School of Life Sciences

  • United Kingdom

Research Output 1968 2020

2019

The detrimental effect of asymmetric dimethylarginine on cholesterol efflux of macrophage foam cells: Role of the NOX/ROS signaling

Chen, C-H., Zhao, J-F., Hsu, C-P., Kou, Y. R., Lu, T-M. & Lee, T-S., 1 Nov 2019, In : Free Radical Biology and Medicine. 143, p. 354-365 12 p.

Research output: Contribution to journalArticle

Foam Cells
Macrophages
Foams
Cholesterol
Metabolism

The dormancy-specific regulator, SutA, is intrinsically disordered and modulates transcription initiation in Pseudomonas aeruginosa

Bergkessel, M., Babin, B. M., VanderVelde, D., Sweredoski, M. J., Moradian, A., Eggleston-Rangel, R., Hess, S., Tirrell, D. A., Artsimovitch, I. & Newman, D. K., 10 Sep 2019, In : Molecular Microbiology. 112, 3, p. 992-1009 18 p.

Research output: Contribution to journalArticle

DNA-Directed RNA Polymerases
Pseudomonas aeruginosa
Sigma Factor
Holoenzymes
Housekeeping
10 Downloads (Pure)

The Dundee Resource for Sequence Analysis and Structure Prediction

MacGowan, S., Madeira, F., Britto-Borges, T., Warowny, M., Drozdetskiy, A., Procter, J. & Barton, G., 11 Nov 2019, In : Protein Science.

Research output: Contribution to journalArticle

Open Access
File
Sequence Analysis
Workflow
Sequence Alignment
Population Genetics
Parity
1 Citation (Scopus)
38 Downloads (Pure)
Open Access
File
Ubiquitin-Protein Ligases
Ubiquitin
Esters
Ubiquitin C
Macrophages
31 Downloads (Pure)

The ERC1 scaffold protein implicated in cell motility drives the assembly of a liquid phase

Sala, K., Corbetta, A., Minici, C., Tonoli, D., Murray, D. H., Cammarota, E., Ribolla, L., Ramella, M., Fesce, R., Mazza, D., Degano, M. & de Curtis, I., 19 Sep 2019, In : Scientific Reports. 9, p. 1-14 14 p., 13530.

Research output: Contribution to journalArticle

Open Access
File
Cell Movement
Proteins
Electron Microscopy
Cell Membrane
Drive

The Face of Chromatin Variants

Flaus, A. & Owen-Hughes, T., 5 Sep 2019, In : Cell. 178, 6, p. 1284-1286 3 p.

Research output: Contribution to journalArticle

Chromatin Assembly and Disassembly
Hinges
Histones
Chromatin
Protein Isoforms
17 Downloads (Pure)

The future of Blue Carbon science

Macreadie, P. I., Anton, A., Raven, J. A., Beaumont, N., Connolly, R. M., Friess, D. A., Kelleway, J. J., Kennedy, H., Kuwae, T., Lavery, P. S., Lovelock, C. E., Smale, D. A., Apostolaki, E. T., Atwood, T. B., Baldock, J., Bianchi, T. S., Chmura, G. L., Eyre, B. D., Fourqurean, J. W., Hall-Spencer, J. M. & 16 others, Huxham, M., Hendriks, I. E., Krause-Jensen, D., Laffoley, D., Luisetti, T., Marbà, N., Masque, P., McGlathery, K. J., Megonigal, J. P., Murdiyarso, D., Russell, B. D., Santos, R., Serrano, O., Silliman, B. R., Watanabe, K. & Duarte, C. M., 5 Sep 2019, In : Nature Communications. 10, 1, p. 1-13 13 p., 3998.

Research output: Contribution to journalArticle

Open Access
File
Carbon
carbon
ecosystems
Ecosystem
Ecosystems
1 Citation (Scopus)
22 Downloads (Pure)

The highly divergent Jekyll genes, required for sexual reproduction, are lineage specific for the related grass tribes Triticeae and Bromeae

Radchuk, V., Sharma, R., Potokina, E., Radchuk, R., Weier, D., Munz, E., Schreiber, M., Mascher, M., Stein, N., Wicker, T., Kilian, B. & Borisjuk, L., Jun 2019, In : Plant Journal. 98, 6, p. 961-974 14 p.

Research output: Contribution to journalArticle

Open Access
File
Poaceae
sexual reproduction
Reproduction
Hordeum
grasses
10 Downloads (Pure)

The Identification of Potential Therapeutic Targets for Cutaneous Squamous Cell Carcinoma

McHugh, A., Fernandes, K., Chinner, N., Ibrahim, A. F. M., Garg, A. K., Boag, G., Hepburn, L. A., Proby, C. M., Leigh, I. M. & Saville, M. K., 6 Nov 2019, In : Journal of Investigative Dermatology. 37 p.

Research output: Contribution to journalArticle

Open Access
File
Squamous Cell Carcinoma
Skin
Anaphase-Promoting Complex-Cyclosome
Therapeutics
Ubiquitin
38 Downloads (Pure)

The identification of small molecule inhibitors of the plant inositol phosphorylceramide synthase which demonstrate herbicidal activity

Pinneh, E. C., Mina, J. G., Stark, M. J. R., Lindell, S. D., Luemmen, P., Knight, M. R., Steel, P. G. & Denny, P. W., 30 May 2019, In : Scientific Reports. 9, p. 1-8 8 p., 8083.

Research output: Contribution to journalArticle

Open Access
File
Herbicides
Inositol
Yeasts
Arabidopsis
Enzymes
61 Downloads (Pure)

The KDM4/JMJD2 histone demethylases are required for hematopoietic stem cell maintenance

Agger, K., Nishimura, K., Miyagi, S., Messling, J-E., Rasmussen, K. D. & Helin, K., 21 Aug 2019, In : Blood. 14 p.

Research output: Contribution to journalArticle

Open Access
File
Histone Demethylases
Hematopoiesis
Hematopoietic Stem Cells
Stem cells
Genes
26 Downloads (Pure)

The kinetochore and the origin of eukaryotic chromosome segregation

Field, M. C., 25 Jun 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 26, p. 12596-12598 3 p.

Research output: Contribution to journalComment/debate

Open Access
File
4 Downloads (Pure)

The L7Ae proteins mediate a widespread and highly functional protein-RNA interaction

Lilley, D. M. J., Apr 2019, In : Biochemist. 41, 2, p. 40-44 5 p.

Research output: Contribution to journalArticle

Open Access
File
RNA
Proteins
Small Nucleolar Ribonucleoproteins
Nucleotide Motifs
Adenine
2 Citations (Scopus)
55 Downloads (Pure)

The lipid environment determines the activity of the Escherichia coli ammonium transporter AmtB

Mirandela, G. D., Tamburrino, G., Hoskisson, P. A., Zachariae, U. & Javelle, A., Feb 2019, In : FASEB Journal. 33, 2, p. 1989-1999 11 p.

Research output: Contribution to journalArticle

Open Access
File
Phosphatidylglycerols
Ammonium Compounds
Escherichia coli
Lipids
Protein Unfolding

The L-type amino acid transporter LAT1 inhibits osteoclastogenesis and maintains bone homeostasis through the mTORC1 pathway

Ozaki, K., Yamada, T., Horie, T., Ishizaki, A., Hiraiwa, M., Iezaki, T., Park, G., Fukasawa, K., Kamada, H., Tokumura, K., Motono, M., Kaneda, K., Ogawa, K., Ochi, H., Sato, S., Kobayashi, Y., Shi, Y-B., Taylor, P. M. & Hinoi, E., 9 Jul 2019, In : Science Signaling. 12, 589, p. 1-14 14 p., aaw3921.

Research output: Contribution to journalArticle

Amino Acid Transport Systems
Osteoclasts
Osteogenesis
Bone
Homeostasis
4 Downloads (Pure)

The oomycete microbe-associated molecular pattern Pep-13 triggers SERK3/BAK1-independent plant immunity

Wang, H., He, H., Qi, Y., McLellan, H., Tian, Z., Birch, P. R. J. & Tian, Z., Feb 2019, In : Plant Cell Reports. 38, 2, p. 173-182 10 p.

Research output: Contribution to journalArticle

Open Access
File
brassinosteroids
Oomycetes
phosphotransferases (kinases)
immunity
microorganisms

The plant pathogen Pectobacterium atrosepticum contains a functional formate hydrogenlyase-2 complex

Finney, A. J., Lowden, R., Fleszar, M., Albareda, M., Coulthurst, S. J. & Sargent, F., 17 Aug 2019, In : Molecular Microbiology. 27 p.

Research output: Contribution to journalArticle

Pectobacterium
Hydrogen
formic acid
Genes
Formate Dehydrogenases
4 Citations (Scopus)
36 Downloads (Pure)

Therapeutic approaches to enhance PINK1/Parkin mediated mitophagy for the treatment of Parkinson's disease

Miller, S. & Muqit, M. M. K., 13 Jul 2019, In : Neuroscience Letters. 705, p. 7-13 7 p.

Research output: Contribution to journalReview article

Open Access
File
Mitochondrial Degradation
Parkinson Disease
Biomarkers
Ubiquitin-Specific Proteases
Therapeutics
4 Citations (Scopus)
89 Downloads (Pure)

The role of RNA structure in translational regulation by L7Ae protein in archaea

Huang, L., Ashraf, S. & Lilley, D. M. J., Jan 2019, In : RNA: a Publication of the RNA Society. 25, 1, p. 60-69 10 p.

Research output: Contribution to journalArticle

Open Access
File
Archaea
Archaeoglobus fulgidus
RNA
Untranslated Regions
Proteins

The S phase checkpoint promotes the Smc5/6 complex dependent SUMOylation of Pol2, the catalytic subunit of DNA polymerase ε

Winczura, A., Appanah, R., Tatham, M. H., Hay, R. T. & De Piccoli, G., 25 Nov 2019, In : PLoS Genetics. 15, 11, p. 1-26 26 p., e1008427.

Research output: Contribution to journalArticle

Open Access
File
S Phase Cell Cycle Checkpoints
Catalytic DNA
Sumoylation
DNA-directed DNA polymerase
protein subunits
4 Citations (Scopus)
32 Downloads (Pure)

The strange case of AMPK and cancer: Dr Jekyll or Mr Hyde? †

Vara-Ciruelos, D., Russell, F. M. & Hardie, D. G., 10 Jul 2019, In : Open Biology. 9, 7, p. 1-21 21 p., 190099.

Research output: Contribution to journalArticle

Open Access
File
AMP-Activated Protein Kinases
Adenosine Monophosphate
Neoplasms
Tumors
DNA Damage
3 Citations (Scopus)

The Structure and Stability of the Disulfide-Linked γS-Crystallin Dimer Provide Insight into Oxidation Products Associated with Lens Cataract Formation

Thorn, D. C., Grosas, A. B., Mabbitt, P. D., Ray, N. J., Jackson, C. J. & Carver, J. A., 1 Feb 2019, In : Journal of Molecular Biology. 431, 3, p. 483-497 15 p.

Research output: Contribution to journalArticle

Crystallins
Disulfides
Cataract
Lenses
Crystalline Lens
1 Citation (Scopus)
88 Downloads (Pure)
Open Access
File
Burkholderia pseudomallei
Lipopolysaccharides
Lipid A
Carrier Proteins
lipids
2 Citations (Scopus)
65 Downloads (Pure)

The switch between acute and persistent paramyxovirus infection caused by single amino acid substitutions in the RNA polymerase P subunit

Young, D. F., Wignall-Fleming, E. B., Busse, D. C., Pickin, M. J., Hankinson, J., Randall, E. M., Tavendale, A., Davison, A. J., Lamont, D., Tregoning, J. S., Goodbourn, S. & Randall, R. E., 11 Feb 2019, In : PLoS Pathogens. 15, 2, p. 1-24 24 p., e1007561.

Research output: Contribution to journalArticle

Open Access
File
Amino Acid Substitution
DNA-Directed RNA Polymerases
Parainfluenza Virus 5
Infection
RNA Virus Infections
8 Citations (Scopus)
113 Downloads (Pure)

The Type VI secretion system: a versatile bacterial weapon

Coulthurst, S., 1 May 2019, In : Microbiology. 165, 5, p. 503-515 13 p., 000789.

Research output: Contribution to journalReview article

Open Access
File
Weapons
Protein Array Analysis
Eukaryotic Cells
Gram-Negative Bacteria
Proteins
9 Citations (Scopus)
55 Downloads (Pure)

TP53 mutation status divides myelodysplastic syndromes with complex karyotypes into distinct prognostic subgroups

International Working Group for MDS Molecular Prognostic Committee, Haase, D., Stevenson, K. E., Neuberg, D., Maciejewski, J. P., Nazha, A., Sekeres, M. A., Ebert, B. L., Garcia-Manero, G., Haferlach, C., Haferlach, T., Kern, W., Ogawa, S., Nagata, Y., Yoshida, K., Graubert, T. A., Walter, M. J., List, A. F., Komrokji, R. S., Padron, E. & 31 others, Sallman, D., Papaemmanuil, E., Campbell, P. J., Savona, M. R., Seegmiller, A., Adès, L., Fenaux, P., Shih, L. Y., Bowen, D., Groves, M. J., Tauro, S., Fontenay, M., Kosmider, O., Bar-Natan, M., Steensma, D., Stone, R., Heuser, M., Thol, F., Cazzola, M., Malcovati, L., Karsan, A., Ganster, C., Hellström-Lindberg, E., Boultwood, J., Pellagatti, A., Santini, V., Quek, L., Vyas, P., Tüchler, H., Greenberg, P. L. & Bejar, R., Jul 2019, In : Leukemia. 33, 7, p. 1747-1758 12 p.

Research output: Contribution to journalArticle

Open Access
File
Myelodysplastic Syndromes
Karyotype
Mutation
Chromosome Aberrations
Critical Care
3 Citations (Scopus)
11 Downloads (Pure)

Tracing the ancestry of modern bread wheats

Pont, C., Leroy, T., Seidel, M., Tondelli, A., Duchemin, W., Armisen, D., Lang, D., Bustos-Korts, D., Goué, N., Balfourier, F., Molnár-Láng, M., Lage, J., Kilian, B., Özkan, H., Waite, D., Dyer, S., Letellier, T., Alaux, M., Russell, J., Keller, B. & 9 others, van Eeuwijk, F., Spannagl, M., Mayer, K. F. X., Waugh, R., Stein, N., Cattivelli, L., Haberer, G., Charmet, G. & Salse, J., 1 May 2019, In : Nature Genetics. 51, 5, p. 905-911 7 p.

Research output: Contribution to journalArticle

Open Access
File
Bread
Triticum
Exome
Civilization
Breeding

Tracing the evolutionary routes of plant-microbiota interactions

Escudero-Martinez, C. & Bulgarelli, D., 2019, In : Current Opinion in Microbiology. 49, p. 34-40 7 p.

Research output: Contribution to journalReview article

Microbiota
Soil
Plant Development
Genomics
Microbiology
6 Citations (Scopus)
99 Downloads (Pure)

Tracking disease resistance deployment in potato breeding by enrichment sequencing

Armstrong, M., Vossen, J. H., Lim, J. T-Y., Hutten, R. C. B., Xu, J., Strachan, S. M., Harrower, B., Champouret, N., Gilroy, E. M. & Hein, I., Feb 2019, In : Plant Biotechnology Journal. 17, 2, p. 540-549 10 p.

Research output: Contribution to journalArticle

Open Access
File
Disease Resistance
Solanum tuberosum
Breeding
disease resistance
potatoes
18 Downloads (Pure)

TRAIP drives replisome disassembly and mitotic DNA repair synthesis at sites of incomplete DNA replication

Sonneville, R., Bhowmick, R., Hoffmann, S., Mailand, N., Hickson, I. D. & Labib, K., 23 Sep 2019, In : eLife. 8, p. 1-19 19 p., 48686.

Research output: Contribution to journalArticle

Open Access
File
DNA Replication
Mitosis
DNA Repair
Repair
DNA
8 Citations (Scopus)
70 Downloads (Pure)

Transcriptome, proteome and draft genome of Euglena gracilis

Ebenezer, T., Zoltner, M., Burrell, A., Nenarokova, A., Novák Vanclová, A. M. G., Prasad, B., Soukal, P., Santana-Molina, C., O'Neill, E., Nankissoor, N. N., Vadakedath, N., Daiker, V., Obado, S., Silva-Pereira, S., Jackson, A. P., Devos, D. P., Lukeš, J., Lebert, M., Vaughan, S., Hampl, V. & 5 others, Carrington, M., Ginger, M. L., Dacks, J. B., Kelly, S. & Field, M., 7 Feb 2019, In : BMC Biology. 17, p. 1-23 23 p., 11.

Research output: Contribution to journalArticle

Open Access
File
Euglena gracilis
Proteome
proteome
Transcriptome
transcriptome
1 Citation (Scopus)
73 Downloads (Pure)

Transient Receptor Potential V Channels Are Essential for Glucose Sensing by Aldolase and AMPK

Li, M., Zhang, C-S., Zong, Y., Feng, J-W., Ma, T., Hu, M., Lin, Z., Li, X., Xie, C., Wu, Y., Jiang, D., Li, Y., Zhang, C., Tian, X., Wang, W., Yang, Y., Chen, J., Cui, J., Wu, Y-Q., Chen, X. & 11 others, Liu, Q-F., Wu, J., Lin, S-Y., Ye, Z., Liu, Y., Piao, H-L., Yu, L., Zhou, Z., Xie, X-S., Hardie, D. G. & Lin, S-C., 3 Sep 2019, In : Cell Metabolism. 30, 3, p. 508-524.e12 17 p.

Research output: Contribution to journalArticle

Open Access
File
Transient Receptor Potential Channels
Fructose-Bisphosphate Aldolase
AMP-Activated Protein Kinases
Glucose
Endoplasmic Reticulum
Quartz
Selenium
Biofilms
Mercury
selenium
1 Citation (Scopus)
99 Downloads (Pure)

Triggering MSR1 promotes JNK-mediated inflammation in IL-4 activated macrophages

Guo, M., Härtlova, A., Gierlinski, M., Prescott, A., Castellvi, J., Hernandez Losa, J., Petersen, S. K., Wenzel, U. A., Dill, B., Emmerich, C. H., Ramon Y Cajal, S., Russell, D. G. & Trost, M., 3 Jun 2019, In : EMBO Journal. 38, 11, p. 1-15 15 p., e100299.

Research output: Contribution to journalArticle

Open Access
File
Scavenger Receptors
Macrophages
Interleukin-4
Inflammation
Chemical activation
23 Downloads (Pure)

Trypanosoma cruzi phosphomannomutase and guanosine diphosphate-mannose pyrophosphorylase ligandability assessment

Zmuda, F., Shepherd, S. M., Ferguson, M. A. J., Gray, D. W., Torrie, L. S. & De Rycker, M., Oct 2019, In : Antimicrobial Agents and Chemotherapy. 63, 10, p. 1-11 11 p., e01082-19.

Research output: Contribution to journalArticle

Open Access
File
Guanosine Diphosphate Mannose
Trypanosoma cruzi
Chagas Disease
Enzymes
Glycoconjugates
3 Citations (Scopus)
32 Downloads (Pure)

Unanchored tri-NEDD8 inhibits PARP-1 to protect from oxidative stress-induced cell death

Keuss, M. J., Hjerpe, R., Hsia, O., Gourlay, R., Burchmore, R., Trost, M. & Kurz, T., 15 Mar 2019, In : EMBO Journal. 38, 6, p. 1-21 21 p., e100024.

Research output: Contribution to journalArticle

Open Access
File
Oxidative stress
Poly(ADP-ribose) Polymerases
Cell death
Oxidative Stress
Cell Death
80 Downloads (Pure)

Understanding Coeliac Disease

Nabizadeh, G., Murray, C. (ed.), Vaughan, P. (ed.), Woof, J., Horner, R., Laird, C., Larkin, A., Miller, N., Quinn, K., Robinson, H., Wilson, L. & Fitt, M. (ed.), 1 May 2019, University of Dundee: UniVerse. 25 p.

Research output: Book/ReportBook

Open Access
File
Celiac Disease
Nutritionists
Reading
Parents
2 Citations (Scopus)
67 Downloads (Pure)

Value of hospital antimicrobial stewardship programs [ASPs]: a systematic review

Nathwani, D., Varghese, D., Stephens, J., Ansari, W., Martin, S. & Charbonneau, C., 12 Feb 2019, In : Antimicrobial Resistance and Infection Control. 8, p. 1-13 13 p., 35.

Research output: Contribution to journalReview article

Open Access
File
Length of Stay
Cost Savings
Economics
Health Expenditures
Anti-Bacterial Agents

Ways to unwind with HROB, a new player in homologous recombination

Saredi, G. & Rouse, J., 1 Oct 2019, In : Genes & Development. 33, 19-20, p. 1293-1294 2 p.

Research output: Contribution to journalReview article

Homologous Recombination
DNA Repair
Minichromosome Maintenance Proteins
Double-Stranded DNA Breaks
DNA
9 Downloads (Pure)
Open Access
File
Asymmetric Cell Division
Drosophila
Cell Polarity
Cell Division
Stem Cells
47 Downloads (Pure)

Why Engage? Our staff and students on the benefits of public engagement

Lambert, H. & Stanley-Wall, N., 2019, 16 p. Dundee : University of Dundee.

Research output: Other contribution

Open Access
File

Wnt regulates amino-acid transporter Slc7a5 and so constrains the integrated stress response in mouse embryos

Poncet, N., Halley, P., Lipina, C., Gierlinski, M., Dady, A., Singer, G., Febrer, M., Shi, Y-B., Yamaguchi, T. P., Taylor, P. & Storey, K., 2 Dec 2019, In : EMBO Reports. 20 p., e48469.

Research output: Contribution to journalArticle

Open Access
File
Amino Acid Transport Systems
Embryonic Structures
Morphogenesis
Tissue
Defects
2 Citations (Scopus)
49 Downloads (Pure)

“Wild barley serves as a source for biofortification of barley grains”

Wiegmann, M., Thomas, W. T. B., Bull, H. J., Flavell, A. J., Zeyner, A., Peiter, E., Pillen, K. & Maurer, A., Jun 2019, In : Plant Science. 283, p. 83-94 12 p.

Research output: Contribution to journalArticle

Open Access
File
biofortification
Hordeum
nutrient content
barley
Food

∆Np63/p40 correlates with the location and phenotype of basal/mesenchymal cancer stem-like cells in human ER+ and HER2+ breast cancers

Liu, Y., Nekulova, M., Nenutil, R., Horakova, I., Appleyard, M. V., Murray, K., Holcakova, J., Galoczova, M., Quinlan, P., Jordan, L. B., Purdie, C. A., Vojtesek, B., Thompson, A. M. & Coates, P. J., 7 Oct 2019, In : Journal of Pathology: Clinical Research.

Research output: Contribution to journalArticle

Neoplastic Stem Cells
Mesenchymal Stromal Cells
Breast Neoplasms
Phenotype
Neoplasms
2018
1 Citation (Scopus)
100 Downloads (Pure)

(Poly)phenol-digested metabolites modulate alpha-synuclein toxicity by regulating proteostasis

Macedo, D., Jardim, C., Figueira, I., Almeida, A. F., McDougall, G. J., Stewart, D., Yuste, J. E., Tomás-Barberán, F. A., Tenreiro, S., Outeiro, T. F. & Santos, C. N., 3 May 2018, In : Scientific Reports. 8, 1, p. 1-15 15 p., 6965.

Research output: Contribution to journalArticle

Open Access
File
alpha-Synuclein
Phenol
Phenols
Parkinson Disease
Digestion

2,4-Diamino-6-methylpyrimidines for the potential treatment of Chagas’ disease

Thomas, M. G., De Rycker, M., Cotillo Torrejon, I., Thomas, J., Riley, J., Spinks, D., Read, K. D., Miles, T. J., Gilbert, I. H. & Wyatt, P. G., 1 Oct 2018, In : Bioorganic & Medicinal Chemistry Letters. 28, 18, p. 3025-3030 6 p.

Research output: Contribution to journalArticle

Chagas Disease
Parasites
Nifurtimox
Trypanosoma cruzi
Screening
7 Citations (Scopus)
96 Downloads (Pure)

2-Mercapto-Quinazolinones as Inhibitors of Type II NADH Dehydrogenase and Mycobacterium tuberculosis: Structure-Activity Relationships, Mechanism of Action and Absorption, Distribution, Metabolism, and Excretion Characterization

Murugesan, D., Ray, P. C., Bayliss, T., Prosser, G. A., Harrison, J. R., Green, K., Soares De Melo, C., Feng, T. S., Street, L. J., Chibale, K., Warner, D. F., Mizrahi, V., Epemolu, O., Scullion, P., Ellis, L., Riley, J., Shishikura, Y., Ferguson, L., Osuna-Cabello, M., Read, K. D. & 10 others, Green, S. R., Lamprecht, D. A., Steyn, A. J. C., Ioerger, T. R., Sacchettini, J., Rhee, K. Y., Arora, K., Barry, C. E., Wyatt, P. G. & Boshoff, H. I. M., 8 Jun 2018, In : ACS Infectious Diseases. 4, 6, p. 954-969 16 p.

Research output: Contribution to journalArticle

Open Access
File
Quinazolinones
Structure-Activity Relationship
Mycobacterium tuberculosis
Adenosine Triphosphate
Allosteric Site
17 Citations (Scopus)
77 Downloads (Pure)

3-Fluoro-4-hydroxyprolines: Synthesis, conformational analysis and stereoselective recognition by the VHL E3 ubiquitin ligase for targeted protein degradation

Testa, A., Lucas, X., Castro, G., Chan, K. H., Wright, J., Runcie, A., Gadd, M., Harrison, W. T. A., Ko, E. J., Fletcher, D. & Ciulli, A., 25 Jul 2018, In : Journal of the American Chemical Society. 140, 29, p. 9299-9313 15 p.

Research output: Contribution to journalArticle

Open Access
File
Hydroxyproline
Ubiquitin-Protein Ligases
Proteolysis
Proteins
Degradation
111 Downloads (Pure)

6-hydroxydopamine (6-OHDA) Oxidative Stress Assay for Observing Dopaminergic Neuron Loss in Caenorhabditis elegans

Offenburger, S-L. & Gartner, A., 20 Sep 2018, In : Bio-Protocol. 8, 18, 12 p., e3025.

Research output: Contribution to journalArticle

Open Access
File
Oxidopamine
Dopaminergic Neurons
Caenorhabditis elegans
Oxidative Stress
Cell Death
1 Citation (Scopus)
148 Downloads (Pure)

6-OHDA-induced dopaminergic neurodegeneration in Caenorhabditis elegans is promoted by the engulfment pathway and inhibited by the transthyretin-related protein TTR-33

Offenburger, S-L., Ho, X. Y., Tachie-Menson, T., Coakley, S., Hilliard, M. A. & Gartner, A., 18 Jan 2018, In : PLoS Genetics. 14, 1, p. 1-27 27 p., e1007125.

Research output: Contribution to journalArticle

Open Access
File
prealbumin
Prealbumin
Oxidopamine
Caenorhabditis elegans
Oxidative Stress