• 11542 Citations
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1988 …2019
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Research Output 1988 2019

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Article
2004
103 Citations (Scopus)

The in vivo role of PtdIns(3,4,5)P3 binding to PDK1 PH domain defined by knockin mutation

McManus, E. J., Collins, B. J., Ashby, P. R., Prescott, A. R., Murray-Tait, V., Armit, L. J., Arthur, J. S. C. & Alessi, D. R., 19 May 2004, In : EMBO Journal. 23, 10, p. 2071-2082 12 p.

Research output: Contribution to journalArticle

3-Phosphoinositide-Dependent Protein Kinases
Proto-Oncogene Proteins c-akt
Mutation
Ribosomal Protein S6 Kinases
Embryonic Structures
66 Citations (Scopus)

WNK1, the kinase mutated in an inherited high-blood-pressure syndrome, is a novel PKB (protein kinase B)/Akt substrate

Vitari, A. C., Deak, M., Collins, B. J., Morrice, N., Prescott, A. R., Phelan, A., Humphreys, S. & Alessi, D. R., 15 Feb 2004, In : Biochemical Journal. 378, 1, p. 257-268 12 p.

Research output: Contribution to journalArticle

Proto-Oncogene Proteins c-akt
Phosphorylation
Blood pressure
Phosphotransferases
Hypertension
2003
73 Citations (Scopus)

Cajal body proteins SMN and Coilin show differential dynamic behaviour in vivo

Sleeman, J. E., Trinkle-Mulcahy, L., Prescott, A. R., Ogg, S. C. & Lamond, A. I., 1 Apr 2003, In : Journal of Cell Science. 116, 10, p. 2039-2050 12 p.

Research output: Contribution to journalArticle

Motor Neurons
Mitosis
Proteins
Fluorescence Recovery After Photobleaching
Telophase
11 Citations (Scopus)

Cholesterol oxides mediated changes in cytoskeletal organisation involves Rho GTPases

Girão, H., Pereira, P., Ramalho, J., Quinlan, R. & Prescott, A., 1 Dec 2003, In : Experimental Cell Research. 291, 2, p. 502-513 12 p.

Research output: Contribution to journalArticle

rho GTP-Binding Proteins
Pseudopodia
Oxides
Cholesterol
Vimentin
16 Citations (Scopus)
4 Citations (Scopus)

Identification of a novel intercellular structure in late-stage differentiating lens cells

Dahm, R. & Prescott, A. R., 10 Feb 2003, In : Ophthalmic Research. 35, 1, p. 2-7 6 p.

Research output: Contribution to journalArticle

Lenses
Organelles
Reticulum
Nuclear Envelope
Golgi Apparatus
37 Citations (Scopus)

Interaction of the protein tyrosine phosphatase PTPL1 with the PtdIns(3,4)P2-binding adaptor protein TAPP1

Kimber, W. A., Deak, M., Prescott, A. R. & Alessi, D. R., 1 Dec 2003, In : Biochemical Journal. 376, 2, p. 525-535 11 p.

Research output: Contribution to journalArticle

Protein Tyrosine Phosphatases
Carrier Proteins
Proteins
Cell membranes
Phosphoric Monoester Hydrolases
68 Citations (Scopus)

Knockout of the intermediate filament protein CP49 destabilises the lens fibre cell cytoskeleton and decreases lens optical quality, but does not induce cataract

Sandilands, A., Prescott, A. R., Wegener, A., Zoltoski, R. K., Hutcheson, A. M., Masaki, S., Kuszak, J. R. & Quinlan, R. A., Mar 2003, In : Experimental Eye Research. 76, 3, p. 385-391 7 p.

Research output: Contribution to journalArticle

Intermediate Filament Proteins
Cytoskeleton
Cataract
Lenses
Cell Membrane
225 Citations (Scopus)

Loss of Kindlin-1, a human homolog of the Caenorhabditis elegans actin–extracellular-matrix linker protein UNC-112, causes Kindler syndrome

Siegel, D. H., Ashton, G. H. S., Penagos, H. G., Lee, J. V., Feiler, H. S., Wilhelmsen, K. C., South, A. P., Smith, F., Prescott, A. R., Wessagowit, V., Oyama, N., Akiyama, M., Al Aboud, D., Al Aboud, K., Al Githami, A., Al Hawsawi, K., Al Ismaily, A., Al-Suwaid, R., Atherton, D. J., Caputo, R. & 22 others, Fine, J-D., Frieden, I. J., Fuchs, E., Haber, R. M., Harada, T., Kitajima, Y., Mallory, S. B., Ogawa, H., Sahin, S., Shimizu, H., Suga, Y., Tadini, G., Tsuchiya, K., Wiebe, C. B., Wojnarowska, F., Zaghloul, A. B., Hamada, T., Mallipeddi, R., Eady, R. A. J., McLean, I., McGrath, J. A. & Epstein, E. H., 2003, In : American Journal of Human Genetics. 73, 1, p. 174-187 14 p.

Research output: Contribution to journalArticle

304 Citations (Scopus)

MO25α/β interact with STRADα/β enhancing their ability to bind, activate and localize LKB1 in the cytoplasm

Boudeau, J., Baas, A. F., Deak, M., Morrice, N. A., Kieloch, A., Schutkowski, M., Prescott, A. R., Clevers, H. C. & Alessi, D. R., 1 Oct 2003, In : EMBO Journal. 22, 19, p. 5102-5114 13 p.

Research output: Contribution to journalArticle

Protein Isoforms
Cytoplasm
Peutz-Jeghers Syndrome
Cell Polarity
Cell proliferation
89 Citations (Scopus)

Nodulation of Mimosa spp. by the β-Proteobacterium Ralstonia taiwanensis

Chen, W-M., James, E. K., Prescott, A. R., Kierans, M. & Sprent, J. I., Dec 2003, In : Molecular Plant-Microbe Interactions. 16, 12, p. 1051-1061 11 p.

Research output: Contribution to journalArticle

Ralstonia
Mimosa
Mimosa pudica
Proteobacteria
nitrogenase
58 Citations (Scopus)

Nuclear speckle localisation of the small heat shock protein αB-crystallin and its inhibition by the R120G cardiomyopathy-linked mutation

Van Den Ijssel, P., Wheelock, R., Prescott, A., Russell, P. & Quinlan, R. A., Jul 2003, In : Experimental Cell Research. 287, 2, p. 249-261 13 p.

Research output: Contribution to journalArticle

Small Heat-Shock Proteins
Crystallins
Cardiomyopathies
Mutation
IgA receptor
26 Citations (Scopus)

Observation of keratin particles showing fast bidirectional movement colocalized with microtubules

Liovic, M., Mogensen, M. M., Prescott, A. R. & Lane, E. B., 2003, In : Journal of Cell Science. 116, 8, p. 1417-1427 11 p.

Research output: Contribution to journalArticle

Keratins
Microtubules
Observation
Intermediate Filaments
Epithelial Cells
109 Citations (Scopus)

Time-lapse Imaging Reveals Dynamic Relocalization of PP1γ throughout the Mammalian Cell Cycle

Trinkle-Mulcahy, L., Andrews, P. D., Wickramasinghe, S., Sleeman, J., Prescott, A., Lam, Y. W., Lyon, C., Swedlow, J. R. & Lamond, A. I., 1 Jan 2003, In : Molecular Biology of the Cell. 14, 1, p. 107-117 11 p.

Research output: Contribution to journalArticle

Time-Lapse Imaging
Protein Phosphatase 1
Cell Cycle
Proteins
Telophase
2002
112 Citations (Scopus)

Altered aggregation properties of mutant γ-crystallins cause inherited cataract

Sandilands, A., Hutcheson, A. M., Long, H. A., Prescott, A. R., Vrensen, G., Loster, J., Klopp, N., Lutz, R. B., Graw, J., Masaki, S., Dobson, C. M., MacPhee, C. E. & Quinlan, R. A., Nov 2002, In : The EMBO Journal. 21, 22, p. 6005-6014 10 p.

Research output: Contribution to journalArticle

Crystallins
Cataract
Agglomeration
Amyloid
Lenses
22 Citations (Scopus)
Nuclear Matrix
Lenses
Cell Differentiation
Epithelial Cells
Staining and Labeling
241 Citations (Scopus)

Essential role of PDK1 in regulating cell size and development in mice

Lawlor, M. A., Mora, A., Ashby, P. R., Williams, M. R., Murray-Tait, V., Malone, L., Prescott, A. R., Lucocq, J. M. & Alessi, D. R., 15 Jul 2002, In : EMBO Journal. 21, 14, p. 3728-3738 11 p.

Research output: Contribution to journalArticle

Open Access
Insulin
Cell Size
Animals
Phosphotransferases
Chemical activation
98 Citations (Scopus)

Fin development in a cartilaginous fish and the origin of vertebrate limbs

Tanaka, M., Munsterberg, A., Anderson, W. G., Prescott, A. R., Hazon, N. & Tickle, C., 4 Apr 2002, In : Nature. 416, 6880, p. 527-531 5 p.

Research output: Contribution to journalArticle

Dogfish
Vertebrates
Fishes
Extremities
Chick Embryo
121 Citations (Scopus)

Inhibition of autophagy in mitotic animal cells

Eskelinen, E-L., Prescott, A. R., Cooper, J., Brachmann, S. M., Wang, L., Tang, X., Backer, J. M. & Lucocq, J. M., 2002, In : Traffic. 3, 12, p. 878-893 16 p.

Research output: Contribution to journalArticle

Autophagy
Phosphatidylinositols
Animals
Phosphotransferases
Cells
10 Citations (Scopus)

Morphological changes and nuclear pore clustering during nuclear degradation in differentiating bovine lens fibre cells

Dahm, R. & Prescott, A. R., 1 Dec 2002, In : Ophthalmic Research. 34, 5, p. 288-294 7 p.

Research output: Contribution to journalArticle

Nuclear Pore
Lenses
Cluster Analysis
Organelles
Cell Differentiation
121 Citations (Scopus)
136 Downloads (Pure)
Open Access
File
Adenomatous Polyposis Coli Protein
Adenomatous Polyposis Coli
Microtubules
Epithelial Cells
Licensure
179 Citations (Scopus)

Two novel phosphorylation sites on FKHR that are critical for its nuclear exclusion

Rena, G., Woods, Y. L., Prescott, A. R., Peggie, M., Unterman, T. G., Williams, M. R. & Cohen, P., 2002, In : The EMBO Journal. 21, 9, p. 2263-2271 9 p.

Research output: Contribution to journalArticle

Phosphorylation
Proto-Oncogene Proteins c-akt
Somatomedins
Embryonic Stem Cells
Stem cells
2001
15 Citations (Scopus)

An essential role for calmodulin in regulating human T cell aggregation

Fagerholm, S. C., Prescott, A., Cohen, P., Gahmberg, C. G. & Lehto, V-P. (ed.), 28 Feb 2001, In : FEBS Letters. 491, 1-2, p. 131-6 6 p.

Research output: Contribution to journalArticle

Cell Aggregation
T-cells
Calmodulin
Actins
Agglomeration
49 Citations (Scopus)

Antagonistic action of Six3 and Prox1 at the γ-crystallin promoter

Lengler, J., Krausz, E., Tomarev, S., Prescott, A., Quinlan, R. A. & Graw, J., 15 Jan 2001, In : Nucleic Acids Research. 29, 2, p. 515-526 12 p.

Research output: Contribution to journalArticle

Crystallins
Lenses
Cell Line
Crystalline Lens
Transfection
50 Citations (Scopus)

Evidence for prebudding arrest of ER export in animal cell mitosis and its role in generating Golgi partitioning intermediates

Prescott, A. R., Farmaki, T., Thomson, C., James, J., Paccaud, J-P., Tang, B-L., Hong, W., Quinn, M., Ponnambalam, S. & Lucocq, J., May 2001, In : Traffic. 2, 5, p. 321-335 15 p.

Research output: Contribution to journalArticle

Mutant Proteins
Mitosis
Endoplasmic Reticulum
Recycling
Animals
67 Citations (Scopus)

Molecular characterisation of mitochondrial and cytosolic trypanothione-dependent tryparedoxin peroxidases in Trypanosoma brucei

Tetaud, E., Giroud, C., Prescott, A. R., Parkin, D. W., Baltz, D., Biteau, N., Baltz, T. & Fairlamb, A. H., Sep 2001, In : Molecular and Biochemical Parasitology. 116, 2, p. 171-183 13 p.

Research output: Contribution to journalArticle

Trypanosoma brucei brucei
Crithidia fasciculata
NADP
Hydrogen Peroxide
Peroxiredoxins
44 Citations (Scopus)

Nuclear localization of protein phosphatase 5 is dependent on the carboxy-terminal region

Borthwick, E. B., Zeke, T., Prescott, A. R. & Cohen, P. T. W., 2 Mar 2001, In : FEBS Letters. 491, 3, p. 279-284 6 p.

Research output: Contribution to journalArticle

Phosphoprotein Phosphatases
Cytoplasm
HeLa Cells
Phosphoric Monoester Hydrolases
Carcinogens
199 Citations (Scopus)
Phosphorylation
Rhabdomyosarcoma
Transcriptional Activation
14-3-3 Proteins
Proto-Oncogene Proteins c-akt
46 Citations (Scopus)

The trigger to cell death determines the efficiency with which dying cells are cleared by neighbours

Wiegand, U. K., Corbach, S., Prescott, A. R., Savill, J. & Spruce, B. A., 2001, In : Cell Death & Differentiation. 8, 7, p. 734-746 13 p.

Research output: Contribution to journalArticle

Cell Death
Staurosporine
Etoposide
Phagocytes
Initiator Caspases
2000
48 Citations (Scopus)

A role for the actin cytoskeleton in the hormonal and growth-factor-mediated activation of protein kinase B

Peyrollier, K., Hajduch, E., Gray, A., Litherland, G. J., Prescott, A. R., Leslie, N. R. & Hundal, H. S., 15 Dec 2000, In : Biochemical Journal. 352, 3, p. 617-622 6 p.

Research output: Contribution to journalArticle

Proto-Oncogene Proteins c-akt
Phosphatidylinositols
Actin Cytoskeleton
Actins
Intercellular Signaling Peptides and Proteins
199 Citations (Scopus)

Rac is required for constitutive macropinocytosis by dendritic cells but does not control its downregulation

West, M. A., Prescott, A. R., Eskelinen, E. L., Ridley, A. J. & Watts, C., 15 Jul 2000, In : Current Biology. 10, 14, p. 839-848 10 p.

Research output: Contribution to journalArticle

dendritic cells
Dendritic Cells
Down-Regulation
lipopolysaccharides
Lipopolysaccharides
84 Citations (Scopus)

Rapid induction of apoptosis mediated by peptides that bind initiation factor eIF4E

Herbert, T. P., Fåhraeus, R., Prescott, A., Lane, D. P. & Proud, C. G., 1 Jun 2000, In : Current Biology. 10, 13, p. 793-796 4 p.

Research output: Contribution to journalArticle

Peptide Initiation Factors
apoptosis
peptides
Apoptosis
Peptides
7 Citations (Scopus)

Rhabdomyosarcoma ρ0 cells: Isolation and characterization of a mitochondrial DNA depleted cell line with 'muscle-like' properties

Vergani, L., Prescott, A. R. & Holt, I. J., 1 Aug 2000, In : Neuromuscular Disorders . 10, 6, p. 454-459 6 p.

Research output: Contribution to journalArticle

Rhabdomyosarcoma
Cell Separation
Mitochondrial DNA
Cell Line
Muscles
38 Citations (Scopus)

The manganese cation disrupts membrane dynamics along the secretory pathway

Towler, M. C., Prescott, A. R., James, J., Lucocq, J. M. & Ponnambalam, S., 25 Aug 2000, In : Experimental Cell Research. 259, 1, p. 167-179 13 p.

Research output: Contribution to journalArticle

Secretory Pathway
Manganese
Endoplasmic Reticulum
Cations
Golgi Apparatus
52 Citations (Scopus)
DEAD-box RNA Helicases
Telophase
Nuclear Proteins
Proteins
RNA Helicases
26 Citations (Scopus)

Up-regulation of novel intermediate filament proteins in primary fiber cells: An indicator of all vertebrate lens fiber differentiation?

Ireland, M. E., Wallace, P., Sandilands, A., Poosch, M., Kasper, M., Graw, J., Liu, A., Maisel, H., Prescott, A. R., Hutcheson, A. M., Goebel, D. & Quinlan, R. A., 1 Jan 2000, In : Anatomical Record. 258, 1, p. 25-33 9 p.

Research output: Contribution to journalArticle

intermediate filament proteins
Intermediate Filament Proteins
fiber cells
Lens
Lenses
1999
59 Citations (Scopus)

Forward and retrograde trafficking in mitotic animal cells ER-Golgi transport arrest restricts protein export from the ER into COPII-coated structures

Farmaki, T., Ponnambalam, S., Prescott, A. R., Clausen, H., Tang, B. L., Hong, W. & Lucocq, J. M., 1 Mar 1999, In : Journal of Cell Science. 112, 5, p. 589-600 12 p.

Research output: Contribution to journalArticle

Recycling
Protein Transport
Proteins
Immunoelectron Microscopy
Enzymes
55 Citations (Scopus)

Gap junctions containing α8-connexin (MP70) in the adult mammalian lens epithelium suggests a re-evaluation of its role in the lens

Dahm, R., van Marle, J., Prescott, A. R. & Quinlan, R. A., Jul 1999, In : Experimental Eye Research. 69, 1, p. 45-56 12 p.

Research output: Contribution to journalArticle

Connexins
Gap Junctions
Lenses
Epithelium
Epithelial Cells
302 Citations (Scopus)

Intermediate filament interactions can be altered by HSP27 and αB-crystallin

Der Perng, M., Cairns, L., Van Den IJssel, P., Prescott, A., Hutcheson, A. M. & Quinlan, R. A., 1 Jul 1999, In : Journal of Cell Science. 112, 13, p. 2099-2112 14 p.

Research output: Contribution to journalArticle

Crystallins
Intermediate Filaments
Small Heat-Shock Proteins
MCF-7 Cells
Gels
34 Citations (Scopus)

Membrane ruffling, macropinocytosis and antigen presentation in the absence of gelsolin in murine dendritic cells

West, M. A., Antoniou, A. N., Prescott, A. R., Azuma, T., Kwiatkowski, D. J. & Watts, C., Nov 1999, In : European Journal of Immunology. 29, 11, p. 3450-3455 6 p.

Research output: Contribution to journalArticle

Gelsolin
Antigen Presentation
Dendritic Cells
Membranes
Actin Cytoskeleton
52 Citations (Scopus)

Nuclear organisation of NIPP1, a regulatory subunit of protein phosphatase 1 that associates with pre-mRNA splicing factors

Trinkle-Mulcahy, L., Ajuh, P., Prescott, A., Claverie-Martin, F., Cohen, S., Lamond, A. I. & Cohen, P., 19 Feb 1999, In : Journal of Cell Science. 112, 2, p. 157-168 12 p.

Research output: Contribution to journalArticle

Open Access
Protein Phosphatase 1
RNA Precursors
Phosphoprotein Phosphatases
Carrier Proteins
Binding Sites
31 Citations (Scopus)

The eye lens cytoskeleton

Quinlan, R. A., Sandilands, A., Procter, J. E., Prescott, A. R., Hutcheson, A. M., Dahm, R., Gribbon, C., Wallace, P. & Carter, J. M., May 1999, In : Eye (Basingstoke). 13, 3, p. 409-416 8 p.

Research output: Contribution to journalArticle

Crystalline Lens
Cytoskeleton
Lenses
Intermediate Filaments
Cell Shape
1998
343 Citations (Scopus)

AMP-activated protein kinase: Greater AMP dependence, and preferential nuclear localization, of complexes containing the α2 isoform

Salt, I., Celler, J. W., Hawley, S. A., Prescott, A., Woods, A., Carling, D. & Hardie, D. G., 15 Aug 1998, In : Biochemical Journal. 334, 1, p. 177-187 11 p.

Research output: Contribution to journalArticle

AMP-Activated Protein Kinases
Adenosine Monophosphate
Protein Isoforms
Phosphotransferases
Adenosine Triphosphate
61 Citations (Scopus)

Changes in the nucleolar and coiled body compartments precede lamina and chromatin reorganization during fibre cell denucleation in the bovine lens

Dahm, R., Gribbon, C., Quinlan, R. A. & Prescott, A. R., Mar 1998, In : European Journal of Cell Biology. 75, 3, p. 237-246 10 p.

Research output: Contribution to journalArticle

Coiled Bodies
Lenses
Chromatin
Apoptosis
Mitochondrial Degradation
6 Citations (Scopus)

Susceptibility of lens epithelial and fibre cells at different stages of differentiation to apoptosis

Dahm, R., Gribbon, C., Quinlan, R. A. & Prescott, A. R., Nov 1998, In : Biochemical Society Transactions. 26, 4, p. 118 1 p., S349.

Research output: Contribution to journalArticle

60 Citations (Scopus)

Three murine cataract mutants (Cat2) are defective in different γ- crystallin genes

Klopp, N., Favor, J., Löster, J., Lutz, R. B., Neuhäuser-Klaus, A., Prescott, A., Pretsch, W., Quinlan, R. A., Sandilands, A., Vrensen, G. F. J. M. & Graw, J., 1 Sep 1998, In : Genomics. 52, 2, p. 152-158 7 p.

Research output: Contribution to journalArticle

Crystallins
Cataract
Mutation
Genes
Exons
1997
35 Citations (Scopus)

Antigen endocytosis and presentation mediated by human membrane IgG1 in the absence of the IgA/Igβ dimer

Knight, A. M., Lucocq, J. M., Prescott, A. R., Ponnambalam, S. & Watts, C., 1 Jul 1997, In : EMBO Journal. 16, 13, p. 3842-3850 9 p.

Research output: Contribution to journalArticle

Antigen Presentation
Endocytosis
Dimers
Immunoglobulin A
Immunoglobulin G
276 Citations (Scopus)
Histocompatibility
Major Histocompatibility Complex
Dendritic Cells
Bone Marrow
Antigens
106 Citations (Scopus)

Distinct compartmentalization of TGN46 and β1,4-galactosyltransferase in HeLa cells

Prescott, A. R., Lucocq, J. M., James, J., Lister, J. M. & Ponnambalam, S., Mar 1997, In : European Journal of Cell Biology. 72, 3, p. 238-246 9 p.

Research output: Contribution to journalArticle

Galactosyltransferases
HeLa Cells
Confocal Microscopy
Immunoelectron Microscopy
Golgi Apparatus