School of Life Sciences

  • United Kingdom

Research Output 1968 2020

Article
8 Citations (Scopus)
69 Downloads (Pure)

Antigen receptor control of methionine metabolism in T cells

Sinclair, L. V., Howden, A., Brenes Murillo, A., Spinelli, L., Hukelmann, J., Macintyre, A. N., Liu, X., Thomson, S., Taylor, P., Rathmell, J. C., Locasale, J. W., Lamond, A. & Cantrell, D. A., 27 Mar 2019, In : eLife. 8, 29 p., e44210.

Research output: Contribution to journalArticle

Open Access
File
Antigen Receptors
T-cells
Metabolism
Methionine
T-Lymphocytes
4 Citations (Scopus)

Antimicrobial Prescribing in Hospitalized Adults Stratified by Age Data from the ESAC Point-Prevalence Surveys

Zarb, P., Amadeo, B., Muller, A., Drapier, N., Vankerckhoven, V., Davey, P., Goossens, H. & ESAC-3 Hosp Care Subproject Grp, 2012, In : Drugs & Aging. 29, 1, p. 53-62 10 p.

Research output: Contribution to journalArticle

223 Citations (Scopus)

Antioxidant/Pro-oxidant Equilibrium Regulates HIF-1a and NF-kB Redox Sensitivity: EVIDENCE FOR INHIBITION BY GLUTATHIONE OXIDATION IN ALVEOLAR EPITHELIAL CELLS

Haddad, J. J. E., Olver, R. E. & Land, S. C., 14 Jul 2000, In : Journal of Biological Chemistry. 275, 28, p. 21130-21139 10 p.

Research output: Contribution to journalArticle

Alveolar Epithelial Cells
Glutathione Disulfide
NF-kappa B
Oxidation-Reduction
Glutathione
52 Citations (Scopus)

Antioxidant capacity, total phenolic and ascorbate content as a function of the genetic diversity of leek (Allium ampeloprasum var. porrum)

Bernaert, N., De Paepe, D., Bouten, C., De Clercq, H., Stewart, D., Van Bockstaele, E., De Loose, M. & Van Droogenbroeck, B., 15 Sep 2012, In : Food Chemistry. 134, 2, p. 669-677 9 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
33 Downloads (Pure)

Antioxidant Rich Potato Improves Arterial Stiffness in Healthy Adults

Tsang, C., Smail, N. F., Almoosawi, S., McDougall, G. J. M. & Al-Dujaili, E. A. S., Sep 2018, In : Plant Foods for Human Nutrition. 73, 3, p. 203-208 6 p.

Research output: Contribution to journalArticle

Open Access
File
Vascular Stiffness
Anthocyanins
Solanum tuberosum
Pulse Wave Analysis
anthocyanins
34 Citations (Scopus)

Antiparasitic chemotherapy: from genomes to mechanisms

Horn, D. & Duraisingh, M. T., Jan 2014, In : Annual Review of Pharmacology and Toxicology. 54, p. 71-94 24 p.

Research output: Contribution to journalArticle

Antiparasitic Agents
Chemotherapy
Genes
Genome
Drug Therapy
26 Citations (Scopus)

Antiplasmodial activity of a series of 1,3,5-triazine-substituted polyamines

Klenke, B., Barrett, M. P., Brun, R. & Gilbert, I. H., Aug 2003, In : Journal of Antimicrobial Chemotherapy. 52, 2, p. 290-293 4 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
115 Downloads (Pure)

Anti-trypanosomal 8-hydroxyl naphthyridines are chelators of divalent transition metals

Wall, R. J., Moniz, S., Thomas, M., Norval, S., Ko, E. J., Marco, M., Miles, T. J., Gilbert, I., Horn, D., Fairlamb, A. & Wyllie, S., Aug 2018, In : Antimicrobial Agents and Chemotherapy. 62, 8, p. 1-15 15 p., e00235-18.

Research output: Contribution to journalArticle

Open Access
File
Naphthyridines
Chelating Agents
Hydroxyl Radical
Metals
Trypanosoma brucei brucei
3 Citations (Scopus)
42 Downloads (Pure)

Antitrypanosomatid Pharmacomodulation at Position 3 of the 8-Nitroquinolin-2(1H)-one Scaffold Using Palladium-Catalysed Cross-Coupling Reactions

Pedron, J., Boudot, C., Bourgeade-Delmas, S., Sournia-Saquet, A., Paloque, L., Rastegari, M., Abdoulaye, M., El-Kashef, H., Bonduelle, C., Pratviel, G., Wyllie, S., Fairlamb, A. H., Courtioux, B., Verhaeghe, P. & Valentin, A., 22 Oct 2018, In : ChemMedChem. 13, 20, p. 2217-2228 12 p.

Research output: Contribution to journalArticle

Open Access
File
Nitroquinolines
Cross Reactions
Palladium
Scaffolds
Nitroreductases
23 Citations (Scopus)

Antitumor Quinol PMX464 Is a Cytocidal Anti-trypanosomal Inhibitor Targeting Trypanothione Metabolism

Konig, J., Wyllie, S., Wells, G., Stevens, M. F., Wyatt, P. G. & Fairlamb, A. H., 11 Mar 2011, In : Journal of Biological Chemistry. 286, 10, p. 8523-8533 11 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

An ultra-high density genetic linkage map of perennial ryegrass (Lolium perenne) using genotyping by sequencing (GBS) based on a reference shotgun genome assembly

Velmurugan, J., Mollison, E., Barth, S., Marshall, D., Milne, L., Creevey, C. J., Lynch, B., Meally, H., McCabe, M. & Milbourne, D., 1 Jul 2016, In : Annals of Botany. 118, 1, p. 71-87 17 p.

Research output: Contribution to journalArticle

genome assembly
Lolium perenne
genotyping
chromosome mapping
genome
43 Citations (Scopus)
126 Downloads (Pure)

An unexpected twist to the activation of IKKβ: TAK1 primes IKKβ for activation by autophosphorylation

Zhang, J., Clark, K., Lawrence, T., Peggie, M. W. & Cohen, P., 1 Aug 2014, In : Biochemical Journal. 461, 3, p. 531-537 7 p.

Research output: Contribution to journalArticle

Open Access
File
I-kappa B Kinase
Phosphorylation
Transforming Growth Factors
Phosphotransferases
Chemical activation
94 Citations (Scopus)

An unusual N-terminal deletion of the laminin α3a isoform leads to the chronic granulation tissue disorder laryngo-onycho-cutaneous syndrome

McLean, W. H. I., Irvine, A. D., Hamill, K. J., Whittock, N. V., Coleman-Campbell, C. M., Mellerio, J. E., Ashton, G. S., Dopping-Hepenstal, P. J. H., Eady, R. A. J., Jamil, T., Phillips, R. J., Shabbir, S. G., Haroon, T. S., Khurshid, K., Moore, J. E., Page, B., Darling, J., Atherton, D. J., van Steensel, M. A. M., Munro, C. S. & 2 others, Smith, F. J. D. & McGrath, J. A., 2003, In : Human Molecular Genetics. 12, 18, p. 2395-2409 15 p.

Research output: Contribution to journalArticle

Granulation Tissue
Laminin
Protein Isoforms
Exons
Keratinocytes
50 Citations (Scopus)

An unusual twin: his arrangement in the pore of ammonia channels is essential for substrate conductance

Javelle, A., Lupo, D., Zheng, L., Li, X-D., Winkler, F. K. & Merrick, M., 2006, In : Journal of Biological Chemistry. 281, 51, p. 39492-8 7 p.

Research output: Contribution to journalArticle

Ammonia
Histidine
Substrates
Escherichia coli
Glutamic Acid
48 Citations (Scopus)

A patch clamp study of the nicotinic acetylcholine receptor of bovine adrenomedullary chromaffin cells in culture.

Nooney, J. M., Peters, J. A. & Lambert, J. J., 1 Sep 1992, In : The Journal of Physiology. 455, 1, p. 503-527 25 p.

Research output: Contribution to journalArticle

Hexamethonium
Chromaffin Cells
Nicotinic Receptors
Trimethaphan
Mecamylamine
16 Citations (Scopus)
95 Downloads (Pure)

A pathway for Parkinson's Disease LRRK2 kinase to block primary cilia and Sonic hedgehog signaling in the brain

Dhekne, H. S., Yanatori, I., Gomez, R. C., Tonelli, F., Diez, F., Schüle, B., Steger, M., Alessi, D. R. & Pfeffer, S. R., 6 Nov 2018, In : eLife. 7, p. 1-26 26 p., e40202.

Research output: Contribution to journalArticle

Open Access
File
Aptitude
Hedgehogs
Cilia
Neurons
Parkinson Disease
19 Citations (Scopus)

A Patient Suffering from Hypokalemic Periodic Paralysis Is Deficient in Skeletal Muscle ATP-sensitive K+ channels

Jovanovic, S., Du, Q., Mukhopadhyay, S., Swingler, R., Buckley, R., McEachen, J. & Jovanovic, A., May 2008, In : Clinical and Translational Science. 1, 1, p. 71-74 4 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

APC at a glance

Nathke, I., 2004, In : Journal of Cell Science. 117, Pt 21, p. 4873-4875 3 p.

Research output: Contribution to journalArticle

157 Citations (Scopus)

A periodicity of ∼1 hour in X-ray emission from the active galaxy RE J1034+396

Gierliński, M., Middleton, M., Ward, M. & Done, C., 18 Sep 2008, In : Nature. 455, 7211, p. 369-371 3 p.

Research output: Contribution to journalArticle

active galaxies
periodic variations
active galactic nuclei
x rays
oscillations
1 Citation (Scopus)
42 Downloads (Pure)

APETALA2 control of barley internode elongation

Patil, V., McDermott, H. I., Mcallister, T., Cummins, M., Clara Silva, J., Mollison, E., Meikle, R., Morris, J. A., Hedley, P. E., Waugh, R., Dockter, C., Hansson, M. & McKim, S., 12 Jun 2019, In : Development. 146, 11, p. 1-16 16 p., 170373.

Research output: Contribution to journalArticle

Open Access
File
Gibberellins
Hordeum
Inflorescence
Growth
MicroRNAs
6 Citations (Scopus)
103 Downloads (Pure)

A phenomenological description of BslA assemblies across multiple length scales

Morris, R. J., Bromley, K. M., Stanley-Wall, N. & MacPhee, C. E., 28 Jul 2016, In : Philosophical Transactions of the Royal Society A - Mathematical Physical and Engineering Sciences. 374, 2072, p. 1-14 14 p., 20150131.

Research output: Contribution to journalArticle

Open Access
File
Multiple Scales
Length Scale
assemblies
Bubble
air
897 Citations (Scopus)

A physical, genetic and functional sequence assembly of the barley genome

Mayer, K. F. X., Waugh, R., Brown, J. W. S., Schulman, A., Langridge, P., Platzer, M., Fincher, G. B., Muehlbauer, G. J., Sato, K., Close, T. J., Wise, R. P., Stein, N. & International Barley Genome Sequencing Consortium, 29 Nov 2012, In : Nature. 491, 7426, p. 711-716 6 p.

Research output: Contribution to journalArticle

Hordeum
Genome
Plant Genome
Nonsense Codon
Haploidy
44 Citations (Scopus)
225 Downloads (Pure)

A Phytophthora infestans RXLR effector targets plant PP1c isoforms that promote late blight disease

Boevink, P. C., Wang, X., McLellan, H., He, Q., Naqvi, S., Armstrong, M. R., Zhang, W., Hein, I., Gilroy, E. M., Tian, Z. & Birch, P. R. J., 29 Jan 2016, In : Nature Communications. 7, 10311.

Research output: Contribution to journalArticle

Open Access
File
blight
Phytophthora infestans
effectors
Protein Phosphatase 1
Plant Proteins
65 Citations (Scopus)

Apical abscission alters cell polarity and dismantles the primary cilium during neurogenesis

Das, R. M. & Storey, K. G., 10 Jan 2014, In : Science. 343, 6167, p. 200-204 5 p.

Research output: Contribution to journalArticle

Cell Polarity
Cilia
Neurogenesis
cdc Genes
Neural Tube
9 Citations (Scopus)
107 Downloads (Pure)

aPKC-mediated displacement and actomyosin-mediated retention polarize Miranda in Drosophila neuroblasts

Hannaford, M. R., Ramat, A., Loyer, N. & Januschke, J., 24 Jan 2018, In : eLife. 7, 22 p., e29939.

Research output: Contribution to journalArticle

Open Access
File
Actomyosin
Interphase
Nuclear Envelope
Neurology
Nervous System
36 Citations (Scopus)

A plant virus movement protein forms ringlike complexes with the major nucleolar protein, fibrillarin, in vitro

Canetta, E., Kim, S. H., Kalinina, N. O., Shaw, J., Adya, A. K., Gillespie, T., Brown, J. W. S. & Taliansky, M., 29 Feb 2008, In : Journal of Molecular Biology. 376, 4, p. 932-937 6 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)
71 Downloads (Pure)

A Plasmodium-like virulence effector of the soybean cyst nematode suppresses plant innate immunity

Noon, J. B., Qi, M., Sill, D. N., Muppirala, U., Eves-van den Akker, S., Maier, T. R., Dobbs, D., Mitchum, M. G., Hewezi, T. & Baum, T. J., Oct 2016, In : New Phytologist. 212, 2, p. 444-460 17 p.

Research output: Contribution to journalArticle

Open Access
File
Plant Immunity
Heterodera glycines
Plasmodium
Soybeans
Innate Immunity
12 Downloads (Pure)

A platform for target prediction of phenotypic screening hit molecules

Homeyer, N., van Deursen, R., Ochoa-Montaño, B., Heikamp, K., Ray, P., Zuccotto, F., Blundell, T. L. & Gilbert, I. H., 24 Oct 2019, In : Journal of Molecular Graphics & Modelling. 95, p. 1-9 9 p., 107485.

Research output: Contribution to journalArticle

Open Access
File
Screening
screening
platforms
Ligands
Proteins
26 Citations (Scopus)

A point prevalence survey of antibiotic prescriptions: benchmarking and patterns of use

Aldeyab, M. A., Kearney, M. P., McElnay, J. C., Magee, F. A., Conlon, G., Gill, D., Davey, P., Muller, A., Goossens, H., Scott, M. G. & ESAC Hosp Care Subproject Grp, Feb 2011, In : British Journal of Clinical Pharmacology. 71, 2, p. 293-296 4 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

A positive numerical scheme for a mixed-type partial differential equation model for fungal growth

Boswell, G. P., Jacobs, H., Davidson, F. A., Gadd, G. M. & Ritz, K., 20 Jun 2003, In : Applied Mathematics and Computation. 138, 2-3, p. 321-340 20 p.

Research output: Contribution to journalArticle

20 Downloads (Pure)

A post-transcriptional respiratome regulon in trypanosomes

Trenaman, A., Glover, L., Hutchinson, S. & Horn, D., 26 Jul 2019, In : Nucleic Acids Research. 47, 13, p. 7063-7077 15 p.

Research output: Contribution to journalArticle

Open Access
File
Regulon
Trypanosomiasis
Membrane Glycoproteins
Trypanosoma brucei brucei
RNA-Binding Proteins
2 Citations (Scopus)
62 Downloads (Pure)

A potato STRUBBELIG-RECEPTOR FAMILY member, StLRPK1, associates with StSERK3A/BAK1 and activates immunity

Wang, H., Chen, Y., Wu, X., Long, Z., Sun, C., Wang, H., Wang, S., Birch, P. R. J. & Tian, Z., 1 Dec 2018, In : Journal of Experimental Botany. 69, 22, p. 5573-5586 14 p.

Research output: Contribution to journalArticle

Open Access
File
Plant Immunity
Phytophthora infestans
Solanum tuberosum
Immunity
immunity
123 Citations (Scopus)

Application of active and kinase-deficient kinome collection for identification of kinases regulating hedgehog signaling

Varjosalo, M., Bjorklund, M., Cheng, F., Syvanen, H., Kivioja, T., Kilpinen, S., Sun, Z., Kallioniemi, O., Stunnenberg, H. G., He, W-W., Ojala, P. & Taipale, J., 2 May 2008, In : Cell. 133, 3, p. 537-548 12 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Application of a novel highly sensitive activity-based probe for detection of cathepsin G

Zou, F., Schmon, M., Sienczyk, M., Grzywa, R., Palesch, D., Boehm, B. O., Sun, Z. L., Watts, C., Schirmbeck, R. & Burster, T., 2012, In : Analytical Biochemistry. 421, 2, p. 667-72 6 p.

Research output: Contribution to journalArticle

Cathepsin G
Human Herpesvirus 4
Viruses
Serine Proteases
Cathepsin D
9 Citations (Scopus)
13 Downloads (Pure)
Open Access
File
Metabolism
Liver
Biological Availability
Pharmaceutical Preparations
Nelfinavir

Application of a relativistic accretion disc model to GRO J1655-40 ASCA spectrum

Gierliński, M., Maciołek-Niedźwiecki, A., Magdziarz, P. & Ebisawa, K., 1 Dec 1999, In : Astronomische Nachrichten. 320, 4-5, p. 350 1 p.

Research output: Contribution to journalArticle

65 Citations (Scopus)

Application of a relativistic accretion disc model to X-ray spectra of LMC X-1 and GRO J1655-40

Gierliński, M., Maciołek-Niedźwiecki, A. & Ebisawa, K., 11 Aug 2001, In : Monthly Notices of the Royal Astronomical Society. 325, 3, p. 1253-1265 13 p.

Research output: Contribution to journalArticle

Open Access
accretion disks
accretion
x rays
inclination
radiation pressure
70 Downloads (Pure)

Application of a Sensitive and Reproducible Label-Free Proteomic Approach to Explore the Proteome of Individual Meiotic-Phase Barley Anthers

Lewandowska, D., Zhang, R., Colas, I., Uzrek, N. & Waugh, R., 2 Apr 2019, In : Frontiers in Plant Science. 10, p. 1-15 15 p., 393.

Research output: Contribution to journalArticle

Open Access
File
proteome
proteomics
anthers
meiosis
barley
33 Citations (Scopus)

Application of Bayesian Belief Networks to quantify and map areas at risk to soil threats: Using soil compaction as an example

Troldborg, M., Aalders, I., Towers, W., Hallett, P. D., McKenzie, B. M., Bengough, A. G., Lilly, A., Ball, B. C. & Hough, R. L., Aug 2013, In : Soil & Tillage Research. 132, p. 56-68 13 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Application of electrospray mass spectrometry to the structural determination of glycosylphosphatidylinositol membrane anchors

Nett, I. R. E., Mehlert, A., Lamont, D. & Ferguson, M. A. J., May 2010, In : Glycobiology. 20, 5, p. 576-585 10 p.

Research output: Contribution to journalArticle

81 Citations (Scopus)

Application of fragment growing and fragment linking to the discovery of inhibitors of Mycobacterium tuberculosis pantothenate synthetase

Hung, A. W., Silvestre, H. L., Wen, S., Ciulli, A., Blundell, T. L. & Abell, C., 26 Oct 2009, In : Angewandte Chemie International Edition. 48, 45, p. 8452-8456 5 p.

Research output: Contribution to journalArticle

pantothenate synthetase
X ray crystallography
Sulfonamides
Enzyme Inhibitors
Calorimetry
37 Citations (Scopus)

Application of fragment screening and merging to the discovery of inhibitors of the Mycobacterium tuberculosis cytochrome P450 CYP121

Hudson, S. A., McLean, K. J., Surade, S., Yang, Y-Q., Leys, D., Ciulli, A., Munro, A. W. & Abell, C., 10 Sep 2012, In : Angewandte Chemie International Edition. 51, 37, p. 9311-9316 6 p.

Research output: Contribution to journalArticle

Merging
Cytochrome P-450 Enzyme System
Screening
Lead compounds
Binding sites
606 Citations (Scopus)

Application of multiple sequence alignment profiles to improve protein secondary structure prediction

Cuff, J. A. & Barton, G. J., 15 Aug 2000, In : Proteins: Structure, Function, and Bioinformatics. 40, 3, p. 502-511 10 p.

Research output: Contribution to journalArticle

Secondary Protein Structure
Sequence Alignment
Proteins
Computer program listings
Servers
15 Citations (Scopus)

Application of RNAi to genomic drug target validation in schistosomes

Guidi, A., Mansour, N. R., Paveley, R. A., Carruthers, I. M., Besnard, J., Hopkins, A. L., Gilbert, I. H. & Bickle, Q. D., 20 May 2015, In : PLoS Neglected Tropical Diseases. 9, 5, 22 p., e0003801.

Research output: Contribution to journalArticle

RNA Interference
p38 Mitogen-Activated Protein Kinases
Phosphotransferases
Essential Genes
Pharmaceutical Preparations
23 Citations (Scopus)

Approaches to modelling mineral weathering by fungi

Rosling, A., Roose, T., Herrmann, A. M., Davidson, F. A., Finlay, R. D. & Gadd, G. M., 2009, In : Fungal Biology Reviews. 23, 4, p. 138-144 7 p.

Research output: Contribution to journalArticle

Minerals
Fungi
Soil
Plant Roots
Ecosystem
10 Citations (Scopus)
103 Downloads (Pure)

A practical method using a network of fixed infrared sensors for estimating crop canopy conductance and evaporation rate

Jones, H. G., Hutchinson, P. A., May, T., Jamali, H. & Deery, D. M., Jan 2018, In : Biosystems Engineering. 165, p. 59-69 11 p.

Research output: Contribution to journalArticle

Open Access
File
evaporation rate
Crops
Evaporation
evaporation
canopy
3 Citations (Scopus)
pyrophosphomevalonate decarboxylase
diphosphates
Trypanosoma brucei brucei
enzymes
Mevalonic Acid

A probe for nascent DNA in intact nuclei

Blow, J. J., 1987, In : Trends in Genetics. 3, p. 233 1 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

A PROLOG approach to analysing protein structure

Barton, G. J. & Rawlings, C. J., 1 Jan 1990, In : Tetrahedron Computer Methodology. 3, 6 PART C, p. 739-756 18 p.

Research output: Contribution to journalArticle

Proteins
Computer programming languages
PROLOG (programming language)
Sanders
Logic programming