Projects per year
Personal profile
Biography
Adrian setup his lab in 2013 to study how cell cycle networks preserve genome stability and protect cells against cancer.
He completed his PhD in cardiomyocyte cell signalling (King College London) before moving on to postdoctoral positions in protein phosphorylation signalling (with Peter Parker, CRUK London Research Institute) and chromosome segregation (with Geert Kops, UMC Utrecht)
Research
The Saurin lab studies how the cell cycle is controlled and how this breaks down to drive genome instability and cancer evolution. They focus on understanding how kinase and phosphatases work together to drive key cell cycle transitions, and how these enzymes can be inhibited to prevent cell division and treat cancer.
They use a range of approaches to tackle these problems, including quantitative cell biology, synthetic biology, biochemistry and computation modelling. However, much of their day-to-day work involves single cell microscopy assays.
For further information including an up-to-date list of projects please visit: www.SaurinLab.com
Teaching
Adrian runs the 4th year Cancer Biology module. He also teaches on other undergraduate modules, and on the BMSc and MSci postgraduate courses.
Keywords
- Q Science (General)
- Kinase
- Phosphatase
- signal transduction
- mitosis
- cell biology
- cell cycle
- Cell Signalling
- Cancer Biology
- cancer research
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
Fingerprint
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Investigating the Mechanism of Action of Cdk4/6 Inhibitors: Why Are They Such Groud-Breaking Chemotherapeutics
Petty, R. (Investigator) & Saurin, A. (Investigator)
Project: Research
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Targeted Anti-Cancer Therapy with CDK4/6 Inhibitors (Studentship - Fraser Fellowships Doctoral Training Programme (DTP) in Precision Cancer Medicine)
Petty, R. (Investigator) & Saurin, A. (Investigator)
Project: Research
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Protein Phosphorylation Dynamics: Investigating A New Dimension Of Regulatory Control
Saurin, A. (Investigator)
1/04/22 → 31/07/26
Project: Research
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A Fully Integrated FLIM-FRET System For Imaging Dynamic Protein - Protein Interactions And Protein Turnover In Single Live Cells And Model Organisms
Appleton, P. (Investigator), Dinkova-Kostova, A. (Investigator), Hiom, K. (Investigator), Januschke, J. (Investigator), MacDonald, M. (Investigator), Saurin, A. (Investigator), Swedlow, J. (Investigator), Tanaka, T. (Investigator) & Weijer, K. (Investigator)
Biotechnology and Biological Sciences Research Council
1/11/20 → 31/03/21
Project: Research
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Method Development for Quantitative Assessment of Protein Turnover in Live Cells at Subcellular Resolution
Dinkova-Kostova, A. (Investigator), Muqit, M. (Investigator) & Saurin, A. (Investigator)
1/03/18 → 31/12/19
Project: Research
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PHD1-dependent hydroxylation of RepoMan (CDCA2) on P604 modulates the control of mitotic progression
Druker, J., Jiang, H., Shakir, D., Child, F., Alvarez, V., Platani, M., Corno, A., Alabert, C., Saurin, A. T., Swedlow, J. (Lead / Corresponding author), Rocha, S. (Lead / Corresponding author) & Lamond, A. (Lead / Corresponding author), 9 Feb 2026, In: eLife. 14, 28 p., RP108131.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
A chemical-genetic system to rapidly inhibit the PP2A-B56 phosphatase reveals a role at metaphase kinetochores
Allan, L. A., Corno, A., Valverde, J., Toth, R., Ly, T. & Saurin, A. T. (Lead / Corresponding author), 29 Mar 2025, (E-pub ahead of print) In: Nature Communications. 16, 15 p., 3069.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Link opens in a new tab Citations (Scopus)107 Downloads (Pure) -
A fluorescence lifetime-based FLIM-timer for measuring the protein turnover of transcription factor Nrf2 in live cells
Dikovskaya, D. (Lead / Corresponding author), Bento-Pereira, C., Shiga, K., Corno, A., Higgins, M., Toth, R., Saurin, A. T. & Dinkova-Kostova, A., 14 Aug 2025, In: Scientific Reports. 15, 14 p., 29772.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Link opens in a new tab Citation (Scopus)48 Downloads (Pure) -
A chemical-genetic system to rapidly inhibit the PP2A-B56 phosphatase
Allan, L., Corno, A., Valverde, J., Toth, R., Ly, T. & Saurin, A., 23 Jul 2024, BioRxiv, 14 p.Research output: Working paper/Preprint › Preprint
File -
Elraglusib Induces Cytotoxicity via Direct Microtubule Destabilization Independently of GSK3 Inhibition
Coats, J. (Lead / Corresponding author), Li, S., Tanaka, T., Tauro, S., Sutherland, C. & Saurin, A. T. (Lead / Corresponding author), Nov 2024, In: Cancer Research Communications. 4, 11, p. 3013-3024 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Link opens in a new tab Citations (Scopus)80 Downloads (Pure)
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EACR 2026 Congress (Budapest, Hungary)
Saurin, A. (Speaker)
11 Jun 2026Activity: Talk or presentation types › Invited talk
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EACR Signalling Circuits in Cancer (online meeting)
Saurin, A. (Speaker)
11 Feb 2026Activity: Talk or presentation types › Invited talk
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EMBO Phosphatases: from basic research to translation (Wurzburg, Germany)
Saurin, A. (Speaker)
27 Jul 2025 → 31 Jul 2025Activity: Talk or presentation types › Invited talk
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American Association of Cancer Research (AACR) Annual Meeting (San Diego, CA, USA)
Saurin, A. (Speaker)
8 Apr 2024Activity: Talk or presentation types › Invited talk
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The 6th International RB Conference (Santa Cruz, CA, USA)
Saurin, A. (Speaker)
16 Apr 2024Activity: Talk or presentation types › Invited talk
Press/Media
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Scottish scientists make major discovery in battle to treat cancer
7/12/23
1 item of Media coverage
Press/Media: Research
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Journal of Cell Science: Cell Scientist to Watch
1/07/21
1 item of Media coverage
Press/Media: Research
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How a ‘traffic light controller’ helps protect against cancer
5/11/20
1 Media contribution
Press/Media: Research
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Dundee University cancer cell research funding boost
22/01/16
1 item of Media coverage
Press/Media: Research