• 11542 Citations
  • 61 h-Index
1988 …2019
If you made any changes in Pure these will be visible here soon.

Research Output 1988 2019

Filter
Article
2011
45 Citations (Scopus)

A Systemic Lupus Erythematosus-associated R77H Substitution in the CD11b Chain of the Mac-1 Integrin Compromises Leukocyte Adhesion and Phagocytosis

MacPherson, M., Lek, H. S., Prescott, A. & Fagerholm, S. C., 13 May 2011, In : Journal of Biological Chemistry. 286, 19, p. 17303-17310 8 p.

Research output: Contribution to journalArticle

229 Citations (Scopus)

Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2

Deng, X., Dzamko, N., Prescott, A., Davies, P., Liu, Q., Yang, Q., Lee, J-D., Patricelli, M. P., Nomanbhoy, T. K., Alessi, D. R. & Gray, N. S., Apr 2011, In : Nature Chemical Biology. 7, 4, p. 203-205 3 p.

Research output: Contribution to journalArticle

58 Citations (Scopus)
108 Citations (Scopus)

Regulation of the NKCC2 ion cotransporter by SPAK-OSR1-dependent and -independent pathways

Richardson, C., Sakamoto, K., de los Heros, P., Deak, M., Campbell, D. G., Prescott, A. R. & Alessi, D. R., 1 Mar 2011, In : Journal of Cell Science. 124, 5, p. 789-800 12 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

TTBK2 kinase substrate specificity and the impact of spinocerebellar-ataxia-causing mutations on expression, activity, localization and development

Bouskila, M., Esoof, N., Gay, L., Fang, E. H., Deak, M., Begley, M. J., Cantley, L. C., Prescott, A., Storey, K. G. & Alessi, D. R., 2011, In : Biochemical Journal. 437, p. 157-167 11 p.

Research output: Contribution to journalArticle

65 Citations (Scopus)

YuaB Functions Synergistically with the Exopolysaccharide and TasA Amyloid Fibers To Allow Biofilm Formation by Bacillus subtilis

Ostrowski, A., Mehert, A., Prescott, A., Kiley, T. B. & Stanley-Wall, N. R., Sep 2011, In : Journal of Bacteriology. 193, 18, p. 4821-4831 11 p.

Research output: Contribution to journalArticle

2010
196 Citations (Scopus)

14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization

Nichols, R. J., Dzamko, N., Morrice, N. A., Campbell, D. G., Deak, M., Ordureau, A., Macartney, T., Tong, Y., Shen, J., Prescott, A. R. & Alessi, D. R., 15 Sep 2010, In : Biochemical Journal. 430, p. 393-404 12 p.

Research output: Contribution to journalArticle

86 Citations (Scopus)

Dendritic cell podosomes are protrusive and invade the extracellular matrix using metalloproteinase MMP-14

Gawden-Bone, C., Zhou, Z., King, E., Prescott, A., Watts, C. & Lucocq, J., 1 May 2010, In : Journal of Cell Science. 123, 9, p. 1427-1437 11 p.

Research output: Contribution to journalArticle

203 Citations (Scopus)

Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser(910)/Ser(935), disruption of 14-3-3 binding and altered cytoplasmic localization

Dzamko, N., Deak, M., Hentati, F., Reith, A. D., Prescott, A. R., Alessi, D. R. & Nichols, R. J., 15 Sep 2010, In : Biochemical Journal. 430, p. 405-413 9 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Molecular mechanism of elongation factor 1A inhibition by a Legionella pneumophila glycosyltransferase

Hurtado-Guerrero, R., Zusman, T., Pathak, S., Ibrahim, A. F. M., Shepherd, S., Prescott, A., Segal, G. & van Aalten, D. M. F., 15 Mar 2010, In : Biochemical Journal. 426, p. 281-292 12 p.

Research output: Contribution to journalArticle

86 Citations (Scopus)

New Roles for the LKB1-NUAK Pathway in Controlling Myosin Phosphatase Complexes and Cell Adhesion

Zagorska, A., Deak, M., Campbell, D. G., Banerjee, S., Hirano, M., Aizawa, S., Prescott, A. R. & Alessi, D. R., 30 Mar 2010, In : Science Signaling. 3, 115, p. - 13 p., ra25.

Research output: Contribution to journalArticle

2009
25 Citations (Scopus)

Activated cAMP receptors switch encystation into sporulation

Kawabe, Y., Morio, T., James, J. L., Prescott, A. R., Tanaka, Y. & Schaap, P., 28 Apr 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 17, p. 7089-7094 6 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)
39 Citations (Scopus)

Novel MHC Class I Structures on Exosomes

Lynch, S., Santos, S. G., Campbell, E. C., Nimmo, A. M. S., Botting, C., Prescott, A., Antoniou, A. N. & Powis, S. J., 1 Aug 2009, In : Journal of Immunology. 183, 3, p. 1884-1891 8 p.

Research output: Contribution to journalArticle

81 Citations (Scopus)

The Talpid3 gene (KIAA0586) encodes a centrosomal protein that is essential for primary cilia formation

Yin, Y., Bangs, F., Paton, I. R., Prescott, A., James, J., Davey, M. G., Whitley, P., Genikhovich, G., Technau, U., Burt, D. W. & Tickle, C., 15 Feb 2009, In : Development. 136, 4, p. 655-664 10 p.

Research output: Contribution to journalArticle

2008
29 Citations (Scopus)

A role for ARF6 in dendritic cell podosome formation and migration

Svensson, H. G., West, M. A., Mollahan, P., Prescott, A. R., Zaru, R. & Watts, C., Mar 2008, In : European Journal of Immunology. 38, 3, p. 818-828 11 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Depletion of protein phosphatase 4 in human cells reveals essential roles in centrosome maturation, cell migration and the regulation of Rho GTPases

Martin-Granados, C., Philp, A., Oxenham, S. K., Prescott, A. R. & Cohen, P. T. W., 2008, In : International Journal of Biochemistry & Cell Biology. 40, 10, p. 2315-2332 18 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Expression and localisation of apical junctional complex proteins in lens epithelial cells

Sugiyama, Y., Prescott, A. R., Tholozan, F. M. D., Ohno, S. & Quinlan, R. A., Jul 2008, In : Experimental Eye Research. 87, 1, p. 64-70 7 p.

Research output: Contribution to journalArticle

49 Citations (Scopus)
154 Downloads (Pure)

TLR ligand-induced podosome disassembly in dendritic cells is ADAM17 dependent

West, M. A., Prescott, A. R., Chan, K. M., Zhou, Z., Rose-John, S., Scheller, J. & Watts, C., 8 Sep 2008, In : Journal of Cell Biology. 182, 5, p. 993-1005 13 p.

Research output: Contribution to journalArticle

Open Access
File
97 Citations (Scopus)

TPL2-mediated activation of ERK1 and ERK2 regulates the processing of pre-TNF alpha in LPS-stimulated macrophages

Rousseau, S., Papoutsopoulou, M., Symons, A., Cook, D., Lucocq, J. M., Prescott, A. R., O'Garra, A., Ley, S. C. & Cohen, P., 15 Jan 2008, In : Journal of Cell Science. 121, 2, p. 149-154 6 p.

Research output: Contribution to journalArticle

2007
124 Citations (Scopus)

Burkholderia phymatum is a highly effective nitrogen-fixing symbiont of Mimosa spp. and fixes nitrogen ex planta

Elliott, G. N., Chen, W-M., Chou, J-H., Wang, H-C., Sheu, S-Y., Perin, L., Reis, V. M., Moulin, L., Simon, M. F., Bontemps, C., Sutherland, J. M., Bessi, R., de Faria, S. M., Trinick, M. J., Prescott, A. R., Sprent, J. I. & James, E. K., 2007, In : New Phytologist. 173, 1, p. 168-180 13 p.

Research output: Contribution to journalArticle

Mimosa
Burkholderia
Plantae
symbionts
Nitrogen
16 Citations (Scopus)
27 Downloads (Pure)

Endocytosis of DNA-Hsp65 Alters the pH of the Late Endosome/Lysosome and Interferes with Antigen Presentation

Trombone, A. P. F., Silva, C. L., Lima, K. M., Oliver, C., Jamur, M. C., Prescott, A. R. & Coelho-Castelo, A. A. M., 26 Sep 2007, In : PLoS ONE. 2, 9, e923.

Research output: Contribution to journalArticle

Open Access
File
antigen presentation
endosomes
Endosomes
Antigen Presentation
lysosomes
46 Citations (Scopus)

FGF-2 Release from the Lens Capsule by MMP-2 Maintains Lens Epithelial Cell Viability

Tholozan, F. M. D., Gribbon, C., Li, Z., Goldberg, M. W., Prescott, A. R., McKie, N. & Quinlan, R. A., 1 Nov 2007, In : Molecular Biology of the Cell. 18, 11, p. 4222-4231 10 p.

Research output: Contribution to journalArticle

Matrix Metalloproteinase 2
Fibroblast Growth Factor 2
Lenses
Capsules
Cell Survival
49 Citations (Scopus)

Ninein is released from the centrosome and moves bi-directionally along microtubules

Moss, D. K., Bellett, G., Carter, J. M., Liovic, M., Keynton, J., Prescott, A. R., Lane, E. B. & Mogensen, M. M., 1 Sep 2007, In : Journal of Cell Science. 120, 17, p. 3064-3074 11 p.

Research output: Contribution to journalArticle

Centrosome
Microtubules
Epithelial Cells
Cytoplasm
Adherens Junctions
52 Citations (Scopus)

Proximal effects of Toll-like receptor activation in dendritic cells

Watts, C., Zaru, R., Prescott, A. R., Wallin, R. P. & West, M. A., Feb 2007, In : Current Opinion in Immunology. 19, 1, p. 73-8 6 p.

Research output: Contribution to journalArticle

Toll-Like Receptors
Dendritic Cells
Phagosomes
Endosomes
Antigen Presentation
106 Citations (Scopus)

Regulation of activity and localization of the WNK1 protein kinase by hyperosmotic stress

Zagórska, A., Pozo-Guisado, E., Boudeau, J., Vitari, A. C., Rafiqi, F. H., Thastrup, J., Deak, M., Campbell, D. G., Morrice, N. A., Prescott, A. R. & Alessi, D. R., 1 Jan 2007, In : Journal of Cell Biology. 176, 1, p. 89-100 12 p.

Research output: Contribution to journalArticle

Protein Kinases
Phosphotransferases
Phosphorylation
Proline
Alanine
8 Citations (Scopus)

Reorganization of centrosomal marker proteins coincides with epithelial cell differentiation in the vertebrate lens

Dahm, R., Procter, J. E., Ireland, M. E., Lo, W-K., Mogensen, M. M., Quinlan, R. A. & Prescott, A. R., Nov 2007, In : Experimental Eye Research. 85, 5, p. 696-713 18 p.

Research output: Contribution to journalArticle

2006
150 Citations (Scopus)

Deficiency of LKB1 in heart prevents ischemia-mediated activation of AMPKalpha2 but not AMPKalpha

Sakamoto, K., Zarrinpashneh, E., Budas, G., Pouleur, A-C., Dutta, A., Prescott, A. R., Vanoverschelde, J-L., Ashworth, A., Jovanovic, A., Alessi, D. & Bertrand, L., 2006, In : American Journal of Physiology, Endocrinology and Metabolism. 290, 5, p. E780-E788

Research output: Contribution to journalArticle

Ischemia
Myocardium
Phosphorylation
Acetyl-CoA Carboxylase
AMP-Activated Protein Kinases
15 Citations (Scopus)
39 Downloads (Pure)

Increased SK3 expression in DM1 lens cells leads to impaired growth through a greater calcium-induced fragility

Rhodes, J. D., Monckton, D. G., McAbney, J. P., Prescott, A. R. & Duncan, G., 15 Dec 2006, In : Human Molecular Genetics. 15, 24, p. 3559-3568 10 p.

Research output: Contribution to journalArticle

Open Access
File
Lenses
Cataract
Calcium
Growth
Cell Death
46 Citations (Scopus)

Regulation of the polarity kinases PAR-1/MARK by 14-3-3 interaction and phosphorylation

Göransson, O., Deak, M., Wullschleger, S., Morrice, N. A., Prescott, A. R. & Alessi, D. R., 20 Sep 2006, In : Journal of Cell Science. 119, 19, p. 4059-4070 12 p.

Research output: Contribution to journalArticle

Phosphotransferases
Phosphorylation
Protein Isoforms
Cytoplasm
Cell Membrane
82 Citations (Scopus)

The Alexander Disease–Causing Glial Fibrillary Acidic Protein Mutant, R416W, Accumulates into Rosenthal Fibers by a Pathway That Involves Filament Aggregation and the Association of αB-Crystallin and HSP27

Perng, M. D., Su, M., Wen, S. F., Li, R., Gibbon, T., Prescott, A. R., Brenner, M. & Quinlan, R. A., Aug 2006, In : American Journal of Human Genetics. 79, 2, p. 197-213 17 p.

Research output: Contribution to journalArticle

Crystallins
Glial Fibrillary Acidic Protein
Alexander Disease
Astrocytes
Mutation
64 Citations (Scopus)

The C Terminus of Lens Aquaporin 0 Interacts with the Cytoskeletal Proteins Filensin and CP49

Rose, K. M. L., Gourdie, R. G., Prescott, A. R., Quinlan, R. A., Crouch, R. K. & Schey, K. L., Apr 2006, In : Investigative Ophthalmology and Visual Science. 47, 4, p. 1562-1570 9 p.

Research output: Contribution to journalArticle

Cytoskeletal Proteins
Lenses
Aquaporins
Immunoelectron Microscopy
Proteomics
63 Citations (Scopus)

The ubiquitin-associated domain of AMPK-related kinases regulates conformation and LKB1-mediated phosphorylation and activation

Jaleel, M., Villa, F., Deak, M., Toth, R., Prescott, A. R., van Aalten, D. M. F. & Alessi, D. R., 15 Mar 2006, In : Biochemical Journal. 394, 3, p. 545-555 11 p.

Research output: Contribution to journalArticle

Phosphorylation
AMP-Activated Protein Kinases
Ubiquitin
Conformations
Phosphotransferases
2005
76 Citations (Scopus)

14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK

Al-Hakim, A. K., Göransson, O., Deak, M., Toth, R., Campbell, D. G., Morrice, N. A., Prescott, A. R. & Alessi, D. R., 1 Dec 2005, In : Journal of Cell Science. 118, 23, p. 5661-5673 13 p.

Research output: Contribution to journalArticle

AMP-Activated Protein Kinases
Protein Isoforms
Protein Kinases
Ubiquitin-Specific Proteases
ATP Translocases Mitochondrial ADP
202 Citations (Scopus)

Molecular mechanisms of kinetochore capture by spindle microtubules

Tanaka, K., Mukae, N., Dewar, H., Breugel, M. V., James, E. K., Prescott, A. R., Antony, C. & Tanaka, T. U., 2005, In : Nature. 434, 7036, p. 987-994 8 p.

Research output: Contribution to journalArticle

kinetochores
microtubules
kinesin
chromosome segregation
centromeres
128 Citations (Scopus)

Proof that Burkholderia Strains Form Effective Symbioses with Legumes: a Study of Novel Mimosa-Nodulating Strains from South America

Chen, W. M., De Faria, S. M., Straliotto, R., Pitard, R. M., Simões-Araùjo, J. L., Chou, J. H., Chou, Y-J., Barrios, E., Prescott, A. R., Elliott, G. N., Sprent, J. I., Young, J. P. W. & James, E. K., 3 Nov 2005, In : Applied and Environmental Microbiology. 71, 11, p. 7461-7471 11 p.

Research output: Contribution to journalArticle

Mimosa
Burkholderia
Symbiosis
South America
symbiosis
26 Citations (Scopus)

Sigma Receptor Antagonists Inhibit Human Lens Cell Growth and Induce Pigmentation

Wang, L., Prescott, A. R., Spruce, B. A., Sanderson, J. & Duncan, G., Apr 2005, In : Investigative Ophthalmology and Visual Science. 46, 4, p. 1403-1408 6 p.

Research output: Contribution to journalArticle

sigma Receptors
Pigmentation
Lenses
Growth
Monophenol Monooxygenase
60 Citations (Scopus)

The suppression of galactose metabolism in procylic form Trypanosoma brucei causes cessation of cell growth and alters procyclin glycoprotein structure and copy number

Roper, J. R., Guther, M. L. S., MacRae, J. I., Prescott, A. R., Hallyburton, I., Acosta-Serrano, A. & Ferguson, M. A. J., 20 May 2005, In : Journal of Biological Chemistry. 280, 20, p. 19728-19736 9 p.

Research output: Contribution to journalArticle

57 Citations (Scopus)

Trypanosoma brucei glycoproteins contain novel giant poly-N-acetyllactosamine carbohydrate chains

Atrih, A., Richardson, J. M., Prescott, A. R. & Ferguson, M. A. J., 14 Jan 2005, In : Journal of Biological Chemistry. 280, 2, p. 865-871 7 p.

Research output: Contribution to journalArticle

2004
112 Citations (Scopus)

Analysis of the LKB1-STRAD-MO25 complex

Boudeau, J., Scott, J. W., Resta, N., Deak, M., Kieloch, A., Komander, D., Hardie, D. G., Prescott, A. R., van Aalten, D. M. F. & Alessi, D. R., 15 Dec 2004, In : Journal of Cell Science. 117, 26, p. 6365-6375 11 p.

Research output: Contribution to journalArticle

Neoplasms
Peutz-Jeghers Syndrome
Armadillos
AMP-Activated Protein Kinases
Protein-Serine-Threonine Kinases
90 Citations (Scopus)

A proteomic approach to identify early molecular targets of oxidative stress in human epithelial lens cells

Paron, I., D'Elia, A., D'Ambrosio, C., Scaloni, A., D'Aurizio, F., Prescott, A., Damante, G. & Tell, G., 15 Mar 2004, In : Biochemical Journal. 378, 3, p. 929-937 9 p.

Research output: Contribution to journalArticle

Oxidative stress
Proteomics
Lenses
Oxidative Stress
Epithelial Cells
39 Citations (Scopus)

Bfsp2 mutation found in mouse 129 strains causes the loss of CP49 and induces vimentin-dependent changes in the lens fibre cell cytoskeleton

Sandilands, A., Wang, X., Hutcheson, A. M., James, J., Prescott, A. R., Wegener, A., Pekny, M., Gong, X. & Quinlan, R. A., 1 Jan 2004, In : Experimental Eye Research. 78, 1, p. 109-123 15 p.

Research output: Contribution to journalArticle

129 Strain Mouse
Vimentin
Cytoskeleton
Lenses
Exons
83 Citations (Scopus)

Desmin aggregate formation by R120G αB-crystallin is caused by altered filament interactions and is dependent upon network status in cells

Perng, M. D., Wen, S. F., van den Ijssel, P., Prescott, A. R. & Quinlan, R. A., 1 May 2004, In : Molecular Biology of the Cell. 15, 5, p. 2335-2346 12 p.

Research output: Contribution to journalArticle

Crystallins
Desmin
Mutation
Muscular Diseases
Transfection
365 Citations (Scopus)

Enhanced dendritic cell antigen capture via toll-like receptor-induced actin remodeling

West, M., Wallin, R. P. A., Matthews, S., Svensson, H. G., Zaru, R., Ljunggren, H-G., Prescott, A. R. & Watts, C., 2004, In : Science. 305, 5687, p. 1153-1157 5 p.

Research output: Contribution to journalArticle

Toll-Like Receptors
Dendritic Cells
Actins
Antigens
Antigen Presentation
36 Citations (Scopus)

Inositol phospholipids regulate the guanine-nucleotide-exchange factor Tiam1 by facilitating its binding to the plasma membrane and regulating GDP/GTP exchange on Rac1

Fleming, I. N., Batty, I. H., Prescott, A. R., Gray, A., Kular, G. S., Stewart, H. & Downes, C. P., 15 Sep 2004, In : Biochemical Journal. 382, 3, p. 857-865 9 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 4,5-Diphosphate
Guanine Nucleotide Exchange Factors
Cell membranes
Phosphatidylinositols
Guanosine Triphosphate
52 Citations (Scopus)

p14 arf promotes small ubiquitin-like modifier conjugation of Werners helicase

Woods, Y. L., Xirodimas, D. P., Prescott, A. R., Sparks, A., Lane, D. P. & Saville, M. K., 2004, In : Journal of Biological Chemistry. 279, 48, p. 50157-50166 10 p.

Research output: Contribution to journalArticle

Ubiquitin
Tumors
Neoplasms
Peptide Hydrolases
Enzymes
129 Strain Mouse
Vimentin
Cytoskeleton
Lenses
Mutation
124 Citations (Scopus)

Small molecule antagonists of the σ-1 receptor cause selective release of the death program in tumor and self-reliant cells and inhibit tumor growth in vitro and in vivo

Spruce, B. A., Campbell, L. A., McTavish, N., Cooper, M. A., Appleyard, M. V. L., O'Neill, M., Howie, J., Samson, J., Watt, S., Murray, K., McLean, D., Leslie, N. R., Safrany, S. T., Ferguson, M. J., Peters, J. A., Prescott, A. R., Box, G., Hayes, A., Nutley, B., Raynaud, F. & 4 others, Downes, C. P., Lambert, J. J., Thompson, A. M. & Eccles, S., 2004, In : Cancer Research. 64, 1, p. 4875-4886 12 p.

Research output: Contribution to journalArticle

Growth
Neoplasms
Apoptosis
Caspases
Calcium
131 Citations (Scopus)

Structural insights into the regulation of PDK1 by phosphoinositides and inositol phosphates

Komander, D., Fairservice, A., Deak, M., Kular, G. S., Prescott, A. R., Downes, C. P., Safrany, S. T., Alessi, D. R. & Van Aalten, D. M. F., 13 Oct 2004, In : EMBO Journal. 23, 20, p. 3918-3928 11 p.

Research output: Contribution to journalArticle

3-Phosphoinositide-Dependent Protein Kinases
Inositol Phosphates
Phosphatidylinositols
Cytosol
90-kDa Ribosomal Protein S6 Kinases