School of Life Sciences

  • United Kingdom

Research Output 1968 2020

1989
145 Citations (Scopus)

Replication occurs at discrete foci spaced throughout nuclei replicating in vitro

Mills, A. D., Blow, J. J., White, J. G., Amos, W. B., Wilcock, D. & Laskey, R. A., Nov 1989, In : Journal of Cell Science. 94 , 3, p. 471-477 7 p.

Research output: Contribution to journalArticle

DNA Replication
Biotin
Xenopus
Replicon
Streptavidin
117 Citations (Scopus)

S phase of the cell cycle

Laskey, R. A., Fairman, M. P. & Blow, J. J., 3 Nov 1989, In : Science. 246, 4930, p. 609-614 6 p.

Research output: Contribution to journalArticle

DNA Replication
S Phase
Cell Cycle
Chromosomes
Chromosome Structures
5 Citations (Scopus)

Stability of neuron and glial number in the parabigeminal nucleus of the ageing mouse

Sturrock, R. R., 1989, In : Cells Tissues Organs. 134, 4, p. 322-326 5 p.

Research output: Contribution to journalArticle

Neuroglia
Neurons
Retinal Ganglion Cells
Synapses
Young Adult

Structure function studies on Leishmania surface membrane proteins.

Olafson, R. W., Dwek, R. A., Rademacher, T. W., Chang, K-P. & Ferguson, M. A. J., 1989, Leishmaniasis : the current status and new strategies for control. Proceedings of the NATO Advanced Study Institute, Zakynthos (Greece), 1987. Hart, D. T. (ed.). New York: Plenum Press, p. 619-627 9 p. ( NATO ASI series. Series A: Life sciences; vol. 163).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

20 Citations (Scopus)

The major type-1 protein phosphatase catalytic subunits are the same gene products in rabbit skeletal muscle and rabbit liver

Cohen, P. T. W., Schelling, D. L., da Cruz e Silva, O. B., Barker, H. M. & Cohen, P., 1 Jun 1989, In : BBA - Gene Structure and Expression. 1008, 1, p. 125-128 4 p.

Research output: Contribution to journalArticle

Protein Phosphatase 1
Liver
Muscle
Skeletal Muscle
Genes
77 Citations (Scopus)
Molecular Mechanisms of Pharmacological Action
Chromaffin Cells
Anticonvulsants
Cell Culture Techniques
Neuroblastoma

The membrane attachment of the variant surface glycoprotein coat of Trypanosoma brucei

Ferguson, M. A. J. & Homans, S. W., 1989, New Strategies in Parasitology: proceedings of an international symposium. McAdam, K. P. W. J. (ed.). Edinburgh: Churchill Livingstone, p. 120-139 20 p. (Frontiers of infectious diseases).

Research output: Chapter in Book/Report/Conference proceedingChapter

Parasitology
Trypanosoma brucei brucei
Parasitic Diseases
Membrane Glycoproteins
Acquired Immunodeficiency Syndrome
105 Citations (Scopus)

The properties of 5-HT3 receptors in clonal cell lines studied by patch-clamp techniques

Lambert, J. J., Peters, J. A., Hales, T. G. & Dempster, J., May 1989, In : British Journal of Pharmacology. 97, 1, p. 27-40 14 p.

Research output: Contribution to journalArticle

Receptors, Serotonin, 5-HT3
Patch-Clamp Techniques
Serotonin
Cell Line
Ondansetron
106 Citations (Scopus)
54 Downloads (Pure)

The role of cyclin synthesis, modification and destruction in the control of cell division

Minshull, J., Pines, J., Golsteyn, R., Standart, N., Mackie, S., Colman, A., Blow, J., Ruderman, J. V., Wu, M. & Hunt, T., Feb 1989, In : Journal of Cell Science. 1989, Supplement 12, p. 77-97 21 p.

Research output: Contribution to journalArticle

Open Access
File
Cyclins
Cell Division
Bivalvia
Anura
Cyclin B
272 Citations (Scopus)

Translation of cyclin mRNA is necessary for extracts of activated xenopus eggs to enter mitosis

Minshull, J., Blow, J. J. & Hunt, T., 24 Mar 1989, In : Cell. 56, 6, p. 947-956 10 p.

Research output: Contribution to journalArticle

Cyclins
Protein Biosynthesis
Xenopus
Mitosis
Eggs
1988
441 Citations (Scopus)

A role for the nuclear envelope in controlling DNA replication within the cell cycle

Blow, J. J. & Laskey, R. A., 7 Apr 1988, In : Nature. 332, 6164, p. 546-548 3 p.

Research output: Contribution to journalLetter

Nuclear Envelope
DNA Replication
Cell Cycle
Mitosis
DNA
920 Citations (Scopus)

Cell surface anchoring of proteins via glycosyl-phosphatidylinositol structures

Ferguson, M. A. J. & Williams, A. F., 1988, In : Annual Review of Biochemistry. 57, p. 285-320 36 p.

Research output: Contribution to journalReview article

185 Citations (Scopus)

Endoscopic injection of adrenaline for actively bleeding ulcers: a randomised trial

Chung, S. C. S., Leung, J. W. C., Steele, R. J. C., Crofts, T. J. & Li, A. K., 1988, In : BMJ (Clinical Research Ed.). 296, 6637, p. 1631-1633 3 p.

Research output: Contribution to journalArticle

Epinephrine
Ulcer
Hemorrhage
Injections
Endoscopy
2 Citations (Scopus)

Eukaryotic DNA replication reconstituted outside the cell

Blow, J. J., May 1988, In : BioEssays. 8, 5, p. 149-152 4 p.

Research output: Contribution to journalArticle

Cell-Free System
DNA Replication
Cell Cycle
Cells
DNA

Identification of glycosyl-phosphatidylinositol membrane anchors by fatty acid labelling

Ferguson, M. A. J., 1988, Post-translational modification of protein by lipids: a laboratory manual. Brodbeck, U. & Bordier, C. (eds.). Springer Verlag

Research output: Chapter in Book/Report/Conference proceedingChapter

15 Citations (Scopus)

Immunogenic and Antigenic Epitopes of Immunoglobulins Binding of Human Monoclonal Anti‐D Antibodies to FcRI on the Monocyte‐Like U937 Cell Line

Walker, M. R., Kumpel, B. M., Thompson, K., Woof, J. M., Burton, D. R. & Jefferis, R., Nov 1988, In : Vox Sanguinis. 55, 4, p. 222-228 7 p.

Research output: Contribution to journalArticle

U937 Cells
Rosette Formation
Immunoglobulins
Epitopes
Immunoglobulin G
18 Citations (Scopus)

LOPAL and SCAMP: techniques for the comparison and display of protein structures

Barton, G. J. & Sternberg, M. J. E., Dec 1988, In : Journal of Molecular Graphics. 6, 4, p. 190-196 7 p.

Research output: Contribution to journalArticle

Display devices
Proteins
Sequence Alignment
Least-Squares Analysis
Dynamic programming
19 Citations (Scopus)

Membrane and communication properties of tissue cultured human lens epithelial cells

Stewart, S., Duncan, G., Marcantonio, J. M. & Prescott, A. R., Nov 1988, In : Investigative Ophthalmology and Visual Science. 29, 11, p. 1713-1725 13 p.

Research output: Contribution to journalArticle

Lenses
Epithelial Cells
Communication
Membranes
Coloring Agents
22 Citations (Scopus)

Membrane and junctional properties of the isolated frog lens epithelium

Duncan, G., Stewart, S., Prescott, A. R. & Warn, R. M., Jun 1988, In : The Journal of Membrane Biology. 102, 3, p. 195-204 10 p.

Research output: Contribution to journalArticle

Anura
Lenses
Coloring Agents
Epithelium
Octanols
252 Citations (Scopus)

Modulation of the GABAA receptor by depressant barbiturates and pregnane steroids

Peters, J. A., Kirkness, E. F., Callachan, H., Lambert, J. J. & Turner, A. J., Aug 1988, In : British Journal of Pharmacology. 94, 4, p. 1257-1269 13 p.

Research output: Contribution to journalArticle

Pregnanes
Muscimol
Barbiturates
GABA-A Receptors
Steroids
19 Citations (Scopus)

Parasite glycoconjugates: towards the exploitation of their structure

Ferguson, M. A. J. & Homans, S. W., 1988, In : Parasite Immunology. 10, 5, p. 465-479 15 p.

Research output: Contribution to journalEditorial

31 Citations (Scopus)

Phosphorylation of the glycogen-binding subunit of protein phosphatase-1G in response to adrenalin

MacKintosh, C., Campbell, D. G., Hiraga, A. & Cohen, P., 1988, In : FEBS Letters. 234, 1, p. 189-194 6 p.

Research output: Contribution to journalArticle

69 Citations (Scopus)

Primary structure of the site on bovine hormone-sensitive lipase phosphorylated by cyclic AMP-dependent protein kinase

Garton, A. J., Campbell, D. G., Cohen, P. & Yeaman, S. J., 29 Feb 1988, In : FEBS Letters. 229, 1, p. 68-72 5 p.

Research output: Contribution to journalArticle

Open Access
Sterol Esterase
Cyclic AMP-Dependent Protein Kinases
Protein Kinases
Proteins
poly(prolylprolylglycine)15
26 Citations (Scopus)

Purification and regulatory properties of isocitrate lyase from Escherichia coli ML308

MacKintosh, C. & Nimmo, H. G., 15 Feb 1988, In : Biochemical Journal. 250, 1, p. 25-31 7 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Resolution of sequence discrepancies in the ORF1 region of the Kluyveromyces lactis plasmid k1

Stark, M. J. R., 25 Jan 1988, In : Nucleic Acids Research. 16, 2, p. 771 1 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Scanning electron microscopy and the transformed phenotype

Linstead, P., Jennings, B., Prescott, A., Hawley, P., Warn, R. & Gibson, I., 1988, In : Micron And Microscopica Acta. 19, 3, p. 155-162 8 p.

Research output: Contribution to journalArticle

ras Genes
Electron Scanning Microscopy
Proto-Oncogene Proteins p21(ras)
Phenotype
Oncogene Proteins
146 Citations (Scopus)

Steps in the assembly of replication-competent nuclei in a cell-free system from Xenopus eggs

Sheehan, M. A., Mills, A. D., Sleeman, A. M., Laskey, R. A. & Blow, J. J., Jan 1988, In : Journal of Cell Biology. 106, 1, p. 1-12 12 p.

Research output: Contribution to journalArticle

Cell-Free System
Xenopus
Eggs
Chromatin
Membranes
18 Citations (Scopus)

The glycosyl-phosphatidylinositol membrane anchor of Trypanosoma brucei variant surface glycoprotein

Ferguson, M. A. J., Homans, S. W., Dwek, R. A. & Rademacher, T. W., 1988, In : Biochemical Society Transactions. 16, 3, p. 265-268 4 p.

Research output: Contribution to journalArticle

1987
131 Citations (Scopus)

Actions of synthetic and endogenous steroids on the GABAA receptor

Lambert, J. J., Peters, J. A. & Cottrell, G. A., 1 Jan 1987, In : Trends in Pharmacological Sciences. 8, 6, p. 224-227 4 p.

Research output: Contribution to journalReview article

GABA-A Receptors
Steroids
Steroid hormones
Hypnosis
gamma-Aminobutyric Acid
37 Citations (Scopus)

AIDS vaccine predictions

Coates, A. R. M., Cookson, J., Barton, G. J., Zvelebil, M. J. & Sternberg, M. J. E., 9 Apr 1987, In : Nature. 326, 6113, p. 549-550 2 p.

Research output: Contribution to journalLetter

A probe for nascent DNA in intact nuclei

Blow, J. J., 1987, In : Trends in Genetics. 3, p. 233 1 p.

Research output: Contribution to journalArticle

386 Citations (Scopus)

A strategy for the rapid multiple alignment of protein sequences: confidence levels from tertiary structure comparisons

Barton, G. J. & Sternberg, M. J. E., 20 Nov 1987, In : Journal of Molecular Biology. 198, 2, p. 327-337 11 p.

Research output: Contribution to journalArticle

Sequence Alignment
Proteins
Globins
Transferrin
Disulfides
25 Citations (Scopus)

Chromosome replication in cell-free systems from Xenopus eggs

Blow, J. J., Dilworth, S. M., Dingwall, C., Mills, A. D. & Laskey, R. A., 15 Dec 1987, In : Philosophical Transactions of the Royal Society B - Biological Sciences. 317, 1187, p. 483-494 12 p.

Research output: Contribution to journalArticle

cell free system
Cell-Free System
Xenopus
Chromosomes
Eggs
107 Citations (Scopus)

Evaluation and improvements in the automatic alignment of protein sequences

Barton, G. J. & Sternberg, M. J., 1 Feb 1987, In : Protein Science. 1, 2, p. 89-94 6 p.

Research output: Contribution to journalArticle

Sequence Alignment
Secondary Protein Structure
Sequence Homology
Proteins
Testing
9 Citations (Scopus)

Hepatic metastases in Hong Kong Chinese: evidence for an East-West difference in gastric cancer

Steele, R. J. C., Chung, S. C., Li, A. K. & Crofts, T. J., 1987, In : Annals of the Royal College of Surgeons of England. 69, 2, p. 61-63 3 p.

Research output: Contribution to journalArticle

Hong Kong
Stomach Neoplasms
Neoplasm Metastasis
Liver
Incidence
59 Citations (Scopus)

In vivo labelling of intermediates in the discontinuous synthesis of mRNAs in Trypanosoma brucei

Laird, P. W., Zomerdijk, J. C. B. M., de Korte, D. & Borst, P., 1987, In : EMBO Journal. 6, 4, p. 1055-1062 8 p.

Research output: Contribution to journalArticle

95 Citations (Scopus)

Isolation and sequence analysis of a cDNA clone encoding a type-1 protein phosphatase catalytic subunit: Homology with protein phosphatase 2A

Berndt, N., Campbell, D. G., Caudwell, F. B., Cohen, P., da Cruz e Silva, E. F., da Cruz e Silva, O. B. & Cohen, P. T. W., 2 Nov 1987, In : FEBS Letters. 223, 2, p. 340-346 7 p.

Research output: Contribution to journalArticle

Open Access
Protein Phosphatase 1
Protein Phosphatase 2
Sequence Analysis
Complementary DNA
Clone Cells
11 Citations (Scopus)

Many strands converge

Blow, J., 8 Apr 1987, In : Nature. 326, 6112, p. 441-442 2 p.

Research output: Contribution to journalArticle

155 Citations (Scopus)

Modulation of GABAA receptor activity by alphaxalone

Cottrell, G. A., Lambert, J. J. & Peters, J. A., Mar 1987, In : British Journal of Pharmacology. 90, 3, p. 491-500 10 p.

Research output: Contribution to journalArticle

GABA-A Receptors
gamma-Aminobutyric Acid
Membranes
Acetylcholine
Chromaffin Cells
18 Citations (Scopus)

Molecular cloning and over-expression of the glyoxylate bypass operon from Escherichia coli ML308

el-Mansi, E. M., MacKintosh, C., Duncan, K., Holms, W. H. & Nimmo, H. G., 1987, In : Biochemical Journal. 242, 3, p. 661-665 5 p.

Research output: Contribution to journalArticle

75 Citations (Scopus)

Nuclei act as independent and integrated units of replication in a Xenopus cell-free DNA replication system

Blow, J. J. & Watson, J. V., Jul 1987, In : EMBO Journal. 6, 7, p. 1997-2002 6 p.

Research output: Contribution to journalArticle

Replicon
Xenopus
DNA Replication
DNA
Biotin
18 Citations (Scopus)

Prediction of antigenic determinants and secondary structures of the major AIDS virus proteins

Sternberg, M. J. E., Barton, G. J., Zvelebil, M. J., Cookson, J. & Coates, A. R. M., 29 Jun 1987, In : FEBS Letters. 218, 2, p. 231-237 7 p.

Research output: Contribution to journalArticle

Viruses
Epitopes
Vaccines
Genes
HIV
358 Citations (Scopus)

Prediction of protein secondary structure and active sites using the alignment of homologous sequences

Zvelebil, M. J., Barton, G. J., Taylor, W. R. & Sternberg, M. J. E., 20 Jun 1987, In : Journal of Molecular Biology. 195, 4, p. 957-961 5 p.

Research output: Contribution to journalLetter

Secondary Protein Structure
Sequence Homology
Catalytic Domain
Insertional Mutagenesis
Enzymes
25 Citations (Scopus)

Primary structure analysis proves that protein phosphatases 2C1 and 2C2 are isozymes

McGowan, C. H., Campbell, D. G. & Cohen, P., 14 Sep 1987, In : BBA - Molecular Cell Research. 930, 2, p. 279-282 4 p.

Research output: Contribution to journalArticle

Phosphoprotein Phosphatases
Isoenzymes
Trypsin
Peptides
Enzymes
17 Citations (Scopus)

Regulation of the enzymes at the branchpoint between the citric-acid cycle and the glyoxylate bypass in escherichia-coli

Nimmo, H. G., Borthwick, A. C., el-Mansi, E. M., Holms, W. H., Mackintosh, C. & Nimmo, G. A., 1987, In : Biochemical Society Symposium. 54, p. 93-101 9 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)

Structural studies on the glycophospholipid membrane anchor of Trypanosoma brucei variant surface glycoprotein

Ferguson, M. A. J., Dwek, R. A., Homans, S. W. & Rademacher, T. W., 1987, Host-parasite cellular and molecular interactions in protozoal infections. Chang, K. P. & Snary, D. (eds.). Berlin: Springer Verlag, p. 19-28 10 p. (NATO ASI series. Series H: Cell biology; vol. 11).

Research output: Chapter in Book/Report/Conference proceedingChapter

glycophospholipids
variant surface glycoproteins
Trypanosoma brucei
antigenic variation
organisms
47 Citations (Scopus)

The effects of selenium and copper deficiencies on glutathione S-transferase and glutathione peroxidase in rat liver

Arthur, J. R., Morrice, P. C., Nicol, F., Beddows, S. E., Boyd, R., Hayes, J. D. & Beckett, G. J., 1 Dec 1987, In : Biochemical Journal. 248, 2, p. 539-44 6 p.

Research output: Contribution to journalArticle

Selenium
Glutathione Peroxidase
Glutathione Transferase
Liver
Rats

Transsplicing in Trypansomes

Laird, P. W., Zomerdijk, J. C. B. M. & Borst, P., 1987.

Research output: Contribution to conferencePoster

Transsplicing in Trypansomes

Laird, P. W., Zomerdijk, J. C. B. M. & Borst, P., 1987, In : Journal of Cellular Biochemistry. 35, Suppl. 11C, p. 54-54 1 p.

Research output: Contribution to journalMeeting abstract

10 Citations (Scopus)

Two cases of eosinophilic enteritis presenting as large bowel perforation and small bowel haemorrhage

Steele, R. J. C., Mok, S. D., Crofts, T. J. & Li, A. K., 1987, In : Australian and New Zealand Journal of Surgery. 57, 5, p. 335-336 2 p.

Research output: Contribution to journalArticle

Hemorrhage
Eosinophilic enteropathy