Keyphrases
Proteolysis Targeting chimera (PROTAC)
100%
Stereochemical Inversion
50%
Linker
50%
Binding Affinity
50%
Cyclohexyl
50%
Chimera Protein
50%
Patent Review
50%
E3 Ligase Ligands
50%
Targeted Protein Degradation
50%
Von Hippel-Lindau
50%
Degradation Activity
12%
E3 Ubiquitin Ligase
10%
Physicochemical Properties
10%
Chemical Space
7%
Conformational Rigidity
6%
Cyclohexyl Group
6%
Small Molecule Degrader
6%
Co-crystal Structure
6%
High-resolution
6%
E3 Ligase
6%
Target Binding
6%
Binary Complexes
6%
Long-range Interactions
6%
Leucine-rich Repeat Kinase 2 (LRRK2)
6%
Stereocenters
6%
Binding Mode
6%
Cell Degradation
6%
Degrader
6%
Ternary Complex
6%
Ternary Complex Formation
6%
Heterobifunctional
6%
VHL Ligand
6%
Ligand Binding Affinity
6%
Pharmacokinetic Properties
6%
Biochemistry, Genetics and Molecular Biology
Proteolysis
100%
Ubiquitin Ligase
58%
Protein Catabolism
50%
Conformation
50%
Binding Affinity
50%
Ubiquitin-Conjugating Enzyme
16%
Ternary Complex
16%
Complex Formation
8%
Ligand Binding
8%
Crystal Structure
8%
Pharmacokinetic Properties
8%
LRRK2
8%
Rigidity
8%
Small Molecule
8%
Tumor Suppressor Protein
8%
Ubiquitin
8%
Proteasome
8%
