rees, D. C., Stevenson, D. & Sundaram, H., 23 May 1997, In : Journal of Medicinal Chemistry. 40, 11, p. 1668-1681 14 p.

Research output: Contribution to journalArticle

GABA-A Receptors
Anesthetics
Steroids
Water
Pregnanolone
18 Citations (Scopus)

A neural protection racket: AMPK and the GABAB receptor

Hardie, D. G. & Frenguelli, B. G., 18 Jan 2007, In : Neuron. 53, 2, p. 159-162 4 p.

Research output: Contribution to journalArticle

AMP-Activated Protein Kinases
GABA-B Receptors
Neurons
Phosphorylation
Neuroprotection
87 Citations (Scopus)
133 Downloads (Pure)

An evaluation of genotyping by sequencing (GBS) to map the Breviaristatum-e (ari-e) locus in cultivated barley

Liu, H., Bayer, M., Druka, A., Russell, J. R., Hackett, C. A., Poland, J., Ramsay, L., Hedley, P. E. & Waugh, R., 6 Feb 2014, In : BMC Genomics. 15, 11 p., 104.

Research output: Contribution to journalArticle

Open Access
File
Hordeum
Chromosomes
Quantitative Trait Loci
Genes
Population
13 Citations (Scopus)

An evolutionarily conserved, alternatively spliced, intron in the p68/DDX5 DEAD-box RNA helicase gene encodes a novel miRNA

Moore, H. C., Johnston, M., Nicol, S. M., Bourdon, J-C., Thompson, A. M., Hutvagner, G. & Fuller-Pace, F. V., Apr 2011, In : RNA: a Publication of the RNA Society. 17, 4, p. 555-562 8 p.

Research output: Contribution to journalArticle

61 Citations (Scopus)

An evolutionarily conserved pathway controls proteasome homeostasis

Rousseau, A. & Bertolotti, A., 3 Aug 2016, In : Nature. 536, 7615, p. 184-189 6 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Homeostasis
Yeasts
Mitogen-Activated Protein Kinases
Cell Survival
20 Citations (Scopus)

A new Dictyostelium prestalk cell sub-type

Yamada, Y., Kay, R. R., Bloomfield, G., Ross, S., Ivens, A. & Williams, J. G., 15 Mar 2010, In : Developmental Biology. 339, 2, p. 390-397 8 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

A new family of transcription factors

Yamada, Y., Wang, H-Y., Fukuzawa, M., Barton, G. J. & Williams, J. G., 15 Sep 2008, In : Development. 135, 18, p. 3093-3101 9 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

A new kind of membrane-tethered eukaryotic transcription factor that shares an auto-proteolytic processing mechanism with bacteriophage tail-spike proteins

Senoo, H., Araki, T., Fukuzawa, M. & Williams, J. G., 2013, In : Journal of Cell Science. n/a, 133231.

Research output: Contribution to journalArticle

Regulator Genes
Myelin Sheath
Cell Differentiation
Transcription Factors
Dictyostelium
10 Citations (Scopus)

A new lead hydroxycarbonate produced during transformation of lead metal by the soil fungus paecilomyces javanicus

Rhee, Y. J., Hillier, S. & Gadd, G. M., 15 Mar 2016, In : Geomicrobiology Journal. 33, 3-4, p. 250-260 11 p.

Research output: Contribution to journalArticle

Paecilomyces
Fungi
Minerals
Soil
Metals
25 Citations (Scopus)

A new physical interpretation of plant root capacitance

Dietrich, R. C., Bengough, A. G., Jones, H. G. & White, P. J., Oct 2012, In : Journal of Experimental Botany. 63, 17, p. 6149-6159 11 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

A new proteinaceous pathogen-associated molecular pattern (PAMP) identified in Ascomycete fungi induces cell death in Solanaceae

Franco-Orozco, B., Berepiki, A., Ruiz, O., Gamble, L., Griffe, L. L., Wang, S., Birch, P. R. J., Kanyuka, K. & Avrova, A., Jun 2017, In : New Phytologist. 214, 4, p. 1657-1672 16 p.

Research output: Contribution to journalArticle

Solanaceae
Ascomycota
Nicotiana benthamiana
cell death
Fungi
2 Citations (Scopus)

A new protein kinase cascade

Hardie, D. G., Apr 2014, In : Nature Reviews Molecular Cell Biology. 15, 4, p. 223 1 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

A new role for Ran in ensuring precise duplication of chromosomal DNA

Blow, J. J., 2003, In : Cell. 113, 1, p. 2-4 3 p.

