School of Medicine

  • United Kingdom

Research Output 1972 2020

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Article
2020

Abnormal Reward Valuation and Event-Related Connectivity in Unmedicated Major Depressive Disorder

Rupprechter, S., Stankevicius, A., Huys, Q. J. M., Seriès, P. & Steele, D., 7 Jan 2020, In : Psychological Medicine.

Research output: Contribution to journalArticle

Major Depressive Disorder
Reward
Gyrus Cinguli
Depression
Decision Making

Addressing the Challenge of Polypharmacy

Mair, A., Wilson, M. & Dreischulte, T., Jan 2020, In : Annual Review of Pharmacology and Toxicology. 60

Research output: Contribution to journalArticle

Drug interactions
Drug therapy
Polypharmacy
Medicine
Aging of materials
3 Downloads (Pure)

A Mendelian randomization study provides evidence that adiposity and dyslipidemia lead to lower urinary albumin creatinine ratio, a marker of microvascular function

Casanova, F., Wood, A. R., Yaghootkar, H., Beaumont, R. N., Jones, S. E., Gooding, K. M., Aizawa, K., Strain, W. D., Hattersley, A. T., Khan, F., Shore, A. C., Frayling, T. M. & Tyrrell, J., 8 Jan 2020, In : Diabetes.

Research output: Contribution to journalArticle

Open Access
File
Adiposity
Dyslipidemias
Random Allocation
Albumins
Creatinine

An initial evaluation of the effect of a novel regional block needle with tip-tracking technology on the novice performance of cadaveric ultrasound-guided sciatic nerve block

McLeod, G. A., McKendrick, M., Taylor, A., Sadler, A., Halcrow, J., Mustafa, A., Seeley, J., Raju, P. & McKendrick, G., 1 Jan 2020, In : Anaesthesia. 75, 1, p. 80-88 10 p.

Research output: Contribution to journalArticle

Nerve Block
Sciatic Nerve
Needles
Technology
Cadaver

Anti-inflammatory reliever therapy for asthma

Lipworth, B., Chan, R. & RuiWen Kuo, C., Jan 2020, In : Annals of Allergy, Asthma & Immunology. 124, 1, p. 13-15 3 p.

Research output: Contribution to journalArticle

2 Downloads (Pure)
Open Access
File
Type 1 Diabetes Mellitus
Hypoglycemia
Epinephrine
Research Personnel
Neurobehavioral Manifestations

A rare case of non-clostridial infection in a non-diabetic patient

Darat, H. N., Kanodia, A. K., Yong, A. & Ram, B., 8 Jan 2020, In : BMJ Case Reports. 13, 1, e233467.

Research output: Contribution to journalArticle

Neck
Infection
Abscess
Suppuration
Fever

Balloon Eustachian tuboplasty for Eustachian tube dysfunction: report of long-term outcomes in a UK population

McMurran, A. E. L., Hogg, G. E., Gordon, S., Spielmann, P. M. & Jones, S. E., 8 Jan 2020, In : Journal of Laryngology and Otology. p. 1-7 7 p.

Research output: Contribution to journalArticle

Eustachian Tube
Population
Acoustic Impedance Tests
Conductive Hearing Loss
Otitis Media with Effusion
35 Downloads (Pure)

Cannabidiol induces antioxidant pathways in keratinocytes by targeting BACH1

Casares Perez, L., García, V., Garrido-Rodríguez, M., Millán, E., Collado, J. A., García-Martín, A., Peñarando, J., Calzado, M. A., de la Vega, L. & Muñoz, E., Jan 2020, In : Redox Biology. 28, p. 1-15 15 p., 101321.

Research output: Contribution to journalArticle

Open Access
File
Cannabidiol
Keratinocytes
Antioxidants
Heme Oxygenase-1
Skin
5 Downloads (Pure)

Effects of once-weekly semaglutide vs once-daily canagliflozin on body composition in type 2 diabetes: a substudy of the SUSTAIN 8 randomised, controlled clinical trial

McCrimmon, R., Catarig, A-M., Frias, J. P., Lausvig, N. L., le Roux, C. W., Thielke, D. & Lingvay, I., 2 Jan 2020, In : Diabetologia. 13 p.

Research output: Contribution to journalArticle

Open Access
File
Body Composition
Type 2 Diabetes Mellitus
Randomized Controlled Trials
Fats
Therapeutics

Exploration of temporal bone anatomy using mixed reality (HoloLens): development of a mixed reality anatomy teaching resource prototype

Maniam, P., Schnell, P., Dan, L., Portelli, R., Erolin, C., Mountain, R. & Wilkinson, T., 2020, In : Journal of Visual Communication in Medicine. 43, 1, p. 17-26 10 p.

Research output: Contribution to journalArticle

Temporal Bone
Anatomy
Teaching
Technology
Anatomic Models

Functional herniated choroid plexus in brain parenchyma following VP shunt removal

El Sheikh, M., Fadelalla, M., Kanodia, A. K., Kouli, O., Peebles, M. & Hossain-Ibrahim, K., 8 Jan 2020, In : British Journal of Neurosurgery. p. 1-4 4 p.

Research output: Contribution to journalArticle

Ventriculoperitoneal Shunt
Choroid Plexus
Ependyma
Parietal Lobe
Astrocytoma

Genetic Risk and Atrial Fibrillation in Patients with Heart Failure

Kloosterman, M., Santema, B. T., Roselli, C., Nelson, C. P., Koekemoer, A., Romaine, S. P. R., Van Gelder, I. C., Lam, C. S. P., Artola, V. A., Lang, C., Ng, L. L., Metra, M., Anker, S. D., Filippatos, G. S., Dickstein, K., Ponikowski, P., van der Harst, P., Meer, P. V. D., Van Veldhuisen, D. J., Benjamin, E. J. & 3 others, Voors, A. A., Samani, N. J. & Rienstra, M., 9 Jan 2020, In : European Journal of Heart Failure. 21, 12

Research output: Contribution to journalArticle

Open Access
Atrial Fibrillation
Heart Failure
Single Nucleotide Polymorphism
Atrial Flutter
Genome-Wide Association Study
2 Downloads (Pure)

Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure

Doney, A., Mordi, I., Palmer, C. N., Parry, H., Veluchamy, A. & Lang, C. C., 9 Jan 2020, In : Nature Communications. 11, 1, p. 1-12 12 p., 163.

Research output: Contribution to journalArticle

Open Access
File
Mendelian Randomization Analysis
pathogenesis
genome
Heart Failure
Genes

Impact of EMA regulatory label changes on systemic diclofenac initiation, discontinuation, and switching to other pain medicines in Scotland, England, Denmark, and The Netherlands

Morales, D. R., Morant, S. V., MacDonald, T. M., Mackenzie, I. S., Doney, A. S. F., Mitchell, L., Bennie, M., Robertson, C., Hallas, J., Pottegard, A., Ernst, M. T., Wei, L., Nicholson, L., Morris, C., M C, R., Overbeek, J. A., Smits, E. & W V, R., 3 Jan 2020, In : Pharmacoepidemiology and Drug Safety. 10 p.

Research output: Contribution to journalArticle

Diclofenac
Scotland
Denmark
England
Netherlands

Joint optimization based on direct sparse stereo visual-inertial odometry

Wen, S., Zhao, Y., Zhang, H., Lam, H. K. & Manfredi, L., 10 Jan 2020, In : Autonomous Robots. 19 p.

Research output: Contribution to journalArticle

Units of measurement
Cameras
Gravitation
Fusion reactions
Pixels

Neuromyelitis optica spectrum disorder and active tuberculosis

Grieve, J. K., Day, S., Connell, D. & O'Riordan, J., 2 Jan 2020, In : BMJ Case Reports. 13, 1, e231524.

Research output: Contribution to journalArticle

Neuromyelitis Optica
Tuberculosis
Infection
Light

Prospective international multicenter pectopexy trial: Interim results and findings post surgery

Noé, G. K., Schiermeier, S., Papathemelis, T., Fuellers, U., Khudyakov, A., Altmann, H. H., Borowski, S., Morawski, P. P., Gantert, M., De Vree, B., Zbigniew, T., Ugarteburu, R. G. & Anapolski, M., Jan 2020, In : European Journal of Obstetrics and Gynecology and Reproductive Biology. 244, p. 81-86 6 p.

Research output: Contribution to journalArticle

Multicenter Studies
Defecation
Intestinal Obstruction
Infection
Hysterectomy

Teaching, reflecting, and learning: The value of an intercalated medical education programme

Muir, F., Bruce, J. & McConville, K., 14 Jan 2020, In : Medical Teacher. 6 p.

Research output: Contribution to journalArticle

Teaching
learning
Values
education
confidence

The Metastatic Early Prognostic (MEP) score

Downie, S., Lai, F. Y., Joss, J., Adamson, D. & Jariwala, A. C., 1 Jan 2020, In : The bone & joint journal. 102-B, 1, p. 72-81 10 p.

Research output: Contribution to journalArticle

Mortality
Hip Fractures
Neoplasm Metastasis
Thigh
Trauma Centers

The year in cardiology: aorta and peripheral circulation

Heiss, C., Pitcher, A., Belch, J. J. F., De Carlo, M., Reinecke, H., Baumgartner, I., Mazzolai, L. & Aboyans, V., 6 Jan 2020, In : European Heart Journal.

Research output: Contribution to journalArticle

Translating clinical trials into improved real-world management of pain: Convergence of translational, population-based and primary care research

Gilron, I., Blyth, F. M. & Smith, B., Jan 2020, In : Pain. 161, 1, p. 36-42 7 p.

Research output: Contribution to journalArticle

Ultrasound Capsule Endoscopy With a Mechanically Scanning Micro-ultrasound: A Porcine Study

Qiu, Y., Huang, Y., Zhang, Z., Cox, B. F., Liu, R., Hong, J., Mu, P., Lay, H. S., Cummins, G., Desmulliez, M. P. Y., Clutton, E., Zheng, H., Qiu, W. & Cochran, S., 3 Jan 2020, In : Ultrasound in Medicine and Biology.

Research output: Contribution to journalArticle

Capsule Endoscopy
capsules
Swine
Equipment and Supplies
scanning
2019
87 Downloads (Pure)

3D-printing based Transducer Holder for Robotic Assisted Ultrasound Guided HIFU

Wang, J., Xiao, X., Huang, Z. & Melzer, A., Jul 2019, In : Procedia Manufacturing. 30, p. 3-10 8 p.

Research output: Contribution to journalArticle

Open Access
File
Robotic arms
Printing
Transducers
Robotics
Ultrasonics
2 Citations (Scopus)
29 Downloads (Pure)

4 DOFs hollow soft pneumatic actuator – HOSE

Manfredi, L., Putzu, F., Guler, S., Huan, Y. & Cuschieri, A., 28 Jan 2019, In : Materials Research Express. 6, 4, 045703.

Research output: Contribution to journalArticle

Open Access
File
Pneumatic actuators
Actuators
Degrees of freedom (mechanics)
Rubber
Torque

4th ESPT Conference: pharmacogenomics and personalized medicine - research progress and clinical implementation

Sipeky, C., Llerena, A., Manolopoulos, V. G., Pearson, E., Mlakar, V., Gozzo, L., Simmaco, M., Marchetti, P., Re, M. D., Stankovic, S., Meyer, U., Cascorbi, I., Ingelman-Sundberg, M., Suarez-Kurtz, G., Marc, J., Katsila, T., Paulmichl, M., Nofziger, C., Ansari, M., Drago, F. & 1 others, van Schaik, R. H., Oct 2019, In : Pharmacogenomics. 20, 15, p. 1063-1069 7 p.

Research output: Contribution to journalArticle

Precision Medicine
Pharmacogenetics
Research
Sicily
Italy
4 Downloads (Pure)

A 2 × 2 factorial, randomised, open-label trial to determine the clinical and cost-effectiveness of hypertonic saline (HTS 6%) and carbocisteine for airway clearance versus usual care over 52 weeks in adults with bronchiectasis: a protocol for the CLEAR clinical trial

Bradley, J. M., Anand, R., O'Neill, B., Ferguson, K., Clarke, M., Carroll, M., Chalmers, J., De Soyza, A., Duckers, J., Hill, A. T., Loebinger, M. R., Copeland, F., Gardner, E., Campbell, C., Agus, A., McGuire, A., Boyle, R., McKinney, F., Dickson, N., McAuley, D. F. & 1 others, Elborn, S., 19 Dec 2019, In : Trials. 20, 1, p. 1-10 10 p., 747.

Research output: Contribution to journalArticle

Open Access
File
Bronchiectasis
Cost-Benefit Analysis
Clinical Trials
Standard of Care
Sputum
14 Downloads (Pure)

A 30-Year Clinical and Magnetic Resonance Imaging Observational Study of Multiple Sclerosis and Clinically Isolated Syndromes

Chung, K. K., Altmann, D., Barkhof, F., Miszkiel, K., Brex, P. A., O'Riordan, J., Ebner, M., Prados, F., Cardoso, M. J., Vercauteren, T., Ourselin, S., Thompson, A., Ciccarelli, O. & Chard, D. T., 25 Nov 2019, In : Annals of Neurology. 11 p.

Research output: Contribution to journalArticle

Open Access
File
Multiple Sclerosis
Observational Studies
Magnetic Resonance Imaging
Chronic Progressive Multiple Sclerosis
Relapsing-Remitting Multiple Sclerosis
2 Citations (Scopus)
67 Downloads (Pure)

A balanced approach to identifying, prioritising and evaluating all potential consequences of quality improvement: modified Delphi study

Toma, M., Dreischulte, T., Gray, N. M. . & Guthrie, B., 23 Mar 2019, In : BMJ Open. 9, 3, p. 1-11 11 p., e023890.

Research output: Contribution to journalArticle

Open Access
File
Delphi Technique
Quality Improvement
Workload
Delivery of Health Care
26 Downloads (Pure)

Ability of verbal autopsy data to detect deaths due to uncontrolled hyperglycaemia: testing existing methods and development and validation of a novel weighted score

Blackstock, S., Witham, M. D., Wade, A. N., Crampin, A., Beran, D., Ogle, G. D. & Davies, J. I., 18 Oct 2019, In : BMJ Open. 9, 10, p. 1-8 8 p., e026331.

Research output: Contribution to journalArticle

Open Access
File
Hyperglycemia
Autopsy
Physicians
Malawi
South Africa
Ankle Fractures
Ankle Joint
Ligaments
Cadaver
Ankle

A case of aneurysmal subarchnoid haemorrhage and superficial siderosis complicated by prospagnosia, simultagnosia and alexia without agraphia

Fadelalla, M., Kanodia, A., Elsheikh, M., Ellis, J., Smith, V. & Hossain-Ibrahim, K., 2 Dec 2019, In : British Journal of Neurosurgery. p. 1-4 4 p.

Research output: Contribution to journalArticle

Pure Alexia
Prosopagnosia
Siderosis
Dyslexia
Subarachnoid Hemorrhage

A case of dissection in an ACUSEAL-modified HeRO graft

Bradley, N. A., Guthrie, G. & Suttie, S., 16 Dec 2019, In : Journal of Vascular Access. 4 p.

Research output: Contribution to journalArticle

Dissection
Transplants
Catheterization
False Aneurysm
Hematoma
7 Citations (Scopus)
27 Downloads (Pure)

A catalog of genetic loci associated with kidney function from analyses of a million individuals

LifeLines Cohort Study, Wuttke, M., Li, Y., Li, M., Sieber, K. B., Feitosa, M. F., Gorski, M., Tin, A., Wang, L., Chu, A. Y., Hoppmann, A., Kirsten, H., Giri, A., Chai, J-F., Sveinbjornsson, G., Tayo, B. O., Nutile, T., Fuchsberger, C., Marten, J., Cocca, M. & 33 others, Ghasemi, S., Xu, Y., Horn, K., Noce, D., van der Most, P. J., Sedaghat, S., Yu, Z., Akiyama, M., Afaq, S., Ahluwalia, T. S., Almgren, P., Amin, N., Ärnlöv, J., Bakker, S. J. L., Bansal, N., Baptista, D., Bergmann, S., Biggs, M. L., Biino, G., Boehnke, M., Boerwinkle, E., Boissel, M., Bottinger, E. P., Boutin, T. S., Brenner, H., Brumat, M., Burkhardt, R., Butterworth, A. S., Campana, E., Campbell, A., Smith, B. H., Köttgen, A. & Pattaro, C., Jun 2019, In : Nature Genetics. 51, 6, p. 957-972 16 p.

Research output: Contribution to journalArticle

Open Access
File
Genetic Loci
Kidney
Glomerular Filtration Rate
Chronic Renal Insufficiency
Translational Medical Research

Accidental bite injury

Mackie, L. & Laverick, S., 9 Aug 2019, In : British Dental Journal. 227, 3, p. 177 1 p.

Research output: Contribution to journalArticle

Accuracy and repeatability of a semi-quantitative barefoot pressure measurement method for clinical use: The Derks Calculation Method

Maetzler, M., Bochdansky, T. & Abboud, R. J., Jun 2019, In : Foot. 39, p. 136-139 4 p.

Research output: Contribution to journalArticle

Heel
Pressure
Confidence Intervals
Foot
Gait
8 Citations (Scopus)
56 Downloads (Pure)

Accuracy of High-Speed Video Analysis to Diagnose Primary Ciliary Dyskinesia

Rubbo, B., Shoemark, A., Jackson, C. L., Hirst, R., Thompson, J., Hayes, J., Frost, E., Copeland, F., Hogg, C., O'Callaghan, C., Reading, I. & Lucas, J. S., 1 May 2019, In : Chest. 155, 5, p. 1008-1017 10 p.

Research output: Contribution to journalArticle

Open Access
File
Kartagener Syndrome
Video Microscopy
Routine Diagnostic Tests
Guidelines
Referral and Consultation
52 Downloads (Pure)

Achieving Self-Directed Integrated Cancer Aftercare (ASICA) in melanoma: protocol for a randomised patient-focused pilot trial of delivering the ASICA intervention as a means to earlier detection of recurrent and second primary melanoma

Murchie, P., Masthoff, J., Walter, F. M., Rahman, K., Allan, J. L., Burrows, N., Proby, C., Lee, A. J., Johnston, M., Durrani, A., Depasquale, I., Brant, B., Neilson, A., Meredith, F., Treweek, S., Hall, S. & McDonald, A., 3 Jun 2019, In : Trials. 20, 1, p. 1-11 11 p., 318.

Research output: Contribution to journalArticle

Open Access
File
Aftercare
Melanoma
Self-Examination
Neoplasms
Skin
2 Citations (Scopus)
76 Downloads (Pure)

A cognitive forcing tool to mitigate cognitive bias: A randomised control trial

O'Sullivan, E. D. & Schofield, S. J., 8 Jan 2019, In : BMC Medical Education. 19, 1, p. 1-8 8 p., 12.

Research output: Contribution to journalArticle

Open Access
File
trend
diagnostic
Ireland
medical student
republic
Long-Term Potentiation
Estrogen Receptors
Synapses
Synaptic Transmission
AMPA Receptors
3 Citations (Scopus)
73 Downloads (Pure)

Acute effects of electronic and tobacco cigarettes on vascular and respiratory function in healthy volunteers: a cross-over study

Kerr, D. M. I., Brooksbank, K. J. M., Taylor, R. G., Pinel, K., Rios, F. J., Touyz, R. M. & Delles, C., Jan 2019, In : Journal of Hypertension. 37, 1, p. 154-166 13 p.

Research output: Contribution to journalArticle

Open Access
File
Cross-Over Studies
Tobacco
Blood Vessels
Healthy Volunteers
Smoking
69 Downloads (Pure)

Adaptation and Implementation of a Mobile Phone-Based Remote Symptom Monitoring System for People With Cancer in Europe

Furlong, E., Darley, A., Fox, P., Buick, A., Kotronoulas, G., Miller, M., Flowerday, A., Miaskowski, C., Patiraki, E., Katsaragakis, S., Ream, E., Armes, J., Gaiger, A., Berg, G., McCrone, P., Donnan, P., McCann, L. & Maguire, R., 14 Mar 2019, In : JMIR Cancer. 5, 1, p. 1-14 14 p., e10813.

Research output: Contribution to journalArticle

Open Access
File
Cell Phones
Communication
Technology
Neoplasms
Randomized Controlled Trials
9 Downloads (Pure)

A Deep Learning Framework for Predicting Response to Therapy in Cancer

Sakellaropoulos, T., Vougas, K., Narang, S., Koinis, F., Kotsinas, A., Polyzos, A., Moss, T. J., Piha-Paul, S., Zhou, H., Kardala, E., Damianidou, E., Alexopoulos, L. G., Aifantis, I., Townsend, P. A., Panayiotidis, M. I., Sfikakis, P., Bartek, J., Fitzgerald, R. C., Thanos, D., Mills Shaw, K. R. & 3 others, Petty, R., Tsirigos, A. & Gorgoulis, V. G., 10 Dec 2019, In : Cell Reports. 29, 11, p. 3367-3373.e4 12 p.

Research output: Contribution to journalArticle

Open Access
File
Learning systems
Learning
Workflow
Gene expression
Pharmaceutical Preparations

Adherence to once-daily and twice-daily direct acting antiviral therapy for hepatitis C infection among people with recent injection drug use or current opioid agonist therapy

Cunningham, E. B., Hajarizadeh, B., Amin, J., Litwin, A. H., Gane, E., Cooper, C., Lacombe, K., Hellard, M., Read, P., Powis, J., Dalgard, O., Bruneau, J., Matthews, G. V., Feld, J. J., Dillon, J. F., Shaw, D., Bruggmann, P., Conway, B., Fraser, C., Marks, P. & 2 others, Dore, G. J. & Grebely, J., 2 Nov 2019, In : Clinical Infectious Diseases.

Research output: Contribution to journalArticle

Hepatitis C
Opioid Analgesics
Antiviral Agents
Injections
Infection
3 Citations (Scopus)

A domestication history of dynamic adaptation and genomic deterioration in Sorghum

Smith, O., Nicholson, W., Kistler, L., Mace, E., Clapham, A., Rose, P., Stevens, C., Ware, R., Samavedam, S., Barker, G., Jordan, D., Fuller, D. Q. & Allaby, R. G., 8 Apr 2019, In : Nature Plants. 5, 4, p. 369-379 11 p.

Research output: Contribution to journalArticle

domestication
Sorghum (Poaceae)
deterioration
introgression
genomics

A dynamic reference change value model applied to ongoing assessment of the steady state of a biomarker using more than two serial results

Lund, F., Hyltoft Petersen, P. & Fraser, C. G., 25 Feb 2019, In : Annals of Clinical Biochemistry. 56, 2, p. 283-294 12 p.

Research output: Contribution to journalArticle

Biomarkers
Reference Values
1 Citation (Scopus)
44 Downloads (Pure)

A European multicentre drug utilisation study of the impact of regulatory measures on prescribing of codeine for pain in children

Hedenmalm, K., Blake, K., Donegan, K., Macia, M. A., Gil, M., Williams, J., Montero, D., Candore, G., Morales, D., Kurz, X. & Arlett, P., Aug 2019, In : Pharmacoepidemiology and Drug Safety. 28, 8, p. 1086-1096 11 p.

Research output: Contribution to journalArticle

Open Access
File
Drug Utilization
Codeine
Germany
Adenoidectomy
Pain
1 Citation (Scopus)
48 Downloads (Pure)

A Genome-Wide Association Study for Susceptibility to Visual Experience-Induced Myopia

Huang, Y., Kee, C-S., Hocking, P. M., Williams, C., Yip, S. P. & Guggenheim, J. A., 1 Feb 2019, In : Investigative Ophthalmology & Visual Science. 60, 2, p. 559-569 11 p.

Research output: Contribution to journalArticle

Open Access
File
Genome-Wide Association Study
Myopia
Refractive Errors
Genetic Predisposition to Disease
Genetic Markers

A genome-wide association study implicates that the TTC39C gene is associated with diabetic maculopathy with decreased visual acuity

Meng, W., Chan, B., Ezeonwumelu, C., Hebert, H., Campbell, A., Soler, V. & Palmer, C., 2 Jul 2019, In : Ophthalmic Genetics. 40, 3, p. 252-258 7 p.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Visual Acuity
Health
Genes
Genome