School of Life Sciences

  • United Kingdom

Research Output 1968 2020

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Review article
24 Citations (Scopus)

6-phosphogluconate dehydrogenase: A target for drugs in African trypanosomes

Hanau, S., Rinaldi, E., Dallocchio, F., Gilbert, I. H., Dardonville, C., Adams, M. J., Gover, S. & Barrett, M. P., Oct 2004, In : Current Topics in Medicinal Chemistry. 11, 19, p. 2639-2650 12 p.

Research output: Contribution to journalReview article

85 Citations (Scopus)

A clock-work somite

Dale, K. J. & Pourquié, O., 24 Jan 2000, In : BioEssays. 22, 1, p. 72-83 12 p.

Research output: Contribution to journalReview article

Somites
Periodicity
Clocks
Vertebrates
Homeobox Genes
51 Citations (Scopus)

A comment on the colour-colour diagrams of low-mass X-ray binaries

Gierliński, M. & Done, C., 21 Apr 2002, In : Monthly Notices of the Royal Astronomical Society. 331, 4, p. L47-L50 4 p.

Research output: Contribution to journalReview article

Open Access
color-color diagram
diagram
atolls
atoll
x rays
12 Citations (Scopus)

Acquisition and metabolism of carbon in the Ochrophyta other than diatoms

Raven, J. A. & Giordano, M., 5 Sep 2017, In : Philosophical Transactions of the Royal Society B - Biological Sciences. 372, 1728

Research output: Contribution to journalReview article

Diatoms
Bacillariophyceae
Metabolism
Phaeophyta
Phaeophyceae
131 Citations (Scopus)

Actions of synthetic and endogenous steroids on the GABAA receptor

Lambert, J. J., Peters, J. A. & Cottrell, G. A., 1 Jan 1987, In : Trends in Pharmacological Sciences. 8, 6, p. 224-227 4 p.

Research output: Contribution to journalReview article

GABA-A Receptors
Steroids
Steroid hormones
Hypnosis
gamma-Aminobutyric Acid
1 Citation (Scopus)
105 Downloads (Pure)

Adaptation and therapeutic exploitation of the plasma membrane of African trypanosomes

Quintana, J. F., Canavate Del Pino, R., Yamada, K., Zhang, N. & Field, M., 20 Jul 2018, In : Genes. 9, 7, 16 p., 368.

Research output: Contribution to journalReview article

Open Access
File
Immune Evasion
Trypanosomiasis
Cell Membrane
Membranes
Organelles
16 Citations (Scopus)

Advances in bacterial transcriptome and transposon insertion-site profiling using second-generation sequencing

Febrer, M., McLay, K., Caccamo, M., Twomey, K. B. & Ryan, R. . P., 1 Nov 2011, In : Trends in Biotechnology. 29, 11, p. 586-594 9 p.

Research output: Contribution to journalReview article

1 Citation (Scopus)
163 Downloads (Pure)

Advances in targeted degradation of endogenous proteins

Roth, S., Fulcher, L. & Sapkota, G., 27 Apr 2019, In : Cellular and Molecular Life Sciences. 76, 14, p. 2761-2777 17 p.

Research output: Contribution to journalReview article

Open Access
File
Proteolysis
Proteins
Clustered Regularly Interspaced Short Palindromic Repeats
Gene Targeting
Protein Biosynthesis
4 Citations (Scopus)

Affinity methods for phosphorylation-dependent interactions.

Moorhead, G. & MacKintosh, C., 1 Jan 2004, In : Methods in Molecular Biology (Clifton, N.J.). 261, p. 469-478 10 p.

Research output: Contribution to journalReview article

Phosphorylation
Proteins
Phosphopeptides
Phosphoprotein Phosphatases
Phosphoproteins
90 Citations (Scopus)

A key role for the GINS complex at DNA replication forks

Labib, K. & Gambus, A., Jun 2007, In : Trends in Cell Biology. 17, 6, p. 271-278 8 p.

Research output: Contribution to journalReview article

16 Citations (Scopus)

Altered calcium regulation in freshly isolated aortic smooth muscle cells from bile duct-ligated rats: Role of nitric oxide

Atucha, N. M., Iyu, D., De Rycker, M., Soler, A. & García-Estañ, J., Feb 2003, In : Cell Calcium. 33, 2, p. 129-135 7 p.

Research output: Contribution to journalReview article

Bile Ducts
Smooth Muscle Myocytes
Nitric Oxide
Calcium
Ligation
190 Citations (Scopus)

Amino acid transceptors: gate keepers of nutrient exchange and regulators of nutrient signaling

Hundal, H. S. & Taylor, P. M., Apr 2009, In : American Journal of Physiology, Endocrinology and Metabolism. 296, 4, p. E603-E613 11 p.

Research output: Contribution to journalReview article

846 Citations (Scopus)

AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function

Hardie, D. G., 15 Sep 2011, In : Genes & Development. 25, 18, p. 1895-1908 14 p.

Research output: Contribution to journalReview article

84 Citations (Scopus)

AMP-activated protein kinase: a sensor of glycogen as well as AMP and ATP?

McBride, A. & Hardie, D. G., May 2009, In : Acta Physiologica. 196, 1, p. 99-113 15 p.

Research output: Contribution to journalReview article

111 Citations (Scopus)

AMP-activated protein kinase: also regulated by ADP?

Hardie, D. G., Carling, D. & Gamblin, S. J., Sep 2011, In : Trends in Biochemical Sciences. 36, 9, p. 470-477 8 p.

Research output: Contribution to journalReview article

127 Citations (Scopus)
83 Downloads (Pure)

AMP-activated protein kinase: a key regulator of energy balance with many roles in human disease

Hardie, D. G., Dec 2014, In : Journal of Internal Medicine. 276, 6, p. 543-559 17 p.

Research output: Contribution to journalReview article

Open Access
File
AMP-Activated Protein Kinases
Salicylates
Metformin
Virus Diseases
Aspirin
226 Citations (Scopus)
89 Downloads (Pure)

AMP-Activated Protein Kinase: A Target for Drugs both Ancient and Modern

Hardie, D. G., Ross, F. A. & Hawley, S. A., 26 Oct 2012, In : Chemistry & Biology. 19, 10, p. 1222-36 15 p.

Research output: Contribution to journalReview article

Open Access
File
AMP-Activated Protein Kinases
Cyclic AMP-Dependent Protein Kinases
Metformin
Adenosine Triphosphate
Medical problems
42 Citations (Scopus)
77 Downloads (Pure)

AMP-Activated Protein Kinase: An Ubiquitous Signaling Pathway With Key Roles in the Cardiovascular System

Salt, I. P. & Hardie, D. G., 26 May 2017, In : Circulation Research. 120, 11, p. 1825-1841 17 p.

Research output: Contribution to journalReview article

Open Access
File
AMP-Activated Protein Kinases
Cardiovascular System
Blood Vessels
Homeostasis
Anti-Inflammatory Agents
92 Citations (Scopus)

AMP-Activated Protein Kinase: Maintaining Energy Homeostasis at the Cellular and Whole-Body Levels

Hardie, D. G., Jul 2014, In : Annual Review of Nutrition. 34, p. 31-55 25 p.

Research output: Contribution to journalReview article

AMP-Activated Protein Kinases
Adenosine Monophosphate
Protein Kinases
Homeostasis
Adenosine Triphosphate
23 Citations (Scopus)
102 Downloads (Pure)

AMP-activated protein kinase - not just an energy sensor

Hardie, D. G. & Lin, S-C., 22 Sep 2017, In : F1000 Research. 6, p. 1-11 11 p., 1724.

Research output: Contribution to journalReview article

Open Access
File
AMP-Activated Protein Kinases
Sensors
Adenine Nucleotides
Adenosine Triphosphate
Eukaryota
1771 Citations (Scopus)
119 Downloads (Pure)

AMPK: a nutrient and energy sensor that maintains energy homeostasis

Hardie, D. G., Ross, F. A. & Hawley, S. A., 1 Apr 2012, In : Nature Reviews Molecular Cell Biology. 13, 4, p. 251-262 12 p.

Research output: Contribution to journalReview article

Open Access
File
AMP-Activated Protein Kinases
Homeostasis
Adenosine Triphosphate
Food
Biosynthetic Pathways
42 Citations (Scopus)

AMPK: mediating the metabolic effects of salicylate-based drugs?

Steinberg, G. R., Dandapani, M. & Hardie, D. G., Oct 2013, In : Trends in Endocrinology and Metabolism. 24, 10, p. 481-487 7 p.

Research output: Contribution to journalReview article

AMP-Activated Protein Kinases
Salicylates
Pharmaceutical Preparations
Aspirin
Prostaglandin-Endoperoxide Synthases
248 Citations (Scopus)
248 Downloads (Pure)

AMPK: an energy-sensing pathway with multiple inputs and outputs

Hardie, D. G., Schaffer, B. E. & Brunet, A., Mar 2016, In : Trends in Cell Biology. 26, 3, p. 190-201 12 p.

Research output: Contribution to journalReview article

Open Access
File
AMP-Activated Protein Kinases
Adenosine Monophosphate
Phosphotransferases
Adenosine Triphosphate
Phosphorylation
229 Citations (Scopus)

AMPK: positive and negative regulation, and its role in whole-body energy homeostasis

Hardie, D. G., Apr 2015, In : Current Opinion in Cell Biology. 33, April, p. 1-7 7 p.

Research output: Contribution to journalReview article

AMP-Activated Protein Kinases
Homeostasis
Phosphorylation
Physiological Stress
Lysosomes
59 Citations (Scopus)
87 Downloads (Pure)

AMPK: a cellular energy sensor primarily regulated by AMP

Gowans, G. J. & Hardie, D. G., 1 Feb 2014, In : Biochemical Society Transactions. 42, 1, p. 71-75 5 p.

Research output: Contribution to journalReview article

Open Access
File
AMP-Activated Protein Kinases
Adenosine Monophosphate
Adenosine Triphosphate
Adenosine Diphosphate
Sensors
113 Citations (Scopus)
172 Downloads (Pure)

AMPK: Sensing Glucose as well as Cellular Energy Status

Lin, S-C. & Hardie, D., 6 Feb 2018, In : Cell Metabolism. 27, 2, p. 299-313 15 p.

Research output: Contribution to journalReview article

Open Access
File
AMP-Activated Protein Kinases
Glucose
Adenosine Triphosphatases
Fructose-Bisphosphate Aldolase
Adenosine Triphosphate
172 Citations (Scopus)

An additional role for SUMO in ubiquitin-mediated proteolysis

Geoffroy, M-C. & Hay, R. T., Aug 2009, In : Nature Reviews Molecular Cell Biology. 10, 8, p. 564-568 5 p.

Research output: Contribution to journalReview article

20 Citations (Scopus)

Analysis of branched nucleic acid structure using comparative gel electrophoresis

Lilley, D. M. J., Feb 2008, In : Quarterly Reviews of Biophysics. 41, 1, p. 139 39 p.

Research output: Contribution to journalReview article

147 Citations (Scopus)

Analysis of plant diversity with retrotransposon-based molecular markers

Kalendar, R., Flavell, A. J., Ellis, T. H. N., Sjakste, T., Moisy, C. & Schulman, A. H., Apr 2011, In : Heredity. 106, 4, p. 520-530 11 p.

Research output: Contribution to journalReview article

1 Citation (Scopus)
50 Downloads (Pure)

A New Front in Microbial Warfare—Delivery of Antifungal Effectors by the Type VI Secretion System

Trunk, K., Coulthurst, S. & Quinn, J., Jun 2019, In : Journal of Fungi. 5, 2, p. 1-13 13 p., 50.

Research output: Contribution to journalReview article

Open Access
File
Weapons
Fungi
Microbiota
Autophagy
Gram-Negative Bacteria
4 Citations (Scopus)
102 Downloads (Pure)

An outlook on protein S-acylation in plants: what are the next steps?

Hemsley, P. A., 31 Jan 2017, In : Journal of Experimental Botany. 12, 1, p. 3155-3164 10 p.

Research output: Contribution to journalReview article

Open Access
File
acylation
Acylation
Protein S
Membrane Proteins
proteins
47 Citations (Scopus)
175 Downloads (Pure)

Antibiotics and antibiotic resistance genes in global lakes: A review and meta-analysis

Yang, Y., Song, W., Lin, H., Wang, W., Du, L. & Xing, W., Jul 2018, In : Environment International. 116, p. 60-73 14 p.

Research output: Contribution to journalReview article

Open Access
File
antibiotic resistance
meta-analysis
antibiotics
gene
lake
101 Citations (Scopus)
196 Downloads (Pure)
Open Access
File
Drug Discovery
Public Health
Neglected Diseases
Disease Eradication
African Trypanosomiasis
13 Citations (Scopus)
99 Downloads (Pure)

A Perspective on CRN Proteins in the Genomics Age: Evolution, Classification, Delivery and Function Revisited

Amaro, T. M. M. M., Thilliez, G. J. A., Motion, G. B. & Huitema, E., 3 Feb 2017, In : Frontiers in Plant Science. 8, p. 1-12 12 p., 99.

Research output: Contribution to journalReview article

Open Access
File
taxonomy
genomics
proteins
immunity
virulence
23 Citations (Scopus)

A perspective on proteomics in cell biology

Ahmad, Y. & Lamond, A. I., Apr 2014, In : Trends in Cell Biology. 24, 4, p. 257-264 8 p.

Research output: Contribution to journalReview article

Open Access
Proteomics
Cell Biology
Mass Spectrometry
Proteins
Technology
67 Citations (Scopus)

A pivotal role for the response regulator DegU in controlling multicellular behaviour

Murray, E. J., Kiley, T. B. & Stanley-Wall, N. R., Jan 2009, In : Microbiology. 155, p. 18 8 p.

Research output: Contribution to journalReview article

1 Citation (Scopus)

A rnyxobacterial S-motility protein dances with poles

Huitema, E. & Viollier, P. H., Jun 2006, In : Trends in Microbiology. 14, 6, p. 247-248 2 p.

Research output: Contribution to journalReview article

80 Citations (Scopus)

Assembly of membrane-bound respiratory complexes by the Tat protein-transport system

Sargent, F., Berks, B. C. & Palmer, T., Aug 2002, In : Archives of Microbiology. 178, 2, p. 77-84 8 p.

Research output: Contribution to journalReview article

52 Citations (Scopus)

Assessing brain free fraction in early drug discovery

Read, K. D. & Braggio, S., Mar 2010, In : Expert Opinion on Drug Metabolism & Toxicology. 6, 3, p. 337-344 8 p.

Research output: Contribution to journalReview article

1192 Citations (Scopus)

A unified classification system for eukaryotic transposable elements

Wicker, T., Sabot, F., Hua-Van, A., Bennetzen, J. L., Capy, P., Chalhoub, B., Flavell, A., Leroy, P., Morgante, M., Panaud, O., Paux, E., SanMiguel, P. & Schulman, A. H., Dec 2007, In : Nature Reviews Genetics. 8, 12, p. 973-982 10 p.

Research output: Contribution to journalReview article

35 Citations (Scopus)
35 Downloads (Pure)

BACE-1 Inhibitors: From Recent Single-Target Molecules to Multitarget Compounds for Alzheimer's Disease

Prati, F., Bottegoni, G., Bolognesi, M. L. & Cavalli, A., 8 Feb 2018, In : Journal of Medicinal Chemistry. 61, 3, p. 619-637 19 p.

Research output: Contribution to journalReview article

Open Access
File
Alzheimer Disease
Drug Discovery
Amyloid
Amyloid beta-Protein Precursor
Pharmaceutical Preparations

Bifunctional chemical probes inducing protein-protein interactions

Maniaci, C. & Ciulli, A., Oct 2019, In : Current Opinion in Chemical Biology. 52, p. 145-156 12 p.

Research output: Contribution to journalReview article

Ubiquitin-Protein Ligases
Adhesives
Proteolysis
Ligands
Molecular recognition

Bill Whelan's impact on my life and career

Cohen, P., Dec 2015, In : Molecular Aspects of Medicine. 46, p. 11-13 3 p.

Research output: Contribution to journalReview article

Glycogen Synthase
Transferases
Tyrosine
Demonstrations
glycogenin
67 Citations (Scopus)

Biogeography of nodulated legumes and their nitrogen-fixing symbionts

Sprent, J. I., Ardley, J. & James, E. K., 31 May 2017, In : New Phytologist. 215, 1, p. 40-56 17 p.

Research output: Contribution to journalReview article

Fabaceae
symbionts
Rhizobium
Nitrogen
legumes
76 Citations (Scopus)

Bioimage informatics for experimental biology

Swedlow, J. R., Goldberg, I. G., Eliceiri, K. W. & OME Consortium, 2009, In : Annual Review of Biophysics. 38, p. 327-346 20 p.

Research output: Contribution to journalReview article

27 Citations (Scopus)

Bi-orienting chromosomes: acrobatics on the mitotic spindle

Tanaka, T. U., Dec 2008, In : Chromosoma. 117, 6, p. 521-533 13 p.

Research output: Contribution to journalReview article

625 Citations (Scopus)
9 Citations (Scopus)
104 Downloads (Pure)

Biotic interactions as drivers of algal origin and evolution

Brodie, J., Ball, S. G., Bouget, F-Y., Chan, C. X., De Clerck, O., Cock, J. M., Gachon, C. M. M., Grossman, A. R., Mock, T., Raven, J. A., Saha, M., Smith, A. G., Vardi, A., Yoon, H. S. & Bhattacharya, D., 16 Oct 2017, In : New Phytologist. 216, 3, p. 670-681 12 p.

Research output: Contribution to journalReview article

Open Access
File
algae
Ecosystem
Coral Reefs
Eutrophication
Knowledge Bases

Blue carbon: past, present and future, with emphasis on macroalgae

Raven, J., Oct 2018, In : Biology Letters. 14, 10, p. 1-5 5 p., 20180336.

Research output: Contribution to journalReview article

Seaweed
macroalgae
Carbon
carbon
Temperature
3 Citations (Scopus)
102 Downloads (Pure)

Breaking Bad: How Viruses Subvert the Cell Cycle

Fan, Y., Sanyal, S. & Bruzzone, R., 19 Nov 2018, In : Frontiers in Cellular and Infection Microbiology. 8, p. 1-28 28 p., 396.

Research output: Contribution to journalReview article

Open Access
File
Cell Cycle
Viruses
Antigen Presentation
Protein Transport
Humoral Immunity