Projects per year
Personal profile
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Dive into the research topics where Alessio Ciulli is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Small Molecule Assisted Protein-Protein Interaction Mapping via Peroxidase Activity (MapPEX)
Ciulli, A. (Investigator)
1/07/24 → 30/06/26
Project: Research
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EUbOPEN: Enabling and Unlocking biology in the OPEN (Joint with Goethe University Frankfurt, University of Oxford, Karolinska Institute and 9 others)
Ciulli, A. (Investigator)
COMMISSION OF THE EUROPEAN COMMUNITIES
1/05/20 → 31/10/25
Project: Research
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Green PROTACs – bringing targeted protein degradation to plants for rapid research progress
Ciulli, A. (Investigator) & Hemsley, P. (Investigator)
Project: Research
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ISCEM-DD (Joint with University Of Glasgow)
Ciulli, A. (Investigator) & Nakasone, M. (Investigator)
Project: Research
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The efflux pump ABCC1/MRP1 constitutively restricts PROTAC sensitivity in cancer cells
Wolf, G., Craigon, C., Teoh, S. T., Essletzbichler, P., Onstein, S., Cassidy, D., Uijttewaal, E. C. H., Dvorak, V., Cao, Y., Bensimon, A., Elling, U., Ciulli, A. & Superti-Furga, G. (Lead / Corresponding author), 20 Feb 2025, In: Cell Chemical Biology. 32, 2, p. 291-306.e6 23 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Thoughts for the future
Alkhalaf, L. M., Arrowsmith, C., Balskus, E. P., Bergamini, G., Bhandari, R., Chang, C. J., Chen, P., Chen, X., Ciulli, A., Cricco, J. A., Davis, B. G., Delbianco, M., Dudareva, N., Dueber, E., Ferguson, F., de Giuseppe, P. O., Hamachi, I., Hammond, M. C., Hatzios, S. K. & Do Heo, W. & 29 others, , Jan 2025, In: Nature Chemical Biology. 21, p. 6-15 10 p.Research output: Contribution to journal › Comment/debate
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Combination of AID2 and BromoTag expands the utility of degron-based protein knockdowns
Hatoyama, Y., Islam, M., Bond, A. G., Hayashi, K. I., Ciulli, A. & Kanemaki, M. T. (Lead / Corresponding author), 10 Sept 2024, In: EMBO Reports. 25, 9, p. 4062-4077 16 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Confounding Factors in Targeted Degradation of Short-Lived Proteins
Vetma, V., Perez, L. C., Eliaš, J., Stingu, A., Kombara, A., Gmaschitz, T., Braun, N., Ciftci, T., Dahmann, G., Diers, E., Gerstberger, T., Greb, P., Kidd, G., Kofink, C., Puoti, I., Spiteri, V., Trainor, N., Weinstabl, H., Westermaier, Y. & Whitworth, C. & 6 others, , 19 Jul 2024, In: ACS Chemical Biology. 19, 7, p. 1484-1494 11 p.Research output: Contribution to journal › Article › peer-review
7 Citations (Scopus) -
Design of a Cereblon construct for crystallographic and biophysical studies of protein degraders
Kroupova, A., Spiteri, V., Rutter, Z., Furihata, H., Darren, D., Ramachandran, S., Chakraborti, S., Haubrich, K., Pethe, J., Gonzales, D., Wijaya, A., Rodriguez-Rios, M., Sturbaut, M., Lynch, D., Farnaby, W., Nakasone, M., Zollman, D. (Lead / Corresponding author) & Ciulli, A. (Lead / Corresponding author), 15 Oct 2024, In: Nature Communications. 15, 1, p. 8885 14 p., 8885.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)29 Downloads (Pure)
Datasets
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Crystal Structure of compound 4 in complex with KRAS G12V C118S GDP and pVHL:ElonginC:ElonginB
Zollman, D. (Creator), Farnaby, W. (Creator) & Ciulli, A. (Creator), Research Collaboratory for Structural Bioinformatics Protein Data Bank, 6 Dec 2023
DOI: 10.2210/pdb8qw7/pdb
Dataset
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Targeting cancer with small molecule panKRAS degraders
Vetma, V. (Creator) & Ciulli, A. (Creator), ProteomeXchange, 1 Oct 2024
https://proteomecentral.proteomexchange.org/cgi/GetDataset?ID=PXD045460 and one more link, https://www.ebi.ac.uk/pride/archive/projects/PXD045460 (show fewer)
