School of Life Sciences

  • United Kingdom

Research Output 1968 2020

2 Citations (Scopus)

Advanced electrical array interconnections for ultrasound probes integrated in surgical needles

Schiavone, G., Jones, T., Price, D., McPhillips, R., Qiu, Z., Demore, C. E. M., Jiang, Y., Meggs, C., Mahboob, S. O., Eljamel, S., Button, T. W., Cochran, S. & Desmulliez, M. P. Y., 30 Jan 2015, Proceedings of the 2014 IEEE 16th Electronics Packaging Technology Conference (EPTC 2014). IEEE, p. 88-93 6 p. 7028266

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Needles
Ultrasonics
Transducers
Electronic equipment
Neurosurgery
4 Citations (Scopus)
2 Citations (Scopus)
57 Downloads (Pure)
Open Access
File
Stainless Steel
Polytetrafluoroethylene
Polytetrafluoroethylenes
titanium oxides
Titanium dioxide
16 Citations (Scopus)

Advances in bacterial transcriptome and transposon insertion-site profiling using second-generation sequencing

Febrer, M., McLay, K., Caccamo, M., Twomey, K. B. & Ryan, R. . P., 1 Nov 2011, In : Trends in Biotechnology. 29, 11, p. 586-594 9 p.

Research output: Contribution to journalReview article

1 Citation (Scopus)
164 Downloads (Pure)

Advances in targeted degradation of endogenous proteins

Roth, S., Fulcher, L. & Sapkota, G., 27 Apr 2019, In : Cellular and Molecular Life Sciences. 76, 14, p. 2761-2777 17 p.

Research output: Contribution to journalReview article

Open Access
File
Proteolysis
Proteins
Clustered Regularly Interspaced Short Palindromic Repeats
Gene Targeting
Protein Biosynthesis
50 Citations (Scopus)

Advancing cell biology through proteomics in space and time (PROSPECTS)

Lamond, A. I., Uhlen, M., Horning, S., Makarov, A., Robinson, C. V., Serrano, L., Hartl, F. U., Baumeister, W., Werenskiold, A. K., Andersen, J. S., Vorm, O., Linial, M., Aebersold, R. & Mann, M., 1 Mar 2012, In : Molecular & Cellular Proteomics. 11, 3

Research output: Contribution to journalArticle

Cytology
Proteomics
Cell Biology
Specifications
Proteins

Adverse effects of high glucose levels on somite and limb development in avian embryos

Chen, Y., Wang, G., Ma, Z., Li, Y., Wang, X., Cheng, X., Chuai, M., Tang, S., Lee, K. K. H. & Yang, X., 2014, In : Food and Chemical Toxicology. 71, September, p. 1-9 9 p.

Research output: Contribution to journalArticle

Somites
limbs (animal)
embryo (animal)
Embryonic Structures
Extremities
57 Citations (Scopus)
268 Downloads (Pure)

A dyad of lymphoblastic lysosomal cysteine proteases degrades the antileukemic drug L-asparaginase

Patel, N., Krishnan, S., Offman, M. N., Krol, M., Moss, C. X., Leighton, C., van Delft, F. W., Holland, M., Liu, J., Alexander, S., Dempsey, C., Ariffin, H., Essink, M., Eden, T. O. B., Watts, C., Bates, P. A. & Saha, V., 2009, In : Journal of Clinical Investigation. 119, 7, p. 1964-1973 10 p.

Research output: Contribution to journalArticle

Open Access
File
34 Citations (Scopus)
110 Downloads (Pure)

A dynamic microtubule cytoskeleton directs medial actomyosin function during tube formation

Booth, A. J. R., Blanchard, G. B., Adams, R. J. & Röper, K., 9 Jun 2014, In : Developmental Cell. 29, 5, p. 562-576 15 p.

Research output: Contribution to journalArticle

Open Access
File
Actomyosin
Cytoskeleton
Microtubules
Constriction
Plakins
26 Citations (Scopus)
163 Downloads (Pure)

Aerobic and anaerobic biosynthesis of nano-selenium for remediation of mercury contaminated soil

Wang, X., Zhang, D., Pan, X., Lee, D. J., Al-Misned, F. A., Mortuza, M. G. & Gadd, G. M., 1 Mar 2017, In : Chemosphere. 170, p. 266-273 8 p.

Research output: Contribution to journalArticle

Open Access
File
Biosynthesis
Selenium
Remediation
Mercury
selenium
30 Citations (Scopus)

A facile reporter system for the experimental identification of twin-arginine translocation (Tat) signal peptides from all kingdoms of life

Widdick, D. A., Eijlander, R. T., van Dijl, J. M., Kuipers, O. P. & Palmer, T., 18 Jan 2008, In : Journal of Molecular Biology. 375, 3, p. 595-603 9 p.

Research output: Contribution to journalArticle

10 Downloads (Pure)

A family of Type VI secretion system effector proteins that form ion-selective pores

Mariano, G., Trunk, K., Williams, D. J., Monlezun, L., Strahl, H., Pitt, S. J. & Coulthurst, S., 2 Dec 2019, In : Nature Communications. 10, 1, p. 1-15 15 p.

Research output: Contribution to journalArticle

Open Access
File
effectors
secretions
Genes
Ions
proteins
4 Citations (Scopus)

Affinity methods for phosphorylation-dependent interactions.

Moorhead, G. & MacKintosh, C., 1 Jan 2004, In : Methods in Molecular Biology (Clifton, N.J.). 261, p. 469-478 10 p.

Research output: Contribution to journalReview article

Phosphorylation
Proteins
Phosphopeptides
Phosphoprotein Phosphatases
Phosphoproteins
19 Citations (Scopus)

Affinity purification of diverse plant and human 14-3-3-binding partners

Milne, F. C., Moorhead, G., Pozuelo-Rubio, M., Wong, B., Kulma, A., Harthill, J. E., Villadsen, D., Cotelle, V. & MacKintosh, C., Aug 2002, In : Biochemical Society Transactions. 30, 4, p. 379-381 3 p.

Research output: Contribution to journalArticle

66 Citations (Scopus)

A fission yeast general translation factor reveals links between protein synthesis and cell cycle controls

Grallert, B., Kearsey, SE., Lenhard, M., Carlson, CR., Nurse, P., Boye, E. & Labib, K., 2000, In : Journal of Cell Science. 113, 8, p. 1447-1458 12 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

A fluorescence lifetime-based assay for serine and threonine kinases that is suitable for high-throughput screening

Paterson, M. J., Dunsmore, C. J., Hurteaux, R., Maltman, B. A., Cotton, G. J. & Gray, A., 1 Jul 2010, In : Analytical Biochemistry. 402, 1, p. 54-64 11 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

A fluorescent in vitro assay to investigate paralog-specific SUMO conjugation

Eisenhardt, N., Chaugule, V. K. & Pichler, A., 2016, SUMO: methods and protocols. Rodriguez, M. S. (ed.). New York: Springer , Vol. 1475. p. 67-78 12 p. (Methods in molecular biology; vol. 1475).

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Sumoylation
Small Ubiquitin-Related Modifier Proteins
Ubiquitin-Protein Ligases
Ubiquitin
Enzymes
38 Citations (Scopus)

A fragment-based approach to probing adenosine recognition sites by using dynamic combinatorial chemistry

Scott, D. E., Dawes, G. J., Ando, M., Abell, C. & Ciulli, A., 23 Nov 2009, In : ChemBioChem. 10, 17, p. 2772-2779 8 p.

Research output: Contribution to journalArticle

pantothenate synthetase
Adenosine
Disulfides
Carrier Proteins
Enzymes
6 Citations (Scopus)
151 Downloads (Pure)

African trypanosomes evade immune clearance by O-glycosylation of the VSG surface coat

Pinger, J., Nešić, D., Ali, L., Aresta-Branco, F., Lilic, M., Chowdhury, S., Kim, H. S., Verdi, J., Raper, J., Ferguson, M. A. J., Papavasiliou, F. N. & Stebbins, C. E., Aug 2018, In : Nature Microbiology. 3, 8, p. 932-938 7 p.

Research output: Contribution to journalArticle

Open Access
File
Trypanosomiasis
Membrane Glycoproteins
Glycosylation
Antigenic Variation
Immunity

A fully-automated insonation system for in vitro investigations of ultrasound-mediated targeted drug delivery

Stewart, F., Liu, Y., Roncin, P., Newton, I. P., Huang, Z., Nathke, I. & Cochran, S., 2 Nov 2017. 1 p.

Research output: Contribution to conferencePaper

delivery
drugs
transducers
endoscopes
hyperthermia
239 Citations (Scopus)

A functional genomics approach identifies candidate effectors from the aphid species Myzus persicae (green peach aphid)

Bos, J. I. B., Prince, D., Pitino, M., Maffei, M. E., Win, J. & Hogenhout, S. A., 18 Nov 2010, In : PLoS Genetics. 6, 11, e1001216.

Research output: Contribution to journalArticle

Aphids
Myzus persicae
Genomics
aphid
Aphidoidea
136 Citations (Scopus)

A functional "knockout" of human keratin 14

Rugg, E. L., McLean, W. H., Lane, E. B., Pitera, R., McMillan, J. R., Dopping-Hepenstal, P. J., Navsaria, H. A., Leigh, I. M. & Eady, R. A., 1 Nov 1994, In : Genes & Development. 8, 21, p. 2563-2573 11 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
91 Downloads (Pure)

A Functional Link Between Bir1 and the Saccharomyces cerevisiae Ctf19 Kinetochore Complex Revealed Through Quantitative Fitness Analysis

Makrantoni, V., Ciesiolka, A., Lawless, C., Fernius, J., Marston, A. L., Lydall, D. & Stark, M. J. R., 7 Sep 2017, In : G3 : Genes, Genomes, Genetics. 7, 9, p. 3203-3215 13 p.

Research output: Contribution to journalArticle

Open Access
File
Kinetochores
Gene Knockout Techniques
Saccharomyces cerevisiae
Nonsense Mediated mRNA Decay
Large Ribosome Subunits
3 Citations (Scopus)
149 Downloads (Pure)

A functional SUMO-motif in the active site of PIM1 promotes its degradation via RNF4, and stimulates protein kinase activity

Iyer, R. S., Chatham, L., Sleigh, R. & Meek, D. W., 15 Jun 2017, In : Scientific Reports. 7, p. 1-14 14 p., 3598.

Research output: Contribution to journalArticle

Open Access
File
Sumoylation
Ubiquitin
Protein Kinases
Catalytic Domain
Substrate Specificity
5 Citations (Scopus)

A Gadolinium Spin Label with Both a Narrow Central Transition and Short Tether for Use in Double Electron Electron Resonance Distance Measurements

Shah, A., Roux, A., Starck, M., Mosely, J. A., Stevens, M., Norman, D. G., Hunter, R. I., El Mkami, H., Smith, G. M., Parker, D. & Lovett, J. E., 4 Mar 2019, In : Inorganic Chemistry. 58, 5, p. 3015-3025 11 p.

Research output: Contribution to journalArticle

Electron resonance
Spin Labels
Distance measurement
Gadolinium
gadolinium
16 Citations (Scopus)
3 Citations (Scopus)
117 Downloads (Pure)

A gene of the β3-glycosyltransferase family encodes N-acetylglucosaminyltransferase II function in Trypanosoma brucei

Damerow, M., Graalfs, F., Guther, M. L. S., Mehlert, A., Izquierdo, L. & Ferguson, M. A. J., 24 Jun 2016, In : Journal of Biological Chemistry. 291, 26, p. 13834-13845 12 p.

Research output: Contribution to journalArticle

Open Access
File
Glycosyltransferases
Trypanosoma brucei brucei
Polysaccharides
Genes
Pathogens
10 Citations (Scopus)

A general and efficient approach for the construction of RNA oligonucleotides containing a 5'-phosphorothiolate linkage

Li, N-S., Frederiksen, J. K., Koo, S. C., Lu, J., Wilson, T. J., Lilley, D. M. J. & Piccirilli, J. A., Mar 2011, In : Nucleic Acids Research. 39, 5, p. - 16 p., e31.

Research output: Contribution to journalArticle

11 Citations (Scopus)
86 Downloads (Pure)

A Generic Platform for Cellular Screening Against Ubiquitin Ligases

Maculins, T., Carter, N., Dorval, T., Hudson, K., Nissink, J. W. M., Hay, R. T. & Alwan, H., 8 Jan 2016, In : Scientific Reports. 6, 18940.

Research output: Contribution to journalArticle

Open Access
File
Ubiquitin-Protein Ligases
Ligases
Ubiquitin
Ubiquitination
Technology
38 Citations (Scopus)

A genetic analysis of in vivo selenate reduction by Salmonella enterica serovar Typhimurium LT2 and Escherichia coli K12

Guymer, D., Maillard, J. & Sargent, F., Jun 2009, In : Archives of Microbiology. 191, 6, p. 519-528 10 p.

Research output: Contribution to journalArticle

181 Citations (Scopus)

A Genetic Interaction Map of RNA-Processing Factors Reveals Links between Sem1/Dss1-Containing Complexes and mRNA Export and Splicing

Wilmes, G. M., Bergkessel, M., Bandyopadhyay, S., Shales, M., Braberg, H., Cagney, G., Collins, S. R., Whitworth, G. B., Kress, T. L., Weissman, J. S., Ideker, T., Guthrie, C. & Krogan, N. J., 5 Dec 2008, In : Molecular Cell. 32, 5, p. 735-746 12 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
RNA
Messenger RNA
Essential Genes
RNA Precursors
44 Citations (Scopus)

A genetic screen for suppressors of Escherichia coli Tat signal peptide mutations establishes a critical role for the second arginine within the twin-arginine motif

Buchanan, G., Sargent, F., Berks, B. C. & Palmer, T., Dec 2001, In : Archives of Microbiology. 177, 1, p. 107-112 6 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)
105 Downloads (Pure)

A genome wide association scan for (1,3;1,4)-β-glucan content in the grain of contemporary 2-row Spring and Winter barleys

Houston, K., Russell, J., Schreiber, M., Halpin, C., Oakey, H., Washington, J. M., Booth, A., Shirley, N., Burton, R. A., Fincher, G. B. & Waugh, R., 17 Oct 2014, In : BMC Genomics. 15, 15 p., 907.

Research output: Contribution to journalArticle

Open Access
File
Genome-Wide Association Study
Hordeum
Genes
Genome
Molecular Sequence Annotation
8 Citations (Scopus)

A genome-wide association study for culm cellulose content in barley reveals candidate genes co-expressed with members of the Cellulose Synthase A gene family

Houston, K., Burton, R. A., Sznajder, B., Rafalski, A. J., Dhugga, K. S., Mather, D. E., Taylor, J., Steffenson, B. J., Waugh, R. & Fincher, G. B., 8 Jul 2015, In : PLoS ONE. 10, 7, 21 p., e0130890.

Research output: Contribution to journalArticle

cellulose synthase
Genome-Wide Association Study
Hordeum
Cellulose
cellulose
5 Citations (Scopus)
145 Downloads (Pure)

A Genome Wide Association Study of arabinoxylan content in 2-row spring barley grain

Hassan, A. S., Houston, K., Lahnstein, J., Shirley, N., Schwerdt, J. G., Gidley, M. J., Waugh, R., Little, A. & Burton, R. A., 3 Aug 2017, In : PLoS ONE. 12, 8, p. 1-19 19 p., e0182537.

Research output: Contribution to journalArticle

Open Access
File
arabinoxylan
Genome-Wide Association Study
spring barley
Hordeum
Genes
37 Citations (Scopus)

Age-related HMG-CoA reductase deregulation depends on ROS-induced p38 activation

Pallottini, V., Martini, C., Cavallini, G., Bergamini, E., Mustard, K. J., Hardie, D. G. & Trentalance, A., 2007, In : Mechanisms of Ageing and Development. 128, 11-12, p. 688-695 8 p.

Research output: Contribution to journalArticle

Aggregation of Nontuberculous Mycobacteria in Vitro and in Situ

DePas, W., Bergkessel, M. & Newman, D. K., Sep 2017, In : Pediatric Pulmonology. 52, S47, p. S342 1 p., 336.

Research output: Contribution to journalConference article

Nontuberculous Mycobacteria
Mycobacterium smegmatis
Cystic Fibrosis
Glycerol
Infection
12 Downloads (Pure)

Aggregation of nontuberculous mycobacteria is regulated by carbon-nitrogen balance

Depas, W. H., Bergkessel, M. & Newman, D. K., Aug 2019, In : MBio. 10, 4, p. 1-17 17 p., e01715-19.

Research output: Contribution to journalArticle

Open Access
File
Nontuberculous Mycobacteria
Nitrogen
Carbon
Biofilms
Mycobacterium smegmatis
4 Citations (Scopus)
89 Downloads (Pure)
Open Access
File
Sulfolobus acidocaldarius
Glycosylation
Amino Acids
Proteins
Phosphotransferases
30 Citations (Scopus)

Agrosuppression: a bioassay for the hypersensitive response suited to high-throughput screening

Kamoun, S., Hamada, W. & Huitema, E., Jan 2003, In : Molecular Plant - Microbe Interactions. 16, 1, p. 7-13 7 p.

Research output: Contribution to journalArticle

191 Citations (Scopus)

A GSK3-binding peptide from FRAT1 selectively inhibits the GSK3-catalysed phosphorylation of Axin and β-catenin

Thomas, G. M., Frame, S., Goedert, M., Nathke, I., Polakis, P. & Cohen, P., 1999, In : FEBS Letters. 458, 2, p. 247-251 5 p.

Research output: Contribution to journalArticle

Glycogen Synthase Kinase 3
Catenins
Phosphorylation
T-cells
T-Cell Lymphoma
65 Citations (Scopus)

A guanine nucleobase important for catalysis by the VS ribozyme

Wilson, T. J., McLeod, A. C. & Lilley, D. M. J., 16 May 2007, In : EMBO Journal. 26, 10, p. 2489-2500 12 p.

Research output: Contribution to journalArticle

Catalytic RNA
Guanine
Catalysis
Substrates
Acids
20 Citations (Scopus)

A H3K9/S10 methyl-phospho switch modulates Polycomb and Pol II binding at repressed genes during differentiation

Sabbattini, P., Sjoberg, M., Nikic, S., Frangini, A., Holmqvist, P-H., Kunowska, N., Carroll, T., Brookes, E., Arthur, S. J., Pombo, A. & Dillon, N., 15 Mar 2014, In : Molecular Biology of the Cell. 25, 6, p. 904-915 12 p.

Research output: Contribution to journalArticle

S 10
Phosphotransferases
Aurora Kinase B
Genes
RNA Polymerase II
40 Citations (Scopus)
Hemeproteins
Turtles
Hepatocytes
Oxygen
Proteins
6 Citations (Scopus)

A Hes1-based oscillator in cultured cells and its potential implications for the segmentation clock

Dale, J. K. & Maroto, M., 2003, In : BioEssays. 25, 3, p. 200-203 4 p.

Research output: Contribution to journalArticle

Periodicity
Clocks
Cultured Cells
Cells
Biological Clocks
11 Citations (Scopus)

A high-content, cell-based screen identifies micropolyin, a new inhibitor of microtubule dynamics

De Rycker, M., Rigoreau, L., Dowding, S. & Parker, P. J., Jun 2009, In : Chemical Biology and Drug Design. 73, 6, p. 599-610 12 p.

Research output: Contribution to journalArticle

Microtubules
Tubulin
Prometaphase
M Phase Cell Cycle Checkpoints
Biological Phenomena
224 Citations (Scopus)

A high density barley microsatellite consensus map with 775 SSR loci

Varshney, R. K., Marcel, T. C., Ramsay, L., Russell, J., Röder, M. S., Stein, N., Waugh, R., Langridge, P., Niks, R. E. & Graner, A., 1 Apr 2007, In : Theoretical and Applied Genetics. 114, 6, p. 1091-1103 13 p.

Research output: Contribution to journalArticle

Hordeum
Microsatellite Repeats
barley
microsatellite repeats
loci
1 Citation (Scopus)
96 Downloads (Pure)

A highly compact packaging concept for ultrasound transducer arrays embedded in neurosurgical needles

Schiavone, G., Jones, T., Price, D., Mcphillips, R., Jiang, Y., Qiu, Z., Meggs, C., Mahboob, S. O., Eljamel, S., Button, T. W., Demore, C. E. M., Cochran, S. & Desmulliez, M. P. Y., Sep 2017, In : Microsystem Technologies. 23, 9, p. 3881-3891 11 p.

Research output: Contribution to journalArticle

Open Access
File
packaging
needles
Needles
Transducers
Packaging
32 Downloads (Pure)

A highly mutagenised barley (cv. Golden Promise) TILLING population coupled with strategies for screening-by-sequencing

Schreiber, M., Barakate, A., Uzrek, N., Macaulay, M., Sourdille, A., Morris, J., Hedley, P. E., Ramsay, L. & Waugh, R., 24 Aug 2019, In : Plant Methods. 15, p. 1-14 14 p., 99.

Research output: Contribution to journalArticle

Open Access
File
Hordeum
barley
screening
mutation
Mutation
43 Citations (Scopus)
139 Downloads (Pure)

A high quality Arabidopsis transcriptome for accurate transcript-level analysis of alternative splicing

Zhang, R., Calixto, C. P. G., Marquez, Y., Venhuizen, P., Tzioutziou, N. A., Guo, W., Spensley, M., Entizne, J. C., Lewandowska, D., ten Have, S., Frei dit Frey, N., Hirt, H., James, A. B., Nimmo, H. G., Barta, A., Kalyna, M. & Brown, J. W. S., 19 May 2017, In : Nucleic Acids Research. 45, 9, p. 5061-5073 13 p.

Research output: Contribution to journalArticle

Open Access
File
Alternative Splicing
Transcriptome
Arabidopsis
Protein Isoforms
RNA