Projects per year
Personal profile
Biography
Adrian setup his lab in 2013 to study how cell cycle networks preserve genome stability and protect cells against cancer.
He completed his PhD in cardiomyocyte cell signalling (King College London) before moving on to postdoctoral positions in protein phosphorylation signalling (with Peter Parker, CRUK London Research Institute) and chromosome segregation (with Geert Kops, UMC Utrecht)
Research
The Saurin lab studies how the cell cycle is controlled and how this breaks down to drive genome instability and cancer evolution. They focus on understanding how kinase and phosphatases work together to drive key cell cycle transitions, and how these enzymes can be inhibited to prevent cell division and treat cancer.
They use a range of approaches to tackle these problems, including quantitative cell biology, synthetic biology, biochemistry and computation modelling. However, much of their day-to-day work involves single cell microscopy assays.
For further information including an up-to-date list of projects please visit: www.SaurinLab.com
Teaching
Adrian runs the 4th year Cancer Biology module. He also teaches on other undergraduate modules, and on the BMSc and MSci postgraduate courses.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Keywords
- Q Science (General)
- Kinase
- Phosphatase
- signal transduction
- mitosis
- cell biology
- cell cycle
- Cell Signalling
- Cancer Biology
- cancer research
Fingerprint
Dive into the research topics where Adrian Saurin is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 1 Similar Profiles
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
-
Protein Phosphorylation Dynamics: Investigating A New Dimension Of Regulatory Control
Saurin, A. (Investigator)
1/04/22 → 31/03/26
Project: Research
-
Investigating the Mechanism of Action of Cdk4/6 Inhibitors: Why Are They Such Groud-Breaking Chemotherapeutics
Petty, R. (Investigator) & Saurin, A. (Investigator)
Project: Research
-
Targeted Anti-Cancer Therapy with CDK4/6 Inhibitors (Studentship - Fraser Fellowships Doctoral Training Programme (DTP) in Precision Cancer Medicine)
Petty, R. (Investigator) & Saurin, A. (Investigator)
Project: Research
-
A Fully Integrated FLIM-FRET System For Imaging Dynamic Protein - Protein Interactions And Protein Turnover In Single Live Cells And Model Organisms
Appleton, P. (Investigator), Dinkova-Kostova, A. (Investigator), Hiom, K. (Investigator), Januschke, J. (Investigator), MacDonald, M. (Investigator), Saurin, A. (Investigator), Swedlow, J. (Investigator), Tanaka, T. (Investigator) & Weijer, K. (Investigator)
Biotechnology and Biological Sciences Research Council
1/11/20 → 31/03/21
Project: Research
-
Method Development for Quantitative Assessment of Protein Turnover in Live Cells at Subcellular Resolution
Dinkova-Kostova, A. (Investigator), Muqit, M. (Investigator) & Saurin, A. (Investigator)
1/03/18 → 31/12/19
Project: Research
-
A chemical-genetic system to rapidly inhibit the PP2A-B56 phosphatase
Allan, L., Corno, A., Valverde, J., Toth, R., Ly, T. & Saurin, A., 23 Jul 2024, BioRxiv, 14 p.Research output: Working paper/Preprint › Preprint
File3 Downloads (Pure) -
Elraglusib Induces Cytotoxicity via Direct Microtubule Destabilization Independently of GSK3 Inhibition
Coats, J. (Lead / Corresponding author), Li, S., Tanaka, T., Tauro, S., Sutherland, C. & Saurin, A. T. (Lead / Corresponding author), Nov 2024, In: Cancer Research Communications. 4, 11, p. 3013-3024 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)15 Downloads (Pure) -
The search for CDK4/6 inhibitor biomarkers has been hampered by inappropriate proliferation assays
Foy, R. (Lead / Corresponding author), Lew, K. X. & Saurin, A. T. (Lead / Corresponding author), 4 Mar 2024, In: NPJ Breast Cancer. 10, 11 p., 19.Research output: Contribution to journal › Article › peer-review
Open AccessFile9 Citations (Scopus)99 Downloads (Pure) -
A bifunctional kinase–phosphatase module balances mitotic checkpoint strength and kinetochore–microtubule attachment stability
Corno, A., Cordeiro, M. H., Allan, L. A., Lim, Q. W., Harrington, E., Smith, R. J. & Saurin, A. T., 16 Oct 2023, In: EMBO Journal. 42, 20, 22 p., e112630.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Citations (Scopus)95 Downloads (Pure) -
CDK4/6 inhibitor-mediated cell overgrowth triggers osmotic and replication stress to promote senescence
Crozier, L., Foy, R., Adib, R., Kar, A., Holt, J. A., Pareri, A. U., Valverde, J. M., Rivera, R., Weston, W. A., Wilson, R., Regnault, C., Whitfield, P., Badonyi, M., Bennett, L. G., Vernon, E. G., Gamble, A., Marsh, J. A., Staples, C. J., Saurin, A. T. & Barr, A. R. & 1 others, , 16 Nov 2023, In: Molecular Cell. 83, 22, p. 4062-4077.e5 21 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile29 Citations (Scopus)91 Downloads (Pure)
-
American Association of Cancer Research (AACR) Annual Meeting (San Diego, CA, USA)
Saurin, A. (Speaker)
8 Apr 2024Activity: Talk or presentation types › Invited talk
-
Invited Seminar (The Francis Crick Institute, London)
Saurin, A. (Speaker)
1 May 2024Activity: Talk or presentation types › Invited talk
-
The 6th International RB Conference (Santa Cruz, CA, USA)
Saurin, A. (Speaker)
16 Apr 2024Activity: Talk or presentation types › Invited talk
-
Signal Regulation by Protein Phosphatases - Mechanisms and Pathways (Copenhagen, Denmark)
Saurin, A. (Speaker)
6 Aug 2023Activity: Talk or presentation types › Invited talk
-
Invited Seminar (University of Newcastle) - "The origins of complexity in protein phosphorylation networks and anti-cancer treatments"
Saurin, A. (Speaker)
15 Nov 2023Activity: Talk or presentation types › Invited talk
Press/Media
-
Scottish scientists make major discovery in battle to treat cancer
7/12/23
1 item of Media coverage
Press/Media: Research
-
Journal of Cell Science: Cell Scientist to Watch
1/07/21
1 item of Media coverage
Press/Media: Research
-
How a ‘traffic light controller’ helps protect against cancer
5/11/20
1 Media contribution
Press/Media: Research
-
Dundee University cancer cell research funding boost
22/01/16
1 item of Media coverage
Press/Media: Research