Research output: Contribution to journalArticle

Chromosome Duplication
Replication Origin
Monomeric GTP-Binding Proteins
Licensure
Cells
28 Citations (Scopus)

An exceptionally high nucleotide and haplotype diversity and a signature of positive selection for the eIF4E resistance gene in barley are revealed by allele mining and phylogenetic analyses of natural populations

Hofinger, B. J., Russell, J. R., Bass, C. G., Baldwin, T., Dos Reis, M., Hedley, P. E., Li, Y., MacAulay, M., Waugh, R., Hammond-Kosack, K. E. & Kanyuka, K., 24 Aug 2011, In : Molecular Ecology. 20, 17, p. 3653-3668 16 p.

Research output: Contribution to journalArticle

Eukaryotic Initiation Factor-4E
Eukaryotic Initiation Factors
Hordeum
barley
Haplotypes
1 Citation (Scopus)
48 Downloads (Pure)

An Extensively Humanized Mouse Model to Predict Pathways of Drug Disposition and Drug/Drug Interactions, and to Facilitate Design of Clinical Trials

Henderson, C. J., Kapelyukh, Y., Scheer, N., Rode, A., McLaren, A., MacLeod, K., Lin, D., Wright, J., Stanley, L. A. & Wolf, C. R., Jun 2019, In : Drug Metabolism and Disposition. 47, 6, p. 601-615 15 p.

Research output: Contribution to journalArticle

Open Access
File
Drug Interactions
Clinical Trials
Pharmaceutical Preparations
Pharmacokinetics
Cytochrome P-450 CYP3A
86 Citations (Scopus)

A next-generation dual-recombinase system for time- and host-specific targeting of pancreatic cancer

Schönhuber, N., Seidler, B., Schuck, K., Veltkamp, C., Schachtler, C., Zukowska, M., Eser, S., Feyerabend, T. B., Paul, M. C., Eser, P., Klein, S., Lowy, A. M., Banerjee, R., Yang, F., Lee, C-L., Moding, E. J., Kirsch, D. G., Scheideler, A., Alessi, D. R., Varela, I. & 8 others, Bradley, A., Kind, A., Schnieke, A. E., Rodewald, H-R., Rad, R., Schmid, R. M., Schneider, G. & Saur, D., Nov 2014, In : Nature Medicine. 20, 11, p. 1340-1347 8 p.

Research output: Contribution to journalArticle

Recombinases
Pancreatic Neoplasms
Tumors
Neoplasms
Tumor Microenvironment
70 Citations (Scopus)

An extreme cytoplasmic bottleneck in the modern European cultivated potato (Solanum tuberosum) is not reflected in decreased levels of nuclear diversity

Provan, J., Powell, W., Dewar, H., Bryan, G., Machray, G. C. & Waugh, R., 22 Mar 1999, In : Proceedings of the Royal Society B: Biological Sciences. 266, 1419, p. 633-639 7 p.

Research output: Contribution to journalArticle

Solanum tuberosum
potato
Microsatellite Repeats
cytoplasm
Genes
9 Citations (Scopus)

Angiogenesis is repressed by ethanol exposure during chick embryonic development

Wang, G., Zhong, S., Zhang, S., Ma, Z., Chen, J., Lu, W., Cheng, X., Chuai, M., Lee, K. K. H., Lu, D. & Yang, X., May 2016, In : Journal of Applied Toxicology. 36, 5, p. 692-701

Research output: Contribution to journalArticle

67 Citations (Scopus)

An hnRNP-like RNA-binding protein affects alternative splicing by in vivo interaction with transcripts in Arabidopsis thaliana

Streitner, C., Köster, T., Simpson, C. G., Shaw, P., Danisman, S., Brown, J. W. S. & Staiger, D., Dec 2012, In : Nucleic Acids Research. 40, 22, p. 11240-11255 16 p.

Research output: Contribution to journalArticle

Heterogeneous-Nuclear Ribonucleoproteins
RNA-Binding Proteins
Alternative Splicing
Arabidopsis
RNA Splice Sites
24 Citations (Scopus)
138 Downloads (Pure)

ANIA: ANnotation and Integrated Analysis of the 14-3-3 interactome

Tinti, M., Madeira, F., Murugesan, G., Hoxhaj, G., Toth, R. & Mackintosh, C., 2014, In : Database: the Journal of Biological Databases and Curation. 2014, 15 p., bat085.

