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  • 7 Similar Profiles
Ubiquitin-Protein Ligases Medicine & Life Sciences
pantothenate synthetase Medicine & Life Sciences
Proteolysis Medicine & Life Sciences
Ligands Medicine & Life Sciences
Proteins Medicine & Life Sciences
Molecules Chemical Compounds
Mycobacterium tuberculosis Medicine & Life Sciences
Cullin Proteins Medicine & Life Sciences

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Projects 2013 2022

Research Output 2008 2019

Highly Selective PTK2 Proteolysis Targeting Chimeras (PROTACs) to Probe Focal Adhesion Kinase Scaffolding Functions

Popow, J., Arnhof, H., Bader, G., Berger, H., Ciulli, A., Covini, D., Dank, C., Gmaschitz, T., Greb, P., Karolyi-Özguer, J., Koegl, M., McConnell, D. B., Pearson, M., Rieger, M., Rinnenthal, J., Roessler, V., Schrenk, A., Spina, M., Steurer, S., Trainor, N. & 4 othersTraxler, E., Wieshofer, C., Zoephel, A. & Ettmayer, P., 9 Feb 2019, In : Journal of Medicinal Chemistry.

Research output: Contribution to journalArticle

Focal Adhesion Protein-Tyrosine Kinases
Proteolysis
Hepatocellular Carcinoma
Cell Line
Ubiquitin-Protein Ligases

SPR-measured dissociation kinetics of PROTAC ternary complexes influence target degradation rate

Roy, M., Winkler, S., Hughes, S. J., Whitworth, C., Galant, M., Farnaby, W., Rumpel, K. & Ciulli, A., 5 Feb 2019, In : ACS Chemical Biology.

Research output: Contribution to journalArticle

Proteolysis
Enzyme kinetics
Degradation
Assays
Ubiquitin-Protein Ligases

Spy vs. Spy: Selecting the best reporter for 19F NMR competition experiment

Castro, G. V. D. & Ciulli, A., 2019, In : Chemical Communications. 55, 10, p. 1482-1485 4 p.

Research output: Contribution to journalArticle

Open Access
File
Assays
Screening
Ligands
Nuclear magnetic resonance
Molecules
4 Citations

3-Fluoro-4-hydroxyprolines: Synthesis, conformational analysis and stereoselective recognition by the VHL E3 ubiquitin ligase for targeted protein degradation

Testa, A., Lucas, X., Castro, G., Chan, K. H., Wright, J., Runcie, A., Gadd, M., Harrison, W. T. A., Ko, E. J., Fletcher, D. & Ciulli, A., 25 Jul 2018, In : Journal of the American Chemical Society. 140, 29, p. 9299-9313 15 p.

Research output: Contribution to journalArticle

Open Access
File
Hydroxyproline
Ubiquitin-Protein Ligases
Proteolysis
Proteins
Degradation
26 Citations
Open Access
File
WEB 2086
Proteolysis
Ligands
Ubiquitin-Protein Ligases
Myeloid Cells

Thesis

A ‘bump-&-hole’ approach for engineering allele-selective inhibition of the BET bromodomains

Author: Runcie, A. C., 2019

Supervisor: Ciulli, A. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

File

Ligandability of protein-protein interactions and surfaces on Cullin RING E3 ubiquitin ligases

Author: Cardote, T. A. D. F., 2017

Supervisor: Ciulli, A. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

File

Protein-Protein Interactions and Small Molecule Targeting of the Multisubunit SOCS2-EloBC-Cul5-Rbx2 E3 Ubiquitin Ligase

Author: Kung, W., 2018

Supervisor: Ciulli, A. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

Small-molecule approaches to interrogate the druggability of the VHL E3 Cullin RING Ubiquitin Ligase

Author: Soares, P., 2018

Supervisor: Ciulli, A. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

Structural studies of paired PHD finger-bromodomain chromatin-binding modules: targeting epigenetic readers with chemical probes

Author: Amato, A., 2018

Supervisor: Ciulli, A. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

File