School of Life Sciences

  • United Kingdom

Research Output 1968 2020

Review article
32 Citations (Scopus)
110 Downloads (Pure)

Keeping the home fires burning: AMP-activated protein kinase

Hardie, D. G., Jan 2018, In : Journal of the Royal Society Interface. 15, 138, 23 p., 20170774.

Research output: Contribution to journalReview article

Open Access
File
AMP-Activated Protein Kinases
Fires
Adenosine Triphosphate
Proteins
Adenosine Diphosphate
77 Citations (Scopus)

Kinetochore-microtubule interactions: steps towards bi-orientation

Tanaka, T. U., 15 Dec 2010, In : EMBO Journal. 29, 24, p. 4070-4082 13 p.

Research output: Contribution to journalReview article

81 Citations (Scopus)

Kinetochore-microtubule interactions: the means to the end

Tanaka, T. U. & Desai, A., Feb 2008, In : Current Opinion in Cell Biology. 20, 1, p. 53-63 11 p.

Research output: Contribution to journalReview article

338 Citations (Scopus)
192 Downloads (Pure)

Kinetoplastids: related protozoan pathogens, different diseases

Stuart, K., Brun, R., Croft, S., Fairlamb, A., Guertler, R. E., McKerrow, J., Reed, S. & Tarleton, R., 2008, In : Journal of Clinical Investigation. 118, 4, p. 1301-1310 10 p.

Research output: Contribution to journalReview article

Open Access
File
18 Citations (Scopus)

Laboratory evolution of protein conformational dynamics

Campbell, E. C., Correy, G. J., Mabbitt, P. D., Buckle, A. M., Tokuriki, N. & Jackson, C. J., Jun 2018, In : Current Opinion in Structural Biology. 50, p. 49-57 9 p.

Research output: Contribution to journalReview article

Proteins
16 Citations (Scopus)
298 Downloads (Pure)

Lectin receptors expressed on myeloid cells

Brown, G. D. & Crocker, P. R., 23 Sep 2016, In : Microbiology Spectrum. 4, 5, p. 1-26 26 p.

Research output: Contribution to journalReview article

Open Access
File
Mitogen Receptors
Sialic Acid Binding Immunoglobulin-like Lectins
Myeloid Cells
Lectins
health and disease
11 Citations (Scopus)

Lens intermediate filament proteins.

Sandilands, A., Masaki, S. & Quinlan, R. A., 1 Jan 1998, In : Sub-cellular biochemistry. 31, p. 291-318 28 p.

Research output: Contribution to journalReview article

5 Citations (Scopus)
109 Downloads (Pure)

Leveraging unique structural characteristics of WNK kinases to achieve therapeutic inhibition

Zhang, J., Deng, X. & Kahle, K. T., 18 Oct 2016, In : Science Signaling. 9, 450, p. 1-3 4 p., pe3.

Research output: Contribution to journalReview article

Open Access
File
Phosphotransferases
Member 1 Solute Carrier Family 12
Sodium-Potassium-Chloride Symporters
Therapeutics
Lysine
2 Citations (Scopus)

Lignin engineering to improve saccharification and digestibility in grasses

Halpin, C., Apr 2019, In : Current Opinion in Biotechnology. 56, p. 223-229 7 p.

Research output: Contribution to journalReview article

Saccharification
Lignin
Poaceae
Biosynthesis
Livestock
53 Citations (Scopus)

Linking sequence to phenotype in Phytophthora-plant interactions

Huitema, E., Bos, J. I. B., Tian, M., Win, J., Waugh, M. E. & Kamoun, S., Apr 2004, In : Trends in Microbiology. 12, 4, p. 193-200 8 p.

Research output: Contribution to journalReview article

33 Citations (Scopus)
113 Downloads (Pure)

Lipid modulation of skeletal muscle mass and function

Lipina, C. & Hundal, H. S., Apr 2017, In : Journal of Cachexia, Sarcopenia and Muscle. 8, 2, p. 190-201 12 p.

Research output: Contribution to journalReview article

Open Access
File
Skeletal Muscle
Lipids
Dietary Supplements
Fatty Acids
Obesity
127 Citations (Scopus)

Lipoprotein biogenesis in Gram-positive bacteria: knowing when to hold 'em, knowing when to fold 'em

Hutchings, M. I., Palmer, T., Harrington, D. J. & Sutcliffe, I. C., Jan 2009, In : Trends in Microbiology. 17, 1, p. 13-21 9 p.

Research output: Contribution to journalReview article

9 Citations (Scopus)

Living off the Sun: chlorophylls, bacteriochlorophylls and rhodopsins

Larkum, A. W. D., Ritchie, R. J. & Raven, J. A., Mar 2018, In : Photosynthetica. 56, 1, p. 11-43 33 p.

Research output: Contribution to journalReview article

Viola
Bacteriochlorophylls
algae
rhodopsin
Rhodopsin
77 Citations (Scopus)

Look on the positive side! The orientation, identification and bioenergetics of 'Archaeal' membrane-bound nitrate reductases

Martinez-Espinosa, R. M., Dridge, E. J., Bonete, M. J., Butt, J. N., Butler, C. S., Sargent, F. & Richardson, D. J., Nov 2007, In : FEMS Microbiology Letters. 276, 2, p. 129-139 11 p.

Research output: Contribution to journalReview article

26 Citations (Scopus)
123 Downloads (Pure)

Mammalian mitophagy – from in vitro molecules to in vivo models

Rodger, C. E., McWilliams, T. G. & Ganley, I. G., Apr 2018, In : FEBS Journal. 285, 7, p. 1185-1202 18 p.

Research output: Contribution to journalReview article

Open Access
File
Mitochondrial Degradation
Mitochondria
Mammals
Cells
Health
2 Citations (Scopus)

Management of plantar keratodermas: Lessons from pachyonychia congenita

Porter, R. M., Bravo, A. A. & Smith, F. J. D., Sep 2017, In : Journal of the American Podiatric Medical Association. 107, 5, p. 428-435 8 p.

Research output: Contribution to journalReview article

Pachyonychia Congenita
Bony Callus
Nails
Keratolytic Agents
Exfoliative Dermatitis
105 Downloads (Pure)

Mapping determinants of cytokine signaling via protein engineering

Gorby, C., Martinez-Fabregas, J., Wilmes, S. & Moraga Gonzalez, I., 27 Sep 2018, In : Frontiers in Immunology. 9, 9 p., 2143.

Research output: Contribution to journalReview article

Open Access
File
Protein Engineering
Cytokines
Ligands
Janus Kinases
Cytokine Receptors
39 Citations (Scopus)
120 Downloads (Pure)

Mathematical models for immunology: current state of the art and future research directions

Eftimie, R., Gillard, J. J. & Cantrell, D. A., Oct 2016, In : Bulletin of Mathematical Biology. 78, 10, p. 2091-2134 44 p.

Research output: Contribution to journalReview article

Open Access
File
Immunology
Allergy and Immunology
immunology
Theoretical Models
mathematical models
216 Citations (Scopus)

MCM proteins: evolution, properties, and role in DNA replication

Kearsey, SE. & Labib, K., 16 Jun 1998, In : Biochimica et Biophysica Acta-Gene Structure and Expression. 1398, 2, p. 113-136 24 p.

Research output: Contribution to journalReview article

13 Citations (Scopus)
108 Downloads (Pure)

Mechanism and disease-association of E2 conjugating enzymes: lessons from UBE2T and UBE2L3

Alpi, A. F., Chaugule, V. & Walden, H., 11 Oct 2016, In : Biochemical Journal. 473, 20, p. 3401-3419 19 p.

Research output: Contribution to journalReview article

Open Access
File
Ubiquitin
Enzymes
Ubiquitin-Activating Enzymes
DNA Repair-Deficiency Disorders
Ubiquitin-Protein Ligases
65 Citations (Scopus)

Mechanisms for ATP-dependent chromatin remodelling: the means to the end

Flaus, A. & Owen-Hughes, T., Oct 2011, In : FEBS Journal. 278, 19, p. 3579-3595 17 p.

Research output: Contribution to journalReview article

33 Citations (Scopus)

Mechanisms of RNA catalysis

Lilley, D. M. J., 27 Oct 2011, In : Philosophical Transactions of the Royal Society B - Biological Sciences. 366, 1580, p. 2910-2917 8 p.

Research output: Contribution to journalReview article

13 Citations (Scopus)
93 Downloads (Pure)

Melarsoprol Resistance in African Trypanosomiasis

Fairlamb, A. & Horn, D., Jun 2018, In : Trends in Parasitology. 34, 6, p. 481-492 12 p.

Research output: Contribution to journalReview article

Open Access
File
Melarsoprol
African Trypanosomiasis
Parasites
Drug Resistance
Pharmaceutical Preparations
9 Citations (Scopus)
neurotoxins
Neurotoxins
Cyanobacteria
Biosynthetic Pathways
biosynthesis
56 Citations (Scopus)

Metastases to the breast revisited: radiological-histopathological correlation

Bartella, L., Kaye, J., Perry, N. M., Malhotra, A., Evans, D., Ryan, D., Wells, C. & Vinnicombe, S. J., Jul 2003, In : Clinical Radiology. 58, 7, p. 524-31 8 p.

Research output: Contribution to journalReview article

Breast
Neoplasm Metastasis
Breast Neoplasms
Unnecessary Procedures
Neoplasms
26 Citations (Scopus)

Methylglyoxal metabolism in trypanosomes and leishmania

Wyllie, S. & Fairlamb, A. H., May 2011, In : Seminars in Cell & Developmental Biology. 22, 3, p. 271-277 7 p.

Research output: Contribution to journalReview article

27 Citations (Scopus)
45 Downloads (Pure)

Microbiological and environmental significance of metal-dependent anaerobic oxidation of methane

He, Z., Zhang, Q., Feng, Y., Luo, H., Pan, X. & Gadd, G. M., 1 Jan 2018, In : Science of the Total Environment. 610-611, p. 759-768 10 p.

Research output: Contribution to journalReview article

Open Access
File
Methane
methane
Metals
oxidation
Oxidation
65 Citations (Scopus)

Minimum information about a bioactive entity (MIABE)

Orchard, S., Al-Lazikani, B., Bryant, S., Clark, D., Calder, E., Dix, I., Engkvist, O., Forster, M., Gaulton, A., Gilson, M., Glen, R., Grigorov, M., Hammond-Kosack, K., Harland, L., Hopkins, A., Larminie, C., Lynch, N., Mann, R. K., Murray-Rust, P., Lo Piparo, E. & 6 others, Southan, C., Steinbeck, C., Wishart, D., Hermjakob, H., Overington, J. & Thornton, J., Sep 2011, In : Nature Reviews Drug Discovery. 10, 9, p. 661-669 9 p.

Research output: Contribution to journalReview article

21 Citations (Scopus)

Mitochondrial Function and Cell Size: An Allometric Relationship

Miettinen, T. P. & Björklund, M., Jun 2017, In : Trends in Cell Biology. 27, 6, p. 393-402 10 p.

Research output: Contribution to journalReview article

Mitochondrial Size
Cell Size
Mitochondrial Dynamics
Metabolic Diseases
Oxygen Consumption
128 Citations (Scopus)

Modulation of native and recombinant GABAA receptors by endogenous and synthetic neuroactive steroids

Lambert, J. J., Belelli, D., Harney, S. C., Peters, J. A. & Frenguelli, B. G., Nov 2001, In : Brain Research Reviews. 37, 1-3, p. 68-80 13 p.

Research output: Contribution to journalReview article

GABA-A Receptors
Pregnanes
Steroids
Neurotransmitter Agents
Central Nervous System
25 Citations (Scopus)

Molecular barley breeding

Rae, S. J., Macaulay, M., Ramsay, L., Leigh, F., Matthews, D., O'Sullivan, D. M., Donini, P., Morris, P. C., Powell, W., Marshall, D. F., Waugh, R. & Thomas, W. T. B., 1 Dec 2007, In : Euphytica. 158, 3, p. 295-303 9 p.

Research output: Contribution to journalReview article

DNA Shuffling
Hordeum
Gene Pool
barley
marker-assisted selection
55 Citations (Scopus)
123 Downloads (Pure)

Molecular effects of resistance elicitors from biological origin and their potential for crop protection

Wiesel, L., Newton, A. C., Elliott, I., Booty, D., Gilroy, E. M., Birch, P. R. J. & Hein, I., 21 Nov 2014, In : Frontiers in Plant Science. 5, 655, 13 p., 655.

Research output: Contribution to journalReview article

Open Access
File
plant protection
microorganisms
pathogens
plant response
virulence
1 Citation (Scopus)

Molecular genetics methods for human intermediate filament diseases

Smith, F. J. D., Sandilands, A. & McLean, W. H. I., 1 Dec 2004, In : Methods in Cell Biology. 2004, 78, p. 131-161 31 p.

Research output: Contribution to journalReview article

89 Citations (Scopus)

Molecular mechanisms underlying the control of antigenic variation in African trypanosomes

Horn, D. & McCulloch, R., Dec 2010, In : Current Opinion in Microbiology. 13, 6, p. 700-705 6 p.

Research output: Contribution to journalReview article

35 Citations (Scopus)
141 Downloads (Pure)
Open Access
File
Molecular recognition
Drug Design
Proteins
Cell signaling
Adhesives
4 Citations (Scopus)
36 Downloads (Pure)

mRNA cap regulation in mammalian cell function and fate

Galloway, A. & Cowling, V., Mar 2019, In : Biochimica et Biophysica Acta - Gene Regulatory Mechanisms. 1862, 3, p. 270-279 10 p.

Research output: Contribution to journalReview article

Open Access
File
Cells
Messenger RNA
RNA Polymerase II
RNA
Cell Physiological Phenomena
51 Citations (Scopus)

Multiple roles for protein palmitoylation in plants

Hemsley, P. A. & Grierson, C. S., Jun 2008, In : Trends in Plant Science. 13, 6, p. 295-302 8 p.

Research output: Contribution to journalReview article

acylation
proteins
guanosinetriphosphatase
cells
G-proteins
16 Citations (Scopus)

Myc regulation of mRNA cap methylation

Cowling, V. H. & Cole, M. D., Jun 2010, In : Genes and Cancer. 1, 6, p. 576-579 4 p.

Research output: Contribution to journalReview article

Methylation
myc Genes
Messenger RNA
RNA Polymerase II
Genes
6 Citations (Scopus)

Myc up-regulates formation of the mRNA methyl cap

Cowling, V. H., Dec 2010, In : Biochemical Society Transactions. 38, p. 1598-1601 4 p.

Research output: Contribution to journalReview article

Nanocomplejos del receptor para el antígeno de linfocitos T: Agruparse para cooperar

Translated title of the contribution: T cell receptor nanocomplexes: Cooperating clustersSchamel, W. W. A., Van Santen, H. M., Swamy, M. & Alarcón, B., 1 Dec 2008, In : Anales de la Real Academia Nacional de Farmacia. 74, 4, p. 727-742 16 p.

Research output: Contribution to journalReview article

T-Cell Antigen Receptor
Ligands
T-Lymphocytes
Adaptive Immunity
Detergents
1542 Citations (Scopus)

Network pharmacology: the next paradigm in drug discovery

Hopkins, A. L., Nov 2008, In : Nature Chemical Biology. 4, 11, p. 682-690 9 p.

Research output: Contribution to journalReview article

127 Citations (Scopus)

Neuroactive steroids and inhibitory neurotransmission: Mechanisms of action and physiological relevance

Belelli, D., Herd, M. B., Mitchell, E. A., Peden, D. R., Vardy, A. W., Gentet, L. & Lambert, J. J., 27 Mar 2006, In : Neuroscience. 138, 3, p. 821-829 9 p.

Research output: Contribution to journalReview article

Synaptic Transmission
Neurotransmitter Agents
GABA-A Receptors
Steroids
Brain
387 Citations (Scopus)

Neurosteroid modulation of GABAA receptors

Lambert, J. J., Belelli, D., Peden, D. R., Vardy, A. W. & Peters, J. A., Sep 2003, In : Progress in neurobiology. 71, 1, p. 67-80 14 p.

Research output: Contribution to journalReview article

GABA-A Receptors
Neurotransmitter Agents
Steroids
GABA Receptors
Pregnanes
670 Citations (Scopus)

Neurosteroids and GABAA receptor function

Lambert, J. J., Belelli, D., Hill-Venning, C. & Peters, J. A., Sep 1995, In : Trends in Pharmacological Sciences. 16, 9, p. 295-303 9 p.

Research output: Contribution to journalReview article

GABA-A Receptors
Neurotransmitter Agents
Steroids
Endocrine Glands
Modulators
61 Citations (Scopus)
8 Citations (Scopus)
120 Downloads (Pure)

Nuclear DNA Replication in Trypanosomatids: There Are No Easy Methods for Solving Difficult Problems

da Silva, M. S., Pavani, R. S., Damasceno, J. D., Marques, C. A., McCulloch, R., Tosi, L. R. O. & Elias, M. C., Nov 2017, In : Trends in Parasitology. 33, 11, p. 858-874 17 p.

Research output: Contribution to journalReview article

Open Access
File
DNA Replication
Eukaryota
Parasites
Origin Recognition Complex
Disease Eradication
22 Citations (Scopus)

Nuclear functions in space and time: Gene expression in a dynamic, constrained environment

Trinkle-Mulcahy, L. & Lamond, A. I., 18 Jun 2008, In : FEBS Letters. 582, 14, p. 1960-1970 11 p.

Research output: Contribution to journalReview article

13 Citations (Scopus)

Nuclear organization and transcriptional dynamics in Dictyostelium

Stevense, M., Chubb, J. R. & Muramoto, T., May 2011, In : Development, Growth & Differentiation. 53, 4, p. 576-586 11 p.

Research output: Contribution to journalReview article

2 Citations (Scopus)

Nucleosome remodelling: structural insights into ATP-dependent remodelling enzymes

Sundaramoorthy, R., Apr 2019, In : Essays in Biochemistry. 63, 1, p. 45-58 14 p.

Research output: Contribution to journalReview article

Nucleosomes
Adenosine Triphosphate
Chromatin Assembly and Disassembly
DNA sequences
Enzymes

Ocean acidification as a multiple driver: How interactions between changing seawater carbonate parameters affect marine life

Hurd, C. L., Beardall, J., Comeau, S., Cornwall, C. E., Havenhand, J. N., Munday, P. L., Parker, L. M., Raven, J. A. & McGraw, C. M., 29 Nov 2019, In : Marine and Freshwater Research.

Research output: Contribution to journalReview article

carbonate system
inorganic carbon
carbonates
seawater
carbonate