Projects per year
Personal profile
Biography
Adrian graduated with first class honours from the University of Leeds in 1997 before moving to London to study for a PhD at Kings College in Professor Michael Marber’s laboratory at the Department of Cardiology. Following his PhD, Adrian moved to the Protein Phosphorylation laboratory at CRUK’s London Research Institute (headed by Professor Peter Parker), where he first became fascinated by the process of cell division. He subsequently moved to UMC Utrecht, in The Netherlands, to study the role of protein kinases during mitosis in the lab of Professor Geert Kops. Adrian relocated back to the UK in March 2013 to set up his own lab in Dundee studying the spatial regulation of mitotic signalling networks.
Teaching
I am currently module lead for Cancer Biology (a 4th year undergraduate honours module). I also teach on other 3rd and 4th year undergraduate modules, as well as on the BMSc and MSci postgraduate courses.
Research
In the lab we address fundamental questions about chromosome segregation and the cell cycle in an effort to understand why this process goes wrong so frequently in tumour cells. We also focus on some basic cell signalling concepts that have widespread implications outside of cell division. In particular, we aim to uncover how kinases and phosphatases work together to control signal responses. This is important because this "signal integration" allows binary switch like responses to control complex biological outputs.
We are also investigating the mechanisms of action of some widely used anti-cancer drugs that target the cell cycle. The aim is to use this information to better guide personalised patient treatment.
We use a range of approaches to tackle these problems, including quantitiative cell biology, synthetic biology, biochemistry and computation modelling. However, much of our day to day work involves single cell assays and microscopy.
For further information including an up-to-date list of project please visit: www.SaurinLab.com
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Keywords
- Q Science (General)
- Kinase
- Phosphatase
- signal transduction
- mitosis
- cell biology
- cell cycle
- Cell Signalling
- Cancer Biology
- cancer research
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Network
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Protein Phosphorylation Dynamics: Investigating A New Dimension Of Regulatory Control
1/04/22 → 31/03/25
Project: Research
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A Fully Integrated FLIM-FRET System For Imaging Dynamic Protein - Protein Interactions And Protein Turnover In Single Live Cells And Model Organisms
Appleton, P., Dinkova-Kostova, A., Hiom, K., Januschke, J., MacDonald, M., Saurin, A., Swedlow, J., Tanaka, T. & Weijer, K.
Biotechnology and Biological Sciences Research Council
1/11/20 → 31/03/21
Project: Research
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CDK4/6 inhibitors induce replication stress to cause long-term cell cycle withdrawal
Crozier, L., Foy, R., Mouery, B. L., Whitaker, R. H., Corno, A., Spanos, C., Ly, T., Cook, J. G. & Saurin, A., 15 Mar 2022, In: EMBO Journal. 41, 6, 20 p., e108599.Research output: Contribution to journal › Article › peer-review
Open AccessFile11 Citations (Scopus)262 Downloads (Pure) -
Cell overgrowth during G1 arrest triggers an osmotic stress response and chronic p38 activation to promote cell cycle exit
Crozier, L., Foy, R., Adib, R., Badonyi, M., Kar, A., Holt, J. A., Wilson, R., Regnault, C., Whitfield, P., Marsh, J. A., Saurin, A., Barr, A. R. & Ly, T., 8 Sep 2022, Cold Spring Harbour Laboratory: BioRxiv, 26 p.Research output: Working paper/Preprint › Preprint
Open AccessFile1 Downloads (Pure) -
Cyclin B1 scaffolds MAD1 at the kinetochore corona to activate the mitotic checkpoint
Allan, L. A., Reis, M. C., Ciossani, G., Huigs in ‘t Veld, P. J., Wohlgemuth, S., Kops, G. J. P. L., Musacchio, A. & Saurin, A. T., 17 Jun 2020, In: EMBO Journal. 39, 12, 16 p., e103180.Research output: Contribution to journal › Article › peer-review
Open AccessFile25 Citations (Scopus)182 Downloads (Pure) -
Kinetochore phosphatases suppress autonomous Polo-like kinase 1 activity to control the mitotic checkpoint
Cordeiro, M. H., Smith, R. J. & Saurin, A. T., 7 Dec 2020, In: Journal of Cell Biology. 219, 12, 27 p., e202002020.Research output: Contribution to journal › Article › peer-review
Open AccessFile17 Citations (Scopus)53 Downloads (Pure) -
Division of labour between PP2A-B56 isoforms at the centromere and kinetochore
Vallardi, G., Allan, L., Crozier, L. & Saurin, A. T., 4 Mar 2019, In: eLife. 8, p. 1-25 25 p., e42619.Research output: Contribution to journal › Article › peer-review
Open AccessFile26 Citations (Scopus)196 Downloads (Pure)
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Signal Regulation by Protein Phosphatases - Mechanisms and Pathways (Copenhagen, Denmark)
Adrian Saurin (Speaker)
6 Aug 2023Activity: Talk or presentation types › Invited talk
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Wellcome Trust (External organisation)
Adrian Saurin (Member)
1 Feb 2022 → …Activity: Membership types › Membership of committee
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Cell Size and Cell Growth Seminar Series (online meeting)
Adrian Saurin (Speaker)
21 Jun 2022Activity: Talk or presentation types › Invited talk
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Invited Seminar (NYU Langone, USA) - "Simple Solutions to Complex Problems: from cell cycle regulation to anti-cancer treatments"
Adrian Saurin (Speaker)
15 Aug 2022Activity: Talk or presentation types › Invited talk
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Invited Seminar (University of Konstanz - online) - "The origins of complexity in protein phosphorylation networks and anti-cancer treatments"
Adrian Saurin (Speaker)
5 Dec 2022Activity: Talk or presentation types › Invited talk
Press / Media
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Journal of Cell Science: Cell Scientist to Watch
1/07/21
1 item of Media coverage
Press/Media: Research
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How a ‘traffic light controller’ helps protect against cancer
5/11/20
1 Media contribution
Press/Media: Research
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Dundee University cancer cell research funding boost
22/01/16
1 item of Media coverage
Press/Media: Research