School of Life Sciences

  • United Kingdom

Research Output 1968 2020

Article
3 Citations (Scopus)
139 Downloads (Pure)

An Oncogenic Role for the Ubiquitin Ligase UBE2O by Targeting AMPK-α2 for Degradation

Hardie, D. G., 13 Feb 2017, In : Cancer Cell. 31, 2, p. 163-165 3 p.

Research output: Contribution to journalArticle

Open Access
File
AMP-Activated Protein Kinases
Ligases
Ubiquitin
Neoplasms
Ubiquitination
206 Citations (Scopus)

A non-hypoxic, ROS-sensitive pathway mediates TNF-α-dependent regulation of HIF-1α

Haddad, J. J. & Land, S. C., 14 Sep 2001, In : FEBS Letters. 505, 2, p. 269-274 6 p.

Research output: Contribution to journalArticle

Hypoxia-Inducible Factor 1
Reactive Oxygen Species
Tumor Necrosis Factor-alpha
Chemical activation
Mitochondria
33 Citations (Scopus)

A non-radioactive method for the assay of many serine/threonine-specific protein kinases

Ross, H., Armstrong, C. G. & Cohen, P., 15 Sep 2002, In : Biochemical Journal. 366, 3, p. 977-981 5 p.

Research output: Contribution to journalArticle

Protein-Serine-Threonine Kinases
Threonine
Protein Kinases
Serine
Assays
29 Citations (Scopus)

An ontology for description of drug discovery investigations

Qi, D., King, R. D., Hopkins, A. L., Bickerton, G. R. J. & Soldatova, L. N., 2010, In : Journal of Integrative Bioinformatics. 7, 3, 13 p., 126.

Research output: Contribution to journalArticle

Drug Discovery
Industry
Referral and Consultation
Vaccines
Research
7 Citations (Scopus)
77 Downloads (Pure)

An optimized method for the extraction of bacterial mRNA from plant roots infected with Escherichia coli O157:H7

Holmes, A., Birse, L., Jackson, R. W. & Holden, N. J., 10 Jun 2014, In : Frontiers in Microbiology. 5, 7 p., 286.

Research output: Contribution to journalArticle

Open Access
File
Plant Roots
Escherichia coli O157
Messenger RNA
Bacterial RNA
Microbial Genes
21 Citations (Scopus)

Anorexigenic and orexigenic hormone modulation of mammalian target of rapamycin complex 1 activity and the regulation of hypothalamic agouti-related protein mRNA expression

Watterson, K. R., Bestow, D., Gallagher, J., Hamilton, D. L., Ashford, F. B., Meakin, P. J. & Ashford, M. L. J., Feb 2013, In : NeuroSignals. 21, 1-2, p. 28-41 14 p.

Research output: Contribution to journalArticle

Agouti-Related Protein
Sirolimus
Hormones
Messenger RNA
AMP-Activated Protein Kinases
46 Citations (Scopus)

A normalised scale for structural genomics target ranking: the OB-Score

Overton, I. M. & Barton, G. J., 10 Jul 2006, In : FEBS Letters. 580, 16, p. 4005-4009 5 p.

Research output: Contribution to journalArticle

Isoelectric Point
Hydrophobicity
Genomics
Hydrophobic and Hydrophilic Interactions
Diffraction
18 Citations (Scopus)

An orphan chemotaxis sensor regulates virulence and antibiotic tolerance in the human pathogen pseudomonas aeruginosa

McLaughlin, H. P., Caly, D. L., McCarthy, Y., Ryan, R. P. & Dow, J. M., 1 Aug 2012, In : PLoS ONE. 7, 8, 10 p., e42205.

Research output: Contribution to journalArticle

Orphaned Children
chemotaxis
Pathogens
Chemotaxis
Pseudomonas aeruginosa
15 Citations (Scopus)

An orthologue of the Myelin-gene regulatory transcription factor regulates Dictyostelium prestalk differentiation

Senoo, H., Fukuzawa, M., Wang, H-Y., Araki, T. & Williams, J. G., 1 Jan 2012, In : International Journal of Developmental Biology. 56, 5, p. 325-332 8 p.

Research output: Contribution to journalArticle

Dictyostelium
Regulator Genes
Myelin Sheath
Transcription Factors
DNA Mutational Analysis
2 Citations (Scopus)
133 Downloads (Pure)

A novel, de novo mutation in PRKAG2 gene: infantile-onset phenotype and signaling pathway involved

Xu, Y., Gray, A., Hardie, D. G., Uzun, A., Shaw, S., Padbury, J., Phornphutkul, C. & Tseng, Y-T., 1 Aug 2017, In : American Journal of Physiology: Heart and Circulatory Physiology. 313, 2, p. H283-H292 10 p.

Research output: Contribution to journalArticle

Open Access
File
Phenotype
Mutation
AMP-Activated Protein Kinases
Genes
Hypertrophic Cardiomyopathy
9 Citations (Scopus)

A novel aerobic mechanism for reductive palladium biomineralization and recovery by escherichia coli

Foulkes, J. M., Deplanche, K., Sargent, F., Macaskie, L. E. & Lloyd, J. R., 15 Mar 2016, In : Geomicrobiology Journal. 33, 3-4, p. 230-236 7 p.

Research output: Contribution to journalArticle

Open Access
Biomineralization
biomineralization
palladium
Palladium
Escherichia coli
13 Citations (Scopus)

A novel allosteric inhibitor of the uridine diphosphate N-acetylglucosamine pyrophosphorylase from Trypanosoma brucei

Urbaniak, M. D., Collie, I. T., Fang, W., Aristotelous, T., Eskilsson, S., Raimi, O. G., Harrison, J., Navratilova, I. H., Frearson, J. A., van Aalten, D. M. F. & Ferguson, M. A. J., 20 Sep 2013, In : ACS Chemical Biology. 8, 9, p. 1981-1987 7 p.

Research output: Contribution to journalArticle

Uridine Diphosphate N-Acetylglucosamine
Trypanosoma brucei brucei
Uridine Triphosphate
Allosteric Site
Enzyme kinetics
12 Citations (Scopus)

A novel approach to the visualisation of heat-induced structural change in bone

Thompson, T. J. U. & Chudek, S., 2007, In : Science & Justice. 47, 2, p. 99-104 6 p.

Research output: Contribution to journalArticle

Hot Temperature
Bone and Bones
Forensic Anthropology
Magnetic Resonance Imaging
111 Citations (Scopus)

A novel biomonitoring system using microbial fuel cells

Kim, M., Hyun, M. S., Gadd, G. M. & Kim, H. J., 2007, In : Journal of Environmental Monitoring. 9, 12, p. 1323-1328 6 p.

Research output: Contribution to journalArticle

97 Citations (Scopus)

A novel class of ligand-gated ion channel is activated by Zn2+

Davies, P. A., Wang, W., Hales, T. G. & Kirkness, E. F., 10 Jan 2003, In : Journal of Biological Chemistry. 278, 2, p. 712-717 6 p.

Research output: Contribution to journalArticle

Ligand-Gated Ion Channels
Rats
Exons
Complementary DNA
Genes
10 Citations (Scopus)

A novel cleavage site within the potato leafroll virus P1 polyprotein

Li, X., Halpin, C. & Ryan, M. D., May 2007, In : Journal of General Virology. 88, 5, p. 1620-1623 4 p.

Research output: Contribution to journalArticle

Polyproteins
Serine Proteases
Solanum tuberosum
Peptide Hydrolases
Viruses
241 Citations (Scopus)

A novel domain in AMP-activated protein kinase causes glycogen storage bodies similar to those seen in hereditary cardiac arrhythmias

Hudson, E. R., Pan, D. A., James, J., Lucocq, J. M., Hawley, S. A., Green, K. A., Baba, O., Terashima, T. & Hardie, D. G., 2003, In : Current Biology. 13, 10, p. 861-866 6 p.

Research output: Contribution to journalArticle

AMP-activated protein kinase
AMP-Activated Protein Kinases
arrhythmia
Glycogen
glycogen
157 Citations (Scopus)

A novel fatty Acyl-CoA Synthetase is required for pollen development and sporopollenin biosynthesis in Arabidopsis

de Azevedo Souza, C., Kim, S. S., Koch, S., Kienow, L., Schneider, K., McKim, S. M., Haughn, G. W., Kombrink, E. & Douglas, C. J., 20 Mar 2009, In : Plant Cell. 21, 2, p. 507-25 19 p.

Research output: Contribution to journalArticle

long-chain-fatty-acid-CoA ligase
Coenzyme A Ligases
Acyl Coenzyme A
Pollen
Arabidopsis
17 Citations (Scopus)

A novel glycosylphosphatidylinositol in African trypanosomes: a possible catabolic intermediate

Milne, K. G., Ferguson, M. A. J. & Englund, P. T., 15 Jan 1999, In : Journal of Biological Chemistry. 274, 3, p. 1465-1471 7 p.

Research output: Contribution to journalArticle

1436 Citations (Scopus)

A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins

Rouse, J., Cohen, P., Trigon, S., Morange, M., Alonso-Llamazares, A., Zamanillo, D., Hunt, T. & Nebreda, A. R., 23 Sep 1994, In : Cell. 78, 6, p. 1027-1037 11 p.

Research output: Contribution to journalArticle

Small Heat-Shock Proteins
Phosphorylation
Protein Kinases
Shock
Phosphotransferases
87 Citations (Scopus)

A novel leptin signalling pathway via PTEN inhibition in hypothalamic cell lines and pancreatic β-cells

Ning, K., Miller, L. C., Laidlaw, H. A., Burgess, L. A., Perera, N. M., Downes, C. P., Leslie, N. R. & Ashford, M. L. J., Jun 2006, In : The EMBO Journal. 25, 11, p. 2377-2387 11 p.

Research output: Contribution to journalArticle

Leptin
Cells
Cell Line
Depolymerization
PTEN Phosphohydrolase
16 Citations (Scopus)
141 Downloads (Pure)

A novel marker, ARM58, confers antimony resistance to Leishmania spp

Nuhs, A., Schäfer, C., Zander, D., Trübe, L., Tejera Nevado, P., Schmidt, S., Arevalo, J., Adaui, V., Maes, L., Dujardin, J-C. & Clos, J., Apr 2014, In : International Journal for Parasitology: Drugs and Drug Resistance. 4, 1, p. 37-47 11 p.

Research output: Contribution to journalArticle

Open Access
File
Antimony
Leishmania
Leishmania braziliensis
Organism Cloning
Genes
160 Citations (Scopus)

A novel multiple-stage antimalarial agent that inhibits protein synthesis

Baragana, B., Hallyburton, I., Lee, M. C. S., Norcross, N. R., Grimaldi, R., Otto, T. D., Proto, W. R., Blagborough, A. M., Meister, S., Wirjanata, G., Ruecker, A., Upton, L. M., Abraham, T. S., Almeida, M. J., Pradhan, A., Porzelle, A., Santos Martinez, M., Bolscher, J. M., Woodland, A., Luksch, T. & 44 others, Norval, S., Zuccotto, F., Thomas, J., Simeons, F., Stojanovski, L., Osuna-Cabello, M., Brock, P. M., Churcher, T. S., Sala, K. A., Zakutansky, S. E., Belén Jiménez-Díaz, M., Maria Sanz, L., Riley, J., Basak, R., Campbell, M., Avery, V. M., Sauerwein, R. W., Dechering, K. J., Noviyanti, R., Campo, B., Frearson, J. A., Angulo-Barturen, I., Ferrer-Bazaga, S., Javier Gamo, F., Wyatt, P. G., Leroy, D., Siegl, P., Delves, M. J., Kyle, D. E., Wittlin, S., Marfurt, J., Price, R. N., Sinden, R. E., Winzeler, E. A., Charman, S. A., Bebrevska, L., Gray, D. W., Campbell, S., Fairlamb, A. H., Willis, P. A., Rayner, J. C., Fidock, D. A., Read, K. D. & Gilbert, I. H., 18 Jun 2015, In : Nature. 522, 7556, p. 315-320 6 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

A novel non-protein-coding infection-specific gene family is clustered throughout the genome of Phytophthora infestans

Avrova, A. O., Whisson, S. C., Pritchard, L., Venter, E., De Luca, S., Hein, I. & Birch, P. R. J., 1 Mar 2007, In : Microbiology. 153, Pt 3, p. 747-759 13 p.

