School of Life Sciences

  • United Kingdom

Research Output 1968 2020

2018
2 Citations (Scopus)

ABIN2 Function Is Required To Suppress DSS-Induced Colitis by a Tpl2-Independent Mechanism

Nanda, S. K., Nagamori, T., Windheim, M., Amu, S., Aviello, G., Patterson-Kane, J., Arthur, J. S. C., Ley, S. C., Fallon, P. & Cohen, P., 1 Dec 2018, In : Journal of Immunology. 201, 11, p. 3373-3382 10 p.

Research output: Contribution to journalArticle

Colitis
Neoplasms
Myofibroblasts
Cyclooxygenase 2
Ubiquitin
1 Citation (Scopus)
49 Downloads (Pure)

Absence of curli in soil-persistent Escherichia coli is mediated by a C-di-GMP signaling defect and suggests evidence of biofilm-independent niche specialization

Somorin, Y. M., Vollmerhausen, T., Waters, N., Pritchard, L., Abram, F., Brennan, F. & O'Byrne, C., 22 Jun 2018, In : Frontiers in Microbiology. 9, p. 1-13 13 p., 1340.

Research output: Contribution to journalArticle

Open Access
File
Biofilms
Soil
Escherichia coli
Quartz
Enterobacteriaceae
2 Citations (Scopus)
59 Downloads (Pure)

A call for public archives for biological image data

Ellenberg, J., Swedlow, J. R., Barlow, M., Cook, C. E., Sarkans, U., Patwardhan, A., Brazma, A. & Birney, E., 30 Oct 2018, In : Nature Methods. 15, 11, p. 849-854 6 p.

Research output: Contribution to journalArticle

Open Access
File
Bioinformatics
Imaging techniques
Computational Biology
Databases
Technology
9 Citations (Scopus)
51 Downloads (Pure)

Accurate Recycling of Parental Histones Reproduces the Histone Modification Landscape during DNA Replication

Reverón-Gómez, N., González-Aguilera, C., Stewart-Morgan, K. R., Petryk, N., Flury, V., Graziano, S., Johansen, J. V., Jakobsen, J. S., Alabert, C. & Groth, A., 18 Oct 2018, In : Molecular Cell. 72, 2, p. 239-249.e5

Research output: Contribution to journalArticle

Open Access
File
Histone Code
Recycling
DNA Replication
Histones
Post Translational Protein Processing
17 Citations (Scopus)
114 Downloads (Pure)

Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity

Pao, K-C., Wood, N. T., Knebel, A., Rafie, K., Stanley, M., Mabbitt, P. D., Sundaramoorthy, R., Hofmann, K., van Aalten, D. M. F. & Virdee, S., 11 Apr 2018, In : Nature. 556, 7701, p. 381-385 5 p.

Research output: Contribution to journalArticle

Open Access
File
Ubiquitin-Protein Ligases
Esterification
Ubiquitin
Genes
Ubiquitination
79 Downloads (Pure)
Open Access
File
Leishmania infantum
promastigotes
visceral leishmaniasis
Amiodarone
Anti-Arrhythmia Agents
87 Downloads (Pure)

Adaptation and therapeutic exploitation of the plasma membrane of African trypanosomes

Quintana, J. F., Canavate Del Pino, R., Yamada, K., Zhang, N. & Field, M., 20 Jul 2018, In : Genes. 9, 7, 16 p., 368.

Research output: Contribution to journalReview article

Open Access
File
Immune Evasion
Trypanosomiasis
Cell Membrane
Membranes
Organelles
10 Citations (Scopus)
104 Downloads (Pure)

A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage

Ladds, M. J. G. W., Van Leeuwen, I. M. M., Drummond, C. J., Chu, S., Healy, A. R., Popova, G., Pastor Fernández, A., Mollick, T., Darekar, S., Sedimbi, S. K., Nekulova, M., Sachweh, M. C. C., Campbell, J., Higgins, M., Tuck, C., Popa, M., Safont, M. M., Gelebart, P., Fandalyuk, Z., Thompson, A. M. & 26 others, Svensson, R., Gustavsson, A. L., Johansson, L., Färnegårdh, K., Yngve, U., Saleh, A., Haraldsson, M., D'Hollander, A. C. A., Franco, M., Zhao, Y., Håkansson, M., Walse, B., Larsson, K., Peat, E. M., Pelechano, V., Lunec, J., Vojtesek, B., Carmena, M., Earnshaw, W. C., McCarthy, A. R., Westwood, N. J., Arsenian-Henriksson, M., Lane, D. P., Bhatia, R., McCormack, E. & Laín, S., 16 Mar 2018, In : Nature Communications. 9, p. 1-14 14 p., 1107.

Research output: Contribution to journalArticle

Open Access
File
dehydrogenases
inhibitors
Tumors
tumors
Cells
6 Citations (Scopus)
120 Downloads (Pure)

African trypanosomes evade immune clearance by O-glycosylation of the VSG surface coat

Pinger, J., Nešić, D., Ali, L., Aresta-Branco, F., Lilic, M., Chowdhury, S., Kim, H. S., Verdi, J., Raper, J., Ferguson, M. A. J., Papavasiliou, F. N. & Stebbins, C. E., Aug 2018, In : Nature Microbiology. 3, 8, p. 932-938 7 p.

Research output: Contribution to journalArticle

Open Access
File
Trypanosomiasis
Membrane Glycoproteins
Glycosylation
Antigenic Variation
Immunity
8 Citations (Scopus)
102 Downloads (Pure)

AKT overactivation can suppress DNA repair via p70S6 kinase-dependent downregulation of MRE11

Piscitello, D., Varshney, D., Lilla, S., Vizioli, M. G., Reid, C., Gorbunova, V., Seluanov, A., Gillespie, D. A. & Adams, P. D., 25 Jan 2018, In : Oncogene. 37, 4, p. 427-438 12 p.

Research output: Contribution to journalArticle

Open Access
File
DNA Repair
Phosphotransferases
Down-Regulation
DNA Damage
Recombinational DNA Repair
72 Downloads (Pure)

Amine Containing Analogs of Sulindac for Cancer Prevention

Mathew, B., Hobrath, J. V., Connelly, M. C., Guy, R. K. & Reynolds, R. C., 31 Jan 2018, In : Open Medicinal Chemistry Journal. 12, p. 1-12 12 p.

Research output: Contribution to journalArticle

Open Access
File
Sulindac
Amines
Libraries
Neoplasms
Adenomatous Polyps
3 Citations (Scopus)
21 Downloads (Pure)

A minimally invasive tool to study immune response and skin barrier in children with atopic dermatitis

Hulshof, L., Hack, D. P., Hasnoe, Q. C. J., Dontje, B., Jakasa, I., Riethmüller, C., McLean, W. H. I., van Aalderen, W. M. C., Van't Land, B., Kezic, S., Sprikkelman, A. B. & Middelkamp-Hup, M. A., 10 Jul 2018, In : British Journal of Dermatology. 10 p.

Research output: Contribution to journalArticle

Open Access
File
Atopic Dermatitis
Skin
Biomarkers
Interleukins
Chemokine CCL8
21 Citations (Scopus)
69 Downloads (Pure)

Amino acid-dependent cMyc expression is essential for NK cell metabolic and functional responses in mice

Loftus, R. M., Assmann, N., Kedia-Mehta, N., O'Brien, K. L., Garcia, A., Gillespie, C., Hukelmann, J. L., Oefner, P. J., Lamond, A. I., Gardiner, C. M., Dettmer, K., Cantrell, D. A., Sinclair, L. V. & Finlay, D. K., 14 Jun 2018, In : Nature Communications. 9, 1, p. 1-15 15 p., 2341.

Research output: Contribution to journalArticle

Open Access
File
Natural Killer Cells
mice
amino acids
Lymphocytes
Glutamine
3 Citations (Scopus)
84 Downloads (Pure)

A Missense Mutation within the Helix Termination Motif of KRT25 Causes Autosomal Dominant Woolly Hair/Hypotrichosis

Yu, X., Chen, F., Ni, C., Zhang, G., Zheng, L., Zhang, J., Li, C., Sandilands, A., Yao, Z. & Li, M., Jan 2018, In : Journal of Investigative Dermatology. 138, 1, p. 230-233 4 p.

Research output: Contribution to journalLetter

Open Access
File
6 Citations (Scopus)
75 Downloads (Pure)

A Molecular Hybridization Approach for the Design of Potent, Highly Selective, and Brain-Penetrant N-Myristoyltransferase Inhibitors

Harrison, J. R., Brand, S., Smith, V., Robinson, D. A., Thompson, S., Smith, A., Davies, K., Mok, N., Torrie, L. S., Collie, I., Hallyburton, I., Norval, S., Simeons, F. R. C., Stojanovski, L., Frearson, J. A., Brenk, R., Wyatt, P. G., Gilbert, I. H. & Read, K. D., 12 Sep 2018, In : Journal of Medicinal Chemistry. 61, 18, p. 8374–8389 16 p.

Research output: Contribution to journalArticle

Open Access
File
African Trypanosomiasis
Trypanosoma brucei brucei
Crystallography
Central Nervous System Diseases
Peripheral Nervous System
1 Citation (Scopus)
44 Downloads (Pure)
Open Access
File
Ions
DNA
Enzymes
Substrate Specificity
Catalytic Domain
105 Citations (Scopus)
144 Downloads (Pure)

AMPK: Sensing Glucose as well as Cellular Energy Status

Lin, S-C. & Hardie, D., 6 Feb 2018, In : Cell Metabolism. 27, 2, p. 299-313 15 p.

Research output: Contribution to journalReview article

Open Access
File
AMP-Activated Protein Kinases
Glucose
Adenosine Triphosphatases
Fructose-Bisphosphate Aldolase
Adenosine Triphosphate
94 Downloads (Pure)

A Multicellular Model of Intestinal Crypt Buckling and Fission

Almet, A. A., Hughes, B. D., Landman, K. A., Näthke, I. S. & Osborne, J. M., Feb 2018, In : Bulletin of Mathematical Biology. 80, 2, p. 335-359 25 p.

Research output: Contribution to journalArticle

Open Access
File
intestinal crypts
buckling
Buckling
Organoids
Tissue
2 Citations (Scopus)
61 Downloads (Pure)

A multifaceted approach to identify non-specific enzyme inhibition: Application to Mycobacterium tuberculosis shikimate kinase

Alturki, M. S., Fuanta, N. R., Jarrard, M. A., Hobrath, J. V., Goodwin, D. C., Rants'o, T. A. & Calderón, A. I., 15 Feb 2018, In : Bioorganic and Medicinal Chemistry Letters. 28, 4, p. 802-808 7 p.

Research output: Contribution to journalArticle

Open Access
File
shikimate kinase
Enzyme inhibition
Mycobacterium tuberculosis
Assays
Screening

An adaptive optics 3D STED microscope for super-resolution imaging of thick samples with background noise suppression using digital image processing

Zdankowski, P., Trusiak, M., Cywinska, M. & Swedlow, J. R., 1 Jan 2018, Speckle 2018: VII International Conference on Speckle Metrology. Jaroszewicz, L. R. & Kujawinska, M. (eds.). Washington: SPIE-International Society for Optical Engineering, Vol. 10834. 9 p. 108342G. (SPIE Proceedings; vol. 10834).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Noise Suppression
Digital Image Processing
Stimulated emission
Adaptive optics
Super-resolution
2 Citations (Scopus)
9 Downloads (Pure)

Analysis of novel missense ATR mutations reveals new splicing defects underlying Seckel Syndrome

Llorens-Agost, M., Luessing, J., van Beneden, A., Eykelenboom, J., O'Reilly, D., Bicknell, L. S., Reynolds, J. J., van Koegelenberg, M., Hurles, M. E., Brady, A. F., Jackson, A. P., Stewart, G. S. & Lowndes, N. F., Dec 2018, In : Human Mutation. 39, 12, p. 1847-1853 7 p.

Research output: Contribution to journalArticle

Open Access
File
Ataxia Telangiectasia
Missense Mutation
Mutation
Microcephaly
Inborn Genetic Diseases

Ancient barley landraces adapted to marginal soils demonstrate exceptional tolerance to manganese limitation

Schmidt, S. B., George, T. S., Brown, L. K., Booth, A., Wishart, J., Hedley, P. E., Martin, P., Russell, J. & Husted, S., 15 Dec 2018, In : Annals of Botany.

Research output: Contribution to journalArticle

landraces
manganese
barley
soil
grain yield
9 Citations (Scopus)
114 Downloads (Pure)

An evolutionarily conserved ribosome-rescue pathway maintains epidermal homeostasis

Liakath-Ali, K., Mills, E. W., Sequeira, I., Lichtenberger, B. M., Pisco, A. O., Sipilä, K. H., Mishra, A., Yoshikawa, H., Wu, C. C-C., Ly, T., Lamond, A. I., Adham, I. M., Green, R. & Watt, F. M., 11 Apr 2018, In : Nature. 556, p. 376-380 5 p.

Research output: Contribution to journalLetter

Open Access
File
Ribosomes
Homeostasis
Stem Cells
Sirolimus
Quality Control

A new Editor-in-Chief for Development

Bray, S., Storey, K. & Brown, K., 27 Mar 2018, In : Development. 145, 6, 2 p., dev165266.

Research output: Contribution to journalEditorial

Open Access
1 Citation (Scopus)
91 Downloads (Pure)

An NMRA-like protein regulates gene expression in Phytophthora capsici to drive the infection cycle on tomato

Pham, J., Stam, R., Heredia, V. M., Csukai, M. & Huitema, E., Jun 2018, In : Molecular Plant - Microbe Interactions. 31, 6, p. 665-677 13 p.

Research output: Contribution to journalArticle

Open Access
File
Phytophthora
Phytophthora capsici
Lycopersicon esculentum
tomatoes
Gene Expression
37 Citations (Scopus)
126 Downloads (Pure)

Antibiotics and antibiotic resistance genes in global lakes: A review and meta-analysis

Yang, Y., Song, W., Lin, H., Wang, W., Du, L. & Xing, W., Jul 2018, In : Environment International. 116, p. 60-73 14 p.

Research output: Contribution to journalReview article

Open Access
File
antibiotic resistance
meta-analysis
antibiotics
gene
lake
9 Citations (Scopus)
91 Downloads (Pure)

Antibody-mediated enhancement aggravates chikungunya virus infection and disease severity

Lum, F-M., Couderc, T., Chia, B-S., Ong, R-Y., Her, Z., Chow, A., Leo, Y-S., Kam, Y-W., Rénia, L., Lecuit, M. & Ng, L. F. P., 30 Jan 2018, In : Scientific Reports. 8, 1, p. 1-14 14 p., 1860.

Research output: Contribution to journalArticle

Open Access
File
Chikungunya virus
Virus Diseases
Antibodies
Viral RNA
Viral Load
2 Citations (Scopus)
7 Downloads (Pure)

Antioxidant Rich Potato Improves Arterial Stiffness in Healthy Adults

Tsang, C., Smail, N. F., Almoosawi, S., McDougall, G. J. M. & Al-Dujaili, E. A. S., Sep 2018, In : Plant Foods for Human Nutrition. 73, 3, p. 203-208 6 p.

Research output: Contribution to journalArticle

Open Access
File
Vascular Stiffness
Anthocyanins
Solanum tuberosum
Pulse Wave Analysis
anthocyanins
1 Citation (Scopus)
86 Downloads (Pure)

Anti-trypanosomal 8-hydroxyl naphthyridines are chelators of divalent transition metals

Wall, R. J., Moniz, S., Thomas, M., Norval, S., Ko, E. J., Marco, M., Miles, T. J., Gilbert, I., Horn, D., Fairlamb, A. & Wyllie, S., Aug 2018, In : Antimicrobial Agents and Chemotherapy. 62, 8, p. 1-15 15 p., e00235-18.

Research output: Contribution to journalArticle

Open Access
File
Naphthyridines
Chelating Agents
Hydroxyl Radical
Metals
Trypanosoma brucei brucei
1 Citation (Scopus)
12 Downloads (Pure)

Antitrypanosomatid Pharmacomodulation at Position 3 of the 8-Nitroquinolin-2(1H)-one Scaffold Using Palladium-Catalysed Cross-Coupling Reactions

Pedron, J., Boudot, C., Bourgeade-Delmas, S., Sournia-Saquet, A., Paloque, L., Rastegari, M., Abdoulaye, M., El-Kashef, H., Bonduelle, C., Pratviel, G., Wyllie, S., Fairlamb, A. H., Courtioux, B., Verhaeghe, P. & Valentin, A., 22 Oct 2018, In : ChemMedChem. 13, 20, p. 2217-2228 12 p.

Research output: Contribution to journalArticle

Open Access
File
Nitroquinolines
Cross Reactions
Palladium
Scaffolds
Nitroreductases
10 Citations (Scopus)
62 Downloads (Pure)

A pathway for Parkinson's Disease LRRK2 kinase to block primary cilia and Sonic hedgehog signaling in the brain

Dhekne, H. S., Yanatori, I., Gomez, R. C., Tonelli, F., Diez, F., Schüle, B., Steger, M., Alessi, D. R. & Pfeffer, S. R., 6 Nov 2018, In : eLife. 7, p. 1-26 26 p., e40202.

Research output: Contribution to journalArticle

Open Access
File
Aptitude
Hedgehogs
Cilia
Neurons
Parkinson Disease
7 Citations (Scopus)
79 Downloads (Pure)

aPKC-mediated displacement and actomyosin-mediated retention polarize Miranda in Drosophila neuroblasts

Hannaford, M. R., Ramat, A., Loyer, N. & Januschke, J., 24 Jan 2018, In : eLife. 7, 22 p., e29939.

Research output: Contribution to journalArticle

Open Access
File
Actomyosin
Interphase
Nuclear Envelope
Neurology
Nervous System
1 Citation (Scopus)
46 Downloads (Pure)

A potato STRUBBELIG-RECEPTOR FAMILY member, StLRPK1, associates with StSERK3A/BAK1 and activates immunity

Wang, H., Chen, Y., Wu, X., Long, Z., Sun, C., Wang, H., Wang, S., Rj Birch, P. & Tian, Z., 26 Nov 2018, In : Journal of Experimental Botany. 69, 22, p. 5573-5586 14 p., ery310.

Research output: Contribution to journalArticle

Open Access
File
Plant Immunity
Phytophthora infestans
Solanum tuberosum
Immunity
immunity
9 Citations (Scopus)
75 Downloads (Pure)

A practical method using a network of fixed infrared sensors for estimating crop canopy conductance and evaporation rate

Jones, H. G., Hutchinson, P. A., May, T., Jamali, H. & Deery, D. M., Jan 2018, In : Biosystems Engineering. 165, p. 59-69 11 p.

Research output: Contribution to journalArticle

Open Access
File
evaporation rate
Crops
Evaporation
evaporation
canopy
59 Downloads (Pure)

A Prototype Therapeutic Capsule Endoscope for Ultrasound-mediated Targeted Drug Delivery

Stewart, F., Verbeni, A., Qiu, Y., Cox, B., Vorstius, J., Newton, I., Huang, Z., Menciassi, A., Nathke, I. & Cochran, S., Jun 2018, In : Journal of Medical Robotics Research. 3, 2, 13 p., 1840001.

Research output: Contribution to journalArticle

Open Access
File
Capsule Endoscopes
Gastrointestinal Diseases
Pharmaceutical Preparations
Capsule Endoscopy
Crohn Disease
4 Citations (Scopus)

A randomized controlled trial protocol assessing the effectiveness, safety and cost-effectiveness of methotrexate vs. ciclosporin in the treatment of severe atopic eczema in children: the TREatment of severe Atopic eczema Trial (TREAT)

Guy's and St Thomas' NHS Foundation Trust, Irvine, A. D., Jones, A. P., Beattie, P., Baron, S., Browne, F., Ashoor, F., O'Neill, L., Rosala-Hallas, A., Sach, T., Spowart, C., Taams, L., Walker, C., Wan, M., Webb, N., Williamson, P. & Flohr, C., Dec 2018, In : British Journal of Dermatology. 179, 6, p. 1297-1306 10 p.

Research output: Contribution to journalArticle

Atopic Dermatitis
Clinical Protocols
Methotrexate
Cyclosporine
Cost-Benefit Analysis
65 Downloads (Pure)

Are PARKIN patients ideal candidates for dopaminergic cell replacement therapies?

Kunath, T., Natalwala, A., Chan, C., Chen, Y., Stecher, B., Taylor, M., Khan, S. & Muqit, M. M. K., 26 Dec 2018, In : European Journal of Neuroscience. 10 p.

Research output: Contribution to journalArticle

Open Access
File
Cell- and Tissue-Based Therapy
Synucleins
Lewy Bodies
Transplants
Mutation
3 Citations (Scopus)
53 Downloads (Pure)

A reversible light- and genotype-dependent acquired thermotolerance response protects the potato plant from damage due to excessive temperature

Trapero-Mozos, A., Ducreux, L. J. M., Bita, C. E., Morris, W., Wiese, C., Morris, J. A., Paterson, C., Hedley, P. E., Hancock, R. D. & Taylor, M., Jun 2018, In : Planta. 247, 6, p. 1377-1392 16 p.

Research output: Contribution to journalArticle

Open Access
File
Solanum tuberosum
heat tolerance
Genotype
potatoes
Light
57 Downloads (Pure)

A role for trypanosomatid aldo-keto reductases in methylglyoxal, prostaglandin and isoprostane metabolism

Roberts, A., Dunne, J., Scullion, S., Norval, S. & Fairlamb, A., 29 Aug 2018, In : Biochemical Journal. 475, 16, p. 2593-2610 18 p.

Research output: Contribution to journalArticle

Open Access
File
Pyruvaldehyde
Isoprostanes
Glyoxal
Metabolism
Prostaglandins
8 Citations (Scopus)
136 Downloads (Pure)

Array-based sequencing of filaggrin gene for comprehensive detection of disease-associated variants

Wong, X. F. C. C., Denil, S. L. I. J., Foo, J. N., Chen, H., Ling Tay, A. S., Haines, R. L., Tang, M. B. Y., McLean, W. H. I., Sandilands, A., Smith, F. J. D., Lane, E. B., Liu, J. & Common, J. E. A., Feb 2018, In : Journal of Allergy and Clinical Immunology. 141, 2, p. 814-816 3 p.

Research output: Contribution to journalLetter

Open Access
File
Atopic Dermatitis
Genes
Costs and Cost Analysis
Polymerase Chain Reaction
filaggrin
3 Citations (Scopus)
60 Downloads (Pure)

Asparaginyl endopeptidase (Legumain) supports human Th1 induction via cathepsin L-mediated intracellular C3 activation

Freeley, S., Cardone, J., Günther, S. C., West, E. E., Reinheckel, T., Watts, C., Kemper, C. & Kolev, M. V., 24 Oct 2018, In : Frontiers in Immunology. 9, p. 1-7 7 p., 2449.

Research output: Contribution to journalArticle

Open Access
File
asparaginylendopeptidase
Cathepsin L
T-Lymphocytes
Thymosin
Complement Receptors
1 Citation (Scopus)
50 Downloads (Pure)

A structural study of the complex between neuroepithelial cell transforming gene 1 (Net1) and RhoA reveals a potential anticancer drug hot spot

Petit, A-P., Garcia-Petit, C., Bueren-Calabuig, J. A., Vuillard, L. M., Ferry, G. & Boutin, J. A., 8 Jun 2018, In : Journal of Biological Chemistry. 293, 23, p. 9064-9077 14 p.

Research output: Contribution to journalArticle

Open Access
File
Neuroepithelial Cells
Oncogenes
Genes
Peptides
Guanine Nucleotide Exchange Factors
3 Citations (Scopus)
51 Downloads (Pure)

A survey of uranium levels in urine and hair of people living in a coal mining area in Yili, Xinjiang, China

Wufuer, R., Song, W., Zhang, D., Pan, X. & Gadd, G. M., Sep 2018, In : Journal of Environmental Radioactivity. 189, p. 168-174 7 p.

Research output: Contribution to journalArticle

Open Access
File
Coal Mining
Uranium
coal mining
Coal mines
hair
2 Citations (Scopus)

A tale of two eras: Phytoplankton composition influenced by oceanic paleochemistry

Giordano, M., Olivieri, C., Ratti, S., Norici, A., Raven, J. A. & Knoll, A. H., Sep 2018, In : Geobiology. 16, 5, p. 498-506 9 p.

Research output: Contribution to journalArticle

chemistry
phytoplankton
oceans
algae
biomass
3 Citations (Scopus)
119 Downloads (Pure)

ATG5 Promotes Death Signaling in Response to the Cyclic Depsipeptides Coibamide A and Apratoxin A

Wan, X., Serrill, J. D., Humphreys, I. R., Tan, M., McPhail, K. L., Ganley, I. G. & Ishmael, J. E., 1 Mar 2018, In : Marine Drugs. 16, 3, p. 1-20 20 p., 77.

Research output: Contribution to journalArticle

Open Access
File
Depsipeptides
Autophagy
Thapsigargin
Biological Products
Fibroblasts
4 Citations (Scopus)
60 Downloads (Pure)

Atg7-Mediated Autophagy Is Involved in the Neural Crest Cell Generation in Chick Embryo

Wang, G., Chen, E., Liang, C., Liang, J., Gao, L., Chuai, M., Münsterberg, A., Bao, Y., Cao, L. & Yang, X., Apr 2018, In : Molecular Neurobiology. 55, 4, p. 3523-3536 14 p.

Research output: Contribution to journalArticle

Open Access
File
Neural Crest
Autophagy
Chick Embryo
Neural Tube
Transfection
4 Citations (Scopus)
84 Downloads (Pure)

Atypical APC/C-dependent degradation of Mcl-1 provides an apoptotic timer during mitotic arrest

Allan, L. A., Skowyra, A., Rogers, K. I., Zeller, D. & Clarke, P. R., 3 Sep 2018, In : The EMBO Journal. 37, 17, p. 1-15 15 p., e96831.

Research output: Contribution to journalArticle

Open Access
File
Anaphase-Promoting Complex-Cyclosome
Mitosis
Degradation
Ubiquitin-Protein Ligases
Isoleucine
1 Citation (Scopus)
43 Downloads (Pure)

Author Correction: Plasmodium APC3 mediates chromosome condensation and cytokinesis during atypical mitosis in male gametogenesis

Wall, R. J., Ferguson, D. J. P., Freville, A., Franke-Fayard, B., Brady, D., Zeeshan, M., Bottrill, A. R., Wheatley, S., Fry, A. M., Janse, C. J., Yamano, H., Holder, A. A., Guttery, D. S. & Tewari, R., 21 Aug 2018, In : Scientific Reports. 8, 1, p. 1-2 2 p., 12814.

Research output: Contribution to journalArticle

Open Access
File
Gametogenesis
Cytokinesis
Plasmodium
Mitosis
Chromosomes
7 Citations (Scopus)
107 Downloads (Pure)

Bace1-dependent amyloid processing regulates hypothalamic leptin sensitivity in obese mice

Meakin, P. J., Jalicy, S. M., Montagut, G., Allsop, D. J. P., Cavellini, D. L., Irvine, S. W., McGinley, C., Liddell, M. K., McNeilly, A. D., Parmionova, K., Liu, Y-R., Bailey, C. S. L., Dale, J. K., Heisler, L. K., McCrimmon, R. J. & Ashford, M. L. J., 8 Jan 2018, In : Scientific Reports. 8, 1, p. 55 16 p., 55.

Research output: Contribution to journalArticle

Open Access
File
Obese Mice
Leptin
Amyloid
Obesity
Homeostasis
31 Citations (Scopus)
18 Downloads (Pure)

BACE-1 Inhibitors: From Recent Single-Target Molecules to Multitarget Compounds for Alzheimer's Disease

Prati, F., Bottegoni, G., Bolognesi, M. L. & Cavalli, A., 8 Feb 2018, In : Journal of Medicinal Chemistry. 61, 3, p. 619-637 19 p.

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Alzheimer Disease
Drug Discovery
Amyloid
Amyloid beta-Protein Precursor
Pharmaceutical Preparations