School of Life Sciences

  • United Kingdom

Research Output 1968 2020

2019
25 Citations (Scopus)

Genebank genomics highlights the diversity of a global barley collection

Milner, S. G., Jost, M., Taketa, S., Mazón, E. R., Himmelbach, A., Oppermann, M., Weise, S., Knüpffer, H., Basterrechea, M., König, P., Schüler, D., Sharma, R., Pasam, R. K., Rutten, T., Guo, G., Xu, D., Zhang, J., Herren, G., Müller, T., Krattinger, S. G. & 14 others, Keller, B., Jiang, Y., González, M. Y., Zhao, Y., Habekuß, A., Färber, S., Ordon, F., Lange, M., Börner, A., Graner, A., Reif, J. C., Scholz, U., Mascher, M. & Stein, N., 2019, In : Nature Genetics. 51, p. 319-326 8 p.

Research output: Contribution to journalArticle

Hordeum
Genomics
Potyviridae
Genome-Wide Association Study
Sample Size
30 Downloads (Pure)

Genetic ablation of purine salvage in Cryptosporidium parvum reveals nucleotide uptake from the host cell

Pawlowic, M., Somepalli, M., Sateriale, A., Herbert, G. T., Gibson, A., Cuny, G. D., Hedstrom, L. & Striepen, B., 30 Sep 2019, In : Proceedings of the National Academy of Sciences. 6 p.

Research output: Contribution to journalArticle

Open Access
File
Cryptosporidium parvum
Cryptosporidium
Purine Nucleotides
Nucleotides
Parasites
62 Downloads (Pure)

Genetic Diversity and Structure of Northern Populations of the Declining Coastal Plant Eryngium maritimum

Ieviņa, B., Rostoks, N., Syed, N. H., Flavell, A. J. & Ievinsh, G., 26 Mar 2019, In : Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences. Section B, 9 p.

Research output: Contribution to journalArticle

Open Access
File
genetic variation
Eryngium maritimum
environmental factors
retrotransposons
genetic drift
1 Citation (Scopus)
6 Downloads (Pure)

Genetic recoding to dissect the roles of site-specific protein O-GlcNAcylation

Gorelik, A., Galan Bartual, S., Borodkin, V., Varghese, J., Ferenbach, A. & van Aalten, D., Nov 2019, In : Nature Structural & Molecular Biology. 26, 11, p. 1071-1077 7 p.

Research output: Contribution to journalArticle

Clustered Regularly Interspaced Short Palindromic Repeats
Proteins
Proteome
Dissection
hexosaminidase C
3 Citations (Scopus)
119 Downloads (Pure)

Genetic variations in A20 DUB domain provide a genetic link to citrullination and neutrophil extracellular traps in systemic lupus erythematosus

Odqvist, L., Jevnikar, Z., Riise, R., Öberg, L., Rhedin, M., Leonard, D., Yrlid, L., Jackson, S., Mattsson, J., Nanda, S., Cohen, P., Knebel, A., Arthur, S., Thörn, K., Svenungsson, E., Jönsen, A., Gunnarsson, I., Tandre, K., Alexsson, A., Kastbom, A. & 10 others, Rantapää-Dahlqvist, S., Eloranta, M-L., Syvänen, A-C., Bengtsson, A., Johansson, P., Sandling, J. K., Sjöwall, C., Rönnblom, L., Collins, B. & Vaarala, O., 12 Jul 2019, In : Annals of the Rheumatic Diseases. 8 p.

Research output: Contribution to journalArticle

Open Access
File
Systemic Lupus Erythematosus
Polymorphism
Clustered Regularly Interspaced Short Palindromic Repeats
Genes
RNA Sequence Analysis
1 Citation (Scopus)
48 Downloads (Pure)

Genome-wide association mapping in a diverse spring barley collection reveals the presence of QTL hotspots and candidate genes for root and shoot architecture traits at seedling stage

Abdel-Ghani, A. H., Sharma, R., Wabila, C., Dhanagond, S., Owais, S. J., Duwayri, M. A., Al-Dalain, S. A., Klukas, C., Chen, D., Lübberstedt, T., von Wirén, N., Graner, A., Kilian, B. & Neumann, K., 23 May 2019, In : BMC Plant Biology. 19, p. 1-19 19 p., 216.

Research output: Contribution to journalArticle

Open Access
File
Hordeum
Seedlings
Genome
Genes
Droughts
2 Citations (Scopus)

Genome-wide association study of inhaled corticosteroid response in admixed children with asthma

Hernandez-Pacheco, N., Farzan, N., Francis, B., Karimi, L., Repnik, K., Vijverberg, S. J., Soares, P., Schieck, M., Gorenjak, M., Forno, E., Eng, C., Oh, S. S., Pérez-Méndez, L., Berce, V., Tavendale, R., Samedy, L. A., Hunstman, S., Hu, D., Meade, K., Farber, H. J. & 21 others, Avila, P. C., Serebrisky, D., Thyne, S. M., Brigino-Buenaventura, E., Rodriguez-Cintron, W., Sen, S., Kumar, R., Lenoir, M., Rodriguez-Santana, J. R., Celedón, J. C., Mukhopadhyay, S., Potočnik, U., Pirmohamed, M., Verhamme, K. M., Kabesch, M., Palmer, C. N. A., Hawcutt, D. B., Flores, C., van der Zee, A. H. M., Burchard, E. G. & Pino-Yanes, M., Jun 2019, In : Clinical and Experimental Allergy. 49, 6, p. 789-798 10 p.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Adrenal Cortex Hormones
Asthma
Hispanic Americans
Population
5 Citations (Scopus)

Global geographical and historical overview of cyanotoxin distribution and cyanobacterial poisonings

Svirčev, Z., Lalić, D., Bojadžija Savić, G., Tokodi, N., Drobac Backović, D., Chen, L., Meriluoto, J. & Codd, G. A., Sep 2019, In : Archives of Toxicology. 93, 9, p. 2429-2481 53 p.

Research output: Contribution to journalReview article

Poisons
Poisoning
Animals
Cyanobacteria
Microcystins
1 Citation (Scopus)
32 Downloads (Pure)

Glyphosate does not substitute for glycine in proteins of actively dividing mammalian cells

Antoniou, M. N., Nicolas, A., Mesnage, R., Biserni, M., Rao, F. V. & Martin, C. V., 8 Aug 2019, In : BMC Research Notes. 12, 1, p. 1-7 7 p., 494.

Research output: Contribution to journalArticle

Open Access
File
glyphosate
Glycine
Cells
Proteins
Bearings (structural)
5 Citations (Scopus)
82 Downloads (Pure)

GPR55 deficiency is associated with increased adiposity and impaired insulin signaling in peripheral metabolic tissues

Lipina, C., Walsh, S. K., Mitchell, S. E., Speakman, J. R., Wainwright, C. L. & Hundal, H., Jan 2019, In : FASEB Journal. 33, 1, p. 1299-1312 14 p.

Research output: Contribution to journalArticle

Open Access
File
Adiposity
G-Protein-Coupled Receptors
Insulin
Tissue
Insulin Resistance
9 Downloads (Pure)

G-quadruplex structures trigger RNA phase separation

Zhang, Y., Yang, M., Duncan, S., Yang, X., Abdelhamid, M. A. S., Huang, L., Zhang, H., Benfey, P. N., Waller, Z. A. E. & Ding, Y., 16 Dec 2019, In : Nucleic Acids Research. 47, 22, p. 11746-11754 9 p.

Research output: Contribution to journalArticle

Open Access
File
G-Quadruplexes
RNA
Cell Separation
Cytoskeleton
Organelles
12 Downloads (Pure)

Group A, B, C, and G Streptococcus Lancefield antigen biosynthesis is initiated by a conserved α-D-GlcNAc-β-1,4-L-rhamnosyltransferase

Zorzoli, A., Meyer, B. H., Adair, E., Torgov, V. I., Veselovsky, V. V., Danilov, L. L., Uhrin, D. & Dorfmueller, H. C., 18 Oct 2019, In : Journal of Biological Chemistry. 294, 42, p. 15237-15256 20 p.

Research output: Contribution to journalArticle

Open Access
File
Biosynthesis
Streptococcus
Carbohydrates
Antigens
Rhamnose
8 Citations (Scopus)

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids

Nakamura, K., Saredi, G., Becker, J. R., Foster, B. M., Nguyen, N. V., Beyer, T. E., Cesa, L. C., Faull, P. A., Lukauskas, S., Frimurer, T., Chapman, J. R., Bartke, T. & Groth, A., 2019, In : Nature Cell Biology. 21, 3, p. 311-318 8 p.

Research output: Contribution to journalArticle

Chromatids
Homologous Recombination
Ankyrin Repeat
G2 Phase
S Phase
3 Citations (Scopus)

Harnessing the potential of germplasm collections

Langridge, P. & Waugh, R., Feb 2019, In : Nature Genetics. 51, 2, p. 200-201 2 p.

Research output: Contribution to journalComment/debate

Informatics
Food Supply
Hordeum
Genomics
Genotype
2 Citations (Scopus)
3 Downloads (Pure)

Heteroaggregation of soil particulate organic matter and biogenic selenium nanoparticles for remediation of elemental mercury contamination

Wang, X., Wang, S., Pan, X. & Gadd, G. M., Apr 2019, In : Chemosphere. 221, p. 486-492 7 p.

Research output: Contribution to journalArticle

Open Access
File
Particulate Matter
Selenium
particulate organic matter
Remediation
Mercury
4 Citations (Scopus)
47 Downloads (Pure)

Hierarchical activation of compartmentalized pools of AMPK depends on severity of nutrient or energy stress

Zong, Y., Zhang, C-S., Li, M., Wang, W., Wang, Z., Hawley, S. A., Ma, T., Feng, J-W., Tian, X., Qi, Q., Wu, Y-Q., Zhang, C., Ye, Z., Lin, S-Y., Piao, H-L., Hardie, D. G. & Lin, S-C., 4 Apr 2019, In : Cell Research. 29, p. 460-473 14 p.

Research output: Contribution to journalArticle

Open Access
File
AMP-Activated Protein Kinases
Adenosine Monophosphate
Food
Mitochondrial Dynamics
Lysosomes

High-Level Expression in Escherichia coli, Purification and Kinetic Characterization of LAPTc, a Trypanosoma cruzi M17-Aminopeptidase

Izquierdo, M., Aguado, M. E., Zoltner, M. & González-Bacerio, J., Apr 2019, In : Protein Journal. 38, 2, p. 167-180 14 p.

Research output: Contribution to journalArticle

Leucyl Aminopeptidase
Aminopeptidases
Trypanosoma cruzi
Escherichia coli
Purification
1 Citation (Scopus)
86 Downloads (Pure)

Highlights of the mini-symposium on extracellular vesicles in inter-organismal communication, held in Munich, Germany, August 2018

Bielska, E., Birch, P. R. J., Buck, A. H., Abreu-Goodger, C., Innes, R. W., Jin, H., Pfaffl, M. W., Robatzek, S., Regev-Rudzki, N., Tisserant, C., Wang, S. & Weiberg, A., 18 Mar 2019, In : Journal of Extracellular Vesicles. 8, 1, p. 1-8 8 p., 1590116.

Research output: Contribution to journalArticle

Open Access
File
Germany
Oomycetes
Extracellular Vesicles
Cell Communication
Extracellular Matrix
6 Citations (Scopus)

Highly Selective PTK2 Proteolysis Targeting Chimeras to Probe Focal Adhesion Kinase Scaffolding Functions

Popow, J., Arnhof, H., Bader, G., Berger, H., Ciulli, A., Covini, D., Dank, C., Gmaschitz, T., Greb, P., Karolyi-Özguer, J., Koegl, M., McConnell, D. B., Pearson, M., Rieger, M., Rinnenthal, J., Roessler, V., Schrenk, A., Spina, M., Steurer, S., Trainor, N. & 4 others, Traxler, E., Wieshofer, C., Zoephel, A. & Ettmayer, P., 14 Mar 2019, In : Journal of Medicinal Chemistry. 62, 5, p. 2508–2520 13 p.

Research output: Contribution to journalArticle

Focal Adhesion Protein-Tyrosine Kinases
Proteolysis
Hepatocellular Carcinoma
Cell Line
Ubiquitin-Protein Ligases
70 Downloads (Pure)

High-resolution experimental and computational electrophysiology reveals weak β-lactam binding events in the porin PorB

Bartsch, A., Llabres, S., Pein, F., Kattner, C., Schön, M., Diehn, M., Tanabe, M., Munk, A., Zachariae, U. & Steinem, C., 4 Feb 2019, In : Scientific Reports. 9, p. 1-11 11 p., 1264.

Research output: Contribution to journalArticle

Open Access
File
Lactams
Porins
Electrophysiology
Anti-Bacterial Agents
Gram-Negative Bacteria
19 Downloads (Pure)

High-Resolution RT-PCR Analysis of Alternative Barley Transcripts

Simpson, C. G., Fuller, J., Rapazote-Flores, P., Mayer, C. D., Calixto, C. P. G., Milne, L., Hedley, P. E., Booth, C., Waugh, R. & Brown, J. W. S., 2019, Barley: Methods and Protocols. Harwood, W. A. (ed.). New York: Humana Press, Vol. 1900. p. 269-281 13 p. (Methods in Molecular Biology).

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Open Access
File
Hordeum
RNA
Polymerase Chain Reaction
Protein Isoforms
Genome
Open Access
Ubiquitin-Protein Ligases
Ubiquitin
Esters
Viral Structures
Toll-Like Receptors
1 Citation (Scopus)

How Plants Grow Up

McKim, S., 18 Mar 2019, In : Journal of Integrative Plant Biology . 61, 3, p. 257-277 21 p.

Research output: Contribution to journalReview article

Bearings (structural)
Hinges
Plant Structures
Inflorescence
Crops
41 Downloads (Pure)
Open Access
File
Differential Expression
Eukaryota
RNA
Gene expression
Gene Expression
5 Citations (Scopus)
21 Downloads (Pure)

Human and computational models of atopic dermatitis: A review and perspectives by an expert panel of the International Eczema Council

Eyerich, K., Brown, S. J., Perez White, B. E., Tanaka, R. J., Bissonette, R., Dhar, S., Bieber, T., Hijnen, D. J., Guttman-Yassky, E., Irvine, A., Thyssen, J. P., Vestergaard, C., Werfel, T., Wollenberg, A., Paller, A. S. & Reynolds, N. J., 1 Jan 2019, In : Journal of Allergy and Clinical Immunology. 143, 1, p. 36-45 10 p.

Research output: Contribution to journalArticle

Open Access
File
Eczema
Atopic Dermatitis
Therapeutics
Biological Models
Precision Medicine
20 Citations (Scopus)

Hypoxia induces rapid changes to histone methylation and reprograms chromatin

Batie, M., Frost, J., Frost, M., Wilson, J. W., Schofield, P. & Rocha, S., 15 Mar 2019, In : Science. 363, 6432, p. 1222-1226 5 p.

Research output: Contribution to journalArticle

Histone Demethylases
Histones
Methylation
Chromatin
Dioxygenases

Identification and characterisation of Helicobacter pylori O-acetylserine-dependent cystathionine β-synthase, a distinct member of the PLP-II family

Devi, S., Tarique, K. F., Ali, M. F., Abdul Rehman, S. A. & Gourinath, S., 21 Aug 2019, In : Molecular Microbiology. 112, 2, p. 718-739 22 p.

Research output: Contribution to journalArticle

Cystathionine
Helicobacter pylori
Cysteine Synthase
Serine
Cysteine
15 Downloads (Pure)

Identification of A Novel Class of Benzofuran Oxoacetic Acid-Derived Ligands that Selectively Activate Cellular EPAC1

Beck, E. M., Parnell, E., Cowley, A., Porter, A., Gillespie, J., Robinson, J., Robinson, L., Pannifer, A. D., Hamon, V., Jones, P., Morrison, A., McElroy, S., Timmerman, M., Rutjes, H., Mahajan, P., Wiejak, J., Luchowska-Stańska, U., Morgan, D., Barker, G., Rehmann, H. & 1 others, Yarwood, S. J., Nov 2019, In : Cells. 8, 11, p. 1-18 18 p., 1468.

Research output: Contribution to journalArticle

Open Access
File
GTP Phosphohydrolases
Cyclic Nucleotides
Assays
Nucleotides
High-Throughput Screening Assays

Identification of Endogenous Adenomatous Polyposis Coli Interaction Partners and β-Catenin-Independent Targets by Proteomics

Popow, O., Paulo, J. A., Tatham, M., Volk, M., Rojas-Fernandez, A., Loyer, N., Newton, I., Januschke, J., Haigis, K. M. & Nathke, I., Sep 2019, In : Molecular Cancer Research. 17, 9, p. 1828-1841 14 p.

Research output: Contribution to journalArticle

Catenins
Adenomatous Polyposis Coli
Proteomics
Phosphotransferases
Colorectal Neoplasms
4 Citations (Scopus)

Identification of GSK3186899/DDD853651 as a Preclinical Development Candidate for the Treatment of Visceral Leishmaniasis

Thomas, M. G., De Rycker, M., Ajakane, M., Albrecht, S., Álvarez-Pedraglio, A. I., Boesche, M., Brand, S., Campbell, L., Cantizani-Perez, J., Cleghorn, L. A. T., Copley, R. C. B., Crouch, S. D., Daugan, A., Drewes, G., Ferrer, S., Ghidelli-Disse, S., Gonzalez, S., Gresham, S. L., Hill, A. P., Hindley, S. J. & 32 others, Lowe, R. M., MacKenzie, C. J., MacLean, L., Manthri, S., Martin, F., Miguel-Siles, J., Nguyen, V. L., Norval, S., Osuna-Cabello, M., Woodland, A., Patterson, S., Pena, I., Quesada-Campos, M. T., Reid, I. H., Revill, C., Riley, J., Ruiz-Gomez, J. R., Shishikura, Y., Simeons, F. R. C., Smith, A., Smith, V. C., Spinks, D., Stojanovski, L., Thomas, J., Thompson, S., Underwood, T., Gray, D. W., Fiandor, J. M., Gilbert, I. H., Wyatt, P. G., Read, K. D. & Miles, T. J., 14 Feb 2019, In : Journal of Medicinal Chemistry. 62, 3, p. 1180-1202 23 p.

Research output: Contribution to journalArticle

Visceral Leishmaniasis
Leishmania major
Leishmania donovani
Standard of Care
Solubility
56 Downloads (Pure)

Identification of inhibitors of an unconventional Trypanosoma brucei kinetochore kinase

Torrie, L., Zuccotto, F., Robinson, D., Gray, D., Gilbert, I. & De Rycker, M., 31 May 2019, In : PLoS ONE. 14, 5, p. 1-16 16 p., e0217828.

Research output: Contribution to journalArticle

Open Access
File
Kinetochores
Trypanosoma brucei
kinetochores
Trypanosoma brucei brucei
phosphotransferases (kinases)
3 Citations (Scopus)
80 Downloads (Pure)

Identification of Leishmania major UDP-Sugar Pyrophosphorylase Inhibitors Using Biosensor-Based Small Molecule Fragment Library Screening

Prakash, O., Führing, J., Post, J., Shepherd, S. M., Eadsforth, T. C., Gray, D., Fedorov, R. & Routier, F. H., 12 Mar 2019, In : Molecules and Cells. 24, 5, p. 1-16 16 p., 996.

Research output: Contribution to journalArticle

Open Access
File
Uridine Diphosphate Sugars
Small Molecule Libraries
Leishmania major
Biosensing Techniques
sugars
1 Citation (Scopus)
49 Downloads (Pure)

Identification of Novel Trypanosoma cruzi Proteasome Inhibitors Using a Luminescence-Based High-Throughput Screening Assay

Zmuda, F., Sastry, L., Shepherd, S. M., Jones, D., Scott, A., Craggs, P. D., Cortes, A., Gray, D. W., Torrie, L. S. & De Rycker, M., Sep 2019, In : Antimicrobial Agents and Chemotherapy. 63, 9, p. 1-15 15 p., e00309-19.

Research output: Contribution to journalArticle

Open Access
File
High-Throughput Screening Assays
Proteasome Inhibitors
Trypanosoma cruzi
Proteasome Endopeptidase Complex
Luminescence
12 Downloads (Pure)

IgA: Structure, function and developability

Woof, J. & de Sousa-Pereira, P., 5 Dec 2019, In : Antibodies. 8, 4, p. 57 30 p.

Research output: Contribution to journalReview article

Open Access
File
Immunoglobulin A
Immunoglobulin Isotypes
Immunoglobulin Heavy Chains
Fc Receptors
Phagocytes
1 Citation (Scopus)
132 Downloads (Pure)

IL-33 regulates cytokine production and neutrophil recruitment via the p38 MAPK-activated kinases MK2/3

McCarthy, P. C., Phair, I. R., Greger, C., Pardali, K., McGuire, V. A., Clark, A. R., Gaestel, M. & Arthur, J. S. C., 17 Jan 2019, In : Immunology and Cell Biology. 97, 1, p. 54-71 18 p.

Research output: Contribution to journalArticle

Open Access
File
Neutrophil Infiltration
Mitogen-Activated Protein Kinase Kinases
p38 Mitogen-Activated Protein Kinases
Mast Cells
Cytokines
4 Citations (Scopus)
31 Downloads (Pure)

Imaging microstructure of the barley rhizosphere: particle packing and root hair influences

Koebernick, N., Daly, K. R., Keyes, S. D., Bengough, A. G., Brown, L. K., Cooper, L. J., George, T. S., Hallett, P. D., Naveed, M., Raffan, A. & Roose, T., 7 Feb 2019, In : New Phytologist. 221, 4, p. 1878-1889

Research output: Contribution to journalArticle

Open Access
File
Rhizosphere
root hairs
Hordeum
microstructure
rhizosphere

Immobilization of elemental mercury by biogenic Se nanoparticles in soils of varying salinity

Wang, X., Pan, X. & Gadd, G. M., 10 Jun 2019, In : Science of the Total Environment. 668, p. 303-309 7 p.

Research output: Contribution to journalArticle

Mercury
Selenium
immobilization
selenium
Nanoparticles
1 Citation (Scopus)
33 Downloads (Pure)

Increased autophagy in EphrinB2-deficient osteocytes is associated with elevated secondary mineralization and brittle bone

Vrahnas, C., Blank, M., Dite, T. A., Tatarczuch, L., Ansari, N., Crimeen-Irwin, B., Nguyen, H., Forwood, M. R., Hu, Y., Ikegame, M., Bambery, K. R., Petibois, C., Mackie, E. J., Tobin, M. J., Smyth, G. K., Oakhill, J. S., Martin, T. J. & Sims, N. A., 31 Jul 2019, In : Nature Communications. 10, 1, 16 p., 3436.

Research output: Contribution to journalArticle

Open Access
File
Osteocytes
Physiologic Calcification
Autophagy
bones
Bone

Inhibition of CorA dependent Magnesium Homeostasis is cidal in Mycobacterium tuberculosis

Park, Y., Ahn, Y-M., Jonnala, S., Oh, S., Fisher, J. M., Goodwin, M. B., Loerger, T. R., Via, L. E., Bayliss, T., Green, S. R., Ray, P. C., Wyatt, P. G., Barry, C. E. & Boshoff, H. I., 23 Sep 2019, In : Antimicrobial Agents and Chemotherapy. 63, 10, p. 1-14 14 p., e01006-19.

Research output: Contribution to journalArticle

Mycobacterium tuberculosis
Magnesium
Homeostasis
Amides
Symporters
1 Citation (Scopus)
101 Downloads (Pure)

Insights into evolving global populations of Phytophthora infestans via new complementary mtDNA haplotype markers and nuclear SSRs

Martin, F. N., Zhang, Y., Cooke, D. E. L., Coffey, M. D., Grünwald, N. J. & Fry, W. E., 2 Jan 2019, In : PLoS ONE. 14, 1, p. 1-24 24 p., e0208606.

Research output: Contribution to journalArticle

Open Access
File
Phytophthora infestans
Mitochondrial DNA
Haplotypes
haplotypes
mitochondrial DNA
34 Downloads (Pure)

Integrative construction of regulatory region networks in 127 human reference epigenomes by matrix factorization

Liu, D., Davila-Velderrain, J., Zhang, Z. & Kellis, M., 22 Aug 2019, In : Nucleic Acids Research. 47, 14, p. 7235-7246 12 p.

Research output: Contribution to journalArticle

Open Access
File
Nucleic Acid Regulatory Sequences
Chromatin
Information Storage and Retrieval
Epigenomics
Genes
4 Citations (Scopus)
5 Downloads (Pure)

Investigating Mitophagy and Mitochondrial Morphology In Vivo Using mito-QC: A Comprehensive Guide

McWilliams, T. G. & Ganley, I. G., 2019, Autophagy: Methods and Protocols. Ktistakis, N. & Florey, O. (eds.). New York: Humana Press, Vol. 1880. p. 621-642 22 p. (Methods in Molecular Biology; vol. 1880).

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Open Access
File
Mitochondrial Degradation
Quality Control
Autophagy
Organelles
Homeostasis
2 Citations (Scopus)

In-vitro antibacterial and anti-encrustation performance of silver-polytetrafluoroethylene nanocomposite coated urinary catheters

Wang, L., Zhang, S., Keatch, R., Corner, G., Nabi, G., Murdoch, S., Davidson, F. & Zhao, Q., 22 Sep 2019, In : Journal of Hospital Infection. 103, 1, p. 55-63 9 p.

Research output: Contribution to journalArticle

Open Access
Nanocomposites
Urinary Catheters
Polytetrafluoroethylene
Silver
Catheters
32 Downloads (Pure)

In vitro reconstitution defines the minimal requirements for Cdc48-dependent disassembly of the CMG helicase in budding yeast

Mukherjee, P. & Labib, K., 10 Sep 2019, In : Cell Reports. 28, 11, p. 2777-2783.e4 11 p.

Research output: Contribution to journalArticle

Open Access
File
Cullin Proteins
Saccharomycetales
Multicarrier modulation
Ligases
Ubiquitin

Isolation, Purification, Generation, and Culture of Osteocytes

Gooi, J. H., Chia, L. Y., Vrahnas, C. & Sims, N. A., 2019, Humana Press. 13 p. (Methods in Molecular Biology (Clifton, N.J.))

Research output: Book/ReportBook

Osteocytes
Osteoblasts
Cell Line
Bone Matrix
Skeleton
23 Citations (Scopus)
240 Downloads (Pure)

Iterative design and optimization of initially inactive Proteolysis Targeting Chimeras (PROTACs) identify VZ185 as a potent, fast and selective von Hippel-Lindau (VHL)-based dual degrader probe of BRD9 and BRD7

Zoppi, V., Hughes, S. J., Maniaci, C., Testa, A., Gmaschitz, T., Wieshofer, C., Koegl, M., Riching, K. M., Daniels, D. L., Spallarossa, A. & Ciulli, A., 24 Jan 2019, In : Journal of Medicinal Chemistry. 62, 2, p. 699-726 28 p.

Research output: Contribution to journalArticle

Open Access
File
Ubiquitination
Ligases
Proteolysis
Chromatin Assembly and Disassembly
Ubiquitin-Protein Ligases
2 Citations (Scopus)
48 Downloads (Pure)

Junction resolving enzymes use multivalency to keep the Holliday junction dynamic

Zhou, R., Yang, O., Declais, A-C., Jin, H., Gwon, G. H., Freeman, A., Cho, Y., Lilley, D. & Ha, T., 1 Mar 2019, In : Nature Chemical Biology. 15, 3, p. 269-275 7 p.

Research output: Contribution to journalArticle

Open Access
File
Cruciform DNA
Enzymes
Genetic Recombination
Bacteriophage T7
Chromosome Segregation
33 Downloads (Pure)

Juxta-membrane S-acylation of plant receptor-like kinases is likely fortuitous and does not necessarily impact upon function

Hurst, C., Wright, K. M., Turnbull, D., Leslie, K., Jones, S. & Hemsley, P., 2019, In : Scientific Reports. 9, p. 1-9 9 p., 12818.

Research output: Contribution to journalArticle

Open Access
File
acylation
phosphotransferases (kinases)
receptors
cysteine
mutation
3 Downloads (Pure)

Kinetics of cytokine receptor trafficking determine signaling and functional selectivity

Martinez-Fabregas, J., Wilmes, S., Wang, L., Hafer, M., Pohler, E., Lokau, J., Garbers, C., Cozzani, A., Piehler, J., Kazemian, M., Mitra, S. & Moraga Gonzalez, I., 27 Nov 2019, In : eLife. 8, p. 1-32 32 p., e49314.

Research output: Contribution to journalArticle

Open Access
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Cytokine Receptors
Kinetics
Interleukin-6
Cytokines
Th17 Cells
36 Downloads (Pure)

Kti12, a PSTK-like tRNA dependent ATPase essential for tRNA modification by Elongator

Krutyhołowa, R., Hammermeister, A., Zabel, R., Abdel-Fattah, W., Reinhardt-Tews, A., Helm, M., Stark, M. J. R., Breunig, K. D., Schaffrath, R. & Glatt, S., 21 May 2019, In : Nucleic Acids Research. 47, 9, p. 4814-4830 17 p.

Research output: Contribution to journalArticle

Open Access
File
Transfer RNA
Adenosine Triphosphatases
Selenocysteine
Anticodon
Hydrolysis