Ciulli, Alessio


If you made any changes in Pure these will be visible here soon.

Fingerprint Dive into the research topics where Alessio Ciulli is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 4 Similar Profiles
Ubiquitin-Protein Ligases Medicine & Life Sciences
Proteolysis Medicine & Life Sciences
pantothenate synthetase Medicine & Life Sciences
Ligands Medicine & Life Sciences
Proteins Medicine & Life Sciences
Molecules Chemical Compounds
Cullin Proteins Medicine & Life Sciences
Mycobacterium tuberculosis Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2013 2022

Research Output 2008 2019

3 Citations (Scopus)

BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design

Farnaby, W., Koegl, M., Roy, M. J., Whitworth, C., Diers, E., Trainor, N., Zollman, D., Steurer, S., Karolyi-Oezguer, J., Riedmueller, C., Gmaschitz, T., Wachter, J., Dank, C., Galant, M., Sharps, B., Rumpel, K., Traxler, E., Gerstberger, T., Schnitzer, R., Petermann, O. & 17 others, Greb, P., Weinstabl, H., Bader, G., Zoephel, A., Weiss-Puxbaum, A., Ehrenhöfer-Wölfer, K., Wöhrle, S., Boehmelt, G., Rinnenthal, J., Arnhof, H., Wiechens, N., Wu, M-Y., Owen-Hughes, T., Ettmayer, P., Pearson, M., McConnell, D. B. & Ciulli, A., Jul 2019, In : Nature Chemical Biology. 15, 7, p. 672-680 9 p.

Research output: Contribution to journalArticle

Adenosine Triphosphatases
Chromatin Assembly and Disassembly

Bifunctional chemical probes inducing protein-protein interactions

Maniaci, C. & Ciulli, A., 13 Aug 2019, In : Current Opinion in Chemical Biology. 52, p. 145-156 12 p.

Research output: Contribution to journalReview article

Ubiquitin-Protein Ligases
1 Citation (Scopus)

Cereblon versus VHL: Hijacking E3 ligases against each other using PROTACs

Girardini, M., Maniaci, C., Hughes, S., Testa, A. & Ciulli, A., 15 Jun 2019, In : Bioorganic & Medicinal Chemistry. 27, 12, p. 2466-2479 14 p.

Research output: Contribution to journalArticle

Open Access
Ubiquitin-Protein Ligases
Cullin Proteins

Design and Characterization of SGK3-PROTAC1, an Isoform Specific SGK3 Kinase PROTAC Degrader

Tovell, H., Testa, A., Zhou, H., Shpiro, N., Crafter, C., Ciulli, A. & Alessi, D., 28 Aug 2019, In : ACS Chemical Biology. 11 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinases
Protein Isoforms

Highly Selective PTK2 Proteolysis Targeting Chimeras to Probe Focal Adhesion Kinase Scaffolding Functions

Popow, J., Arnhof, H., Bader, G., Berger, H., Ciulli, A., Covini, D., Dank, C., Gmaschitz, T., Greb, P., Karolyi-Özguer, J., Koegl, M., McConnell, D. B., Pearson, M., Rieger, M., Rinnenthal, J., Roessler, V., Schrenk, A., Spina, M., Steurer, S., Trainor, N. & 4 others, Traxler, E., Wieshofer, C., Zoephel, A. & Ettmayer, P., 14 Mar 2019, In : Journal of Medicinal Chemistry. 62, 5, p. 2508–2520 13 p.

Research output: Contribution to journalArticle

Focal Adhesion Protein-Tyrosine Kinases
Hepatocellular Carcinoma
Cell Line
Ubiquitin-Protein Ligases


A ‘bump-&-hole’ approach for engineering allele-selective inhibition of the BET bromodomains

Author: Runcie, A. C., 2019

Supervisor: Ciulli, A. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy


Discovery of high quality molecular leads and screening collections for CNS drug targets

Author: Farnaby, W., 2019

Supervisor: Ciulli, A. (Supervisor) & Read, K. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

Fragment-based approaches to probe the surface of the VHL E3 ligase

Author: Castro, G., 2019

Supervisor: Ciulli, A. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

Ligandability of protein-protein interactions and surfaces on Cullin RING E3 ubiquitin ligases

Author: Cardote, T. A. D. F., 2017

Supervisor: Ciulli, A. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy


Protein-Protein Interactions and Small Molecule Targeting of the Multisubunit SOCS2-EloBC-Cul5-Rbx2 E3 Ubiquitin Ligase

Author: Kung, W., 2018

Supervisor: Ciulli, A. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy