• 12105 Citations
  • 62 h-Index
1988 …2020

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2004

Desmin aggregate formation by R120G αB-crystallin is caused by altered filament interactions and is dependent upon network status in cells

Perng, M. D., Wen, S. F., van den Ijssel, P., Prescott, A. R. & Quinlan, R. A., 1 May 2004, In : Molecular Biology of the Cell. 15, 5, p. 2335-2346 12 p.

Research output: Contribution to journalArticle

85 Citations (Scopus)

Enhanced dendritic cell antigen capture via toll-like receptor-induced actin remodeling

West, M., Wallin, R. P. A., Matthews, S., Svensson, H. G., Zaru, R., Ljunggren, H-G., Prescott, A. R. & Watts, C., 2004, In : Science. 305, 5687, p. 1153-1157 5 p.

Research output: Contribution to journalArticle

374 Citations (Scopus)

Inositol phospholipids regulate the guanine-nucleotide-exchange factor Tiam1 by facilitating its binding to the plasma membrane and regulating GDP/GTP exchange on Rac1

Fleming, I. N., Batty, I. H., Prescott, A. R., Gray, A., Kular, G. S., Stewart, H. & Downes, C. P., 15 Sep 2004, In : Biochemical Journal. 382, 3, p. 857-865 9 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

p14 arf promotes small ubiquitin-like modifier conjugation of Werners helicase

Woods, Y. L., Xirodimas, D. P., Prescott, A. R., Sparks, A., Lane, D. P. & Saville, M. K., 2004, In : Journal of Biological Chemistry. 279, 48, p. 50157-50166 10 p.

Research output: Contribution to journalArticle

51 Citations (Scopus)

Small molecule antagonists of the σ-1 receptor cause selective release of the death program in tumor and self-reliant cells and inhibit tumor growth in vitro and in vivo

Spruce, B. A., Campbell, L. A., McTavish, N., Cooper, M. A., Appleyard, M. V. L., O'Neill, M., Howie, J., Samson, J., Watt, S., Murray, K., McLean, D., Leslie, N. R., Safrany, S. T., Ferguson, M. J., Peters, J. A., Prescott, A. R., Box, G., Hayes, A., Nutley, B., Raynaud, F. & 4 others, Downes, C. P., Lambert, J. J., Thompson, A. M. & Eccles, S., 2004, In : Cancer Research. 64, 1, p. 4875-4886 12 p.

Research output: Contribution to journalArticle

133 Citations (Scopus)

Structural insights into the regulation of PDK1 by phosphoinositides and inositol phosphates

Komander, D., Fairservice, A., Deak, M., Kular, G. S., Prescott, A. R., Downes, C. P., Safrany, S. T., Alessi, D. R. & Van Aalten, D. M. F., 13 Oct 2004, In : EMBO Journal. 23, 20, p. 3918-3928 11 p.

Research output: Contribution to journalArticle

135 Citations (Scopus)

The in vivo role of PtdIns(3,4,5)P3 binding to PDK1 PH domain defined by knockin mutation

McManus, E. J., Collins, B. J., Ashby, P. R., Prescott, A. R., Murray-Tait, V., Armit, L. J., Arthur, J. S. C. & Alessi, D. R., 19 May 2004, In : EMBO Journal. 23, 10, p. 2071-2082 12 p.

Research output: Contribution to journalArticle

103 Citations (Scopus)

WNK1, the kinase mutated in an inherited high-blood-pressure syndrome, is a novel PKB (protein kinase B)/Akt substrate

Vitari, A. C., Deak, M., Collins, B. J., Morrice, N., Prescott, A. R., Phelan, A., Humphreys, S. & Alessi, D. R., 15 Feb 2004, In : Biochemical Journal. 378, 1, p. 257-268 12 p.

Research output: Contribution to journalArticle

67 Citations (Scopus)
2003

Cajal body proteins SMN and Coilin show differential dynamic behaviour in vivo

Sleeman, J. E., Trinkle-Mulcahy, L., Prescott, A. R., Ogg, S. C. & Lamond, A. I., 1 Apr 2003, In : Journal of Cell Science. 116, 10, p. 2039-2050 12 p.

Research output: Contribution to journalArticle

73 Citations (Scopus)

Cholesterol oxides mediated changes in cytoskeletal organisation involves Rho GTPases

Girão, H., Pereira, P., Ramalho, J., Quinlan, R. & Prescott, A., 1 Dec 2003, In : Experimental Cell Research. 291, 2, p. 502-513 12 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Identification of a novel intercellular structure in late-stage differentiating lens cells

Dahm, R. & Prescott, A. R., 10 Feb 2003, In : Ophthalmic Research. 35, 1, p. 2-7 6 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Interaction of the protein tyrosine phosphatase PTPL1 with the PtdIns(3,4)P2-binding adaptor protein TAPP1

Kimber, W. A., Deak, M., Prescott, A. R. & Alessi, D. R., 1 Dec 2003, In : Biochemical Journal. 376, 2, p. 525-535 11 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)

Knockout of the intermediate filament protein CP49 destabilises the lens fibre cell cytoskeleton and decreases lens optical quality, but does not induce cataract

Sandilands, A., Prescott, A. R., Wegener, A., Zoltoski, R. K., Hutcheson, A. M., Masaki, S., Kuszak, J. R. & Quinlan, R. A., Mar 2003, In : Experimental Eye Research. 76, 3, p. 385-391 7 p.

Research output: Contribution to journalArticle

70 Citations (Scopus)

Loss of Kindlin-1, a human homolog of the Caenorhabditis elegans actin–extracellular-matrix linker protein UNC-112, causes Kindler syndrome

Siegel, D. H., Ashton, G. H. S., Penagos, H. G., Lee, J. V., Feiler, H. S., Wilhelmsen, K. C., South, A. P., Smith, F., Prescott, A. R., Wessagowit, V., Oyama, N., Akiyama, M., Al Aboud, D., Al Aboud, K., Al Githami, A., Al Hawsawi, K., Al Ismaily, A., Al-Suwaid, R., Atherton, D. J., Caputo, R. & 22 others, Fine, J-D., Frieden, I. J., Fuchs, E., Haber, R. M., Harada, T., Kitajima, Y., Mallory, S. B., Ogawa, H., Sahin, S., Shimizu, H., Suga, Y., Tadini, G., Tsuchiya, K., Wiebe, C. B., Wojnarowska, F., Zaghloul, A. B., Hamada, T., Mallipeddi, R., Eady, R. A. J., McLean, I., McGrath, J. A. & Epstein, E. H., 2003, In : American Journal of Human Genetics. 73, 1, p. 174-187 14 p.

Research output: Contribution to journalArticle

236 Citations (Scopus)

MO25α/β interact with STRADα/β enhancing their ability to bind, activate and localize LKB1 in the cytoplasm

Boudeau, J., Baas, A. F., Deak, M., Morrice, N. A., Kieloch, A., Schutkowski, M., Prescott, A. R., Clevers, H. C. & Alessi, D. R., 1 Oct 2003, In : EMBO Journal. 22, 19, p. 5102-5114 13 p.

Research output: Contribution to journalArticle

314 Citations (Scopus)

Nodulation of Mimosa spp. by the β-Proteobacterium Ralstonia taiwanensis

Chen, W-M., James, E. K., Prescott, A. R., Kierans, M. & Sprent, J. I., Dec 2003, In : Molecular Plant-Microbe Interactions. 16, 12, p. 1051-1061 11 p.

Research output: Contribution to journalArticle

92 Citations (Scopus)

Nuclear speckle localisation of the small heat shock protein αB-crystallin and its inhibition by the R120G cardiomyopathy-linked mutation

Van Den Ijssel, P., Wheelock, R., Prescott, A., Russell, P. & Quinlan, R. A., Jul 2003, In : Experimental Cell Research. 287, 2, p. 249-261 13 p.

Research output: Contribution to journalArticle

60 Citations (Scopus)

Observation of keratin particles showing fast bidirectional movement colocalized with microtubules

Liovic, M., Mogensen, M. M., Prescott, A. R. & Lane, E. B., 2003, In : Journal of Cell Science. 116, 8, p. 1417-1427 11 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

Time-lapse Imaging Reveals Dynamic Relocalization of PP1γ throughout the Mammalian Cell Cycle

Trinkle-Mulcahy, L., Andrews, P. D., Wickramasinghe, S., Sleeman, J., Prescott, A., Lam, Y. W., Lyon, C., Swedlow, J. R. & Lamond, A. I., 1 Jan 2003, In : Molecular Biology of the Cell. 14, 1, p. 107-117 11 p.

Research output: Contribution to journalArticle

114 Citations (Scopus)
2002

Altered aggregation properties of mutant γ-crystallins cause inherited cataract

Sandilands, A., Hutcheson, A. M., Long, H. A., Prescott, A. R., Vrensen, G., Loster, J., Klopp, N., Lutz, R. B., Graw, J., Masaki, S., Dobson, C. M., MacPhee, C. E. & Quinlan, R. A., Nov 2002, In : The EMBO Journal. 21, 22, p. 6005-6014 10 p.

Research output: Contribution to journalArticle

114 Citations (Scopus)
22 Citations (Scopus)

Essential role of PDK1 in regulating cell size and development in mice

Lawlor, M. A., Mora, A., Ashby, P. R., Williams, M. R., Murray-Tait, V., Malone, L., Prescott, A. R., Lucocq, J. M. & Alessi, D. R., 15 Jul 2002, In : EMBO Journal. 21, 14, p. 3728-3738 11 p.

Research output: Contribution to journalArticle

Open Access
249 Citations (Scopus)

Fin development in a cartilaginous fish and the origin of vertebrate limbs

Tanaka, M., Munsterberg, A., Anderson, W. G., Prescott, A. R., Hazon, N. & Tickle, C., 4 Apr 2002, In : Nature. 416, 6880, p. 527-531 5 p.

Research output: Contribution to journalArticle

99 Citations (Scopus)

Inhibition of autophagy in mitotic animal cells

Eskelinen, E-L., Prescott, A. R., Cooper, J., Brachmann, S. M., Wang, L., Tang, X., Backer, J. M. & Lucocq, J. M., 2002, In : Traffic. 3, 12, p. 878-893 16 p.

Research output: Contribution to journalArticle

128 Citations (Scopus)

Morphological changes and nuclear pore clustering during nuclear degradation in differentiating bovine lens fibre cells

Dahm, R. & Prescott, A. R., 1 Dec 2002, In : Ophthalmic Research. 34, 5, p. 288-294 7 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
Open Access
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123 Citations (Scopus)
204 Downloads (Pure)

Two novel phosphorylation sites on FKHR that are critical for its nuclear exclusion

Rena, G., Woods, Y. L., Prescott, A. R., Peggie, M., Unterman, T. G., Williams, M. R. & Cohen, P., 2002, In : The EMBO Journal. 21, 9, p. 2263-2271 9 p.

Research output: Contribution to journalArticle

182 Citations (Scopus)
2001

An essential role for calmodulin in regulating human T cell aggregation

Fagerholm, S. C., Prescott, A., Cohen, P., Gahmberg, C. G. & Lehto, V-P. (ed.), 28 Feb 2001, In : FEBS Letters. 491, 1-2, p. 131-6 6 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Antagonistic action of Six3 and Prox1 at the γ-crystallin promoter

Lengler, J., Krausz, E., Tomarev, S., Prescott, A., Quinlan, R. A. & Graw, J., 15 Jan 2001, In : Nucleic Acids Research. 29, 2, p. 515-526 12 p.

Research output: Contribution to journalArticle

49 Citations (Scopus)

Evidence for prebudding arrest of ER export in animal cell mitosis and its role in generating Golgi partitioning intermediates

Prescott, A. R., Farmaki, T., Thomson, C., James, J., Paccaud, J-P., Tang, B-L., Hong, W., Quinn, M., Ponnambalam, S. & Lucocq, J., May 2001, In : Traffic. 2, 5, p. 321-335 15 p.

Research output: Contribution to journalArticle

50 Citations (Scopus)

Molecular characterisation of mitochondrial and cytosolic trypanothione-dependent tryparedoxin peroxidases in Trypanosoma brucei

Tetaud, E., Giroud, C., Prescott, A. R., Parkin, D. W., Baltz, D., Biteau, N., Baltz, T. & Fairlamb, A. H., Sep 2001, In : Molecular and Biochemical Parasitology. 116, 2, p. 171-183 13 p.

Research output: Contribution to journalArticle

70 Citations (Scopus)

Nuclear localization of protein phosphatase 5 is dependent on the carboxy-terminal region

Borthwick, E. B., Zeke, T., Prescott, A. R. & Cohen, P. T. W., 2 Mar 2001, In : FEBS Letters. 491, 3, p. 279-284 6 p.

Research output: Contribution to journalArticle

45 Citations (Scopus)
203 Citations (Scopus)

The trigger to cell death determines the efficiency with which dying cells are cleared by neighbours

Wiegand, U. K., Corbach, S., Prescott, A. R., Savill, J. & Spruce, B. A., 2001, In : Cell Death & Differentiation. 8, 7, p. 734-746 13 p.

Research output: Contribution to journalArticle

46 Citations (Scopus)
2000

A role for the actin cytoskeleton in the hormonal and growth-factor-mediated activation of protein kinase B

Peyrollier, K., Hajduch, E., Gray, A., Litherland, G. J., Prescott, A. R., Leslie, N. R. & Hundal, H. S., 15 Dec 2000, In : Biochemical Journal. 352, 3, p. 617-622 6 p.

Research output: Contribution to journalArticle

48 Citations (Scopus)

Rac is required for constitutive macropinocytosis by dendritic cells but does not control its downregulation

West, M. A., Prescott, A. R., Eskelinen, E. L., Ridley, A. J. & Watts, C., 15 Jul 2000, In : Current Biology. 10, 14, p. 839-848 10 p.

Research output: Contribution to journalArticle

200 Citations (Scopus)

Rapid induction of apoptosis mediated by peptides that bind initiation factor eIF4E

Herbert, T. P., Fåhraeus, R., Prescott, A., Lane, D. P. & Proud, C. G., 1 Jun 2000, In : Current Biology. 10, 13, p. 793-796 4 p.

Research output: Contribution to journalArticle

85 Citations (Scopus)

Rhabdomyosarcoma ρ0 cells: Isolation and characterization of a mitochondrial DNA depleted cell line with 'muscle-like' properties

Vergani, L., Prescott, A. R. & Holt, I. J., 1 Aug 2000, In : Neuromuscular Disorders . 10, 6, p. 454-459 6 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

The manganese cation disrupts membrane dynamics along the secretory pathway

Towler, M. C., Prescott, A. R., James, J., Lucocq, J. M. & Ponnambalam, S., 25 Aug 2000, In : Experimental Cell Research. 259, 1, p. 167-179 13 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)
53 Citations (Scopus)

Up-regulation of novel intermediate filament proteins in primary fiber cells: An indicator of all vertebrate lens fiber differentiation?

Ireland, M. E., Wallace, P., Sandilands, A., Poosch, M., Kasper, M., Graw, J., Liu, A., Maisel, H., Prescott, A. R., Hutcheson, A. M., Goebel, D. & Quinlan, R. A., 1 Jan 2000, In : Anatomical Record. 258, 1, p. 25-33 9 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)
1999

Forward and retrograde trafficking in mitotic animal cells ER-Golgi transport arrest restricts protein export from the ER into COPII-coated structures

Farmaki, T., Ponnambalam, S., Prescott, A. R., Clausen, H., Tang, B. L., Hong, W. & Lucocq, J. M., 1 Mar 1999, In : Journal of Cell Science. 112, 5, p. 589-600 12 p.

Research output: Contribution to journalArticle

59 Citations (Scopus)

Gap junctions containing α8-connexin (MP70) in the adult mammalian lens epithelium suggests a re-evaluation of its role in the lens

Dahm, R., van Marle, J., Prescott, A. R. & Quinlan, R. A., Jul 1999, In : Experimental Eye Research. 69, 1, p. 45-56 12 p.

Research output: Contribution to journalArticle

55 Citations (Scopus)

Intermediate filament interactions can be altered by HSP27 and αB-crystallin

Der Perng, M., Cairns, L., Van Den IJssel, P., Prescott, A., Hutcheson, A. M. & Quinlan, R. A., 1 Jul 1999, In : Journal of Cell Science. 112, 13, p. 2099-2112 14 p.

Research output: Contribution to journalArticle

307 Citations (Scopus)

Membrane ruffling, macropinocytosis and antigen presentation in the absence of gelsolin in murine dendritic cells

West, M. A., Antoniou, A. N., Prescott, A. R., Azuma, T., Kwiatkowski, D. J. & Watts, C., Nov 1999, In : European Journal of Immunology. 29, 11, p. 3450-3455 6 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)

Nuclear organisation of NIPP1, a regulatory subunit of protein phosphatase 1 that associates with pre-mRNA splicing factors

Trinkle-Mulcahy, L., Ajuh, P., Prescott, A., Claverie-Martin, F., Cohen, S., Lamond, A. I. & Cohen, P., 19 Feb 1999, In : Journal of Cell Science. 112, 2, p. 157-168 12 p.

Research output: Contribution to journalArticle

Open Access
52 Citations (Scopus)

The eye lens cytoskeleton

Quinlan, R. A., Sandilands, A., Procter, J. E., Prescott, A. R., Hutcheson, A. M., Dahm, R., Gribbon, C., Wallace, P. & Carter, J. M., May 1999, In : Eye (Basingstoke). 13, 3, p. 409-416 8 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)
1998

AMP-activated protein kinase: Greater AMP dependence, and preferential nuclear localization, of complexes containing the α2 isoform

Salt, I., Celler, J. W., Hawley, S. A., Prescott, A., Woods, A., Carling, D. & Hardie, D. G., 15 Aug 1998, In : Biochemical Journal. 334, 1, p. 177-187 11 p.

Research output: Contribution to journalArticle

352 Citations (Scopus)