Saurin, Adrian

Dr

  • 1866 Citations
  • 24 h-Index
19992020

Research output per year

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Personal profile

Biography

Adrian graduated with first class honours from the University of Leeds in 1997 before moving to London to study for a PhD at Kings College in Professor Michael Marber’s laboratory at the Department of Cardiology. Following his PhD, Adrian moved to the Protein Phosphorylation laboratory at CRUK’s London Research Institute (headed by Professor Peter Parker), where he first became fascinated by the process of cell division. He subsequently moved to UMC Utrecht, in The Netherlands, to study the role of protein kinases during mitosis in the lab of Professor Geert Kops. Adrian relocated back to the UK in March 2013 to set up his own lab in Dundee studying the spatial regulation of mitotic signalling networks.

Teaching

I currently teach on the Cancer Biology modules for 3rd and 4th year undergraduate students. I also teach on the MRes and MSci postgraduate courses.

Research

In the lab we address fundamental questions about chromosome segregation in an effort to understand why this process goes wrong so frequently in tumour cells. We also focus on some basic cell signalling concepts that have widespread implications outside of cell division. In particular, we aim to uncover how kinases and phosphatases work together to control signal responses. This is important because this "signal integration" allows binary switch like responses to control complex biological outputs.

We use a range of approaches to tackle these problems, including quantitiative cell biology, synthetic biology, biochemistry and computation modelling. However, much of our day to day work involves single cell assays and microscopy: Seeing is believing.

For further information including an up-to-date list of project please visit: www.SaurinLab.com

 

Keywords

  • Q Science (General)
  • Kinase
  • Phosphatase
  • signal transduction
  • mitosis
  • cell biology
  • cell cycle
  • Cell Signalling
  • Cancer Biology
  • cancer research

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Projects

Research Output

Cyclin B1 scaffolds MAD1 at the kinetochore corona to activate the mitotic checkpoint

Allan, L. A., Reis, M. C., Ciossani, G., Huigs in ‘t Veld, P. J., Wohlgemuth, S., Kops, G. J. P. L., Musacchio, A. & Saurin, A. T., 17 Jun 2020, In : EMBO Journal. 39, 12, p. 1-16 16 p., e103180.

Research output: Contribution to journalArticle

Open Access
File
  • 5 Citations (Scopus)
    60 Downloads (Pure)

    Division of labour between PP2A-B56 isoforms at the centromere and kinetochore

    Vallardi, G., Allan, L., Crozier, L. & Saurin, A. T., 4 Mar 2019, In : eLife. 8, p. 1-25 25 p., e42619.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 11 Citations (Scopus)
    159 Downloads (Pure)

    PP1 and PP2A use opposite phospho-dependencies to control distinct processes at the kinetochore

    Smith, R., Henriques Cordeiro, M., Davey, N. E., Vallardi, G., Ciliberto, A., Gross, F. & Saurin, A., 20 Aug 2019, In : Cell Reports. 28, 8, p. 2206-2219.e8 22 p.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 5 Citations (Scopus)
    87 Downloads (Pure)

    The enemy within: Designing a cell-based gameplay system for cancer education

    Sloan, R. J. S. & Saurin, A., 17 Oct 2019, CHI PLAY '19: Extended Abstracts of the Annual Symposium on Computer-Human Interaction in Play. New York: Association for Computing Machinery, p. 117-123 7 p.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  • Open Access
    File
  • 119 Citations (Scopus)
    208 Downloads (Pure)

    Activities

    • 9 Invited talk
    • 2 Oral presentation

    Dynamic Kinetochore Workshop (Paris, France)

    Adrian Saurin (Speaker)

    2019

    Activity: Talk or presentation typesInvited talk

    Molecular Mechanisms of Mitosis (HBIGS Winter School)

    Adrian Saurin (Speaker)

    2019

    Activity: Talk or presentation typesInvited talk

    Cell Cycle Meeting (Trieste, Italy)

    Adrian Saurin (Speaker)

    2019

    Activity: Talk or presentation typesInvited talk

    ASCB Meeting (Washington, US)

    Adrian Saurin (Speaker)

    2019

    Activity: Talk or presentation typesOral presentation

    Roscoff Cell Cycle Meeting (Roscoff, France)

    Adrian Saurin (Speaker)

    2019

    Activity: Talk or presentation typesOral presentation

    Press / Media

    Journal of Cell Science: Cell Scientist to Watch

    Adrian Saurin

    1/07/21

    1 item of Media coverage

    Press/Media: Research

    Dundee University cancer cell research funding boost

    Adrian Saurin

    22/01/16

    1 item of Media coverage

    Press/Media: Research