Research Output per year
Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.
- 5 Similar Profiles
Ubiquitin-Protein Ligases
Medicine & Life Sciences
pantothenate synthetase
Medicine & Life Sciences
Ligands
Medicine & Life Sciences
Proteins
Medicine & Life Sciences
Molecules
Chemical Compounds
Mycobacterium tuberculosis
Medicine & Life Sciences
Proteolysis
Medicine & Life Sciences
Cullin Proteins
Medicine & Life Sciences
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Research Output 2008 2018
3-Fluoro-4-hydroxyprolines: Synthesis, conformational analysis and stereoselective recognition by the VHL E3 ubiquitin ligase for targeted protein degradation
Testa, A., Lucas, X., Castro, G., Chan, K. H., Wright, J., Runcie, A., Gadd, M., Harrison, W. T. A., Ko, E. J., Fletcher, D. & Ciulli, A., 25 Jul 2018, In : Journal of the American Chemical Society. 140, 29, p. 9299-9313 15 p.Research output: Contribution to journal › Article
Open Access
File
Hydroxyproline
Ubiquitin-Protein Ligases
Proteolysis
Proteins
Degradation
Impact of target warhead and linkage vector on inducing protein degradation: comparison of Bromodomain and Extra-Terminal (BET) degraders derived from triazolodiazepine (JQ1) and tetrahydroquinoline (I-BET726) BET inhibitor scaffolds
Chan, K. H., Zengerle, M., Testa, A. & Ciulli, A., 25 Jan 2018, In : Journal of Medicinal Chemistry. 61, 2, p. 504-513 10 p.Research output: Contribution to journal › Article
Open Access
File
WEB 2086
Proteolysis
Ligands
Ubiquitin-Protein Ligases
Myeloid Cells
Optimization of a “Bump-and-Hole” Approach to Allele-Selective BET Bromodomain Inhibition
Runcie, A., Zengerle, M., Chan, K. H., Testa, A., Van Beurden, L., Baud, M., Epemolu, R., Ellis, L., Read, K., Coulthard, V., Brien, A. & Ciulli, A., 9 Mar 2018, In : Chemical Science. 2018, 9, p. 2387-2634 18 p., 2452.Research output: Contribution to journal › Article
Open Access
File
Benzodiazepines
Leucine
Proteins
Cell proliferation
Valine
Surface probing by fragment-based screening and computational methods identifies ligandable pockets on the von Hippel-Lindau (VHL) E3 ubiquitin ligase
Lucas, X., van Molle, I. & Ciulli, A., 24 Jul 2018, In : Journal of Medicinal Chemistry.Research output: Contribution to journal › Article
Ubiquitin-Protein Ligases
Proteins
Homeostasis
X-Rays
Ligands
Targeting ligandable pockets on PHD zinc finger domains by a fragment-based approach
Amato, A., Lucas, X., Bortoluzzi, A., Wright, D. & Ciulli, A., 20 Apr 2018, In : ACS Chemical Biology. 13, 4, p. 915-921 7 p.Research output: Contribution to journal › Article
Open Access
File
Zinc Fingers
Histones
Zinc
Homeodomain Proteins
Plant Structures
Thesis
Ligandability of protein-protein interactions and surfaces on Cullin RING E3 ubiquitin ligases
Author: Cardote, T. A. D. F., 2017Supervisor: Ciulli, A. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
File
Protein-Protein Interactions and Small Molecule Targeting of the Multisubunit SOCS2-EloBC-Cul5-Rbx2 E3 Ubiquitin Ligase
Author: Kung, W., 2018Supervisor: Ciulli, A. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
Small-molecule approaches to interrogate the druggability of the VHL E3 Cullin RING Ubiquitin Ligase
Author: Soares, P., 2018Supervisor: Ciulli, A. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
Structural studies of paired PHD finger-bromodomain chromatin-binding modules: targeting epigenetic readers with chemical probes
Author: Amato, A., 2018Supervisor: Ciulli, A. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
File
VHL inhibitors as chemical probes of the hypoxia signalling pathway
Author: Frost, J., 2018Supervisor: Ciulli, A. (Supervisor) & Rocha, S. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy