If you made any changes in Pure these will be visible here soon.

Personal profile

Biography

Educated at Hymers Collge Hull, before stuying medicine and biochemistry at the University of Edinburgh.

ACADEMIC AND PROFESSIONAL HISTORY

1971-72       Surgical and Medical House Officer, Longmore and Western General Hospitals, Edinburgh

1972-75       Faculty of Medicine Research Scholar, University of Edinburgh (supervisor Dr I B R Bowman)

1975-76       MRC Travelling Fellow, University of Amsterdam (Prof Piet Borst)

1976-80       Research Fellow, University of Edinburgh (Dr I B R Bowman)

1980-81       Research Fellow, London School of Hygiene and Tropical Medicine (Prof W Peters)

1981-87       Assistant Professor, The Rockefeller University, New York (Prof A Cerami)

1987-90       Senior Clinical Lecturer, London School of Hygiene & Tropical Medicine

1990-96        Professor of Molecular Parasitology and Head, Biochemistry & Chemotherapy Unit, LSHTM

1996-           Wellcome Principal Research Fellow, Professor of Biochemistry and Head of Division of Biological Chemistry & Drug Discovery (1996-2102), University of Dundee

2006-           Co-Director Drug Discovery Unit, University of Dundee

Biography

HONOURS AND AWARDS

1987       Seymour H. Hutner Prize, Society of Protozoologists

1988       Frederick Murgatroyd Prize, Royal College of Physicians

1989       Fellow of the Linnean Society, London

1991       Ernst A.H. Friedheim Commemorative Lecture, Rockefeller University, New York

1993       Co-vice chairman (with Immo Scheffler) Gordon Research Conference on Polyamines

1995       Co-chairman (with Immo Scheffler) Gordon Research Conference on Polyamines

1996       John Scaife Commemorative Lecture, Edinburgh

1996       C.A.Wright Medal, British Society for Parasitology

1999       Foreign Corresponding Member, National Academy of Medicine of Buenos Aires, Argentina

2001       Fellow of the Royal Society of Edinburgh

2005       Fellow of the Academy of Medical Sciences

2005       Kitasato Microbial Chemistry Medal, Kitasato Institute, Japan

2005       Commander of the British Empire for services to medical science

2006       3Rs Prize 2006 for Refinement and Reduction of Animal Models of Leishmaniasis

2011       Fellow of the Society of Biology

 

Education/Academic qualification

Doctor of Philosophy, University of Edinburgh

Bachelor of Medicine and Bachelor of Surgery, University of Edinburgh

Bachelor of Science, University of Edinburgh

External positions

Governing Board member & trustee

2010 → …

Keywords

  • RM Therapeutics. Pharmacology
  • Parasitology
  • drug discovery
  • drug resistance
  • mode of drug action
  • malaria
  • African trypanosomiasis
  • leishmaniasis
  • Chagas disease

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

  • 4 Similar Profiles
Trypanosoma brucei brucei Medicine & Life Sciences
Parasites Medicine & Life Sciences
Pharmaceutical Preparations Medicine & Life Sciences
Trypanosomiasis Medicine & Life Sciences
Leishmania donovani Medicine & Life Sciences
Visceral Leishmaniasis Medicine & Life Sciences
African Trypanosomiasis Medicine & Life Sciences
Trypanosoma cruzi Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2013 2022

Research Output 1993 2019

A preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition

Wyllie, S., Brand, S., Thomas, M., De Rycker, M., Chung, C-W., Peña, I., Bingham, R., Bueren-Calabuig, J., Cantizani, J., Cebrian, D., Craggs, P. D., Ferguson, L., Goswami, P., Hobrath, J., Howe, J., Jeacock, L., Ko, E. J., Korczynska, J., MacLean, L., Manthri, S. & 29 othersSantos Martinez, M., Mata-Cantero, L., Moniz, S., Nuhs, A., Osuna-Cabello, M., Pinto, E., Riley, J., Robinson, S., Rowland, P., Simeons, F., Shishikura, Y., Spinks, D., Stojanovski, L., Thomas, J., Thompson, S., Viayna Gaza, E., Wall, R., Zuccotto, F., Horn, D., Ferguson, M., Fairlamb, A., Fiandor, J. M., Martín, J., Gray, D., Miles, T. J., Gilbert, I., Read, K., Marco, M. & Wyatt, P., 8 Apr 2019, In : Proceedings of the National Academy of Sciences. p. 1-6 6 p., 201820175.

Research output: Contribution to journalArticle

Open Access
File
Visceral Leishmaniasis
Proteasome Endopeptidase Complex
Leishmania infantum
Parasites
miltefosine
4 Downloads (Pure)

Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis

Baragaña, B., Forte, B., Choi, R., Nakazawa Hewitt, S., Bueren-Calabuig, J. A., Pisco, J. P., Peet, C., Dranow, D. M., Robinson, D. A., Jansen, C., Norcross, N. R., Vinayak, S., Anderson, M., Brooks, C. F., Cooper, C. A., Damerow, S., Delves, M., Dowers, K., Duffy, J., Edwards, T. E. & 57 othersHallyburton, I., Horst, B. G., Hulverson, M. A., Ferguson, L., Jiménez-Díaz, M. B., Jumani, R. S., Lorimer, D. D., Love, M. S., Maher, S., Matthews, H., McNamara, C. W., Miller, P., O'Neill, S., Ojo, K. K., Osuna-Cabello, M., Pinto, E., Post, J., Riley, J., Rottmann, M., Sanz, L. M., Scullion, P., Sharma, A., Shepherd, S. M., Shishikura, Y., Simeons, F. R. C., Stebbins, E. E., Stojanovski, L., Straschil, U., Tamaki, F. K., Tamjar, J., Torrie, L. S., Vantaux, A., Witkowski, B., Wittlin, S., Yogavel, M., Zuccotto, F., Angulo-Barturen, I., Sinden, R., Baum, J., Gamo, F-J., Mäser, P., Kyle, D. E., Winzeler, E. A., Myler, P. J., Wyatt, P. G., Floyd, D., Matthews, D., Sharma, A., Striepen, B., Huston, C. D., Gray, D. W., Fairlamb, A. H., Pisliakov, A. V., Walpole, C., Read, K. D., Van Voorhis, W. C. & Gilbert, I. H., 2 Apr 2019, In : Proceedings of the National Academy of Sciences. 116, 14, p. 7015-7020 6 p.

Research output: Contribution to journalArticle

Open Access
File
Lysine-tRNA Ligase
Cryptosporidiosis
Cryptosporidium parvum
Malaria
Plasmodium falciparum
17 Downloads (Pure)

Nongenotoxic 3-Nitroimidazo[1,2-a]pyridines Are NTR1 Substrates That Display Potent in Vitro Antileishmanial Activity

Fersing, C., Basmaciyan, L., Boudot, C., Pedron, J., Hutter, S., Cohen, A., Castera-Ducros, C., Primas, N., Laget, M., Casanova, M., Bourgeade-Delmas, S., Piednoel, M., Sournia-Saquet, A., Belle Mbou, V., Courtioux, B., Boutet-Robinet, É., Since, M., Milne, R., Wyllie, S., Fairlamb, A. H. & 5 othersValentin, A., Rathelot, P., Verhaeghe, P., Vanelle, P. & Azas, N., 10 Jan 2019, In : ACS Medicinal Chemistry Letters. 10, 1, p. 34-39 6 p.

Research output: Contribution to journalArticle

Open Access
File
Pyridines
Inhibitory Concentration 50
sulfoxide
miltefosine
Display devices
12 Downloads (Pure)
Open Access
File
Leishmania donovani
Pharmacology
Parasites
Enzymes
Pharmaceutical Preparations
1 Citation (Scopus)

8-Aryl-6-chloro-3-nitro-2-(phenylsulfonylmethyl)imidazo[1,2-a]pyridines as potent antitrypanosomatid molecules bioactivated by type 1 nitroreductases

Fersing, C., Boudot, C., Pedron, J., Hutter, S., Primas, N., Castera-Ducros, C., Bourgeade-Delmas, S., Sournia-Saquet, A., Moreau, A., Cohen, A., Stigliani, J-L., Pratviel, G., Crozet, M. D., Wyllie, S., Fairlamb, A., Valentin, A., Rathelot, P., Azas, N., Courtioux, B., Verhaeghe, P. & 1 othersVanelle, P., 5 Sep 2018, In : European Journal of Medicinal Chemistry. 157, p. 115-126 12 p.

Research output: Contribution to journalArticle

Nitroreductases
Inhibitory Concentration 50
Molecules
miltefosine
Scaffolds

Datasets

Whole Genome Sequencing Variant Call Files for Trypanosoma brucei clones resistant to nifurtimox or fexinidazole

Fairlamb, A. (Creator), Foth, B. (Creator), Berriman, M. (Creator), University of Dundee, 2015

Dataset

File

Press / Media

Tuberculosis drug may also target visceral leishmaniasis

Alan Fairlamb & Kevin Read

24/05/16

1 item of media coverage

Press/Media: Research

Potential new treatment identified for Leishmaniasis

Alan Fairlamb

1/02/122/02/12

2 items of media coverage

Press/Media: Research

Thesis

Arsenic, antimony and visceral leishmaniasis

Author: Perry, M. R., 2014

Supervisor: Fairlamb, A. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

File

Assessment of N-myristoyltransferase and the N-myristoylomeas a potential chemotherapeutic target inTrypanosoma cruzi

Author: Roberts, A., 2014

Supervisor: Fairlamb, A. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

File

Evaluation of Glycogen Synthase Kinase 3 as a drug target in African trypanosomes

Author: Grimaldi, R., 2014

Supervisor: Fairlamb, A. (Supervisor) & Frearson, J. A. (External person) (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

File

Folate transport and drug resistance in the African Trypanosome

Author: Dewar, S., 2017

Supervisor: Fairlamb, A. (Supervisor) & Horn, D. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

File

Nitroaromatic pro-drug activation and resistance in the African trypanosome

Author: Sokolova, A. Y., 2011

Supervisor: Fairlamb, A. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

File