Dataset
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Crystal Structure of compound 3 in complex with KRAS G12V C118S GDP and pVHL:ElonginC:ElonginB
Zollman, D. (Creator), Farnaby, W. (Creator) & Ciulli, A. (Creator), Research Collaboratory for Structural Bioinformatics Protein Data Bank, 6 Dec 2023
DOI: 10.2210/pdb8qw6/pdb
Dataset
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PROTAC-mediated complex of KRAS with VHL/Elongin-B/Elongin-C/Cullin-2/Rbx1
Fischer, G. (Creator), Peter, D. (Creator), Arce-Solano, S. (Creator) & Ciulli, A. (Creator), Research Collaboratory for Structural Bioinformatics Protein Data Bank, 6 Dec 2023
DOI: 10.2210/pdb8qu8/pdb
Dataset
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Targeting cancer with small molecule panKRAS degraders
Vetma, V. (Creator) & Ciulli, A. (Creator), ProteomeXchange, 22 Oct 2024
https://www.ebi.ac.uk/pride/archive/projects/PXD045416 and one more link, https://proteomecentral.proteomexchange.org/cgi/GetDataset?ID=PXD045416 (show fewer)
Dataset
Prizes
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Cancer Research Horizons Further, Faster, Together Industry-Academia Award
Ciulli, A. (Recipient) & McAulay, K. (Recipient), 2024
Prize: Prize (including medals and awards)
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EFMC Prize for Young Medicinal Chemist in Academia
Ciulli, A. (Recipient), 2015
Prize: Prize (including medals and awards)
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Fellow of the Royal Society of Chemistry (FRSC)
Ciulli, A. (Recipient), 2016
Prize: Election to learned society
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Fellow of the Royal Society of Edinburgh
Ciulli, A. (Recipient), 2023
Prize: Election to learned society
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ICBS Young Chemical Biologist Award
Ciulli, A. (Recipient), 2015
Prize: Prize (including medals and awards)
Activities
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Targeted Protein Degradation Talk at Perthshire Society of Natural Science
Ciulli, A. (Speaker)
1 Nov 2024Activity: Other activity types › Public engagement and outreach - public lecture/debate/seminar
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Talk at Café Scientifique
Ciulli, A. (Speaker)
21 Mar 2023Activity: Other activity types › Public engagement and outreach - public lecture/debate/seminar
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Current Opinion in Structural Biology (Journal)
Ciulli, A. (Editorial board member)
2023 → 1 Oct 2024Activity: Publication peer-review and editorial work types › Editorial activity
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CeTPD Outreach Cafe Science - Dunkeld Tour
Cabrita Gulyurtlu, S. (Organiser), Kidd, G. (Organiser), McGreavey, L. (Organiser), Ciulli, A. (Presenter), Zollman, D. (Participant), Robertson, J. (Participant), Gonzales, D. (Participant), Kroupova, A. (Participant), Farnaby, W. (Participant), McAulay, K. (Participant), Chakraborti, S. (Contributor), Diehl, C. (Contributor), Crowe, C. (Participant) & De La Caudra Baste, A. (Participant)
17 May 2023Activity: Other activity types › Public engagement and outreach - festival/exhibition
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8th NovAliX Conference ‘Developing the Synergy between Biophysics and Medicinal Chemistry to Deliver Better Drugs’, Biophysics in Drug Discovery, Munich & virtual, May 9-11, 2022 (Event)
Ciulli, A. (Member)
2022 → …Activity: Membership types › Membership of committee
Press/Media
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£38 million investment in University spinout Amphista therapeutics
16/03/21 → 17/03/21
1 item of Media coverage, 2 Media contributions
Press/Media: Other
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Marie Skłodowska-Curie Fellowship Success for School
10/03/21
1 Media contribution
Press/Media: Research