Adrian Saurin

Personal profile

Biography

Adrian graduated with first class honours from the University of Leeds in 1997 before moving to London to study for a PhD at Kings College in Professor Michael Marber’s laboratory at the Department of Cardiology. Following his PhD, Adrian moved to the Protein Phosphorylation laboratory at CRUK’s London Research Institute (headed by Professor Peter Parker), where he first became fascinated by the process of cell division. He subsequently moved to UMC Utrecht, in The Netherlands, to study the role of protein kinases during mitosis in the lab of Professor Geert Kops. Adrian relocated back to the UK in March 2013 to set up his own lab in Dundee studying the spatial regulation of mitotic signalling networks.

Teaching

I currently teach on the Cancer Biology modules for 3rd and 4th year undergraduate students. I also teach on the MRes and MSci postgraduate courses.

Research

In the lab we address fundamental questions about chromosome segregation in an effort to understand why this process goes wrong so frequently in tumour cells. We also focus on some basic cell signalling concepts that have widespread implications outside of cell division. In particular, we aim to uncover how kinases and phosphatases work together to control signal responses. This is important because this "signal integration" allows binary switch like responses to control complex biological outputs.

We use a range of approaches to tackle these problems, including quantitiative cell biology, synthetic biology, biochemistry and computation modelling. However, much of our day to day work involves single cell assays and microscopy: Seeing is believing.

For further information including an up-to-date list of project please visit: www.SaurinLab.com

Keywords

Q Science (General)
Kinase
Phosphatase
signal transduction
mitosis
cell biology
cell cycle
Cell Signalling
Cancer Biology
cancer research

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Projects

1 Active
2 Not started
6 Finished

Kinase-Phosphatase Coupling at the Kinetochore and the Maintenance of Chromosomal Stability (joint with University of Edinburgh)

Saurin, A.

Cancer Research UK

1/06/16 → 31/05/22

Project: Research

A Fully Integrated FLIM-FRET System For Imaging Dynamic Protein - Protein Interactions And Protein Turnover In Single Live Cells And Model Organisms

Appleton, P., Dinkova-Kostova, A., Hiom, K., Januschke, J., MacDonald, M., Saurin, A., Swedlow, J., Tanaka, T. & Weijer, K.

Biotechnology and Biological Sciences Research Council

1/11/20 → 31/03/21

Project: Research

Investigating the Mechanism of Action of Cdk4/6 Inhibitors: Why Are They Such Groud-Breaking Chemotherapeutics

Petty, R. & Saurin, A.

Project: Research

Method Development for Quantitative Assessment of Protein Turnover in Live Cells at Subcellular Resolution

Dinkova-Kostova, A., Muqit, M. & Saurin, A.

1/03/18 → 31/12/19

Project: Research

Developing a Non-Invasive Measure of Cell Proliferation

Saurin, A.

Royal Society

31/12/14 → 30/12/15

Project: Research

Research Output

1866 Citations
24 h-Index
28 Article
5 Review article
2 Chapter (peer-reviewed)
2 Comment/debate
3 More

Cyclin B1 scaffolds MAD1 at the kinetochore corona to activate the mitotic checkpoint

Allan, L. A., Reis, M. C., Ciossani, G., Huigs in ‘t Veld, P. J., Wohlgemuth, S., Kops, G. J. P. L., Musacchio, A. & Saurin, A. T., 17 Jun 2020, In : EMBO Journal. 39, 12, p. 1-16 16 p., e103180.

Research output: Contribution to journal › Article

Open Access

File

5 Citations (Scopus)

60 Downloads (Pure)

Division of labour between PP2A-B56 isoforms at the centromere and kinetochore

Vallardi, G., Allan, L., Crozier, L. & Saurin, A. T., 4 Mar 2019, In : eLife. 8, p. 1-25 25 p., e42619.

Research output: Contribution to journal › Article

Open Access

File

11 Citations (Scopus)

159 Downloads (Pure)

PP1 and PP2A use opposite phospho-dependencies to control distinct processes at the kinetochore

Smith, R., Henriques Cordeiro, M., Davey, N. E., Vallardi, G., Ciliberto, A., Gross, F. & Saurin, A., 20 Aug 2019, In : Cell Reports. 28, 8, p. 2206-2219.e8 22 p.

Research output: Contribution to journal › Article

Open Access

File

5 Citations (Scopus)

87 Downloads (Pure)

The enemy within: Designing a cell-based gameplay system for cancer education

Sloan, R. J. S. & Saurin, A., 17 Oct 2019, CHI PLAY '19: Extended Abstracts of the Annual Symposium on Computer-Human Interaction in Play. New York: Association for Computing Machinery, p. 117-123 7 p.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution