School of Life Sciences

  • United Kingdom

Research Output 1968 2020

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Review article
2018
24 Citations (Scopus)
200 Downloads (Pure)

Regulation of proteasome assembly and activity in health and disease

Rousseau, A. & Bertolotti, A., 2018, In : Nature Reviews Molecular Cell Biology. 19, 11, p. 697-712 16 p.

Research output: Contribution to journalReview article

Open Access
File
Proteasome Endopeptidase Complex
Health
Autophagy
Protein Transport
Quality Control
5 Citations (Scopus)
104 Downloads (Pure)

Social behaviours by Bacillus subtilis: quorum sensing, kin discrimination and beyond

Kalamara, M., Špacapan, M., Mandic‐Mulec, I. & Stanley-Wall, N., 1 Dec 2018, In : Molecular Microbiology. 110, 6, p. 863-878 16 p.

Research output: Contribution to journalReview article

Open Access
File
Quorum Sensing
Social Behavior
Bacillus subtilis
Bacteria
Nanotubes
7 Citations (Scopus)
91 Downloads (Pure)

The FAM83 family of proteins: from pseudo-PLDs to anchors for CK1 isoforms

Bozatzi, P. & Sapkota, G., 5 Jun 2018, In : Biochemical Society Transactions. 46, 3, p. 761-771 11 p.

Research output: Contribution to journalReview article

Open Access
File
Casein Kinase I
Anchors
Protein Isoforms
Phospholipase D
Protein Kinases
5 Citations (Scopus)

The kink-turn in the structural biology of RNA

Huang, L. & Lilley, D. M. J., 2018, In : Quarterly Reviews of Biophysics. 51, p. 1-32 32 p., e5.

Research output: Contribution to journalReview article

RNA
Metals
Ions
Base Pairing
Carrier Proteins
14 Citations (Scopus)
100 Downloads (Pure)

The regulation of lymphocyte activation and proliferation

Heinzel, S., Marchingo, J. M., Horton, M. B. & Hodgkin, P. D., Apr 2018, In : Current Opinion in Immunology. 51, p. 32-38 7 p.

Research output: Contribution to journalReview article

Open Access
File
Lymphocyte Activation
Antigens
Lymphocytes
T-Lymphocytes
Adaptive Immunity
6 Citations (Scopus)
100 Downloads (Pure)

The second International Symposium on Fungal Stress: ISFUS

Alder-Rangel, A., Bailão, A. M., da Cunha, A. F., Soares, C. M. A., Wang, C., Bonatto, D., Dadachova, E., Hakalehto, E., Eleutherio, E. C. A., Fernandes, É. K. K., Gadd, G. M., Braus, G. H., Braga, G. U. L., Goldman, G. H., Malavazi, I., Hallsworth, J. E., Takemoto, J. Y., Fuller, K. K., Selbmann, L., Corrochano, L. M. & 8 others, von Zeska Kress, M. R., Bertolini, M. C., Schmoll, M., Pedrini, N., Loera, O., Finlay, R. D., Peralta, R. M. & Rangel, D. E. N., 1 Jun 2018, In : Fungal Biology. 122, 6, p. 386-399 14 p.

Research output: Contribution to journalReview article

Open Access
File
industrial microbiology
Industrial Microbiology
insect pathology
Exobiology
Photobiology
9 Citations (Scopus)
27 Downloads (Pure)

The trypanosome alternative oxidase: a potential drug target?

Menzies, S. K., Tulloch, L. B., Florence, G. J. & Smith, T. K., Feb 2018, In : Parasitology. 145, 2, p. 175-183 9 p.

Research output: Contribution to journalReview article

Open Access
File
Trypanosomiasis
African trypanosomiasis
drugs
Trypanosoma brucei
therapeutics
4 Citations (Scopus)
188 Downloads (Pure)

Using Microscale Thermophoresis to Characterize Hits from High-Throughput Screening: A European Lead Factory Perspective

Rainard, J. M., Pandarakalam, G. C. & McElroy, S. P., 1 Mar 2018, In : SLAS Discovery. 23, 3, p. 225-241 17 p.

Research output: Contribution to journalReview article

Open Access
File
Thermophoresis
Industrial plants
Screening
Throughput
Triage
2017
12 Citations (Scopus)

Acquisition and metabolism of carbon in the Ochrophyta other than diatoms

Raven, J. A. & Giordano, M., 5 Sep 2017, In : Philosophical Transactions of the Royal Society B - Biological Sciences. 372, 1728

Research output: Contribution to journalReview article

Diatoms
Bacillariophyceae
Metabolism
Phaeophyta
Phaeophyceae
44 Citations (Scopus)
78 Downloads (Pure)

AMP-Activated Protein Kinase: An Ubiquitous Signaling Pathway With Key Roles in the Cardiovascular System

Salt, I. P. & Hardie, D. G., 26 May 2017, In : Circulation Research. 120, 11, p. 1825-1841 17 p.

Research output: Contribution to journalReview article

Open Access
File
AMP-Activated Protein Kinases
Cardiovascular System
Blood Vessels
Homeostasis
Anti-Inflammatory Agents
23 Citations (Scopus)
104 Downloads (Pure)

AMP-activated protein kinase - not just an energy sensor

Hardie, D. G. & Lin, S-C., 22 Sep 2017, In : F1000 Research. 6, p. 1-11 11 p., 1724.

Research output: Contribution to journalReview article

Open Access
File
AMP-Activated Protein Kinases
Sensors
Adenine Nucleotides
Adenosine Triphosphate
Eukaryota
4 Citations (Scopus)
106 Downloads (Pure)

An outlook on protein S-acylation in plants: what are the next steps?

Hemsley, P. A., 31 Jan 2017, In : Journal of Experimental Botany. 12, 1, p. 3155-3164 10 p.

Research output: Contribution to journalReview article

Open Access
File
acylation
Acylation
Protein S
Membrane Proteins
proteins
102 Citations (Scopus)
201 Downloads (Pure)
Open Access
File
Drug Discovery
Public Health
Neglected Diseases
Disease Eradication
African Trypanosomiasis
13 Citations (Scopus)
103 Downloads (Pure)

A Perspective on CRN Proteins in the Genomics Age: Evolution, Classification, Delivery and Function Revisited

Amaro, T. M. M. M., Thilliez, G. J. A., Motion, G. B. & Huitema, E., 3 Feb 2017, In : Frontiers in Plant Science. 8, p. 1-12 12 p., 99.

Research output: Contribution to journalReview article

Open Access
File
taxonomy
genomics
proteins
immunity
virulence
69 Citations (Scopus)

Biogeography of nodulated legumes and their nitrogen-fixing symbionts

Sprent, J. I., Ardley, J. & James, E. K., 31 May 2017, In : New Phytologist. 215, 1, p. 40-56 17 p.

Research output: Contribution to journalReview article

Fabaceae
symbionts
Rhizobium
Nitrogen
legumes
9 Citations (Scopus)
105 Downloads (Pure)

Biotic interactions as drivers of algal origin and evolution

Brodie, J., Ball, S. G., Bouget, F-Y., Chan, C. X., De Clerck, O., Cock, J. M., Gachon, C. M. M., Grossman, A. R., Mock, T., Raven, J. A., Saha, M., Smith, A. G., Vardi, A., Yoon, H. S. & Bhattacharya, D., 16 Oct 2017, In : New Phytologist. 216, 3, p. 670-681 12 p.

Research output: Contribution to journalReview article

Open Access
File
algae
Ecosystem
Coral Reefs
Eutrophication
Knowledge Bases
10 Citations (Scopus)

Carbon-concentrating mechanisms in seagrasses

Larkum, A. W. D., Davey, P. A., Kuo, J., Ralph, P. J. & Raven, J. A., 1 Jul 2017, In : Journal of Experimental Botany. 68, 14, p. 3773-3784 12 p.

Research output: Contribution to journalReview article

concentrating
Seawater
Chloroplasts
Carbon
Bicarbonates
5 Citations (Scopus)

Consequences of the genotypic loss of mitochondrial Complex i in dinoflagellates and of phenotypic regulation of Complex i content in other photosynthetic organisms

Raven, J. A. & Beardall, J., 17 May 2017, In : Journal of Experimental Botany. 68, 11, p. 2683-2692 10 p.

Research output: Contribution to journalReview article

Dinoflagellida
autotrophs
Iron
iron
Adenosine Triphosphate
6 Citations (Scopus)
132 Downloads (Pure)

Does DNA replication direct locus-specific recombination during host immune evasion by antigenic variation in the African trypanosome?

Devlin, R., Marques, C. A. & McCulloch, R., Jun 2017, In : Current Genetics. 63, 3, p. 441-449 9 p.

