School of Life Sciences

  • United Kingdom

Research Output 1968 2020

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Review article
2017
13 Citations (Scopus)
87 Downloads (Pure)

Turn it down a notch

Carrieri, F. & Dale, J. K., 18 Jan 2017, In : Frontiers in Cell and Developmental Biology. 4, p. 1-9 9 p., 151.

Research output: Contribution to journalReview article

Open Access
File
Somites
Cyclin-Dependent Kinase 8
Phosphorylation
Neural Tube
Ubiquitin-Protein Ligases
11 Citations (Scopus)
122 Downloads (Pure)

Ubiquitin and Parkinson's disease through the looking glass of Genetics

Walden, H. & Muqit, M. M. K., May 2017, In : Biochemical Journal. 474, 9, p. 1439-1451 13 p.

Research output: Contribution to journalReview article

Open Access
File
Ubiquitin
Glass
Parkinson Disease
Proteins
Quality Control
38 Citations (Scopus)
120 Downloads (Pure)

WNK Kinase Signaling in Ion Homeostasis and Human Disease

Shekarabi, M., Zhang, J., Khanna, A. R., Ellison, D. H., Delpire, E. & Kahle, K. T., 7 Feb 2017, In : Cell Metabolism. 25, 2, p. 285-299 15 p.

Research output: Contribution to journalReview article

Open Access
File
Homeostasis
Phosphotransferases
Ions
Cell Size
gamma-Aminobutyric Acid
2016
248 Citations (Scopus)
248 Downloads (Pure)

AMPK: an energy-sensing pathway with multiple inputs and outputs

Hardie, D. G., Schaffer, B. E. & Brunet, A., Mar 2016, In : Trends in Cell Biology. 26, 3, p. 190-201 12 p.

Research output: Contribution to journalReview article

Open Access
File
AMP-Activated Protein Kinases
Adenosine Monophosphate
Phosphotransferases
Adenosine Triphosphate
Phosphorylation
11 Citations (Scopus)
120 Downloads (Pure)

Chemical genetics approaches for selective intervention in epigenetics

Runcie, A. C., Chan, K. H., Zengerle, M. & Ciulli, A., Aug 2016, In : Current Opinion in Chemical Biology. 33, p. 186-194 9 p.

Research output: Contribution to journalReview article

Open Access
File
Epigenomics
Genetics
Genes
Modulation
Molecules
4 Citations (Scopus)
96 Downloads (Pure)

Chemical Ubiquitination for Decrypting a Cellular Code

Stanley, M. & Virdee, S., 11 May 2016, In : Biochemical Journal. 473, 10, p. 1297-1314 18 p.

Research output: Contribution to journalReview article

Open Access
File
Polyubiquitin
Ubiquitination
Ubiquitin
Substrates
Proteins
43 Citations (Scopus)
131 Downloads (Pure)

Drug Resistance in Eukaryotic Microorganisms

Fairlamb, A. H., Gow, N. A. R., Matthews, K. R. & P. Waters, A., Jul 2016, In : Nature Microbiology. 1, p. 1-14 14 p., 16092.

Research output: Contribution to journalReview article

Open Access
File
Drug Resistance
Drug Therapy
Therapeutics
Microbial Drug Resistance
Technology
20 Citations (Scopus)
85 Downloads (Pure)

Epigenetic Regulation of Virulence Gene Expression in Parasitic Protozoa

Duraisingh, M. T. & Horn, D., 11 May 2016, In : Cell Host & Microbe. 19, 5, p. 629-640 12 p.

Research output: Contribution to journalReview article

Open Access
File
Gene Expression Regulation
Epigenomics
Virulence
Parasites
Genetic Epigenesis
25 Citations (Scopus)
135 Downloads (Pure)

Filaggrin failure - from ichthyosis vulgaris to atopic eczema and beyond

McLean, W., 26 Sep 2016, In : British Journal of Dermatology. 175, 52, p. 4-7 4 p.

Research output: Contribution to journalReview article

Open Access
File
Ichthyosis Vulgaris
Atopic Dermatitis
Cornea
Polyproteins
Mutation
19 Citations (Scopus)
126 Downloads (Pure)

From Companion Diagnostics to Theranostics: A New Avenue for Alzheimer's Disease?

Bolognesi, M. L., Gandini, A., Prati, F. & Uliassi, E., 8 Sep 2016, In : Journal of Medicinal Chemistry. 59, 17, p. 7759-7770 12 p.

Research output: Contribution to journalReview article

Open Access
File
Alzheimer Disease
Industry
Research Personnel
Theranostic Nanomedicine
Therapeutics
20 Citations (Scopus)

Intraoperative Ultrasound-Guided Resection of Gliomas: A Meta-Analysis and Review of the Literature

Mahboob, S., McPhillips, R., Qiu, Z., Jiang, Y., Meggs, C., Schiavone, G., Button, T., Desmulliez, M., Demore, C., Cochran, S. & Eljamel, S., Aug 2016, In : World Neurosurgery. 92, p. 255-263 9 p.

Research output: Contribution to journalReview article

Glioma
Meta-Analysis
Computer-Assisted Surgery
Costs and Cost Analysis
Neurosurgery
16 Citations (Scopus)
99 Downloads (Pure)

Is REDD1 a Metabolic Éminence Grise?

Lipina, C. & Hundal, H., Dec 2016, In : Trends in Endocrinology and Metabolism. 27, 12, p. 868-880 13 p.

Research output: Contribution to journalReview article

Open Access
File
Aptitude
Islets of Langerhans
Energy Metabolism
DNA Damage
Cues
15 Citations (Scopus)
284 Downloads (Pure)

Lectin receptors expressed on myeloid cells

Brown, G. D. & Crocker, P. R., 23 Sep 2016, In : Microbiology Spectrum. 4, 5, p. 1-26 26 p.

Research output: Contribution to journalReview article

Open Access
File
Mitogen Receptors
Sialic Acid Binding Immunoglobulin-like Lectins
Myeloid Cells
Lectins
health and disease
4 Citations (Scopus)
97 Downloads (Pure)

Leveraging unique structural characteristics of WNK kinases to achieve therapeutic inhibition

Zhang, J., Deng, X. & Kahle, K. T., 18 Oct 2016, In : Science Signaling. 9, 450, p. 1-3 4 p., pe3.

Research output: Contribution to journalReview article

Open Access
File
Phosphotransferases
Member 1 Solute Carrier Family 12
Sodium-Potassium-Chloride Symporters
Therapeutics
Lysine
36 Citations (Scopus)
107 Downloads (Pure)

Mathematical models for immunology: current state of the art and future research directions

Eftimie, R., Gillard, J. J. & Cantrell, D. A., Oct 2016, In : Bulletin of Mathematical Biology. 78, 10, p. 2091-2134 44 p.

Research output: Contribution to journalReview article

Open Access
File
Immunology
Allergy and Immunology
immunology
Theoretical Models
mathematical models
12 Citations (Scopus)
98 Downloads (Pure)

Mechanism and disease-association of E2 conjugating enzymes: lessons from UBE2T and UBE2L3

Alpi, A. F., Chaugule, V. & Walden, H., 11 Oct 2016, In : Biochemical Journal. 473, 20, p. 3401-3419 19 p.

Research output: Contribution to journalReview article

Open Access
File
Ubiquitin
Enzymes
Ubiquitin-Activating Enzymes
DNA Repair-Deficiency Disorders
Ubiquitin-Protein Ligases
9 Citations (Scopus)

Progress and perspectives in signal transduction, actin dynamics, and movement at the cell and tissue level: lessons from Dictyostelium

Bretschneider, T., Othmer, H. G. & Weijer, C. J., 6 Oct 2016, In : Interface Focus. 6, 5, 16 p.

Research output: Contribution to journalReview article

Signal transduction
Dictyostelium
Machinery
Cell Movement
Actins
58 Citations (Scopus)
1612 Downloads (Pure)

Regulation of AMP-activated protein kinase by natural and synthetic activators

Grahame Hardie, D., Jan 2016, In : Acta Pharmaceutica Sinica B. 6, 1, p. 1-19 19 p.

Research output: Contribution to journalReview article

Open Access
File
AMP-Activated Protein Kinases
Adenosine Triphosphate
Herbivory
Herbal Medicine
Traditional Medicine
12 Citations (Scopus)
81 Downloads (Pure)

The ELF Honest Data Broker: Informatics enabling public-private collaboration in a precompetitive arena

Paillard, G., Cochrane, P., Jones, P. S., Van Hoorn, W. P., Caracoti, A., Van Vlijmen, H. & Pannifer, A. D., 1 Jan 2016, In : Drug Discovery Today. 21, 1, p. 97-102 6 p.

Research output: Contribution to journalReview article

Open Access
File
Informatics
Workflow
Triage
Intellectual Property
Drug Industry
24 Citations (Scopus)
55 Downloads (Pure)

The Kink Turn, a Key Architectural Element in RNA Structure

Huang, L. & Lilley, D. M. J., 27 Feb 2016, In : Journal of Molecular Biology. 428, 5, p. 790-801 12 p.

Research output: Contribution to journalReview article

Open Access
File
Hydrogen
RNA
Adenine
Nucleotides
Metals
42 Citations (Scopus)

The physiology of growth arrest: Uniting molecular and environmental microbiology

Bergkessel, M., Basta, D. W. & Newman, D. K., Sep 2016, In : Nature Reviews Microbiology. 14, 9, p. 549-562 14 p.

Research output: Contribution to journalReview article

Environmental Microbiology
Bacterial Physiological Phenomena
Growth
Electrons
Bacteria
2015
229 Citations (Scopus)

AMPK: positive and negative regulation, and its role in whole-body energy homeostasis

Hardie, D. G., Apr 2015, In : Current Opinion in Cell Biology. 33, April, p. 1-7 7 p.

Research output: Contribution to journalReview article

AMP-Activated Protein Kinases
Homeostasis
Phosphorylation
Physiological Stress
Lysosomes

Bill Whelan's impact on my life and career

Cohen, P., Dec 2015, In : Molecular Aspects of Medicine. 46, p. 11-13 3 p.

Research output: Contribution to journalReview article

Glycogen Synthase
Transferases
Tyrosine
Demonstrations
glycogenin
19 Citations (Scopus)
67 Downloads (Pure)

Parasite Glycobiology: A Bittersweet Symphony

Rodrigues, J. A., Acosta-Serrano, A., Aebi, M., Ferguson, M. A. J., Routier, F. H., Schiller, I., Soares, S., Spencer, D., Titz, A., Wilson, I. B. H. & Izquierdo, L., 12 Nov 2015, In : PLoS Pathogens. 11, 11, e1005169.

Research output: Contribution to journalReview article

Open Access
File
2014
127 Citations (Scopus)
83 Downloads (Pure)

AMP-activated protein kinase: a key regulator of energy balance with many roles in human disease

Hardie, D. G., Dec 2014, In : Journal of Internal Medicine. 276, 6, p. 543-559 17 p.

Research output: Contribution to journalReview article

Open Access
File
AMP-Activated Protein Kinases
Salicylates
Metformin
Virus Diseases
Aspirin
92 Citations (Scopus)

AMP-Activated Protein Kinase: Maintaining Energy Homeostasis at the Cellular and Whole-Body Levels

Hardie, D. G., Jul 2014, In : Annual Review of Nutrition. 34, p. 31-55 25 p.

Research output: Contribution to journalReview article

AMP-Activated Protein Kinases
Adenosine Monophosphate
Protein Kinases
Homeostasis
Adenosine Triphosphate
59 Citations (Scopus)
88 Downloads (Pure)

AMPK: a cellular energy sensor primarily regulated by AMP

Gowans, G. J. & Hardie, D. G., 1 Feb 2014, In : Biochemical Society Transactions. 42, 1, p. 71-75 5 p.

Research output: Contribution to journalReview article

Open Access
File
AMP-Activated Protein Kinases
Adenosine Monophosphate
Adenosine Triphosphate
Adenosine Diphosphate
Sensors
23 Citations (Scopus)

A perspective on proteomics in cell biology

Ahmad, Y. & Lamond, A. I., Apr 2014, In : Trends in Cell Biology. 24, 4, p. 257-264 8 p.

Research output: Contribution to journalReview article

Open Access
Proteomics
Cell Biology
Mass Spectrometry
Proteins
Technology
65 Citations (Scopus)

Cap-binding complex (CBC)

Gonatopoulos-Pournatzis, T. & Cowling, V. H., 15 Jan 2014, In : Biochemical Journal. 457, 2, p. 231-242 12 p.

Research output: Contribution to journalReview article

Gene expression
Gene Expression
Transcription
Messenger RNA
Processing
20 Citations (Scopus)

Immune diseases caused by mutations in kinases and components of the ubiquitin system

Cohen, P., Jun 2014, In : Nature Immunology. 15, 6, p. 521-529 9 p.

Research output: Contribution to journalReview article

Immune System Diseases
Ubiquitin
Phosphotransferases
Mutation
Ubiquitination
54 Citations (Scopus)
111 Downloads (Pure)

Molecular effects of resistance elicitors from biological origin and their potential for crop protection

Wiesel, L., Newton, A. C., Elliott, I., Booty, D., Gilroy, E. M., Birch, P. R. J. & Hein, I., 21 Nov 2014, In : Frontiers in Plant Science. 5, 655, 13 p., 655.

Research output: Contribution to journalReview article

Open Access
File
plant protection
microorganisms
pathogens
plant response
virulence
93 Citations (Scopus)

Oxalate production by fungi: Significance in geomycology, biodeterioration and bioremediation

Gadd, G. M., Bahri-Esfahani, J., Li, Q., Rhee, Y. J., Wei, Z., Fomina, M. & Liang, X., 2014, In : Fungal Biology Reviews. 28, 2-3, p. 36-55 20 p.

Research output: Contribution to journalReview article

Environmental Biodegradation
Oxalates
bioremediation
oxalates
Fungi
51 Citations (Scopus)

Polybacterial human disease: the ills of social networking

Short, F. L., Murdoch, S. L. & Ryan, R. P., Sep 2014, In : Trends in Microbiology. 22, 9, p. 508-516 9 p.

Research output: Contribution to journalReview article

Social Networking
Infection
Biological Phenomena
Virulence
Disease Progression
14 Citations (Scopus)
172 Downloads (Pure)

Stem cell decisions: A twist of fate or a niche market?

Januschke, J. & Nathke, I., Oct 2014, In : Seminars in Cell & Developmental Biology. 34, p. 116-123 8 p.

Research output: Contribution to journalReview article

Open Access
File
Stem Cells
Cell Division
Cues
Centrosome
Maintenance
21 Citations (Scopus)

Structure and function of the hydrophilic Photosystem II assembly proteins: Psb27, Psb28 and Ycf48

Mabbitt, P. D., Wilbanks, S. M. & Eaton-Rye, J. J., Aug 2014, In : Plant Physiology and Biochemistry. 81, p. 96-107 12 p.

Research output: Contribution to journalReview article

Photosystem II Protein Complex
photosystem II
Proteins
proteins
Plastoquinone
23 Citations (Scopus)

The use of tobacco mosaic virus and cowpea mosaic virus for the production of novel metal nanomaterials

Love, A. J., Makarov, V., Yaminsky, I., Kalinina, N. O. & Taliansky, M. E., 20 Jan 2014, In : Virology. 449, p. 133-139 7 p.

Research output: Contribution to journalReview article

Comovirus
Tobacco Mosaic Virus
Nanostructures
Capsid
Metals
2013
42 Citations (Scopus)

AMPK: mediating the metabolic effects of salicylate-based drugs?

Steinberg, G. R., Dandapani, M. & Hardie, D. G., Oct 2013, In : Trends in Endocrinology and Metabolism. 24, 10, p. 481-487 7 p.

Research output: Contribution to journalReview article

AMP-Activated Protein Kinases
Salicylates
Pharmaceutical Preparations
Aspirin
Prostaglandin-Endoperoxide Synthases
67 Citations (Scopus)

Contributions of roots and rootstocks to sustainable, intensified crop production

Gregory, P. J., Atkinson, C. J., Bengough, A. G., Else, M. A., Fernandez-Fernandez, F., Harrison, R. J. & Schmidt, S., Mar 2013, In : Journal of Experimental Botany. 64, 5, p. 1209-1222 14 p.

Research output: Contribution to journalReview article

19 Citations (Scopus)

Cyclic di-nucleotide signaling enters the eukaryote domain

Schaap, P., Nov 2013, In : IUBMB Life. 65, 11, p. 897-903 7 p.

Research output: Contribution to journalReview article

Cyclic Nucleotides
Eukaryota
Nucleotides
Amoeba
Bacteria
120 Citations (Scopus)

Drug resistance in African trypanosomiasis: the melarsoprol and pentamidine story

Baker, N., de Koning, H. P., Maeser, P. & Horn, D., Mar 2013, In : Trends in Parasitology. 29, 3, p. 110-118 9 p.

Research output: Contribution to journalReview article

25 Citations (Scopus)

Functions and mechanisms of fibroblast growth factor (FGF) signalling in Drosophila melanogaster

Muha, V. & Muller, H-A. J., Mar 2013, In : International Journal of Molecular Sciences. 14, 3, p. 5920-5937 18 p.

Research output: Contribution to journalReview article

9 Citations (Scopus)

Geomycology: Fungi as agents of biogeochemical change

Gadd, G. M., 3 Nov 2013, In : Biology and Environment. 113 B, 2, p. 139-153 5 p.

Research output: Contribution to journalReview article

Minerals
Fungi
Metals
metals
fungus
25 Citations (Scopus)

Interactions of photosynthesis with genome size and function

Raven, J. A., Beardall, J., Larkum, A. W. D. & Sanchez-Baracaldo, P., 2013, In : Philosophical Transactions of the Royal Society B - Biological Sciences. 368, 1622, 11 p., 20120264.

Research output: Contribution to journalReview article

28 Citations (Scopus)

Proteomic analysis of clathrin interactions in trypanosomes reveals dynamic evolution of endocytosis

Adung'a, V. O., Gadelha, C. & Field, M. C., Apr 2013, In : Traffic. 14, 4, p. 440-457 18 p.

Research output: Contribution to journalReview article

21 Citations (Scopus)

Receptor-mediated endocytosis for drug delivery in African trypanosomes: Fulfilling Paul Ehrlich's vision of chemotherapy

Alsford, S., Field, M. C. & Horn, D., May 2013, In : Trends in Parasitology. 29, 5, p. 207-212 6 p.

Research output: Contribution to journalReview article

Trypanosomiasis
Membrane Glycoproteins
Endocytosis
Suramin
Drug Therapy
718 Citations (Scopus)

Structure and functions of the bacterial microbiota of plants

Bulgarelli, D., Schlaeppi, K., Spaepen, S., Van Themaat, E. V. L. & Schulze-Lefert, P., 1 Apr 2013, In : Annual Review of Plant Biology. 64, p. 807-838 32 p.

Research output: Contribution to journalReview article

Bacterial Structures
Microbiota
plant growth
rhizodeposition
Bacterial Physiological Phenomena
14 Citations (Scopus)

The mixotrophic nature of photosynthetic plants

Schmidt, S., Raven, J. A. & Paungfoo-Lonhienne, C., 2013, In : Functional Plant Biology. 40, 5, p. 425-438 14 p.

Research output: Contribution to journalReview article

9 Citations (Scopus)

Three wise centromere functions: see no error, hear no break, speak no delay

Tanaka, T. U., Clayton, L. & Natsume, T., Dec 2013, In : EMBO Reports. 14, 12, p. 1073-1083 11 p.

Research output: Contribution to journalReview article

Centromere
Kinetochores
Microtubules
Chromosomes
Chromosome Segregation
2012
226 Citations (Scopus)
90 Downloads (Pure)

AMP-Activated Protein Kinase: A Target for Drugs both Ancient and Modern

Hardie, D. G., Ross, F. A. & Hawley, S. A., 26 Oct 2012, In : Chemistry & Biology. 19, 10, p. 1222-36 15 p.

Research output: Contribution to journalReview article

Open Access
File
AMP-Activated Protein Kinases
Cyclic AMP-Dependent Protein Kinases
Metformin
Adenosine Triphosphate
Medical problems
1771 Citations (Scopus)
119 Downloads (Pure)

AMPK: a nutrient and energy sensor that maintains energy homeostasis

Hardie, D. G., Ross, F. A. & Hawley, S. A., 1 Apr 2012, In : Nature Reviews Molecular Cell Biology. 13, 4, p. 251-262 12 p.

Research output: Contribution to journalReview article

Open Access
File
AMP-Activated Protein Kinases
Homeostasis
Adenosine Triphosphate
Food
Biosynthetic Pathways