Alan Fairlamb

Personal profile

Biography

Educated at Hymers Collge Hull, before stuying medicine and biochemistry at the University of Edinburgh.

ACADEMIC AND PROFESSIONAL HISTORY

1971-72 Surgical and Medical House Officer, Longmore and Western General Hospitals, Edinburgh

1972-75 Faculty of Medicine Research Scholar, University of Edinburgh (supervisor Dr I B R Bowman)

1975-76 MRC Travelling Fellow, University of Amsterdam (Prof Piet Borst)

1976-80 Research Fellow, University of Edinburgh (Dr I B R Bowman)

1980-81 Research Fellow, London School of Hygiene and Tropical Medicine (Prof W Peters)

1981-87 Assistant Professor, The Rockefeller University, New York (Prof A Cerami)

1987-90 Senior Clinical Lecturer, London School of Hygiene & Tropical Medicine

1990-96 Professor of Molecular Parasitology and Head, Biochemistry & Chemotherapy Unit, LSHTM

1996- Wellcome Principal Research Fellow, Professor of Biochemistry and Head of Division of Biological Chemistry & Drug Discovery (1996-2102), University of Dundee

2006- Co-Director Drug Discovery Unit, University of Dundee

Biography

HONOURS AND AWARDS

1987 Seymour H. Hutner Prize, Society of Protozoologists

1988 Frederick Murgatroyd Prize, Royal College of Physicians

1989 Fellow of the Linnean Society, London

1991 Ernst A.H. Friedheim Commemorative Lecture, Rockefeller University, New York

1993 Co-vice chairman (with Immo Scheffler) Gordon Research Conference on Polyamines

1995 Co-chairman (with Immo Scheffler) Gordon Research Conference on Polyamines

1996 John Scaife Commemorative Lecture, Edinburgh

1996 C.A.Wright Medal, British Society for Parasitology

1999 Foreign Corresponding Member, National Academy of Medicine of Buenos Aires, Argentina

2001 Fellow of the Royal Society of Edinburgh

2005 Fellow of the Academy of Medical Sciences

2005 Kitasato Microbial Chemistry Medal, Kitasato Institute, Japan

2005 Commander of the British Empire for services to medical science

2006 3Rs Prize 2006 for Refinement and Reduction of Animal Models of Leishmaniasis

2011 Fellow of the Society of Biology

Education/Academic qualification

Doctor of Philosophy, University of Edinburgh

Award Date: 1 Jan 1975

Bachelor of Medicine and Bachelor of Surgery, University of Edinburgh

Award Date: 1 Jan 1971

Bachelor of Science, University of Edinburgh

Award Date: 1 Jan 1968

External positions

Governing Board member & trustee

2010 → …

Keywords

RM Therapeutics. Pharmacology
Parasitology
drug discovery
drug resistance
mode of drug action
malaria
African trypanosomiasis
leishmaniasis
Chagas disease

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Projects

1 Not started
2 Active
3 Finished

Wellcome Centre for Anti-Infectives Research

Cook, S., Fairlamb, A., Ferguson, M., Field, M., Gilbert, I., Gray, D., Horn, D., Read, K. & Wyatt, P.

Wellcome Trust

1/04/17 → 31/03/22

Project: Research

Chemical Biology: Leveraging Phenotypic Hits Against Kinetoplastids (Strategic Grant)

Fairlamb, A., Field, M., Gilbert, I., Gray, D., Horn, D. & Wyatt, P.

Wellcome Trust

1/01/15 → 30/06/20

Project: Research

A Pipeline of Drugs for Visceral Leishmaniasis and Chagas Disease Through Expertise and Innovation (Preliminary Strategic Award) (Joint with Glaxosmithkline)

Fairlamb, A., Ferguson, M., Field, M., Gilbert, I., Gray, D., Horn, D., Read, K. & Wyatt, P.

Project: Research

Discovery and Development of Drug Candidates for Neglected Diseases (joint with industrial partner)

Fairlamb, A., Ferguson, M., Field, M., Gilbert, I., Gray, D., Horn, D., Read, K. & Wyatt, P.

Wellcome Trust

1/04/17 → 1/07/17

Project: Research

High Throughput Biolayer Interferometry at Dundee for Anti-Microbial and Interaction Studies

Birch, P., Ciulli, A., Fairlamb, A., Gray, D., Hunter, B., Owen-Hughes, T., Palmer, T., Ryan, R., Sargent, F., Stanley-Wall, N. & van Aalten, D.

Biotechnology and Biological Sciences Research Council

22/01/15 → 21/01/16

Project: Research

Research Output

106 Article
8 Review article
3 Comment/debate
3 Editorial
7 More

New 8-nitroquinolinone derivative displaying submicromolar in vitro activities against both Trypanosoma brucei and cruzi

Pedron, J., Boudot, C., Brossas, J., Pinault, E., Bourgeade-Delmas, S., Sournia-Saquet, A., Boutet-Robinet, E., Destere, A., Tronnet, A., Bergé, J., Bonduelle, C., Deraeve, C., Pratviel, G., Stigliani, J-L., Paris, L., Mazier, D., Corvaisier, S., Since, M., Malzert-Freon, A., Wyllie, S. & 5 others, Milne, R., Fairlamb, A. H., Valentin, A., Courtioux, B. & Verhaeghe, P., 6 Feb 2020, In : ACS Medicinal Chemistry Letters.

Research output: Contribution to journal › Article

Open Access

File

18 Downloads (Pure)

The Qi Site of Cytochrome b is a Promiscuous Drug Target in Trypanosoma cruzi and Leishmania donovani: ACS Infectious Diseases

Wall, R. J., Carvalho, S., Milne, R., Bueren-Calabuig, J. A., Moniz, S., Cantizani-Perez, J., MacLean, L., Kessler, A., Cotillo, I., Sastry, L., Manthri, S., Patterson, S., Zuccotto, F., Thompson, S., Martin, J., Marco, M., Miles, T. J., De Rycker, M., Thomas, M. G., Fairlamb, A. H. & 2 others, Gilbert, I. H. & Wyllie, S., 13 Mar 2020, In : ACS Infectious Diseases. 6, 3, p. 515-528 14 p.

Research output: Contribution to journal › Article

Open Access

File

1 Citation (Scopus)

25 Downloads (Pure)

Current and Future Prospects of Nitro-compounds as Drugs for Trypanosomiasis and Leishmaniasis

Fairlamb, A. H. & Patterson, S., 2019, In : Current Medicinal Chemistry. 26, 23, p. 4454-4475 22 p.

Research output: Contribution to journal › Review article

Open Access

File

5 Citations (Scopus)

162 Downloads (Pure)

Fexinidazole for the treatment of human African trypanosomiasis

Fairlamb, A., Dec 2019, In : Drugs of Today . 55, 11, p. 705-712 8 p., 705.

Research output: Contribution to journal › Article

1 Citation (Scopus)

Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis

Baragaña, B., Forte, B., Choi, R., Nakazawa Hewitt, S., Bueren-Calabuig, J. A., Pisco, J. P., Peet, C., Dranow, D. M., Robinson, D. A., Jansen, C., Norcross, N. R., Vinayak, S., Anderson, M., Brooks, C. F., Cooper, C. A., Damerow, S., Delves, M., Dowers, K., Duffy, J., Edwards, T. E. & 57 others, Hallyburton, I., Horst, B. G., Hulverson, M. A., Ferguson, L., Jiménez-Díaz, M. B., Jumani, R. S., Lorimer, D. D., Love, M. S., Maher, S., Matthews, H., McNamara, C. W., Miller, P., O'Neill, S., Ojo, K. K., Osuna-Cabello, M., Pinto, E., Post, J., Riley, J., Rottmann, M., Sanz, L. M., Scullion, P., Sharma, A., Shepherd, S. M., Shishikura, Y., Simeons, F. R. C., Stebbins, E. E., Stojanovski, L., Straschil, U., Tamaki, F. K., Tamjar, J., Torrie, L. S., Vantaux, A., Witkowski, B., Wittlin, S., Yogavel, M., Zuccotto, F., Angulo-Barturen, I., Sinden, R., Baum, J., Gamo, F-J., Mäser, P., Kyle, D. E., Winzeler, E. A., Myler, P. J., Wyatt, P. G., Floyd, D., Matthews, D., Sharma, A., Striepen, B., Huston, C. D., Gray, D. W., Fairlamb, A. H., Pisliakov, A. V., Walpole, C., Read, K. D., Van Voorhis, W. C. & Gilbert, I. H., 2 Apr 2019, In : Proceedings of the National Academy of Sciences. 116, 14, p. 7015-7020 6 p.

Research output: Contribution to journal › Article

Open Access

File