• 12105 Citations
  • 62 h-Index
1988 …2020

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Article
2013

Tmem79/Matt is the matted mouse gene and is a predisposing gene for atopic dermatitis in human subjects

Saunders, S. P., Goh, C. S. M., Brown, S. J., Palmer, C. N. A., Porter, R. M., Cole, C., Campbell, L. E., Gierlinski, M., Barton, G. J., Schneider, G., Balmain, A., Prescott, A. R., Weidinger, S., Baurecht, H., Kabesch, M., Gieger, C., Lee, Y-A., Tavendale, R., Mukhopadhyay, S., Turner, S. W. & 14 others, Madhok, V. B., Sullivan, F. M., Relton, C., Burn, J., Meggitt, S., Smith, C. H., Allen, M. A., Barker, J. N. W. N., Reynolds, N. J., Cordell, H. J., Irvine, A. D., McLean, W. H. I., Sandilands, A. & Fallon, P. G., Nov 2013, In : Journal of Allergy and Clinical Immunology. 132, 5, p. 1121-1129 9 p.

Research output: Contribution to journalArticle

75 Citations (Scopus)
2012

A role for PP1/NIPP1 in steering migration of human cancer cells

Martin-Granados, C., Prescott, A. R., Van Dessel, N., Van Eynde, A., Arocena, M., Klaska, I. P., Görnemann, J., Beullens, M., Bollen, M., Forrester, J. V. & McCaig, C. D., 2012, In : PLoS ONE. 7, 7, e40769.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Cellular Responses to the Metal-Binding Properties of Metformin

Logie, L., Harthill, J., Patel, K., Bacon, S., Hamilton, D. L., Macrae, K., McDougall, G., Wang, H-H., Xue, L., Jiang, H., Sakamoto, K., Prescott, A. R. & Rena, G., Jun 2012, In : Diabetes. 61, 6, p. 1423-1433 11 p.

Research output: Contribution to journalArticle

52 Citations (Scopus)

Evolution of the vertebrate beaded filament protein, Bfsp2: comparing the in vitro assembly properties of a "tailed" zebrafish Bfsp2 to its "tailless" human orthologue

Qu, B., Landsbury, A., Schoenthaler, H. B., Dahm, R., Liu, Y., Clark, J. I., Prescott, A. R. & Quinlan, R. A., Jan 2012, In : Experimental Eye Research. 94, 1, p. 192-202 11 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

The anti-neurodegenerative agent clioquinol regulates the transcription factor FOXO1a

Cameron, A. R., Wallace, K., Logie, L., Prescott, A. R., Unterman, T. G., Harthill, J. & Rena, G., 1 Apr 2012, In : Biochemical Journal. 443, 1, p. 57-64 8 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

ZNRF2 is released from membranes by growth factors and with ZNRF1 regulates the Na+/K+ATPase

Hoxhaj, G., Najafov, A., Toth, R., Campbell, D. G., Prescott, A. R. & MacKintosh, C., 1 Oct 2012, In : Journal of Cell Science. 125, 19, p. 4662-4675 14 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)
2011

An intranucleolar body associated with rDNA

Hutten, S., Prescott, A., James, J., Riesenberg, S., Boulon, S., Lam, Y. W. & Lamond, A. I., Oct 2011, In : Chromosoma. 120, 5, p. 481-499 19 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

A Systemic Lupus Erythematosus-associated R77H Substitution in the CD11b Chain of the Mac-1 Integrin Compromises Leukocyte Adhesion and Phagocytosis

MacPherson, M., Lek, H. S., Prescott, A. & Fagerholm, S. C., 13 May 2011, In : Journal of Biological Chemistry. 286, 19, p. 17303-17310 8 p.

Research output: Contribution to journalArticle

51 Citations (Scopus)

Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2

Deng, X., Dzamko, N., Prescott, A., Davies, P., Liu, Q., Yang, Q., Lee, J-D., Patricelli, M. P., Nomanbhoy, T. K., Alessi, D. R. & Gray, N. S., Apr 2011, In : Nature Chemical Biology. 7, 4, p. 203-205 3 p.

Research output: Contribution to journalArticle

243 Citations (Scopus)

Regulation of the NKCC2 ion cotransporter by SPAK-OSR1-dependent and -independent pathways

Richardson, C., Sakamoto, K., de los Heros, P., Deak, M., Campbell, D. G., Prescott, A. R. & Alessi, D. R., 1 Mar 2011, In : Journal of Cell Science. 124, 5, p. 789-800 12 p.

Research output: Contribution to journalArticle

114 Citations (Scopus)

TTBK2 kinase substrate specificity and the impact of spinocerebellar-ataxia-causing mutations on expression, activity, localization and development

Bouskila, M., Esoof, N., Gay, L., Fang, E. H., Deak, M., Begley, M. J., Cantley, L. C., Prescott, A., Storey, K. G. & Alessi, D. R., 2011, In : Biochemical Journal. 437, p. 157-167 11 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

YuaB Functions Synergistically with the Exopolysaccharide and TasA Amyloid Fibers To Allow Biofilm Formation by Bacillus subtilis

Ostrowski, A., Mehert, A., Prescott, A., Kiley, T. B. & Stanley-Wall, N. R., Sep 2011, In : Journal of Bacteriology. 193, 18, p. 4821-4831 11 p.

Research output: Contribution to journalArticle

68 Citations (Scopus)
2010

14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization

Nichols, R. J., Dzamko, N., Morrice, N. A., Campbell, D. G., Deak, M., Ordureau, A., Macartney, T., Tong, Y., Shen, J., Prescott, A. R. & Alessi, D. R., 15 Sep 2010, In : Biochemical Journal. 430, p. 393-404 12 p.

Research output: Contribution to journalArticle

208 Citations (Scopus)

Dendritic cell podosomes are protrusive and invade the extracellular matrix using metalloproteinase MMP-14

Gawden-Bone, C., Zhou, Z., King, E., Prescott, A., Watts, C. & Lucocq, J., 1 May 2010, In : Journal of Cell Science. 123, 9, p. 1427-1437 11 p.

Research output: Contribution to journalArticle

90 Citations (Scopus)

Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser(910)/Ser(935), disruption of 14-3-3 binding and altered cytoplasmic localization

Dzamko, N., Deak, M., Hentati, F., Reith, A. D., Prescott, A. R., Alessi, D. R. & Nichols, R. J., 15 Sep 2010, In : Biochemical Journal. 430, p. 405-413 9 p.

Research output: Contribution to journalArticle

215 Citations (Scopus)

Molecular mechanism of elongation factor 1A inhibition by a Legionella pneumophila glycosyltransferase

Hurtado-Guerrero, R., Zusman, T., Pathak, S., Ibrahim, A. F. M., Shepherd, S., Prescott, A., Segal, G. & van Aalten, D. M. F., 15 Mar 2010, In : Biochemical Journal. 426, p. 281-292 12 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

New Roles for the LKB1-NUAK Pathway in Controlling Myosin Phosphatase Complexes and Cell Adhesion

Zagorska, A., Deak, M., Campbell, D. G., Banerjee, S., Hirano, M., Aizawa, S., Prescott, A. R. & Alessi, D. R., 30 Mar 2010, In : Science Signaling. 3, 115, p. - 13 p., ra25.

Research output: Contribution to journalArticle

97 Citations (Scopus)
2009

Activated cAMP receptors switch encystation into sporulation

Kawabe, Y., Morio, T., James, J. L., Prescott, A. R., Tanaka, Y. & Schaap, P., 28 Apr 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 17, p. 7089-7094 6 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Novel MHC Class I Structures on Exosomes

Lynch, S., Santos, S. G., Campbell, E. C., Nimmo, A. M. S., Botting, C., Prescott, A., Antoniou, A. N. & Powis, S. J., 1 Aug 2009, In : Journal of Immunology. 183, 3, p. 1884-1891 8 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)

The Talpid3 gene (KIAA0586) encodes a centrosomal protein that is essential for primary cilia formation

Yin, Y., Bangs, F., Paton, I. R., Prescott, A., James, J., Davey, M. G., Whitley, P., Genikhovich, G., Technau, U., Burt, D. W. & Tickle, C., 15 Feb 2009, In : Development. 136, 4, p. 655-664 10 p.

Research output: Contribution to journalArticle

87 Citations (Scopus)
2008

A role for ARF6 in dendritic cell podosome formation and migration

Svensson, H. G., West, M. A., Mollahan, P., Prescott, A. R., Zaru, R. & Watts, C., Mar 2008, In : European Journal of Immunology. 38, 3, p. 818-828 11 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Depletion of protein phosphatase 4 in human cells reveals essential roles in centrosome maturation, cell migration and the regulation of Rho GTPases

Martin-Granados, C., Philp, A., Oxenham, S. K., Prescott, A. R. & Cohen, P. T. W., 2008, In : International Journal of Biochemistry & Cell Biology. 40, 10, p. 2315-2332 18 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Expression and localisation of apical junctional complex proteins in lens epithelial cells

Sugiyama, Y., Prescott, A. R., Tholozan, F. M. D., Ohno, S. & Quinlan, R. A., Jul 2008, In : Experimental Eye Research. 87, 1, p. 64-70 7 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

TLR ligand-induced podosome disassembly in dendritic cells is ADAM17 dependent

West, M. A., Prescott, A. R., Chan, K. M., Zhou, Z., Rose-John, S., Scheller, J. & Watts, C., 8 Sep 2008, In : Journal of Cell Biology. 182, 5, p. 993-1005 13 p.

Research output: Contribution to journalArticle

Open Access
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50 Citations (Scopus)
217 Downloads (Pure)

TPL2-mediated activation of ERK1 and ERK2 regulates the processing of pre-TNF alpha in LPS-stimulated macrophages

Rousseau, S., Papoutsopoulou, M., Symons, A., Cook, D., Lucocq, J. M., Prescott, A. R., O'Garra, A., Ley, S. C. & Cohen, P., 15 Jan 2008, In : Journal of Cell Science. 121, 2, p. 149-154 6 p.

Research output: Contribution to journalArticle

98 Citations (Scopus)
2007

Burkholderia phymatum is a highly effective nitrogen-fixing symbiont of Mimosa spp. and fixes nitrogen ex planta

Elliott, G. N., Chen, W-M., Chou, J-H., Wang, H-C., Sheu, S-Y., Perin, L., Reis, V. M., Moulin, L., Simon, M. F., Bontemps, C., Sutherland, J. M., Bessi, R., de Faria, S. M., Trinick, M. J., Prescott, A. R., Sprent, J. I. & James, E. K., 2007, In : New Phytologist. 173, 1, p. 168-180 13 p.

Research output: Contribution to journalArticle

128 Citations (Scopus)

Endocytosis of DNA-Hsp65 Alters the pH of the Late Endosome/Lysosome and Interferes with Antigen Presentation

Trombone, A. P. F., Silva, C. L., Lima, K. M., Oliver, C., Jamur, M. C., Prescott, A. R. & Coelho-Castelo, A. A. M., 26 Sep 2007, In : PLoS ONE. 2, 9, e923.

Research output: Contribution to journalArticle

Open Access
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17 Citations (Scopus)
84 Downloads (Pure)

FGF-2 Release from the Lens Capsule by MMP-2 Maintains Lens Epithelial Cell Viability

Tholozan, F. M. D., Gribbon, C., Li, Z., Goldberg, M. W., Prescott, A. R., McKie, N. & Quinlan, R. A., 1 Nov 2007, In : Molecular Biology of the Cell. 18, 11, p. 4222-4231 10 p.

Research output: Contribution to journalArticle

49 Citations (Scopus)

Ninein is released from the centrosome and moves bi-directionally along microtubules

Moss, D. K., Bellett, G., Carter, J. M., Liovic, M., Keynton, J., Prescott, A. R., Lane, E. B. & Mogensen, M. M., 1 Sep 2007, In : Journal of Cell Science. 120, 17, p. 3064-3074 11 p.

Research output: Contribution to journalArticle

53 Citations (Scopus)

Proximal effects of Toll-like receptor activation in dendritic cells

Watts, C., Zaru, R., Prescott, A. R., Wallin, R. P. & West, M. A., Feb 2007, In : Current Opinion in Immunology. 19, 1, p. 73-8 6 p.

Research output: Contribution to journalArticle

52 Citations (Scopus)

Regulation of activity and localization of the WNK1 protein kinase by hyperosmotic stress

Zagórska, A., Pozo-Guisado, E., Boudeau, J., Vitari, A. C., Rafiqi, F. H., Thastrup, J., Deak, M., Campbell, D. G., Morrice, N. A., Prescott, A. R. & Alessi, D. R., 1 Jan 2007, In : Journal of Cell Biology. 176, 1, p. 89-100 12 p.

Research output: Contribution to journalArticle

113 Citations (Scopus)

Reorganization of centrosomal marker proteins coincides with epithelial cell differentiation in the vertebrate lens

Dahm, R., Procter, J. E., Ireland, M. E., Lo, W-K., Mogensen, M. M., Quinlan, R. A. & Prescott, A. R., Nov 2007, In : Experimental Eye Research. 85, 5, p. 696-713 18 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)
2006

Deficiency of LKB1 in heart prevents ischemia-mediated activation of AMPKalpha2 but not AMPKalpha

Sakamoto, K., Zarrinpashneh, E., Budas, G., Pouleur, A-C., Dutta, A., Prescott, A. R., Vanoverschelde, J-L., Ashworth, A., Jovanovic, A., Alessi, D. & Bertrand, L., 2006, In : American Journal of Physiology, Endocrinology and Metabolism. 290, 5, p. E780-E788

Research output: Contribution to journalArticle

155 Citations (Scopus)

Increased SK3 expression in DM1 lens cells leads to impaired growth through a greater calcium-induced fragility

Rhodes, J. D., Monckton, D. G., McAbney, J. P., Prescott, A. R. & Duncan, G., 15 Dec 2006, In : Human Molecular Genetics. 15, 24, p. 3559-3568 10 p.

Research output: Contribution to journalArticle

Open Access
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15 Citations (Scopus)
93 Downloads (Pure)

Regulation of the polarity kinases PAR-1/MARK by 14-3-3 interaction and phosphorylation

Göransson, O., Deak, M., Wullschleger, S., Morrice, N. A., Prescott, A. R. & Alessi, D. R., 20 Sep 2006, In : Journal of Cell Science. 119, 19, p. 4059-4070 12 p.

Research output: Contribution to journalArticle

48 Citations (Scopus)

The Alexander Disease–Causing Glial Fibrillary Acidic Protein Mutant, R416W, Accumulates into Rosenthal Fibers by a Pathway That Involves Filament Aggregation and the Association of αB-Crystallin and HSP27

Perng, M. D., Su, M., Wen, S. F., Li, R., Gibbon, T., Prescott, A. R., Brenner, M. & Quinlan, R. A., Aug 2006, In : American Journal of Human Genetics. 79, 2, p. 197-213 17 p.

Research output: Contribution to journalArticle

87 Citations (Scopus)

The C Terminus of Lens Aquaporin 0 Interacts with the Cytoskeletal Proteins Filensin and CP49

Rose, K. M. L., Gourdie, R. G., Prescott, A. R., Quinlan, R. A., Crouch, R. K. & Schey, K. L., Apr 2006, In : Investigative Ophthalmology and Visual Science. 47, 4, p. 1562-1570 9 p.

Research output: Contribution to journalArticle

66 Citations (Scopus)

The ubiquitin-associated domain of AMPK-related kinases regulates conformation and LKB1-mediated phosphorylation and activation

Jaleel, M., Villa, F., Deak, M., Toth, R., Prescott, A. R., van Aalten, D. M. F. & Alessi, D. R., 15 Mar 2006, In : Biochemical Journal. 394, 3, p. 545-555 11 p.

Research output: Contribution to journalArticle

65 Citations (Scopus)
2005

14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK

Al-Hakim, A. K., Göransson, O., Deak, M., Toth, R., Campbell, D. G., Morrice, N. A., Prescott, A. R. & Alessi, D. R., 1 Dec 2005, In : Journal of Cell Science. 118, 23, p. 5661-5673 13 p.

Research output: Contribution to journalArticle

76 Citations (Scopus)

Molecular mechanisms of kinetochore capture by spindle microtubules

Tanaka, K., Mukae, N., Dewar, H., Breugel, M. V., James, E. K., Prescott, A. R., Antony, C. & Tanaka, T. U., 2005, In : Nature. 434, 7036, p. 987-994 8 p.

Research output: Contribution to journalArticle

204 Citations (Scopus)

Proof that Burkholderia Strains Form Effective Symbioses with Legumes: a Study of Novel Mimosa-Nodulating Strains from South America

Chen, W. M., De Faria, S. M., Straliotto, R., Pitard, R. M., Simões-Araùjo, J. L., Chou, J. H., Chou, Y-J., Barrios, E., Prescott, A. R., Elliott, G. N., Sprent, J. I., Young, J. P. W. & James, E. K., 3 Nov 2005, In : Applied and Environmental Microbiology. 71, 11, p. 7461-7471 11 p.

Research output: Contribution to journalArticle

132 Citations (Scopus)

Sigma Receptor Antagonists Inhibit Human Lens Cell Growth and Induce Pigmentation

Wang, L., Prescott, A. R., Spruce, B. A., Sanderson, J. & Duncan, G., Apr 2005, In : Investigative Ophthalmology and Visual Science. 46, 4, p. 1403-1408 6 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

The suppression of galactose metabolism in procylic form Trypanosoma brucei causes cessation of cell growth and alters procyclin glycoprotein structure and copy number

Roper, J. R., Guther, M. L. S., MacRae, J. I., Prescott, A. R., Hallyburton, I., Acosta-Serrano, A. & Ferguson, M. A. J., 20 May 2005, In : Journal of Biological Chemistry. 280, 20, p. 19728-19736 9 p.

Research output: Contribution to journalArticle

60 Citations (Scopus)

Trypanosoma brucei glycoproteins contain novel giant poly-N-acetyllactosamine carbohydrate chains

Atrih, A., Richardson, J. M., Prescott, A. R. & Ferguson, M. A. J., 14 Jan 2005, In : Journal of Biological Chemistry. 280, 2, p. 865-871 7 p.

Research output: Contribution to journalArticle

58 Citations (Scopus)
2004

Analysis of the LKB1-STRAD-MO25 complex

Boudeau, J., Scott, J. W., Resta, N., Deak, M., Kieloch, A., Komander, D., Hardie, D. G., Prescott, A. R., van Aalten, D. M. F. & Alessi, D. R., 15 Dec 2004, In : Journal of Cell Science. 117, 26, p. 6365-6375 11 p.

Research output: Contribution to journalArticle

113 Citations (Scopus)

A proteomic approach to identify early molecular targets of oxidative stress in human epithelial lens cells

Paron, I., D'Elia, A., D'Ambrosio, C., Scaloni, A., D'Aurizio, F., Prescott, A., Damante, G. & Tell, G., 15 Mar 2004, In : Biochemical Journal. 378, 3, p. 929-937 9 p.

Research output: Contribution to journalArticle

90 Citations (Scopus)

Bfsp2 mutation found in mouse 129 strains causes the loss of CP49 and induces vimentin-dependent changes in the lens fibre cell cytoskeleton

Sandilands, A., Wang, X., Hutcheson, A. M., James, J., Prescott, A. R., Wegener, A., Pekny, M., Gong, X. & Quinlan, R. A., 1 Jan 2004, In : Experimental Eye Research. 78, 1, p. 109-123 15 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)