School of Life Sciences

  • United Kingdom

Research Output 1968 2020

Article
13 Citations (Scopus)

A crucial role for β2 integrins in podosome formation, dynamics and Toll-like-receptor-signaled disassembly in dendritic cells

Gawden-Bone, C., West, M. A., Morrison, V. L., Edgar, A. J., McMillan, S. J., Dill, B. D., Trost, M., Prescott, A., Fagerholm, S. C. & Watts, C., 1 Oct 2014, In : Journal of Cell Science. 127, 19, p. 4213-4224 12 p.

Research output: Contribution to journalArticle

Toll-Like Receptors
Integrins
Dendritic Cells
Phosphorylation
Podosomes
96 Citations (Scopus)

A Ctf4 trimer couples the CMG helicase to DNA polymerase α in the eukaryotic replisome

Simon, A. C., Zhou, J. C., Perera, R. L., van Deursen, F., Evrin, C., Ivanova, M. E., Kilkenny, M. L., Renault, L., Kjaer, S., Matak-Vinković, D., Labib, K., Costa, A. & Pellegrini, L., 2014, In : Nature. 510, 7504, p. 293-297 5 p.

Research output: Contribution to journalArticle

DNA-Directed DNA Polymerase
Eukaryota
DNA Helicases
Fungal Proteins
Genomic Instability
26 Citations (Scopus)

Activated cAMP receptors switch encystation into sporulation

Kawabe, Y., Morio, T., James, J. L., Prescott, A. R., Tanaka, Y. & Schaap, P., 28 Apr 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 17, p. 7089-7094 6 p.

Research output: Contribution to journalArticle

116 Citations (Scopus)

Activating K-Ras mutations outwith 'hotspot' codons in sporadic colorectal tumours: implications for personalised cancer medicine

Smith, G., Bounds, R., Wolf, H., Steele, R., Carey, F. & Wolf, R., 16 Feb 2010, In : British Journal of Cancer. 102, 4, p. 693-703 11 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)
89 Downloads (Pure)

Activation of bicyclic nitro-drugs by a novel nitroreductase (NTR2) in Leishmania

Wyllie, S., Roberts, A. J., Norval, S., Patterson, S., Foth, B. J., Berriman, M., Read, K. D. & Fairlamb, A. H., 3 Nov 2016, In : PLoS Pathogens. 12, 11, p. 1-22 22 p., e1005971.

Research output: Contribution to journalArticle

Open Access
File
Nitroreductases
Leishmania
Nitro Compounds
Nifurtimox
Pharmaceutical Preparations
201 Citations (Scopus)
97 Downloads (Pure)

Activation of the canonical IKK complex by K63/M1-linked hybrid ubiquitin chains

Emmerich, C. H., Ordureau, A., Strickson, S., Arthur, J. S. C., Pedrioli, P. G. A., Komander, D. & Cohen, P., 17 Sep 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 38, p. 15247-15252 6 p.

Research output: Contribution to journalArticle

Open Access
File
Polyubiquitin
Ubiquitin
Methionine
Phosphotransferases
Transforming Growth Factor beta
59 Citations (Scopus)

Activation of the neutrophil NADPH oxidase is inhibited by SB 203580, a specific inhibitor of SAPK2/p38

Lal, A. S., Clifton, A. D., Rouse, J., Segal, A. W. & Cohen, P., 7 Jun 1999, In : Biochemical and Biophysical Research Communications. 259, 2, p. 465-470 6 p.

Research output: Contribution to journalArticle

Mitogen-Activated Protein Kinase 11
Neutrophil Activation
NADPH Oxidase
Chemical activation
Tetradecanoylphorbol Acetate
82 Citations (Scopus)

Active defence responses associated with non-host resistance of Arabidopsis thaliana to the oomycete pathogen Phytophthora infestans

Huitema, E., Vleeshouwers, V. G. A. A., Francis, D. M. & Kamoun, S., Nov 2003, In : Molecular Plant Pathology. 4, 6, p. 487-500 14 p.

Research output: Contribution to journalArticle

328 Citations (Scopus)

Active repression of antiapoptotic gene expression by RelA(p65) NF-kB

Campbell, K. J., Rocha, S. & Perkins, N. D., Mar 2004, In : Molecular Cell. 13, 6, p. 853-865 13 p.

Research output: Contribution to journalArticle

Daunorubicin
NF-kappa B
Gene Expression
Neoplasms
Histone Deacetylases
48 Citations (Scopus)

Active site residues in m-calpain: identification by site-directed mutagenesis

Arthur, J. S. C., Gauthier, S. & Elce, J. S., 24 Jul 1995, In : FEBS Letters. 368, 3, p. 397-400 4 p.

Research output: Contribution to journalArticle

Mutagenesis
Calpain
Site-Directed Mutagenesis
Catalytic Domain
Cysteine Proteases
43 Citations (Scopus)
187 Downloads (Pure)

Active Vertex Model for Cell-Resolution Description of Epithelial Tissue Mechanics

Barton, D. L., Henkes, S., Weijer, C. J. & Sknepnek, R., 30 Jun 2017, In : PLoS Computational Biology. 13, 6, 34 p., e1005569.

Research output: Contribution to journalArticle

Open Access
File
Vertex Model
Mechanics
mechanics
epithelium
Epithelium
17 Citations (Scopus)

Active water transport in unicellular algae: where, why, and how

Raven, J. A. & Doblin, M. A., 22 Dec 2014, In : Journal of Experimental Botany. 65, 22, p. 6279-6292 14 p.

Research output: Contribution to journalArticle

algae
Active Biological Transport
Water
Xylem
water
25 Citations (Scopus)
180 Downloads (Pure)

Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity

Pao, K-C., Wood, N. T., Knebel, A., Rafie, K., Stanley, M., Mabbitt, P. D., Sundaramoorthy, R., Hofmann, K., van Aalten, D. M. F. & Virdee, S., 11 Apr 2018, In : Nature. 556, 7701, p. 381-385 5 p.

Research output: Contribution to journalArticle

Open Access
File
Ubiquitin-Protein Ligases
Esterification
Ubiquitin
Genes
Ubiquitination
103 Citations (Scopus)

Activity of any class IA PI3K isoform can sustain cell proliferation and survival

Foukas, L. C., Berenjeno, I. M., Gray, A., Khwaja, A. & Vanhaesebroeck, B., 22 Jun 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 25, p. 11381-11386 6 p.

Research output: Contribution to journalArticle

244 Citations (Scopus)
Phenformin
Muscle Contraction
Skeletal Muscle
AMP-Activated Protein Kinases
Metformin
1 Citation (Scopus)
108 Downloads (Pure)
Open Access
File
Leishmania infantum
promastigotes
visceral leishmaniasis
Amiodarone
Anti-Arrhythmia Agents
4 Citations (Scopus)

A cultivation-independent approach for the genetic and cyanotoxin characterization of colonial cyanobacteria

Lara, Y., Lambion, A., Menzel, D., Codd, G. A. & Wilmotte, A., 2013, In : Aquatic Microbial Ecology. 69, 2, p. 135-143 9 p.

Research output: Contribution to journalArticle

cyanobacterial toxins
Microcystis
Cyanobacteria
cyanobacterium
immunoassays
109 Citations (Scopus)

Acute or chronic upregulation of mitochondrial fatty acid oxidation has no net effect on whole-body energy expenditure or adiposity

Hoehn, K. L., Turner, N., Swarbrick, M. M., Wilks, D., Preston, E., Phua, Y., Joshi, H., Furler, S. M., Larance, M., Hegarty, B. D., Leslie, S. J., Pickford, R., Hoy, A. J., Kraegen, E. W., James, D. E. & Cooney, G. J., 6 Jan 2010, In : Cell Metabolism. 11, 1, p. 70-76 7 p.

Research output: Contribution to journalArticle

Adiposity
Energy Metabolism
Up-Regulation
Fatty Acids
AMP-Activated Protein Kinases
12 Citations (Scopus)

A cyanobacterial light activated adenylyl cyclase partially restores development of a Dictyostelium discoideum, adenylyl cyclase a null mutant

Chen, Z., Raffelberg, S., Losi, A., Schaap, P. & Gärtner, W., 10 Dec 2014, In : Journal of Biotechnology. 191, p. 246-249 4 p.

Research output: Contribution to journalArticle

Dictyostelium
Adenylyl Cyclases
Light
Darkness
Eukaryota
34 Citations (Scopus)

A cyclic GMP-dependent signalling pathway regulates bacterial phytopathogenesis

An, S-Q., Chin, K-H., Febrer, M., McCarthy, Y., Yang, J-G., Liu, C-L., Swarbreck, D., Rogers, J., Dow, J. M., Chou, S-H. & Ryan, R. P., 11 Sep 2013, In : EMBO Journal. 32, 18, p. 2430-2438

Research output: Contribution to journalArticle

Cyclic GMP
Biofilms
Virulence
Xanthomonas campestris
Second Messenger Systems
52 Citations (Scopus)

Acyclic nucleoside analogues as inhibitors of Plasmodium falciparum dUTPase

Nguyen, C., Ruda, G. F., Schipani, A., Kasinathan, G., Leal, I., Musso-Buendia, A., Kaiser, M., Brun, R., Ruiz-Perez, L. M., Sahlberg, B-L., Johansson, N. G., Gonzalez-Pacanowska, D. & Gilbert, I. H., 13 Jul 2006, In : Journal of Medicinal Chemistry. 49, 14, p. 4183-4195 13 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Acyl-CoA binding protein is essential in bloodstream form Trypanosoma brucei

Milne, K. G., Guther, M. L. S. & Ferguson, M. A. J., Feb 2001, In : Molecular and Biochemical Parasitology. 112, 2, p. 301-304 4 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)

Adenomatous polyposis coli and hypoxia-inducible factor-1 alpha have an antagonistic connection

Newton, I. P., Kenneth, N. S., Appleton, P. L., Nathke, I. & Rocha, S., 1 Nov 2010, In : Molecular Biology of the Cell. 21, 21, p. 3630-3638 9 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)
117 Downloads (Pure)

Adenosine-mono-phosphate-activated protein kinase-independent effects of metformin in T cells

Zarrouk, M., Finlay, D. K., Foretz, M., Viollet, B. & Cantrell, D. A., 2 Sep 2014, In : PLoS ONE. 9, 9, 7 p., e106710.

Research output: Contribution to journalArticle

Open Access
File
metformin
AMP-activated protein kinase
T-cells
Adenine Nucleotides
Metformin
10 Citations (Scopus)

A de novo FLCN mutation in a patient with spontaneous pneumothorax and renal cancer; a clinical and molecular evaluation

Menko, F. H., Johannesma, P. C., van Moorselaar, R. J. A., Reinhard, R., van Waesberghe, J. H., Thunnissen, E., Houweling, A. C., Leter, E. M., Waisfisz, Q., van Doorn, M. B., Starink, T. M., Postmus, P. E., Coull, B. J., van Steensel, M. A. M. & Gille, J. J. P., Sep 2013, In : Familial Cancer. 12, 3, p. 373-379 7 p.

Research output: Contribution to journalArticle

Estrone
Kidney Neoplasms
Pneumothorax
Mutation
Neoplasms
4 Citations (Scopus)
137 Downloads (Pure)
Open Access
File
Dictyostelium
Adenylyl Cyclases
Genes
Cell Movement
bis(3',5')-cyclic diguanylic acid
32 Citations (Scopus)

Adenylyl cyclase G is activated by an intramolecular osmosensor

Saran, S., Schaap, P. & Devreotes, P. (ed.), 2004, In : Molecular Biology of the Cell. 15, 3, p. 1479-1486 8 p.

Research output: Contribution to journalArticle

Adenylyl Cyclases
Osmolar Concentration
Dimerization
Catalytic Domain
Cats
13 Citations (Scopus)
130 Downloads (Pure)

A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage

Ladds, M. J. G. W., Van Leeuwen, I. M. M., Drummond, C. J., Chu, S., Healy, A. R., Popova, G., Pastor Fernández, A., Mollick, T., Darekar, S., Sedimbi, S. K., Nekulova, M., Sachweh, M. C. C., Campbell, J., Higgins, M., Tuck, C., Popa, M., Safont, M. M., Gelebart, P., Fandalyuk, Z., Thompson, A. M. & 26 others, Svensson, R., Gustavsson, A. L., Johansson, L., Färnegårdh, K., Yngve, U., Saleh, A., Haraldsson, M., D'Hollander, A. C. A., Franco, M., Zhao, Y., Håkansson, M., Walse, B., Larsson, K., Peat, E. M., Pelechano, V., Lunec, J., Vojtesek, B., Carmena, M., Earnshaw, W. C., McCarthy, A. R., Westwood, N. J., Arsenian-Henriksson, M., Lane, D. P., Bhatia, R., McCormack, E. & Laín, S., 16 Mar 2018, In : Nature Communications. 9, p. 1-14 14 p., 1107.

Research output: Contribution to journalArticle

Open Access
File
dehydrogenases
inhibitors
Tumors
tumors
Cells
22 Citations (Scopus)

A Dictyostelium homologue of the metazoan Cbl proteins regulates STAT signalling

Langenick, J., Araki, T., Yamada, Y. & Williams, J. G., 1 Nov 2008, In : Journal of Cell Science. 121, 21, p. 3524-3530 7 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

A Dictyostelium SH2 adaptor protein required for correct DIF-1 signaling and pattern formation

Sugden, C., Ross, S., Annesley, S. J., Cole, C., Bloomfield, G., Ivens, A., Skelton, J., Fisher, P. R., Barton, G. & Williams, J. G., 15 May 2011, In : Developmental Biology. 353, 2, p. 290-301 12 p.

Research output: Contribution to journalArticle

48 Citations (Scopus)

A direct interaction between the carboxyl-terminal region of CDC5L and the WD40 domain of PLRG1 is essential for pre-mRNA splicing

Ajuh, P., Sleeman, J., Chusainow, J. & Lamond, A. I., 2001, In : Journal of Biological Chemistry. 276, 45, p. 42370-42381 12 p.

Research output: Contribution to journalArticle

RNA Precursors
Multiprotein Complexes
Proteins
Spliceosomes
Fungal Proteins
206 Citations (Scopus)

A discrete period of FGF-induced Erk1/2 signalling is required for vertebrate neural specification

Stavridis, M. P., Lunn, J. S., Collins, B. J. & Storey, K. G., 2007, In : Development. 134, 16, p. 2889-94 6 p.

Research output: Contribution to journalArticle

Fibroblast Growth Factors
Chick Embryo
Embryonic Stem Cells
Phosphatidylinositol 3-Kinases
Vertebrates
3 Citations (Scopus)
122 Downloads (Pure)

A disease resistance locus on potato and tomato chromosome 4 exhibits a conserved multipartite structure displaying different rates of evolution in different lineages

Destefanis, M., Nagy, I., Rigney, B., Bryan, G. J., McLean, K., Hein, I., Griffin, D. & Milbourne, D., 24 Oct 2015, In : Functional Plant Biology. 15, 13 p., 255.

Research output: Contribution to journalArticle

Open Access
File
disease resistance
tomatoes
potatoes
gene conversion
Solanum tuberosum
7 Citations (Scopus)

A dominant mutation in MAPKAPK3, an actor of p38 signaling pathway, causes a new retinal dystrophy involving Bruch's membrane and retinal pigment epithelium

Meunier, I., Lenaers, G., Bocquet, B., Baudoin, C., Piro-Megy, C., Cubizolle, A., Quilès, M., Jean-Charles, A., Cohen, S. Y., Merle, H., Gaudric, A., Labesse, G., Manes, G., Péquignot, M., Cazevieille, C., Dhaenens, C-M., Fichard, A., Ronkina, N., Arthur, J. S. C., Gaestel, M. & 1 others, Hamel, C. P., 1 Mar 2016, In : Human Molecular Genetics. 25, 5, p. 916-26 11 p.

Research output: Contribution to journalArticle

Retinal Dystrophies
Bruch Membrane
Retinal Pigment Epithelium
Retinal Diseases
Mutation
26 Citations (Scopus)

ADS1 encodes a MATE-transporter that negatively regulates plant disease resistance

Sun, X., Gilroy, E. M., Chini, A., Nurmberg, P. L., Hein, I., Lacomme, C., Birch, P. R. J., Hussain, A., Yun, B-W. & Loake, G. J., 2011, In : New Phytologist. 192, 2, p. 471-482 12 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

A dual mechanism of cytoprotection afforded by M-LDH in embryonic heart H9C2 cells

Jovanovic, S., Du, Q., Sukhodub, A. & Jovanovic, A., Aug 2009, In : Biochimica et Biophysica Acta. Molecular Cell Research. 1793, 8, p. 1379-1386 8 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
83 Downloads (Pure)
Open Access
File
Stainless Steel
Polytetrafluoroethylene
Polytetrafluoroethylenes
titanium oxides
Titanium dioxide
50 Citations (Scopus)

Advancing cell biology through proteomics in space and time (PROSPECTS)

Lamond, A. I., Uhlen, M., Horning, S., Makarov, A., Robinson, C. V., Serrano, L., Hartl, F. U., Baumeister, W., Werenskiold, A. K., Andersen, J. S., Vorm, O., Linial, M., Aebersold, R. & Mann, M., 1 Mar 2012, In : Molecular & Cellular Proteomics. 11, 3

Research output: Contribution to journalArticle

Cytology
Proteomics
Cell Biology
Specifications
Proteins

Adverse effects of high glucose levels on somite and limb development in avian embryos

Chen, Y., Wang, G., Ma, Z., Li, Y., Wang, X., Cheng, X., Chuai, M., Tang, S., Lee, K. K. H. & Yang, X., 2014, In : Food and Chemical Toxicology. 71, September, p. 1-9 9 p.

Research output: Contribution to journalArticle

Somites
limbs (animal)
embryo (animal)
Embryonic Structures
Extremities
58 Citations (Scopus)
284 Downloads (Pure)

A dyad of lymphoblastic lysosomal cysteine proteases degrades the antileukemic drug L-asparaginase

Patel, N., Krishnan, S., Offman, M. N., Krol, M., Moss, C. X., Leighton, C., van Delft, F. W., Holland, M., Liu, J., Alexander, S., Dempsey, C., Ariffin, H., Essink, M., Eden, T. O. B., Watts, C., Bates, P. A. & Saha, V., 2009, In : Journal of Clinical Investigation. 119, 7, p. 1964-1973 10 p.

Research output: Contribution to journalArticle

Open Access
File
34 Citations (Scopus)
125 Downloads (Pure)

A dynamic microtubule cytoskeleton directs medial actomyosin function during tube formation

Booth, A. J. R., Blanchard, G. B., Adams, R. J. & Röper, K., 9 Jun 2014, In : Developmental Cell. 29, 5, p. 562-576 15 p.

Research output: Contribution to journalArticle

Open Access
File
Actomyosin
Cytoskeleton
Microtubules
Constriction
Plakins
26 Citations (Scopus)
177 Downloads (Pure)

Aerobic and anaerobic biosynthesis of nano-selenium for remediation of mercury contaminated soil

Wang, X., Zhang, D., Pan, X., Lee, D. J., Al-Misned, F. A., Mortuza, M. G. & Gadd, G. M., 1 Mar 2017, In : Chemosphere. 170, p. 266-273 8 p.

Research output: Contribution to journalArticle

Open Access
File
Biosynthesis
Selenium
Remediation
Mercury
selenium
30 Citations (Scopus)

A facile reporter system for the experimental identification of twin-arginine translocation (Tat) signal peptides from all kingdoms of life

Widdick, D. A., Eijlander, R. T., van Dijl, J. M., Kuipers, O. P. & Palmer, T., 18 Jan 2008, In : Journal of Molecular Biology. 375, 3, p. 595-603 9 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
22 Downloads (Pure)

A family of Type VI secretion system effector proteins that form ion-selective pores

Mariano, G., Trunk, K., Williams, D. J., Monlezun, L., Strahl, H., Pitt, S. J. & Coulthurst, S., 2 Dec 2019, In : Nature Communications. 10, 1, p. 1-15 15 p., 5484.

Research output: Contribution to journalArticle

Open Access
File
effectors
secretions
Genes
Ions
proteins
19 Citations (Scopus)

Affinity purification of diverse plant and human 14-3-3-binding partners

Milne, F. C., Moorhead, G., Pozuelo-Rubio, M., Wong, B., Kulma, A., Harthill, J. E., Villadsen, D., Cotelle, V. & MacKintosh, C., Aug 2002, In : Biochemical Society Transactions. 30, 4, p. 379-381 3 p.

Research output: Contribution to journalArticle

66 Citations (Scopus)

A fission yeast general translation factor reveals links between protein synthesis and cell cycle controls

Grallert, B., Kearsey, SE., Lenhard, M., Carlson, CR., Nurse, P., Boye, E. & Labib, K., 2000, In : Journal of Cell Science. 113, 8, p. 1447-1458 12 p.

Research output: Contribution to journalArticle

A fitness cost resulting from Hamiltonella defensa infection is associated with altered probing and feeding behaviour in Rhopalosiphum padi

Leybourne, D. J., Valentine, T. A., Bos, J. I. B. & Karley, A. J., 2 Jan 2020, In : Journal of Experimental Biology. 223, Pt 1, 207936.

Research output: Contribution to journalArticle

Rhopalosiphum padi
Aphids
Feeding Behavior
feeding behavior
aphid
10 Citations (Scopus)

A fluorescence lifetime-based assay for serine and threonine kinases that is suitable for high-throughput screening

Paterson, M. J., Dunsmore, C. J., Hurteaux, R., Maltman, B. A., Cotton, G. J. & Gray, A., 1 Jul 2010, In : Analytical Biochemistry. 402, 1, p. 54-64 11 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)

A fragment-based approach to probing adenosine recognition sites by using dynamic combinatorial chemistry

Scott, D. E., Dawes, G. J., Ando, M., Abell, C. & Ciulli, A., 23 Nov 2009, In : ChemBioChem. 10, 17, p. 2772-2779 8 p.

Research output: Contribution to journalArticle

pantothenate synthetase
Adenosine
Disulfides
Carrier Proteins
Enzymes
8 Citations (Scopus)
173 Downloads (Pure)

African trypanosomes evade immune clearance by O-glycosylation of the VSG surface coat

Pinger, J., Nešić, D., Ali, L., Aresta-Branco, F., Lilic, M., Chowdhury, S., Kim, H. S., Verdi, J., Raper, J., Ferguson, M. A. J., Papavasiliou, F. N. & Stebbins, C. E., Aug 2018, In : Nature Microbiology. 3, 8, p. 932-938 7 p.

Research output: Contribution to journalArticle

Open Access
File
Trypanosomiasis
Membrane Glycoproteins
Glycosylation
Antigenic Variation
Immunity