Projects per year
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- 7 Similar Profiles
Ubiquitin-Protein Ligases
Medicine & Life Sciences
pantothenate synthetase
Medicine & Life Sciences
Proteolysis
Medicine & Life Sciences
Ligands
Medicine & Life Sciences
Proteins
Medicine & Life Sciences
Molecules
Chemical Compounds
Mycobacterium tuberculosis
Medicine & Life Sciences
Cullin Proteins
Medicine & Life Sciences
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Projects 2013 2022
Understanding the Molecular Details as the Basis of Epigenetic Readers Function (Fellowship)
Bortoluzzi, A. & Ciulli, A.
1/10/15 → 30/09/16
Project: Research
High Throughput Biolayer Interferometry at Dundee for Anti-Microbial and Interaction Studies
Birch, P., Ciulli, A., Fairlamb, A., Gray, D., Hunter, W., Owen-Hughes, T., Palmer, T., Ryan, R., Sargent, F., Stanley-Wall, N. & van Aalten, D.
Biotechnology and Biological Sciences Research Council
22/01/15 → 21/01/16
Project: Research
Research Output 2008 2019
Highly Selective PTK2 Proteolysis Targeting Chimeras (PROTACs) to Probe Focal Adhesion Kinase Scaffolding Functions
Popow, J., Arnhof, H., Bader, G., Berger, H., Ciulli, A., Covini, D., Dank, C., Gmaschitz, T., Greb, P., Karolyi-Özguer, J., Koegl, M., McConnell, D. B., Pearson, M., Rieger, M., Rinnenthal, J., Roessler, V., Schrenk, A., Spina, M., Steurer, S., Trainor, N. & 4 others, 9 Feb 2019, In : Journal of Medicinal Chemistry.Research output: Contribution to journal › Article
Focal Adhesion Protein-Tyrosine Kinases
Proteolysis
Hepatocellular Carcinoma
Cell Line
Ubiquitin-Protein Ligases
SPR-measured dissociation kinetics of PROTAC ternary complexes influence target degradation rate
Roy, M., Winkler, S., Hughes, S. J., Whitworth, C., Galant, M., Farnaby, W., Rumpel, K. & Ciulli, A., 5 Feb 2019, In : ACS Chemical Biology.Research output: Contribution to journal › Article
Proteolysis
Enzyme kinetics
Degradation
Assays
Ubiquitin-Protein Ligases
Spy vs. Spy: Selecting the best reporter for 19F NMR competition experiment
Castro, G. V. D. & Ciulli, A., 2019, In : Chemical Communications. 55, 10, p. 1482-1485 4 p.Research output: Contribution to journal › Article
Open Access
File
Assays
Screening
Ligands
Nuclear magnetic resonance
Molecules
3-Fluoro-4-hydroxyprolines: Synthesis, conformational analysis and stereoselective recognition by the VHL E3 ubiquitin ligase for targeted protein degradation
Testa, A., Lucas, X., Castro, G., Chan, K. H., Wright, J., Runcie, A., Gadd, M., Harrison, W. T. A., Ko, E. J., Fletcher, D. & Ciulli, A., 25 Jul 2018, In : Journal of the American Chemical Society. 140, 29, p. 9299-9313 15 p.Research output: Contribution to journal › Article
Open Access
File
Hydroxyproline
Ubiquitin-Protein Ligases
Proteolysis
Proteins
Degradation
Impact of target warhead and linkage vector on inducing protein degradation: comparison of Bromodomain and Extra-Terminal (BET) degraders derived from triazolodiazepine (JQ1) and tetrahydroquinoline (I-BET726) BET inhibitor scaffolds
Chan, K. H., Zengerle, M., Testa, A. & Ciulli, A., 25 Jan 2018, In : Journal of Medicinal Chemistry. 61, 2, p. 504-513 10 p.Research output: Contribution to journal › Article
Open Access
File
WEB 2086
Proteolysis
Ligands
Ubiquitin-Protein Ligases
Myeloid Cells
Thesis
A ‘bump-&-hole’ approach for engineering allele-selective inhibition of the BET bromodomains
Author: Runcie, A. C., 2019Supervisor: Ciulli, A. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
File
Ligandability of protein-protein interactions and surfaces on Cullin RING E3 ubiquitin ligases
Author: Cardote, T. A. D. F., 2017Supervisor: Ciulli, A. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
File
Protein-Protein Interactions and Small Molecule Targeting of the Multisubunit SOCS2-EloBC-Cul5-Rbx2 E3 Ubiquitin Ligase
Author: Kung, W., 2018Supervisor: Ciulli, A. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
Small-molecule approaches to interrogate the druggability of the VHL E3 Cullin RING Ubiquitin Ligase
Author: Soares, P., 2018Supervisor: Ciulli, A. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
Structural studies of paired PHD finger-bromodomain chromatin-binding modules: targeting epigenetic readers with chemical probes
Author: Amato, A., 2018Supervisor: Ciulli, A. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
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