Saurin, Adrian

Dr

  • 1629 Citations
  • 22 h-Index
19992022
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Personal profile

Biography

Adrian graduated with first class honours from the University of Leeds in 1997 before moving to London to study for a PhD at Kings College in Professor Michael Marber’s laboratory at the Department of Cardiology. Following his PhD, Adrian moved to the Protein Phosphorylation laboratory at CRUK’s London Research Institute (headed by Professor Peter Parker), where he first became fascinated by the process of cell division. He subsequently moved to UMC Utrecht, in The Netherlands, to study the role of protein kinases during mitosis in the lab of Professor Geert Kops. Adrian relocated back to the UK in March 2013 to set up his own lab in Dundee studying the spatial regulation of mitotic signalling networks.

Teaching

I currently teach on the Cancer Biology modules for 3rd and 4th year undergraduate students. I also teach on the MRes and MSci postgraduate courses.

Research

In the lab we address fundamental questions about chromosome segregation in an effort to understand why this process goes wrong so frequently in tumour cells. We also focus on some basic cell signalling concepts that have widespread implications outside of cell division. In particular, we aim to uncover how kinases and phosphatases work together to control signal responses. This is important because this "signal integration" allows binary switch like responses to control complex biological outputs.

We use a range of approaches to tackle these problems, including quantitiative cell biology, synthetic biology, biochemistry and computation modelling. However, much of our day to day work involves single cell assays and microscopy: Seeing is believing.

For further information including an up-to-date list of project please visit: www.SaurinLab.com

 

Keywords

  • Q Science (General)
  • Kinase
  • Phosphatase
  • signal transduction
  • mitosis
  • cell biology
  • cell cycle
  • Cell Signalling
  • Cancer Biology
  • cancer research

Fingerprint Dive into the research topics where Adrian Saurin is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 28 Similar Profiles
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Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2013 2022

Research Output 1999 2019

1 Citation (Scopus)
51 Downloads (Pure)

Division of labour between PP2A-B56 isoforms at the centromere and kinetochore

Vallardi, G., Allan, L., Crozier, L. & Saurin, A. T., 4 Mar 2019, In : eLife. 8, p. 1-25 25 p., e42619.

Research output: Contribution to journalArticle

Open Access
File
Kinetochores
Centromere
Protein Isoforms
Personnel
M Phase Cell Cycle Checkpoints
10 Downloads (Pure)

PP1 and PP2A use opposite phospho-dependencies to control distinct processes at the kinetochore

Smith, R., Henriques Cordeiro, M., Davey, N. E., Vallardi, G., Ciliberto, A., Gross, F. & Saurin, A., 20 Aug 2019, In : Cell Reports. 28, 8, p. 2206-2219.e8 22 p.

Research output: Contribution to journalArticle

Open Access
File
Kinetochores
Phosphoric Monoester Hydrolases
Phosphorylation
Behavior Control
Phosphoprotein Phosphatases
70 Citations (Scopus)
69 Downloads (Pure)
Open Access
File
Chromosomal Instability
Phosphoric Monoester Hydrolases
Phosphotransferases
Chromosomes
Tumors
91 Downloads (Pure)
Open Access
File
Centrosome
Neoplasms
5 Citations (Scopus)

Exploring the Function of Dynamic Phosphorylation-Dephosphorylation Cycles

Gelens, L. & Saurin, A. T., 26 Mar 2018, In : Developmental Cell. 44, 6, p. 659-663 5 p.

Research output: Contribution to journalComment/debate

Open Access
Phosphorylation
Post Translational Protein Processing
Proteins
Molecules

Activities 2013 2019

  • 7 Invited talk

Molecular Mechanisms of Mitosis (HBIGS Winter School)

Adrian Saurin (Speaker)
4 Feb 20197 Feb 2019

Activity: Talk or presentation typesInvited talk

Mechanisms & Models of Cancer. Cold Spring Harbor (New York, US).

Adrian Saurin (Speaker)
2018

Activity: Talk or presentation typesInvited talk

EMBO Dynamic Kinetochore Workshop (Edinburgh, UK).

Adrian Saurin (Speaker)
2017

Activity: Talk or presentation typesInvited talk

EMBO Europhosphatase: Phosphatases in Cell Fates and Decisions (Paris, France).

Adrian Saurin (Speaker)
2017

Activity: Talk or presentation typesInvited talk

Biochemical Society: Phosphatases and Signalling in Health and Disease (Bath, UK).

Adrian Saurin (Speaker)
2016

Activity: Talk or presentation typesInvited talk

Press / Media

Dundee University cancer cell research funding boost

Adrian Saurin

22/01/16

1 item of Media coverage

Press/Media: Research

Thesis

PP2A-B56 isoform specificity at the centromere and kinetochore

Author: Vallardi, G., 2018

Supervisor: Saurin, A. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy