Fairlamb, Alan

Professor

1993 …2022

Research output per year

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Personal profile

Biography

Educated at Hymers Collge Hull, before stuying medicine and biochemistry at the University of Edinburgh.

ACADEMIC AND PROFESSIONAL HISTORY

1971-72       Surgical and Medical House Officer, Longmore and Western General Hospitals, Edinburgh

1972-75       Faculty of Medicine Research Scholar, University of Edinburgh (supervisor Dr I B R Bowman)

1975-76       MRC Travelling Fellow, University of Amsterdam (Prof Piet Borst)

1976-80       Research Fellow, University of Edinburgh (Dr I B R Bowman)

1980-81       Research Fellow, London School of Hygiene and Tropical Medicine (Prof W Peters)

1981-87       Assistant Professor, The Rockefeller University, New York (Prof A Cerami)

1987-90       Senior Clinical Lecturer, London School of Hygiene & Tropical Medicine

1990-96        Professor of Molecular Parasitology and Head, Biochemistry & Chemotherapy Unit, LSHTM

1996-           Wellcome Principal Research Fellow, Professor of Biochemistry and Head of Division of Biological Chemistry & Drug Discovery (1996-2102), University of Dundee

2006-           Co-Director Drug Discovery Unit, University of Dundee

Biography

HONOURS AND AWARDS

1987       Seymour H. Hutner Prize, Society of Protozoologists

1988       Frederick Murgatroyd Prize, Royal College of Physicians

1989       Fellow of the Linnean Society, London

1991       Ernst A.H. Friedheim Commemorative Lecture, Rockefeller University, New York

1993       Co-vice chairman (with Immo Scheffler) Gordon Research Conference on Polyamines

1995       Co-chairman (with Immo Scheffler) Gordon Research Conference on Polyamines

1996       John Scaife Commemorative Lecture, Edinburgh

1996       C.A.Wright Medal, British Society for Parasitology

1999       Foreign Corresponding Member, National Academy of Medicine of Buenos Aires, Argentina

2001       Fellow of the Royal Society of Edinburgh

2005       Fellow of the Academy of Medical Sciences

2005       Kitasato Microbial Chemistry Medal, Kitasato Institute, Japan

2005       Commander of the British Empire for services to medical science

2006       3Rs Prize 2006 for Refinement and Reduction of Animal Models of Leishmaniasis

2011       Fellow of the Society of Biology

 

Education/Academic qualification

Doctor of Philosophy, University of Edinburgh

Award Date: 1 Jan 1975

Bachelor of Medicine and Bachelor of Surgery, University of Edinburgh

Award Date: 1 Jan 1971

Bachelor of Science, University of Edinburgh

Award Date: 1 Jan 1968

External positions

Governing Board member & trustee

2010 → …

Keywords

  • RM Therapeutics. Pharmacology
  • Parasitology
  • drug discovery
  • drug resistance
  • mode of drug action
  • malaria
  • African trypanosomiasis
  • leishmaniasis
  • Chagas disease

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Projects

Research Output

New 8-nitroquinolinone derivative displaying submicromolar in vitro activities against both Trypanosoma brucei and cruzi

Pedron, J., Boudot, C., Brossas, J., Pinault, E., Bourgeade-Delmas, S., Sournia-Saquet, A., Boutet-Robinet, E., Destere, A., Tronnet, A., Bergé, J., Bonduelle, C., Deraeve, C., Pratviel, G., Stigliani, J-L., Paris, L., Mazier, D., Corvaisier, S., Since, M., Malzert-Freon, A., Wyllie, S. & 5 others, Milne, R., Fairlamb, A. H., Valentin, A., Courtioux, B. & Verhaeghe, P., 6 Feb 2020, In : ACS Medicinal Chemistry Letters.

Research output: Contribution to journalArticle

Open Access
File
  • 18 Downloads (Pure)

    The Qi Site of Cytochrome b is a Promiscuous Drug Target in Trypanosoma cruzi and Leishmania donovani: ACS Infectious Diseases

    Wall, R. J., Carvalho, S., Milne, R., Bueren-Calabuig, J. A., Moniz, S., Cantizani-Perez, J., MacLean, L., Kessler, A., Cotillo, I., Sastry, L., Manthri, S., Patterson, S., Zuccotto, F., Thompson, S., Martin, J., Marco, M., Miles, T. J., De Rycker, M., Thomas, M. G., Fairlamb, A. H. & 2 others, Gilbert, I. H. & Wyllie, S., 13 Mar 2020, In : ACS Infectious Diseases. 6, 3, p. 515-528 14 p.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 1 Citation (Scopus)
    25 Downloads (Pure)

    Current and Future Prospects of Nitro-compounds as Drugs for Trypanosomiasis and Leishmaniasis

    Fairlamb, A. H. & Patterson, S., 2019, In : Current Medicinal Chemistry. 26, 23, p. 4454-4475 22 p.

    Research output: Contribution to journalReview article

    Open Access
    File
  • 5 Citations (Scopus)
    162 Downloads (Pure)

    Fexinidazole for the treatment of human African trypanosomiasis

    Fairlamb, A., Dec 2019, In : Drugs of Today . 55, 11, p. 705-712 8 p., 705.

    Research output: Contribution to journalArticle

  • 1 Citation (Scopus)

    Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis

    Baragaña, B., Forte, B., Choi, R., Nakazawa Hewitt, S., Bueren-Calabuig, J. A., Pisco, J. P., Peet, C., Dranow, D. M., Robinson, D. A., Jansen, C., Norcross, N. R., Vinayak, S., Anderson, M., Brooks, C. F., Cooper, C. A., Damerow, S., Delves, M., Dowers, K., Duffy, J., Edwards, T. E. & 57 others, Hallyburton, I., Horst, B. G., Hulverson, M. A., Ferguson, L., Jiménez-Díaz, M. B., Jumani, R. S., Lorimer, D. D., Love, M. S., Maher, S., Matthews, H., McNamara, C. W., Miller, P., O'Neill, S., Ojo, K. K., Osuna-Cabello, M., Pinto, E., Post, J., Riley, J., Rottmann, M., Sanz, L. M., Scullion, P., Sharma, A., Shepherd, S. M., Shishikura, Y., Simeons, F. R. C., Stebbins, E. E., Stojanovski, L., Straschil, U., Tamaki, F. K., Tamjar, J., Torrie, L. S., Vantaux, A., Witkowski, B., Wittlin, S., Yogavel, M., Zuccotto, F., Angulo-Barturen, I., Sinden, R., Baum, J., Gamo, F-J., Mäser, P., Kyle, D. E., Winzeler, E. A., Myler, P. J., Wyatt, P. G., Floyd, D., Matthews, D., Sharma, A., Striepen, B., Huston, C. D., Gray, D. W., Fairlamb, A. H., Pisliakov, A. V., Walpole, C., Read, K. D., Van Voorhis, W. C. & Gilbert, I. H., 2 Apr 2019, In : Proceedings of the National Academy of Sciences. 116, 14, p. 7015-7020 6 p.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 7 Citations (Scopus)
    208 Downloads (Pure)

    Datasets

    Whole Genome Sequencing Variant Call Files for Trypanosoma brucei clones resistant to nifurtimox or fexinidazole

    Fairlamb, A. (Creator), Foth, B. (Creator), Berriman, M. (Creator), University of Dundee, 2015

    Dataset

    File

    Press / Media

    Tuberculosis drug may also target visceral leishmaniasis

    Alan H. Fairlamb & Kevin Read

    24/05/16

    1 item of Media coverage

    Press/Media: Research

    Potential new treatment identified for Leishmaniasis

    Alan H. Fairlamb

    1/02/122/02/12

    2 items of Media coverage

    Press/Media: Research

    Thesis

    Arsenic, antimony and visceral leishmaniasis

    Author: Perry, M. R., 2014

    Supervisor: Fairlamb, A. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy

    File

    Assessment of N-myristoyltransferase and the N-myristoylomeas a potential chemotherapeutic target inTrypanosoma cruzi

    Author: Roberts, A., 2014

    Supervisor: Fairlamb, A. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy

    File

    Evaluation of Glycogen Synthase Kinase 3 as a drug target in African trypanosomes

    Author: Grimaldi, R., 2014

    Supervisor: Fairlamb, A. (Supervisor) & Frearson, J. A. (External person) (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy

    File

    Folate transport and drug resistance in the African Trypanosome

    Author: Dewar, S., 2017

    Supervisor: Fairlamb, A. (Supervisor) & Horn, D. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy

    File

    Nitroaromatic pro-drug activation and resistance in the African trypanosome

    Author: Sokolova, A. Y., 2011

    Supervisor: Fairlamb, A. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy

    File