School of Life Sciences

  • United Kingdom

Research Output 1968 2020

2019
8 Citations (Scopus)

Mitotic CDK Promotes Replisome Disassembly, Fork Breakage, and Complex DNA Rearrangements

Deng, L., Wu, R. A., Sonneville, R., Kochenova, O. V., Labib, K., Pellman, D. & Walter, J. C., 7 Mar 2019, In : Molecular Cell. 73, 5, p. 915-929.e6 22 p.

Research output: Contribution to journalArticle

Gene Rearrangement
DNA Replication
Ubiquitination
Ovum
Xenopus
67 Downloads (Pure)

Molecular and bioinformatics analyses reveal two differentially expressed intracellular GH1 β-glucosidases from the rare alkalophilic fungus Stachybotrys microspora

Abdeljalil, S., Borgi, I., Carvalho, S., Jmal-Hammami, L. & Gargouri, A., 30 Jun 2019, In : Gene. 703, p. 134-144 11 p.

Research output: Contribution to journalArticle

Open Access
File
Stachybotrys
Microsporidia
Glucosidases
Computational Biology
Fungi
26 Downloads (Pure)

Monoallelic expression and epigenetic inheritance sustained by a Trypanosoma brucei variant surface glycoprotein exclusion complex

Correia Faria, J., Glover, L., Hutchinson, S., Boehm, C., Field, M. C. & Horn, D., 9 Jul 2019, In : Nature Communications. 10, p. 1-14 14 p., 3023.

Research output: Contribution to journalArticle

Open Access
File
Trypanosoma Variant Surface Glycoproteins
Trypanosoma brucei brucei
Membrane Glycoproteins
exclusion
Epigenomics

Move to metabolism

Cantrell, D. A., 29 Mar 2019, In : Nature Reviews Immunology. 19, 1 p., 270.

Research output: Contribution to journalComment/debate

Calcium-Calmodulin-Dependent Protein Kinases
AMP-Activated Protein Kinases
T-Cell Antigen Receptor
Phosphotransferases
Adenosine Triphosphate
4 Citations (Scopus)
27 Downloads (Pure)

mRNA cap regulation in mammalian cell function and fate

Galloway, A. & Cowling, V., Mar 2019, In : Biochimica et Biophysica Acta - Gene Regulatory Mechanisms. 1862, 3, p. 270-279 10 p.

Research output: Contribution to journalReview article

Open Access
File
Cells
Messenger RNA
RNA Polymerase II
RNA
Cell Physiological Phenomena
1 Citation (Scopus)
Open Access
Y Chromosome
Chromosomes
Peptides
Ions
Proteomics
1 Citation (Scopus)
28 Downloads (Pure)

Multiomics Analyses of HNF4α Protein Domain Function during Human Pluripotent Stem Cell Differentiation

Wang, Y., Tatham, M. H., Schmidt-Heck, W., Swann, C., Singh-Dolt, K., Meseguer-Ripolles, J., Lucendo-Villarin, B., Kunath, T., Rudd, T. R., Smith, A. J. H., Hengstler, J. G., Godoy, P., Hay, R. T. & Hay, D. C., 28 Jun 2019, In : iScience. 16, p. 206-217 12 p.

Research output: Contribution to journalArticle

Open Access
File
Hepatocyte Nuclear Factors
Pluripotent Stem Cells
Cell Differentiation
Hepatocytes
Liver
11 Downloads (Pure)

Multiple steps characterise ventricular layer attrition to form the ependymal cell lining of the adult mouse spinal cord central canal

Canizares, M. A., Rodrigo Albors, A., Singer, G., Suttie, N., Gorkic, M., Felts, P. & Storey, K. G., 31 Oct 2019, In : Journal of Anatomy. 17 p.

Research output: Contribution to journalArticle

Open Access
File
spinal cord
canal
Spinal Cord
mice
cells

Multi-task learning with a natural metric for quantitative structure activity relationship learning

Sadawi, N., Olier, I., Vanschoren, J., Van Rijn, J. N., Besnard, J., Bickerton, R., Grosan, C., Soldatova, L. & King, R. D., 12 Nov 2019, In : Journal of Cheminformatics. 11, 1, 68.

Research output: Contribution to journalArticle

Open Access
File
activity structure
learning
Assays
drugs
drug
41 Downloads (Pure)

Nitrogen Fertilisers Shape the Composition and Predicted Functions of the Microbiota of Field-Grown Tomato Plants

Caradonia, F., Ronga, D., Catellani, M., Azevedo, C. V. G., Alegria Terrazas, R., Robertson-Albertyn, S., Francia, E. & Bulgarelli, D., 14 Aug 2019, In : Phytobiomes Journal .

Research output: Contribution to journalArticle

Open Access
File
nitrogen fertilizers
tomatoes
microhabitats
rhizosphere
minerals
3 Citations (Scopus)
115 Downloads (Pure)

Nongenotoxic 3-Nitroimidazo[1,2-a]pyridines Are NTR1 Substrates That Display Potent in Vitro Antileishmanial Activity

Fersing, C., Basmaciyan, L., Boudot, C., Pedron, J., Hutter, S., Cohen, A., Castera-Ducros, C., Primas, N., Laget, M., Casanova, M., Bourgeade-Delmas, S., Piednoel, M., Sournia-Saquet, A., Belle Mbou, V., Courtioux, B., Boutet-Robinet, É., Since, M., Milne, R., Wyllie, S., Fairlamb, A. H. & 5 others, Valentin, A., Rathelot, P., Verhaeghe, P., Vanelle, P. & Azas, N., 10 Jan 2019, In : ACS Medicinal Chemistry Letters. 10, 1, p. 34-39 6 p.

Research output: Contribution to journalArticle

Open Access
File
Pyridines
Inhibitory Concentration 50
sulfoxide
miltefosine
Display devices

Nontuberculous Mycobacterial Aggregation is Regulated by C:N Balance

DePas, W., Bergkessel, M. & Newman, D. K., Oct 2019, In : Pediatric Pulmonology. 54, S2, p. S310 1 p., 411.

Research output: Contribution to journalConference article

Nontuberculous Mycobacteria
Zebrafish
Mycobacterium
Phagocytes
Biofilms

Novel mutations in desmoglein 1: Focal palmoplantar keratoderma in milder phenotypes

Zamiri, M., Wilson, N. J., O'Toole, E. A. & Smith, F. J. D., 1 Sep 2019, In : British Journal of Dermatology. 181, 3, p. 618-620 3 p.

Research output: Contribution to journalLetter

Desmoglein 1
Keratin-16
Keratin-1
Desmoplakins
Palmoplantar Keratoderma

Novel pharmacological actions of Trequinsin Hydrochloride improve human sperm cell motility and function

McBrinn, R. C., Fraser, J., Hope, A. G., Gray, D. W., Barratt, C. L. R., Martins da Silva, S. J. & Brown, S. G., 1 Aug 2019, In : British Journal of Pharmacology.

Research output: Contribution to journalArticle

Sperm Motility
Cell Movement
Pharmacology
Spermatozoa
Electrophysiology
21 Downloads (Pure)

Nuclear and cytoplasmic WDR-23 isoforms mediate differential effects on GEN-1 and SKN-1 substrates

Spatola, B. N., Lo, J. Y., Wang, B. & Curran, S. P., 13 Aug 2019, In : Scientific Reports. 9, 1, p. 1-11 11 p., 11783.

Research output: Contribution to journalArticle

Open Access
File
Protein Isoforms
Holliday Junction Resolvases
Ubiquitin-Protein Ligases
Ubiquitination
Proteasome Endopeptidase Complex
1 Citation (Scopus)

Nucleosome remodelling: structural insights into ATP-dependent remodelling enzymes

Sundaramoorthy, R., Apr 2019, In : Essays in Biochemistry. 63, 1, p. 45-58 14 p.

Research output: Contribution to journalReview article

Nucleosomes
Adenosine Triphosphate
Chromatin Assembly and Disassembly
DNA sequences
Enzymes
1 Citation (Scopus)

Obesity Reduces mTORC1 Activity in Mucosal-Associated Invariant T Cells, Driving Defective Metabolic and Functional Responses

O'Brien, A., Loftus, R. M., Pisarska, M. M., Tobin, L. M., Bergin, R., Wood, N. A. W., Foley, C., Mat, A., Tinley, F. C., Bannan, C., Sommerville, G., Veerapen, N., Besra, G. S., Sinclair, L. V., Moynagh, P. N., Lynch, L., Finlay, D. K., O'Shea, D. & Hogan, A. E., 15 Jun 2019, In : Journal of Immunology. 202, 12, p. 3404-3411 8 p.

Research output: Contribution to journalArticle

Obesity
Large Neutral Amino Acid-Transporter 1
Smegmamorpha
RNA Sequence Analysis
mechanistic target of rapamycin complex 1
45 Downloads (Pure)

Oncogenic PIK3CA mutations increase dependency on the mRNA cap methyltransferase, RNMT, in breast cancer cells

Dunn, S., Lombardi, O., Lukoszek, R. & Cowling, V., 17 Apr 2019, In : Open Biology. 9, 4, p. 1-15 15 p., 190052.

Research output: Contribution to journalArticle

Open Access
File
guanine
methyltransferases
Methyltransferases
breast neoplasms
Cells

On the ion coupling mechanism of the MATE transporter ClbM

Krah, A., Huber, R. G., Zachariae, U. & Bond, P. J., 28 Nov 2019, In : Biochimica et Biophysica Acta - Biomembranes. 28 p., 183137.

Research output: Contribution to journalArticle

Poisons
Extrusion
Ions
Conformations
Facings
77 Downloads (Pure)

Optimisation of a Key Cross-Coupling Reaction Towards the Synthesis of a Promising Antileishmanial Compound

Velasco, R. F., Guerrero, C., Fra, G., Moure, A., Miguel-Siles, J., Quesada-Campos, M. T., Ruiz-Gomez, J. R., Gilbert, I. H., Thomas, M. G. & Miles, T. J., 2 May 2019, In : Tetrahedron Letters. 60, 18, p. 1243-1247 5 p.

Research output: Contribution to journalArticle

Open Access
File
Sulfonamides
Cross Reactions
Research
10 Downloads (Pure)

Optimizing the procedure of grain nutrient predictions in barley via hyperspectral imaging

Wiegmann, M., Backhaus, A., Seiffert, U., Thomas, W. T. B., Flavell, A. J., Pillen, K. & Maurer, A., 7 Nov 2019, In : PLoS ONE. 14, 11, p. 1-22 22 p., e0224491.

Research output: Contribution to journalArticle

Open Access
File
Hordeum
Calibration
Nutrients
calibration
barley
21 Downloads (Pure)

Organic acids, siderophores, enzymes and mechanical pressure for black slate bioweathering with the basidiomycete Schizophyllum commune

Kirtzel, J., Ueberschaar, N., Deckert-Gaudig, T., Krause, K., Deckert, V., Gadd, G. M. & Kothe, E., 18 Jul 2019, In : Environmental Microbiology.

Research output: Contribution to journalArticle

Open Access
File
Schizophyllum
Schizophyllum commune
Siderophores
Basidiomycota
siderophore
66 Downloads (Pure)

Organizational innovation for developing new medicines that target aging and age-related conditions

Ford, G. A., Lord, J. M., Ferguson, M. A. J., Bountra, C. & Le Couteur, D. G., 6 Mar 2019, In : The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences. p. 1-4 4 p., glz062.

Research output: Contribution to journalEditorial

Open Access
File
1 Citation (Scopus)
63 Downloads (Pure)

Oscillatory cAMP cell-cell signalling persists during multicellular Dictyostelium development

Singer, G., Araki, T. & Weijer, K., 23 Apr 2019, In : Communications Biology. 2, 1, p. 1-12 12 p., 139.

Research output: Contribution to journalArticle

Open Access
File
Gastropoda
Dictyostelium
Morphogenesis
Cell Movement
Cell Communication

Outstanding questions in mitophagy: what we do and do not know

Montava Garriga, L. & Ganley, I., 9 Jul 2019, In : Journal of Molecular Biology.

Research output: Contribution to journalReview article

Mitochondrial Degradation
Autophagy
Neurodegenerative Diseases
Quality Control
Mitochondria

Pathogenic FAM83g palmoplantar keratoderma mutations inhibit the PAWS1: Ck1α association and attenuate wnt signalling [version 1; peer review: 2 approved]

Wu, K. Z. L., Jones, R. A., Tachie-Menson, T., Macartney, T. J., Wood, N. T., Varghese, J., Gourlay, R., Soares, R. F., Smith, J. C. & Sapkota, G. P., 9 Sep 2019, In : Wellcome Open Research. 4, p. 1-18 18 p., 133.

Research output: Contribution to journalArticle

Open Access
Palmoplantar Keratoderma
Peer Review
Association reactions
Mutation
Genes
23 Downloads (Pure)

Persistent DNA Damage Foci and DNA Replication with a Broken Chromosome in the African Trypanosome

Glover, L., Marques, C., Suska, O. & Horn, D., 9 Jul 2019, In : MBio. 10, 4, p. 1-17 17 p., e01252-19.

Research output: Contribution to journalArticle

Open Access
File
Trypanosomiasis
DNA Replication
DNA Damage
Replication Protein A
Chromosomes
2 Citations (Scopus)
109 Downloads (Pure)
Open Access
File
Leishmania donovani
Pharmacology
Parasites
Enzymes
Pharmaceutical Preparations
2 Citations (Scopus)
63 Downloads (Pure)

Phenformin, but not metformin, delays development of T-cell acute lymphoblastic leukemia/lymphoma via cell-autonomous AMPK activation

Vara Ciruelos, D., Dandapani, M., Russell, F., Grzes, K. M., Atrih, A., Foretz, M., Viollet, B., Lamont, D., Cantrell, D. & Hardie, G., 16 Apr 2019, In : Cell Reports. 27, 3, p. 690-698.e4

Research output: Contribution to journalArticle

Open Access
File
Phenformin
AMP-Activated Protein Kinases
T-cells
Metformin
Precursor Cell Lymphoblastic Leukemia-Lymphoma
41 Downloads (Pure)

Phosphatidylcholine synthesis through cholinephosphate cytidylyltransferase is dispensable in Leishmania major

Moitra, S., Pawlowic, M. C., Hsu, F-F. & Zhang, K., 20 May 2019, In : Scientific Reports. 9, p. 1-13 13 p., 7602.

Research output: Contribution to journalArticle

Open Access
File
Leishmania major
Phosphatidylcholines
Parasites
Choline
Psychodidae
11 Downloads (Pure)

Phosphoproteomics reveals that the hVPS34 regulated SGK3 kinase specifically phosphorylates endosomal proteins including Syntaxin-7, Syntaxin-12, RFIP4 and WDR44

Malik, N., Nirujogi, R. S., Peltier, J., Macartney, T., Wightman, M., Prescott, A., Gourlay, R., Trost, M., Alessi, D. & Karapetsas, A., 30 Oct 2019, In : Biochemical Journal. 476, 20, p. 3081-3107 27 p.

Research output: Contribution to journalArticle

Open Access
File
Qa-SNARE Proteins
Phosphorylation
Phosphotransferases
SNARE Proteins
Substrates
4 Downloads (Pure)
Open Access
File
Amoeba
Phylogeny
Transcription Factors
Spores
Transcriptome
6 Citations (Scopus)
73 Downloads (Pure)

Phytophthora infestans RXLR effectors act in concert at diverse subcellular locations to enhance host colonization

Wang, S., McLellan, H., Bukharova, T., He, Q., Murphy, F., Shi, J., Sun, S., van Weymers, P., Ren, Y., Thilliez, G., Wang, H., Chen, X., Engelhardt, S., Vleeshouwers, V., Gilroy, E. M., Whisson, S. C., Hein, I., Wang, X., Tian, Z., Birch, P. R. J. & 1 others, Boevink, P. C., 1 Jan 2019, In : Journal of Experimental Botany. 70, 1, p. 343-356 14 p., ery360.

