Projects per year
Personal profile
Biography
Educated at Hymers Collge Hull, before stuying medicine and biochemistry at the University of Edinburgh.
ACADEMIC AND PROFESSIONAL HISTORY
1971-72 Surgical and Medical House Officer, Longmore and Western General Hospitals, Edinburgh
1972-75 Faculty of Medicine Research Scholar, University of Edinburgh (supervisor Dr I B R Bowman)
1975-76 MRC Travelling Fellow, University of Amsterdam (Prof Piet Borst)
1976-80 Research Fellow, University of Edinburgh (Dr I B R Bowman)
1980-81 Research Fellow, London School of Hygiene and Tropical Medicine (Prof W Peters)
1981-87 Assistant Professor, The Rockefeller University, New York (Prof A Cerami)
1987-90 Senior Clinical Lecturer, London School of Hygiene & Tropical Medicine
1990-96 Professor of Molecular Parasitology and Head, Biochemistry & Chemotherapy Unit, LSHTM
1996- Wellcome Principal Research Fellow, Professor of Biochemistry and Head of Division of Biological Chemistry & Drug Discovery (1996-2102), University of Dundee
2006- Co-Director Drug Discovery Unit, University of Dundee
Biography
HONOURS AND AWARDS
1987 Seymour H. Hutner Prize, Society of Protozoologists
1988 Frederick Murgatroyd Prize, Royal College of Physicians
1989 Fellow of the Linnean Society, London
1991 Ernst A.H. Friedheim Commemorative Lecture, Rockefeller University, New York
1993 Co-vice chairman (with Immo Scheffler) Gordon Research Conference on Polyamines
1995 Co-chairman (with Immo Scheffler) Gordon Research Conference on Polyamines
1996 John Scaife Commemorative Lecture, Edinburgh
1996 C.A.Wright Medal, British Society for Parasitology
1999 Foreign Corresponding Member, National Academy of Medicine of Buenos Aires, Argentina
2001 Fellow of the Royal Society of Edinburgh
2005 Fellow of the Academy of Medical Sciences
2005 Kitasato Microbial Chemistry Medal, Kitasato Institute, Japan
2005 Commander of the British Empire for services to medical science
2006 3Rs Prize 2006 for Refinement and Reduction of Animal Models of Leishmaniasis
2011 Fellow of the Society of Biology
Education/Academic qualification
Doctor of Philosophy, University of Edinburgh
Bachelor of Medicine and Bachelor of Surgery, University of Edinburgh
Bachelor of Science, University of Edinburgh
External positions
Governing Board member & trustee
2010 → …Keywords
- RM Therapeutics. Pharmacology
- Parasitology
- drug discovery
- drug resistance
- mode of drug action
- malaria
- African trypanosomiasis
- leishmaniasis
- Chagas disease
Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.
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Projects 2013 2022
Wellcome Centre for Anti-Infectives Research
Cook, S., Fairlamb, A., Ferguson, M., Field, M., Gilbert, I., Gray, D., Horn, D., Read, K. & Wyatt, P.
1/04/17 → 31/03/22
Project: Research
Chemical Biology: Leveraging Phenotypic Hits Against Kinetoplastids (Strategic Grant)
Fairlamb, A., Field, M., Gilbert, I., Gray, D., Horn, D. & Wyatt, P.
1/01/15 → 30/06/20
Project: Research
Discovery and Development of Drug Candidates for Neglected Diseases (joint with industrial partner)
Fairlamb, A., Ferguson, M., Field, M., Gilbert, I., Gray, D., Horn, D., Read, K. & Wyatt, P.
1/04/17 → 1/07/17
Project: Research
High Throughput Biolayer Interferometry at Dundee for Anti-Microbial and Interaction Studies
Birch, P., Ciulli, A., Fairlamb, A., Gray, D., Hunter, W., Owen-Hughes, T., Palmer, T., Ryan, R., Sargent, F., Stanley-Wall, N. & van Aalten, D.
Biotechnology and Biological Sciences Research Council
22/01/15 → 21/01/16
Project: Research
Research Output 1995 2019
Nongenotoxic 3-Nitroimidazo[1,2-a]pyridines Are NTR1 Substrates That Display Potent in Vitro Antileishmanial Activity
Fersing, C., Basmaciyan, L., Boudot, C., Pedron, J., Hutter, S., Cohen, A., Castera-Ducros, C., Primas, N., Laget, M., Casanova, M., Bourgeade-Delmas, S., Piednoel, M., Sournia-Saquet, A., Belle Mbou, V., Courtioux, B., Boutet-Robinet, É., Since, M., Milne, R., Wyllie, S., Fairlamb, A. H. & 5 others , 10 Jan 2019, In : ACS Medicinal Chemistry Letters. 10, 1, p. 34-39 6 p.Research output: Contribution to journal › Article
Pharmacological validation of N-myristoyltransferase as a drug target in Leishmania donovani
Corpas Lopez, V., Moniz, S., Thomas, M., Wall, R., Torrie, L., Zander-Dinse, D., Tinti, M., Brand, S., Stojanovski, L., Manthri, S., Hallyburton, I., Zuccotto, F., Wyatt, P., De Rycker, M., Horn, D., Ferguson, M., Clos, J., Read, K., Fairlamb, A., Gilbert, I. & 1 others , Jan 2019, In : ACS Infectious Diseases. 5, 1, p. 111-122 12 p.Research output: Contribution to journal › Article
8-Aryl-6-chloro-3-nitro-2-(phenylsulfonylmethyl)imidazo[1,2-a]pyridines as potent antitrypanosomatid molecules bioactivated by type 1 nitroreductases
Fersing, C., Boudot, C., Pedron, J., Hutter, S., Primas, N., Castera-Ducros, C., Bourgeade-Delmas, S., Sournia-Saquet, A., Moreau, A., Cohen, A., Stigliani, J-L., Pratviel, G., Crozet, M. D., Wyllie, S., Fairlamb, A., Valentin, A., Rathelot, P., Azas, N., Courtioux, B., Verhaeghe, P. & 1 others , 5 Sep 2018, In : European Journal of Medicinal Chemistry. 157, p. 115-126 12 p.Research output: Contribution to journal › Article
Anti-trypanosomal 8-hydroxyl naphthyridines are chelators of divalent transition metals
Wall, R., Moniz, S., Thomas, M., Norval, S., Ko, E. J., Marco, M., Miles, T. J., Gilbert, I., Horn, D., Fairlamb, A. & Wyllie, S., Aug 2018, In : Antimicrobial Agents and Chemotherapy. 62, 8, 15 p., e00235-18.Research output: Contribution to journal › Article
Antitrypanosomatid Pharmacomodulation at Position 3 of the 8-Nitroquinolin-2(1H)-one Scaffold Using Palladium-Catalysed Cross-Coupling Reactions
Pedron, J., Boudot, C., Bourgeade-Delmas, S., Sournia-Saquet, A., Paloque, L., Rastegari, M., Abdoulaye, M., El-Kashef, H., Bonduelle, C., Pratviel, G., Wyllie, S., Fairlamb, A. H., Courtioux, B., Verhaeghe, P. & Valentin, A., 22 Oct 2018, In : ChemMedChem. 13, 20, p. 2217-2228 12 p.Research output: Contribution to journal › Article
Datasets
Whole Genome Sequencing Variant Call Files for Trypanosoma brucei clones resistant to nifurtimox or fexinidazole
Fairlamb, A. (Creator), Foth, B. (Creator), Berriman, M. (Creator), University of Dundee, 2015
DOI: 10.15132/10000107
Dataset
Press / Media
Tuberculosis drug may also target visceral leishmaniasis
24/05/16
1 item of media coverage
Press/Media: Research
Potential new treatment identified for Leishmaniasis
1/02/12 → 2/02/12
2 items of media coverage
Press/Media: Research
Drug breakthrough in fight against neglected diseases
Paul Wyatt, Alan Fairlamb & Michael Ferguson
1/04/10
1 item of media coverage
Press/Media: Research
Thesis
Arsenic, antimony and visceral leishmaniasis
Author: Perry, M. R., 2014Supervisor: Fairlamb, A. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
Assessment of N-myristoyltransferase and the N-myristoylomeas a potential chemotherapeutic target inTrypanosoma cruzi
Author: Roberts, A., 2014Supervisor: Fairlamb, A. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
Evaluation of Glycogen Synthase Kinase 3 as a drug target in African trypanosomes
Author: Grimaldi, R., 2014Supervisor: Fairlamb, A. (Supervisor) & Frearson, J. A. (External person) (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
Folate transport and drug resistance in the African Trypanosome
Author: Dewar, S., 2017Supervisor: Fairlamb, A. (Supervisor) & Horn, D. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
Nitroaromatic pro-drug activation and resistance in the African trypanosome
Author: Sokolova, A. Y., 2011Supervisor: Fairlamb, A. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy