Projects per year
Personal profile
Biography
Adrian graduated with first class honours from the University of Leeds in 1997 before moving to London to study for a PhD at Kings College in Professor Michael Marber’s laboratory at the Department of Cardiology. Following his PhD, Adrian moved to the Protein Phosphorylation laboratory at CRUK’s London Research Institute (headed by Professor Peter Parker), where he first became fascinated by the process of cell division. He subsequently moved to UMC Utrecht, in The Netherlands, to study the role of protein kinases during mitosis in the lab of Professor Geert Kops. Adrian relocated back to the UK in March 2013 to set up his own lab in Dundee studying the spatial regulation of mitotic signalling networks.
Teaching
I currently teach on the Cancer Biology modules for 3rd and 4th year undergraduate students. I also teach on the MRes and MSci postgraduate courses.
Research
In the lab we address fundamental questions about chromosome segregation in an effort to understand why this process goes wrong so frequently in tumour cells. We also focus on some basic cell signalling concepts that have widespread implications outside of cell division. In particular, we aim to uncover how kinases and phosphatases work together to control signal responses. This is important because this "signal integration" allows binary switch like responses to control complex biological outputs.
We use a range of approaches to tackle these problems, including quantitiative cell biology, synthetic biology, biochemistry and computation modelling. However, much of our day to day work involves single cell assays and microscopy: Seeing is believing.
For further information including an up-to-date list of project please visit: www.SaurinLab.com
Keywords
- Q Science (General)
- Kinase
- Phosphatase
- signal transduction
- mitosis
- cell biology
- cell cycle
- Cell Signalling
- Cancer Biology
- cancer research
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Projects
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A Fully Integrated FLIM-FRET System For Imaging Dynamic Protein - Protein Interactions And Protein Turnover In Single Live Cells And Model Organisms
Appleton, P., Dinkova-Kostova, A., Hiom, K., Januschke, J., MacDonald, M., Saurin, A., Swedlow, J., Tanaka, T. & Weijer, K.
Biotechnology and Biological Sciences Research Council
1/11/20 → 31/03/21
Project: Research
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Method Development for Quantitative Assessment of Protein Turnover in Live Cells at Subcellular Resolution
Dinkova-Kostova, A., Muqit, M. & Saurin, A.
1/03/18 → 31/12/19
Project: Research
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Research output
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Cyclin B1 scaffolds MAD1 at the kinetochore corona to activate the mitotic checkpoint
Allan, L. A., Reis, M. C., Ciossani, G., Huigs in ‘t Veld, P. J., Wohlgemuth, S., Kops, G. J. P. L., Musacchio, A. & Saurin, A. T., 17 Jun 2020, In: EMBO Journal. 39, 12, 16 p., e103180.Research output: Contribution to journal › Article › peer-review
Open AccessFile11 Citations (Scopus)116 Downloads (Pure) -
Kinetochore phosphatases suppress autonomous Polo-like kinase 1 activity to control the mitotic checkpoint
Cordeiro, M. H., Smith, R. J. & Saurin, A. T., 7 Dec 2020, In: Journal of Cell Biology. 219, 12, 27 p., e202002020.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Citations (Scopus)55 Downloads (Pure) -
Division of labour between PP2A-B56 isoforms at the centromere and kinetochore
Vallardi, G., Allan, L., Crozier, L. & Saurin, A. T., 4 Mar 2019, In: eLife. 8, p. 1-25 25 p., e42619.Research output: Contribution to journal › Article › peer-review
Open AccessFile16 Citations (Scopus)193 Downloads (Pure) -
PP1 and PP2A use opposite phospho-dependencies to control distinct processes at the kinetochore
Smith, R., Henriques Cordeiro, M., Davey, N. E., Vallardi, G., Ciliberto, A., Gross, F. & Saurin, A., 20 Aug 2019, In: Cell Reports. 28, 8, p. 2206-2219.e8 22 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile12 Citations (Scopus)119 Downloads (Pure) -
The enemy within: Designing a cell-based gameplay system for cancer education
Sloan, R. J. S. & Saurin, A., 17 Oct 2019, CHI PLAY '19: Extended Abstracts of the Annual Symposium on Computer-Human Interaction in Play. New York: Association for Computing Machinery, p. 117-123 7 p.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
Activities
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Cell Cycle Meeting (Trieste, Italy)
Adrian Saurin (Speaker)
2019Activity: Talk or presentation types › Invited talk
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Dynamic Kinetochore Workshop (Paris, France)
Adrian Saurin (Speaker)
2019Activity: Talk or presentation types › Invited talk
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ASCB Meeting (Washington, US)
Adrian Saurin (Speaker)
2019Activity: Talk or presentation types › Oral presentation
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Molecular Mechanisms of Mitosis (HBIGS Winter School)
Adrian Saurin (Speaker)
2019Activity: Talk or presentation types › Invited talk
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Roscoff Cell Cycle Meeting (Roscoff, France)
Adrian Saurin (Speaker)
2019Activity: Talk or presentation types › Oral presentation
Press / Media
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Journal of Cell Science: Cell Scientist to Watch
1/07/21
1 item of Media coverage
Press/Media: Research
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How a ‘traffic light controller’ helps protect against cancer
5/11/20
1 Media contribution
Press/Media: Research
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Dundee University cancer cell research funding boost
22/01/16
1 item of Media coverage
Press/Media: Research