Research output: Contribution to journalArticle

Open Access
File
Phytophthora infestans
Nicotiana benthamiana
Tobacco
pathogens
Infection
56 Downloads (Pure)

Phytophthora infestans RXLR effectors target parallel steps in an immune signal transduction pathway

Ren, Y., Armstrong, M., Qi, Y., McLellan, H., Zhong, C., Du, B., Birch, P. R. J. & Tian, Z., Aug 2019, In : Plant Physiology. 180, 4, p. 2227-2239 13 p.

Research output: Contribution to journalArticle

Open Access
File
Phytophthora infestans
mitogen-activated protein kinase kinase kinase
signal transduction
cell death
Signal Transduction
6 Citations (Scopus)
69 Downloads (Pure)

Pif1-family helicases support fork convergence during DNA replication termination in eukaryotes

Deegan, T., Baxter, J., Ortiz Bazan, M., Yeeles, J. T. P. & Labib, K., 18 Apr 2019, In : Molecular Cell. 74, 2, p. 231-244.e9 24 p.

Research output: Contribution to journalArticle

Open Access
File
Eukaryota
DNA Replication
Type II DNA Topoisomerase
DNA Helicases
Type I DNA Topoisomerase
1 Citation (Scopus)
50 Downloads (Pure)

Pinus Susceptibility to Pitch Canker Triggers Specific Physiological Responses in Symptomatic Plants: An Integrated Approach

Amaral, J., Correia, B., António, C., Rodrigues, A. M., Gómez-Cadenas, A., Valledor, L., Hancock, R. D., Alves, A. & Pinto, G., 24 Apr 2019, In : Frontiers in Plant Science. 10, p. 1-16 16 p., 509.

Research output: Contribution to journalArticle

Open Access
File
plant response
Pinus
Pinus pinea
Fusarium circinatum
Pinus pinaster
14 Citations (Scopus)
78 Downloads (Pure)

Plastics in the marine environment are reservoirs for antibiotic and metal resistance genes

Yang, Y., Liu, G., Song, W., Ye, C., Lin, H., Li, Z. & Liu, W., 1 Feb 2019, In : Environment International. 123, p. 79-86 8 p.

Research output: Contribution to journalArticle

Open Access
File
antibiotics
marine environment
plastic
gene
microbial community

Poly(ADP-Ribosylation) in Age-Related Neurological Disease

McGurk, L., Rifai, O. M. & Bonini, N. M., Aug 2019, In : Trends in Genetics. 35, 8, p. 601-613 13 p.

Research output: Contribution to journalReview article

Neurodegenerative Diseases
Adenosine Diphosphate
Proteins
Poly Adenosine Diphosphate Ribose
Amyotrophic Lateral Sclerosis
1 Citation (Scopus)
49 Downloads (Pure)

Pore timing: the evolutionary origins of the nucleus and nuclear pore complex

Field, M. C. & Rout, M. P., 3 Apr 2019, In : F1000Research. 8, p. 1-11 11 p., 369.

Research output: Contribution to journalReview article

Open Access
File
Nuclear Pore
Eukaryota
Bacteria
Archaea
Cell Nucleus
bioengineering
Infrared imaging
soil water
Transpiration
Cooling

PPM1H phosphatase counteracts LRRK2 signaling by selectively dephosphorylating Rab proteins

Berndsen, K., Lis, P., Yeshaw, W. M., Wawro, P. S., Nirujogi, R., Wightman, M., Macartney, T., Dorward, M., Knebel, A., Tonelli, F., Pfeffer, S. R. & Alessi, D., 12 Nov 2019, In : eLife. 8, p. 1-37 37 p., e50416.

Research output: Contribution to journalArticle

Open Access
File
Phosphoric Monoester Hydrolases
Phosphorylation
Phosphoprotein Phosphatases
Parkinson Disease
rab GTP-Binding Proteins
7 Citations (Scopus)
72 Downloads (Pure)

Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition

Wyllie, S., Brand, S., Thomas, M., De Rycker, M., Chung, C-W., Peña, I., Bingham, R., Bueren-Calabuig, J., Cantizani, J., Cebrian, D., Craggs, P. D., Ferguson, L., Goswami, P., Hobrath, J., Howe, J., Jeacock, L., Ko, E. J., Korczynska, J., MacLean, L., Manthri, S. & 29 others, Santos Martinez, M., Mata-Cantero, L., Moniz, S., Nuhs, A., Osuna-Cabello, M., Pinto, E., Riley, J., Robinson, S., Rowland, P., Simeons, F., Shishikura, Y., Spinks, D., Stojanovski, L., Thomas, J., Thompson, S., Viayna Gaza, E., Wall, R., Zuccotto, F., Horn, D., Ferguson, M., Fairlamb, A., Fiandor, J. M., Martín, J., Gray, D., Miles, T. J., Gilbert, I., Read, K., Marco, M. & Wyatt, P., 7 May 2019, In : Proceedings of the National Academy of Sciences. 116, 19, p. 9318-9323 6 p., 201820175.

Research output: Contribution to journalArticle

Open Access
File
Leishmania infantum
Visceral Leishmaniasis
Proteasome Endopeptidase Complex
Leishmania donovani
Parasites

Pregnancy-induced hypertension is associated with down-regulation of Kir6.1 in human myometrium

Du, Q., Jovanović, S., Tulić, L., Tulić, I. & Jovanović, A., Oct 2019, In : Pregnancy Hypertension. 18, p. 96-98 3 p.

Research output: Contribution to journalArticle

Pregnancy Induced Hypertension
Myometrium
KATP Channels
Down-Regulation
Parturition
1 Citation (Scopus)
4 Downloads (Pure)

Preparation of Barley Pollen Mother Cells for Confocal and Super Resolution Microscopy

Mittmann, S., Arrieta, M., Ramsay, L., Waugh, R. & Colas, I., 2019, Barley: Methods and Protocols. Harwood, W. A. (ed.). New York: Humana Press, Vol. 1900. p. 167-179 13 p. (Methods in Molecular Biology).

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Open Access
File
Hordeum
Pollen
Microscopy
Stem Cells
Genetic Recombination
3 Citations (Scopus)
61 Downloads (Pure)

Probiotics in Extraintestinal Diseases: Current Trends and New Directions

Kiousi, D. E., Karapetsas, A., Karolidou, K., Panayiotidis, M. I., Pappa, A. & Galanis, A., 5 Apr 2019, In : Nutrients. 11, 4, p. 1-26 26 p., 788.

Research output: Contribution to journalReview article

Open Access
File
Probiotics
skin (animal)
probiotics
Illness Behavior
Bone and Bones
26 Downloads (Pure)
Open Access
File
Workflow
Matrix-Assisted Laser Desorption-Ionization Mass Spectrometry
sample preparation
Embryonic Stem Cells
Stem cells
2 Citations (Scopus)
80 Downloads (Pure)
Open Access
File
Skeletal Muscle Fibers
Insulin Resistance
Skeletal Muscle
Insulin
Muscle Cells

Protein degradation for drug discovery

Ciulli, A. & Farnaby, W., Apr 2019, In : Drug Discovery Today: Technologies. 31, p. 1-3 3 p.

Research output: Contribution to journalEditorial

13 Downloads (Pure)
Open Access
File
Trypanosoma brucei brucei
Peer Review
Proteome
Proteomics
Proteins
13 Downloads (Pure)
Open Access
File
Organoids
Crosstalk
Keratinocytes
Proteomics
Skin