Research output: Contribution to journalArticle

Open Access
File
Docks
Phosphoproteins
Phorbol Esters
Proteins
phosphoproteins
4 Citations (Scopus)

An immunocytochemical study of the carbonic anhydrase I isoenzyme in human oral Merkel cells

Christie, K. N., Thomson, C., Hopwood, D., Harper, A. A. & Ogden, G. R., 1996, In : Archives of Oral Biology. 41, 8-9, p. 901-904 4 p.

Research output: Contribution to journalArticle

Carbonic Anhydrase I
Merkel Cells
Isoenzymes
Hard Palate
Mouth Mucosa
5 Citations (Scopus)
302 Downloads (Pure)
Open Access
File
NFI Transcription Factors
Inflammation
Endothelium
Cardiovascular Diseases
Cholesterol
2 Citations (Scopus)
129 Downloads (Pure)

An improved model of the Trypanosoma brucei CTP synthetase glutaminase domain-acivicin complex

de Souza, J. O., Dawson, A. & Hunter, W. N., 20 Apr 2017, In : ChemMedChem. 12, 8, p. 577-579 3 p.

Research output: Contribution to journalArticle

Open Access
File
CTP synthetase
acivicin
Glutaminase
Trypanosoma brucei brucei
Neglected Diseases
33 Citations (Scopus)
85 Downloads (Pure)

An inducible chaperone adapts proteasome assembly to stress

Hanssum, A., Zhong, Z., Rousseau, A., Krzyzosiak, A., Sigurdardottir, A. & Bertolotti, A., 21 Aug 2014, In : Molecular Cell. 55, 4, p. 566-577 12 p.

Research output: Contribution to journalArticle

Open Access
File
Proteasome Endopeptidase Complex
Adenosine Triphosphatases
Proteins
Yeasts
1 Citation (Scopus)
42 Downloads (Pure)

An influenza virus-triggered SUMO switch orchestrates co-opted endogenous retroviruses to stimulate host antiviral immunity

Schmidt, N., Domingues, P., Golebiowski, F., Patzina, C., Tatham, M. H., Hay, R. T. & Hale, B. G., 27 Aug 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 35, p. 17399-17408 10 p.

Research output: Contribution to journalArticle

Open Access
File
Endogenous Retroviruses
Ubiquitin
Orthomyxoviridae
Antiviral Agents
Immunity
29 Citations (Scopus)

An intranucleolar body associated with rDNA

Hutten, S., Prescott, A., James, J., Riesenberg, S., Boulon, S., Lam, Y. W. & Lamond, A. I., Oct 2011, In : Chromosoma. 120, 5, p. 481-499 19 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)
69 Downloads (Pure)

An investigation of causes of false positive single nucleotide polymorphisms using simulated reads from a small eukaryote genome

Ribeiro, A., Golicz, A., Hackett, C. A., Milne, I., Stephen, G., Marshall, D., Flavell, A. J. & Bayer, M., 11 Nov 2015, In : BMC Bioinformatics. 16, 1, p. 1-16 16 p., 382.

Research output: Contribution to journalArticle

Open Access
File
Single nucleotide Polymorphism
Nucleotides
Eukaryota
Polymorphism
False Positive
3 Citations (Scopus)
124 Downloads (Pure)

An NMRA-like protein regulates gene expression in Phytophthora capsici to drive the infection cycle on tomato

Pham, J., Stam, R., Heredia, V. M., Csukai, M. & Huitema, E., Jun 2018, In : Molecular Plant - Microbe Interactions. 31, 6, p. 665-677 13 p.

Research output: Contribution to journalArticle

Open Access
File
Phytophthora
Phytophthora capsici
Lycopersicon esculentum
tomatoes
Gene Expression
11 Citations (Scopus)

An N-Myc truncation analogous to c-Myc-S induces cell proliferation independently of transactivation but dependent on Myc homology box II

Cowling, V. H. & Cole, M. D., 21 Feb 2008, In : Oncogene. 27, 9, p. 1327-1332 6 p.

Research output: Contribution to journalArticle

Proto-Oncogene Proteins c-myc
myc Genes
Codon
Transcriptional Activation
Fibroblasts
19 Citations (Scopus)

An off-line implementation of the stable isotope technique for measurements of alternative respiratory pathway activities

Nagel, O. W., Waldron, S. & Jones, H., Nov 2001, In : Plant Physiology. 127, 3, p. 1279-1286 8 p.

Research output: Contribution to journalArticle