Research output: Contribution to journalArticle

Phytophthora infestans
Genome
Infection
Complementary DNA
Genes
19 Citations (Scopus)

A novel phospholipase from Trypanosoma brucei

Richmond, G. S. & Smith, T. K., Feb 2007, In : Molecular Microbiology. 63, 4, p. 1078-95 18 p.

Research output: Contribution to journalArticle

Trypanosoma brucei brucei
Phospholipases
Phospholipases A
Tsetse Flies
Horizontal Gene Transfer
48 Citations (Scopus)

A novel Phytophthora infestans haustorium-specific membrane protein is required for infection of potato

Avrova, A. O., Boevink, P. C., Young, V., Grenville-Briggs, L. J., van West, P., Birch, P. R. J. & Whisson, S. C., Nov 2008, In : Cellular Microbiology. 10, 11, p. 2271-2284 14 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

A novel protein extracted from foxtail millet bran displays anti-carcinogenic effects in human colon cancer cells

Shan, S., Li, Z., Newton, I. P., Zhao, C., Li, Z. & Guo, M., Jun 2014, In : Toxicology Letters. 227, 2, p. 129-138 10 p.

Research output: Contribution to journalArticle

Setaria Plant
Anticarcinogenic Agents
Colonic Neoplasms
Tumors
Cells
36 Citations (Scopus)

A novel protein transport system involved in the biogenesis of bacterial electron transfer chains

Berks, B. C., Sargent, F., De Leeuw, E., Hinsley, A. P., Stanley, N. R., Jack, R. L., Buchanan, G. & Palmer, T., 2000, In : Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1459, 2-3, p. 325-30 6 p.

Research output: Contribution to journalArticle

Protein Transport
Electrons
Biological membranes
Bacterial Proteins
Membranes
23 Citations (Scopus)

A novel regulation of IRS1 (insulin receptor substrate-1) expression following short term insulin administration

Ruiz-Alcaraz, A. J., Liu, H-K., Cuthbertson, D. J., McManus, E. J., Akhtar, S., Lipina, C., Morris, A. D., Petrie, J. R., Hundal, H. S. & Sutherland, C., 1 Dec 2005, In : Biochemical Journal. 392, p. 345-352 8 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

A novel reporter of notch signalling indicates regulated and random notch activation during vertebrate neurogenesis

Vilas-Boas, F., Fior, R., Swedlow, J. R., Storey, K. G. & Henrique, D., 31 Aug 2011, In : BMC Molecular Biology. 9, p. - 16 p., 58.

Research output: Contribution to journalArticle

23 Citations (Scopus)

A novel role for the yeast protein kinase Dbf2p in vacuolar H+-ATPase function and sorbic acid stress tolerance

Makrantoni, V., Dennison, P., Stark, M. J. R. & Coote, P. J., Dec 2007, In : Microbiology. 153, p. 4016-4026 11 p.

Research output: Contribution to journalArticle

58 Citations (Scopus)

A novel short splice variant of the tumour suppressor LKB1 is required for spermiogenesis

Towler, M. C., Fogarty, S., Hawley, S. A., Pan, D. A., Martin, D. M. A., Morrice, N. A., McCarthy, A., Galardo, M. N., Meroni, S. B., Cigorraga, S. B., Ashworth, A., Sakamoto, K. & Hardie, D. G., 15 Nov 2008, In : Biochemical Journal. 416, 1, p. 1-14 14 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)

A novel site of AKT-mediated phosphorylation in the human MDM2 onco-protein

Milne, D., Kampanis, P., Nicol, S., Dias, S., Campbell, D. G., Fuller-Pace, F. & Meek, D., 5 Nov 2004, In : FEBS Letters. 577, 1-2, p. 270-276 7 p.

Research output: Contribution to journalArticle

Phosphorylation
Tumor Suppressor Protein p53
Ubiquitin-Protein Ligases
Ubiquitination
Proteasome Endopeptidase Complex
50 Citations (Scopus)

A novel TBP-associated factor of SL1 functions in RNA polymerase I transcription

Gorski, J. J., Pathak, S., Panov, K., Kasciukovic, T., Panova, T., Russell, J. & Zomerdijk, J. C. B. M., Mar 2007, In : The EMBO Journal. 26, 6, p. 1560-1568 9 p.

Research output: Contribution to journalArticle

TATA-Binding Protein Associated Factors
RNA Polymerase I
Transcription
Ribosomal DNA
RNA Precursors
54 Citations (Scopus)

A novel thermostable endoglucanase from the wood-decaying fungus Daldinia eschschokii (Ehrenb.: Fr.) Rehm

Karnchanatat, A., Petsom, A., Angvanich, P. S., PiapukieW, J., Whalley, A. J. S., Reynoldsc, C. D., Gadd, G. M. & Sihanonth, P., 4 Apr 2008, In : Enzyme and Microbial Technology. 42, 5, p. 404-413 10 p.

Research output: Contribution to journalArticle

47 Citations (Scopus)

A novel 'two-component' protein containing histidine kinase and response regulator domains required for sporulation in Aspergillus nidulans

Appleyard, M. V. C. L., McPheat, W. L. & Stark, M. J. R., 2000, In : Current Genetics. 37, 6, p. 364-372 9 p.

Research output: Contribution to journalArticle

50 Citations (Scopus)

A novel UBA and UBX domain protein that binds polyubiquitin and VCP and is a substrate for SAPKs

McNeill, H., Knebel, A., Arthur, J. S. C., Cuenda, A. & Cohen, P., 1 Dec 2004, In : Biochemical Journal. 384, Pt 2, p. 391-400 10 p.

Research output: Contribution to journalArticle

Polyubiquitin
Mitogen-Activated Protein Kinase 13
Ubiquitin
Heat-Shock Proteins
Protein Kinases
116 Citations (Scopus)

A novel zinc-regulated human zinc transporter, hZTL1, is localized to the enterocyte apical membrane

Cragg, R. A., Christie, G. R., Phillips, S. R., Russi, R. M., Kury, S., Mathers, J. C., Taylor, P. M. & Ford, D., 21 Jun 2002, In : Journal of Biological Chemistry. 277, 25, p. 22789-22797 9 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)
173 Downloads (Pure)
Open Access
File
plant protection
plant pathogens
gene targeting
plant pests
genome
72 Citations (Scopus)

Anoxia-tolerant hepatocytes: Model system for study of reversible metabolic suppression

Buck, L. T., Land, S. C. & Hochachka, P. W., 1 Jul 1993, In : American Journal of Physiology: Regulatory Integrative and Comparative Physiology. 265, 1 , p. R49-R56 8 p.

Research output: Contribution to journalArticle

Hepatocytes
Adenosine Triphosphate
Trypan Blue
Lactic Acid
Staining and Labeling
97 Citations (Scopus)

An RxLR Effector from Phytophthora infestans Prevents Re-localisation of Two Plant NAC Transcription Factors from the Endoplasmic Reticulum to the Nucleus

McLellan, H., Boevink, P., Armstrong, M., Pritchard, L., Gomez, S., Morales, J., Whisson, S. & Birch, P. R. J., 10 Oct 2013, In : PLoS Pathogens. 9, 10, e1003670.

Research output: Contribution to journalArticle

Phytophthora infestans
Endoplasmic Reticulum
Transcription Factors
Phytophthora
Virulence
49 Citations (Scopus)

Antagonistic action of Six3 and Prox1 at the γ-crystallin promoter

Lengler, J., Krausz, E., Tomarev, S., Prescott, A., Quinlan, R. A. & Graw, J., 15 Jan 2001, In : Nucleic Acids Research. 29, 2, p. 515-526 12 p.

Research output: Contribution to journalArticle

Crystallins
Lenses
Cell Line
Crystalline Lens
Transfection
8 Citations (Scopus)

Antagonistic crosstalk between APC and HIF-1 alpha

Nathke, I. & Rocha, S., 15 May 2011, In : Cell Cycle. 10, 10, p. 1545-1547 3 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)
104 Downloads (Pure)

Antagonistic interaction of BLADE-ON-PETIOLE1 and 2 with BREVIPEDICELLUS and PENNYWISE regulates Arabidopsis inflorescence architecture

Khan, M., Xu, M., Murmu, J., Tabb, P., Liu, Y., Storey, K., McKim, S. M., Douglas, C. J. & Hepworth, S. R., 23 Nov 2011, In : Plant Physiology. 158, 2, p. 946-60 15 p.

Research output: Contribution to journalArticle

Open Access
File
Inflorescence
Arabidopsis
inflorescences
pedicel
internodes
12 Citations (Scopus)
119 Downloads (Pure)

Antibody-mediated enhancement aggravates chikungunya virus infection and disease severity

Lum, F-M., Couderc, T., Chia, B-S., Ong, R-Y., Her, Z., Chow, A., Leo, Y-S., Kam, Y-W., Rénia, L., Lecuit, M. & Ng, L. F. P., 30 Jan 2018, In : Scientific Reports. 8, 1, p. 1-14 14 p., 1860.

Research output: Contribution to journalArticle

Open Access
File
Chikungunya virus
Virus Diseases
Antibodies
Viral RNA
Viral Load
19 Citations (Scopus)

Antifungal therapy in European hospitals: data from the ESAC point-prevalence surveys 2008 and 2009

ESAC-3 Hosp Care Subproject Grp, Oct 2012, In : Clinical Microbiology and Infection. 18, 10, p. E389-E395 7 p.

Research output: Contribution to journalArticle

Fluconazole
caspofungin
Immunocompromised Host
Cross Infection
Quality Improvement
36 Citations (Scopus)

Antigen endocytosis and presentation mediated by human membrane IgG1 in the absence of the IgA/Igβ dimer

Knight, A. M., Lucocq, J. M., Prescott, A. R., Ponnambalam, S. & Watts, C., 1 Jul 1997, In : EMBO Journal. 16, 13, p. 3842-3850 9 p.

Research output: Contribution to journalArticle

Antigen Presentation
Endocytosis
Dimers
Immunoglobulin A
Immunoglobulin G
30 Citations (Scopus)

Antigenic variation in African trypanosomes: the importance of chromosomal and nuclear context in VSG expression control

Glover, L., Hutchinson, S., Alsford, S., McCulloch, R., Field, M. C. & Horn, D., Dec 2013, In : Cellular Microbiology. 15, 12, p. 1984-1993 10 p.

Research output: Contribution to journalArticle

Antigenic Variation
Trypanosomiasis
Membrane Glycoproteins
Telomere
Genetic Recombination
110 Citations (Scopus)
91 Downloads (Pure)

Antigenic variation in African trypanosomes

Horn, D., Jul 2014, In : Molecular and Biochemical Parasitology. 195, 2, p. 123-129 7 p.

Research output: Contribution to journalArticle

Open Access
File
Antigenic Variation
Trypanosomiasis
Membrane Glycoproteins
Trypanosoma brucei brucei
Eukaryota
48 Citations (Scopus)

Antigenic variation in Trypanosoma brucei: a telomeric expression site for variant-specific surface glycoprotein genes with novel features

Zomerdijk, J. C. B. M., Kieft, R., Duyndam, M., Shiels, P. G. & Borst, P., 1991, In : Nucleic Acids Research. 19, 7, p. 1359-1368 10 p.

Research output: Contribution to journalArticle