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Biography
Dr McNeilly is a newly appointed Principal Investigator at the University of Dundee’s Medical School working in the Division of Systems Medicine. Her research focus is upon the impact of diabetes and, in particular, low glucose (hypoglycaemia) on cognitive and vascular function.
Dr McNeilly received her PhD from the University of Edinburgh under the supervision of Professor Ruth Andrew and Professor Brian Walker. Her subsequent Diabetes UK and JDRF funded post-doctoral research positions with Prof Rory McCrimmon (2012-2018) focused on complications associated with repeated exposure to hypoglycaemia in Type 1 diabetes. Through this work, Dr McNeilly identified a vital neuroprotective role for the transcription factor nuclear factor erythroid 2–related factor 2 (Nrf2), providing a novel therapeutic target for managing hypoglycaemia associated complications. Dr McNeilly also proposed the concept of “habituation to hypoglycaemia” as a way of describing the condition of Impaired Awareness of Hypoglycaemia (IAH). In both rodent and clinical studies, introducing a novel “dishabituating” stimulus such as High-Intensity Training or cold exposure has partially restored the symptomatic and hormonal response to hypoglycaemia. Dr McNeilly’s research also covers the role potential role of neuroinflammation and oxidative stress in diabetes-associated cognitive and vascular complications. Dr McNeilly is a member of the IMI funded HypoRESOLVE consortium and is working on Diabetes UK, Wellcome (ISSF) and Tenovus funded projects.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Role of the GSK-3NRF2 Axis In Beta Cell Decline In Type 2 Diabetes
Cantley, J., Hayes, J., McNeilly, A. & Sutherland, C.
18/04/21 → 17/04/24
Project: Research
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The Assessment of Bioenergetic Dysfunction in Chronic Disease
Ashford, M., Cantley, J. & McNeilly, A.
1/11/20 → 31/10/22
Project: Research
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Does Nrf2 Provide Neuroprotection Against Diabetes-Associated Vascular Dysfunction (Fellowship)
4/07/22 → 3/07/24
Project: Research
Research output
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Central deficiency of IL-6Ra in mice impairs glucose-stimulated insulin secretion
McNeilly, A. D., Yianakas, A., Gallagher, J. G., Tarlton, J., Ashford, M. L. J. & McCrimmon, R. J., Jul 2022, In: Molecular Metabolism. 61, 13 p., 101488.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Challenges and solutions for diabetes early career researchers in the COVID-19 recovery - perspectives of the Diabetes UK Innovators in Diabetes
Gage, M. C., Harrington, D., Brierley, G. V., Freathy, R. M., Gabriel, B. M., Gibson, R., McNeilly, A. D., Meek, C. L. & Roberts, L. D., 14 Feb 2022, In: Diabetic Medicine. 39, 3, 6 p., e14698.Research output: Contribution to journal › Letter › peer-review
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Cold-induced dishabituation in rodents exposed to recurrent hypoglycaemia
Vickneson, K., Blackburn, J., Gallagher, J. R., Evans, M. L., de Galan, B. E., Pedersen-Bjergaard, U., Thorens, B., McNeilly, A. D. & McCrimmon, R. J., Jun 2021, In: Diabetologia. 64, p. 1436-1441 6 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)34 Downloads (Pure) -
High Intensity Training as a novel treatment for impaired awareness of HYPOglycaemia in Type 1 DiabeteS [HIT4HYPOS]: Protocol for a randomized parallel-group study
Farrell, C., McNeilly, A., West, D. & McCrimmon, R., 25 Jan 2021, In: Endocrinology, Diabetes & Metabolism. 4, 1, 7 p., e00166.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)38 Downloads (Pure) -
Hypoglycaemia: Still the main drawback of insulin 100 years on: “From man to mouse”
Merchant, H. J. & McNeilly, A. D., Dec 2021, In: Diabetic Medicine. 38, 12, 12 p., e14721.Research output: Contribution to journal › Review article › peer-review
2 Citations (Scopus)
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Dishabituation as a treatment for impaired awareness of hypoglycaemia in type 1 diabetes
Alison McNeilly (Examiner)
5 Nov 2021Activity: Examination types › Examination
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Hypoglycaemia: Still the main drawback of insulin 100 years on: From mouse to man
Alison McNeilly (Speaker)
19 Apr 2021Activity: Talk or presentation types › Invited talk
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Diabetes and the brain: Hypoglycaemia and Habituation
Alison McNeilly (Speaker)
14 Apr 2021Activity: Talk or presentation types › Invited talk
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Welfare and Ethical Use of Animals Committee, University of Dundee
Alison McNeilly (Member)
2020 → …Activity: Other activity types › Other
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Estrogenic modulation of excitatory synaptic transmission at hippocampal temporoammonic-CA1 synapses
Alison McNeilly (Examiner)
4 Apr 2020Activity: Examination types › Examination