Research output: Contribution to journalReview article

Open Access
File
Immune Evasion
Antigenic Variation
Trypanosomiasis
Membrane Glycoproteins
Gene Conversion
40 Citations (Scopus)
119 Downloads (Pure)

Endogenously produced nonclassical vitamin D hydroxy-metabolites act as "biased" agonists on VDR and inverse agonists on RORα and RORγ

Slominski, A. T., Kim, T-K., Hobrath, J. V., Oak, A. S. W., Tang, E. K. Y., Tieu, E. W., Li, W., Tuckey, R. C. & Jetten, A. M., Oct 2017, In : Journal of Steroid Biochemistry and Molecular Biology. 173, p. 42-56 15 p.

Research output: Contribution to journalReview article

Open Access
File
Metabolites
Vitamin D
Secosteroids
Molecular modeling
Ligands
7 Citations (Scopus)
103 Downloads (Pure)

Fats and function: protein lipid modifications in plant cell signalling

Turnbull, D. & Hemsley, P. A., Dec 2017, In : Current Opinion in Plant Biology. 40, p. 63-70 8 p.

Research output: Contribution to journalReview article

Open Access
File
lipids
proteins
cells
acylation
protein transport
16 Citations (Scopus)
243 Downloads (Pure)

Fragment library design, synthesis and expansion: nurturing a synthesis and training platform

Ray, P. C., Kiczun, M., Huggett, M., Lim, A., Prati, F., Gilbert, I. H. & Wyatt, P. G., Jan 2017, In : Drug Discovery Today. 22, 1, p. 43-56 14 p.

Research output: Contribution to journalReview article

Open Access
File
Libraries
Drug Discovery
Space Flight
Pharmaceutical Preparations
Costs and Cost Analysis
4 Citations (Scopus)

High-quality reference transcript datasets hold the key to transcript-specific RNA-sequencing analysis in plants

Brown, J. W. S., Calixto, C. P. G. & Zhang, R., Jan 2017, In : New Phytologist. 213, 2, p. 525-530 6 p.

Research output: Contribution to journalReview article

RNA Sequence Analysis
alternative splicing
Alternative Splicing
sequence analysis
RNA
2 Citations (Scopus)
143 Downloads (Pure)

Holliday junction-resolving enzymes - structures and mechanisms

Lilley, D. M. J., Apr 2017, In : FEBS Letters. 591, 8, p. 1073-1082 10 p.

Research output: Contribution to journalReview article

Open Access
File
Cruciform DNA
Fungal Structures
Eukaryotic Cells
Enzymes
Crystal lattices
7 Citations (Scopus)
105 Downloads (Pure)

Host-pathogen interactions and subversion of autophagy

McEwan, D. G., 12 Dec 2017, In : Essays in Biochemistry. 61, 6, p. 687-697 11 p.

Research output: Contribution to journalReview article

Open Access
File
Host-Pathogen Interactions
Autophagy
Pathogens
Oxygen supply
Amino Acids
14 Citations (Scopus)
655 Downloads (Pure)

How RNA acts as a nuclease: some mechanistic comparisons in the nucleolytic ribozymes

Lilley, D. M. J., 15 Jun 2017, In : Biochemical Society Transactions. 45, 3, p. 683-691 9 p.

Research output: Contribution to journalReview article

Open Access
File
Catalytic RNA
RNA
31 Citations (Scopus)
105 Downloads (Pure)

Hypoxia and inflammation in Cancer, focus on HIF and NF-κB

D'Ignazio, L., Batie, M. & Rocha, S., 9 May 2017, In : Biomedicines. 5, 2, 23 p., 21.

Research output: Contribution to journalReview article

Open Access
File
Crosstalk
Transcription Factors
Inflammation
Neoplasms
Chemical activation
8 Citations (Scopus)

Intraspecific chemical communication in microalgae

Venuleo, M., Raven, J. A. & Giordano, M., 20 Jun 2017, In : New Phytologist. 215, 2, p. 516-530 15 p.

Research output: Contribution to journalReview article

Microalgae
microalgae
animal communication
Hydrobiology
algae
31 Citations (Scopus)
104 Downloads (Pure)

Lipid modulation of skeletal muscle mass and function

Lipina, C. & Hundal, H. S., Apr 2017, In : Journal of Cachexia, Sarcopenia and Muscle. 8, 2, p. 190-201 12 p.

Research output: Contribution to journalReview article

Open Access
File
Skeletal Muscle
Lipids
Dietary Supplements
Fatty Acids
Obesity
2 Citations (Scopus)

Management of plantar keratodermas: Lessons from pachyonychia congenita

Porter, R. M., Bravo, A. A. & Smith, F. J. D., Sep 2017, In : Journal of the American Podiatric Medical Association. 107, 5, p. 428-435 8 p.

Research output: Contribution to journalReview article

Pachyonychia Congenita
Bony Callus
Nails
Keratolytic Agents
Exfoliative Dermatitis
8 Citations (Scopus)
neurotoxins
Neurotoxins
Cyanobacteria
Biosynthetic Pathways
biosynthesis
21 Citations (Scopus)

Mitochondrial Function and Cell Size: An Allometric Relationship

Miettinen, T. P. & Björklund, M., Jun 2017, In : Trends in Cell Biology. 27, 6, p. 393-402 10 p.

Research output: Contribution to journalReview article

Mitochondrial Size
Cell Size
Mitochondrial Dynamics
Metabolic Diseases
Oxygen Consumption
34 Citations (Scopus)
135 Downloads (Pure)
Open Access
File
Molecular recognition
Drug Design
Proteins
Cell signaling
Adhesives
7 Citations (Scopus)
115 Downloads (Pure)

Nuclear DNA Replication in Trypanosomatids: There Are No Easy Methods for Solving Difficult Problems

da Silva, M. S., Pavani, R. S., Damasceno, J. D., Marques, C. A., McCulloch, R., Tosi, L. R. O. & Elias, M. C., Nov 2017, In : Trends in Parasitology. 33, 11, p. 858-874 17 p.

Research output: Contribution to journalReview article

Open Access
File
DNA Replication
Eukaryota
Parasites
Origin Recognition Complex
Disease Eradication
51 Citations (Scopus)
93 Downloads (Pure)

Patterns, receptors and signals: regulation of phagosome maturation

Pauwels, A-M., Trost, M., Beyaert, R. & Hoffmann, E., Jun 2017, In : Trends in Immunology. 28, 6, p. 407-422 16 p.

Research output: Contribution to journalReview article

Open Access
File
Phagosomes
Phagocytes
Antigen-Presenting Cells
Immunity
Homeostasis
5 Citations (Scopus)
99 Downloads (Pure)

Protein Kinases in Pluripotency - Beyond the Usual Suspects

Fernandez-Alonso, R., Bustos, F., Williams, C. A. C. & Findlay, G. M., 19 May 2017, In : Journal of Molecular Biology. 429, 10, p. 1504-1520 17 p.

Research output: Contribution to journalReview article

Open Access
File
Protein Kinases
Phosphorylation
Embryonic Stem Cells
MAP Kinase Signaling System
Fibroblast Growth Factor 2
5 Citations (Scopus)
120 Downloads (Pure)

Recent advances in understanding the roles of whole genome duplications in evolution

MacKintosh, C. & Ferrier, D. E. K., 31 Aug 2017, In : F1000 Research. 6, 9 p., 1623.

Research output: Contribution to journalReview article

Open Access
File
Genes
Genome
Polyploidy
Invertebrates
Eukaryota
30 Citations (Scopus)
348 Downloads (Pure)

Recognition of substrate degrons by E3 ubiquitin ligases and modulation by small-molecule mimicry strategies

Lucas, X. & Ciulli, A., Jun 2017, In : Current Opinion in Structural Biology. 44, p. 101-110 10 p.

Research output: Contribution to journalReview article

Open Access
File
Ubiquitin-Protein Ligases
Proteasome Endopeptidase Complex
Proteolysis
Proteins
Ubiquitination
7 Citations (Scopus)
107 Downloads (Pure)

Regulation and function of CMTR1-dependent mRNA cap methylation

Inesta-Vaquera, F. & Cowling, V. H., Nov 2017, In : Wiley Interdisciplinary Reviews: RNA. 8, 6, p. 1-6 6 p., e1450.

Research output: Contribution to journalReview article

Open Access
File
Methylation
Ribose
Innate Immunity
Messenger RNA
Nucleotides
8 Citations (Scopus)
96 Downloads (Pure)

Regulation of mRNA capping in the cell cycle

Aregger, M. & Cowling, V. H., 2 Jan 2017, In : RNA Biology. 14, 1, p. 11-14 4 p.

Research output: Contribution to journalReview article

Open Access
File
Cell Cycle
Messenger RNA
Methyltransferases
Phosphorylation
Cyclin B1
23 Citations (Scopus)

Root symbionts: Powerful drivers of plant above- and belowground indirect defences

Rasmann, S., Bennett, A., Biere, A., Karley, A. & Guerrieri, E., Dec 2017, In : Insect Science. 24, 6, p. 947-960 14 p.

Research output: Contribution to journalReview article

symbiont
symbionts
Fungi
Soils
Volatile Organic Compounds
18 Citations (Scopus)

The Algal Revolution

Brodie, J., Chan, C. X., De Clerck, O., Cock, J. M., Coelho, S. M., Gachon, C., Grossman, A. R., Mock, T., Raven, J. A., Smith, A. G., Yoon, H. S. & Bhattacharya, D., Aug 2017, In : Trends in Plant Science. 22, 8, p. 726-738 13 p.

Research output: Contribution to journalReview article

algae
biofuels
functional foods
eukaryotic cells
phenotype
3 Citations (Scopus)
115 Downloads (Pure)

The endocannabinoid system: no longer anonymous in the control of nitrergic signalling?

Lipina, C. & Hundal, H. S., 27 Jan 2017, In : Journal of Molecular Cell Biology. 9, 2, p. 91-103 13 p.

Research output: Contribution to journalReview article

Open Access
File
Endocannabinoids
Nitric Oxide
Reactive Nitrogen Species
Signal Transduction
Homeostasis
33 Citations (Scopus)
157 Downloads (Pure)

The Enigmatic Esx Proteins: Looking Beyond Mycobacteria

Unnikrishnan, M., Constantinidou, C., Palmer, T. & Pallen, M. J., Mar 2017, In : Trends in Microbiology. 25, 3, p. 192-204 13 p.

Research output: Contribution to journalReview article

Open Access
File
Mycobacterium
Bacteria
Proteins
Eukaryota
Membrane Proteins
33 Citations (Scopus)

The Evolution of Organellar Coat Complexes and Organization of the Eukaryotic Cell

Rout, M. P. & Field, M. C., Jun 2017, In : Annual Review of Biochemistry. 86, p. 637-657 21 p.

Research output: Contribution to journalReview article

Eukaryotic Cells
Organelles
Biochemistry
Proteins
Monomeric GTP-Binding Proteins
1 Citation (Scopus)

The Guanidine Riboswitch-A Poor Orphan No Longer

Lilley, D. M. J., 16 Feb 2017, In : Cell Chemical Biology. 24, 2, p. 130-131 2 p.

Research output: Contribution to journalReview article

Riboswitch
Guanidine
Gene expression
Ions
Ligands
48 Citations (Scopus)
111 Downloads (Pure)

The mammalian ULK1 complex and autophagy initiation

Zachari, M. & Ganley, I. G., 12 Dec 2017, In : Essays in Biochemistry. 61, 6, p. 585-596 12 p.

Research output: Contribution to journalReview article

Open Access
File
Autophagy
Degradation
Poisons
Protein-Serine-Threonine Kinases
Quality control
207 Citations (Scopus)
118 Downloads (Pure)

The mechanisms of action of metformin

Rena, G., Hardie, D. G. & Pearson, E. R., Sep 2017, In : Diabetologia. 60, 9, p. 1577-1585 9 p.

Research output: Contribution to journalReview article

Open Access
File
Metformin
AMP-Activated Protein Kinases
Glycerolphosphate Dehydrogenase
Glucose
Health Services Needs and Demand
30 Citations (Scopus)

The possible evolution, and future, of CO2-concentrating mechanisms

Raven, J. A., Beardall, J. & Sánchez-Baracaldo, P., 1 Jun 2017, In : Journal of Experimental Botany. 68, 14, p. 3701-3716 16 p.

Research output: Contribution to journalReview article

Ribulose-Bisphosphate Carboxylase
concentrating
carbon dioxide
Carbon Cycle
Oxygenases
16 Citations (Scopus)
108 Downloads (Pure)

The role of hybrid ubiquitin chains in the MyD88 and other innate immune signalling pathways

Cohen, P. & Strickson, S., May 2017, In : Cell Death & Differentiation. 24, p. 1153-1159 7 p.

Research output: Contribution to journalReview article

Open Access
File
Ubiquitin
Ubiquitin-Protein Ligases
TNF Receptor-Associated Factor 6
Phosphotransferases
Mitogen-Activated Protein Kinases