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Biography
Dr McNeilly is a newly appointed Principal Investigator at the University of Dundee’s Medical School working in the Division of Systems Medicine. Her research focus is upon the impact of diabetes and, in particular, low glucose (hypoglycaemia) on cognitive and vascular function.
Dr McNeilly received her PhD from the University of Edinburgh under the supervision of Professor Ruth Andrew and Professor Brian Walker. Her subsequent Diabetes UK and JDRF funded post-doctoral research positions with Prof Rory McCrimmon (2012-2018) focused on complications associated with repeated exposure to hypoglycaemia in Type 1 diabetes. Through this work, Dr McNeilly identified a vital neuroprotective role for the transcription factor nuclear factor erythroid 2–related factor 2 (Nrf2), providing a novel therapeutic target for managing hypoglycaemia associated complications. Dr McNeilly also proposed the concept of “habituation to hypoglycaemia” as a way of describing the condition of Impaired Awareness of Hypoglycaemia (IAH). In both rodent and clinical studies, introducing a novel “dishabituating” stimulus such as High-Intensity Training or cold exposure has partially restored the symptomatic and hormonal response to hypoglycaemia. Dr McNeilly’s research also covers the role potential role of neuroinflammation and oxidative stress in diabetes-associated cognitive and vascular complications. Dr McNeilly is a member of the IMI funded HypoRESOLVE consortium and is working on Diabetes UK, Wellcome (ISSF) and Tenovus funded projects.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Ultra-High Definition Imaging - MRC Equipment Grant
Alessi, D., Banerjee, S., Cantley, J., Corner, G., Hayes, J., Hoskins, P., Kang, L., McNeilly, A., McSorley, H., Murdoch, C. & Rena, G.
1/11/22 → 31/03/23
Project: Research
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Does Nrf2 Provide Neuroprotection Against Diabetes-Associated Vascular Dysfunction (Fellowship)
1/06/22 → 31/05/24
Project: Research
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Role of the GSK-3NRF2 Axis In Beta Cell Decline In Type 2 Diabetes
Cantley, J., Hayes, J., McNeilly, A. & Sutherland, C.
18/04/21 → 17/04/24
Project: Research
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Central deficiency of IL-6Ra in mice impairs glucose-stimulated insulin secretion
McNeilly, A. D., Yianakas, A., Gallagher, J. G., Tarlton, J., Ashford, M. L. J. & McCrimmon, R. J., Jul 2022, In: Molecular Metabolism. 61, 13 p., 101488.Research output: Contribution to journal › Article › peer-review
Open AccessFile11 Downloads (Pure) -
Challenges and solutions for diabetes early career researchers in the COVID-19 recovery - perspectives of the Diabetes UK Innovators in Diabetes
Gage, M. C., Harrington, D., Brierley, G. V., Freathy, R. M., Gabriel, B. M., Gibson, R., McNeilly, A. D., Meek, C. L. & Roberts, L. D., 14 Feb 2022, In: Diabetic Medicine. 39, 3, 6 p., e14698.Research output: Contribution to journal › Letter › peer-review
Open AccessFile5 Downloads (Pure) -
Editorial: metabolic hormones and inflammation
Gage, M. C., Alzaid, F., McNeilly, A. D. & Fisher, E. A., 16 Dec 2022, In: Frontiers in Cardiovascular Medicine. 9, 3 p., 1102900.Research output: Contribution to journal › Editorial › peer-review
Open AccessFile -
Is high-frequency ultrasound a useful process to add value to out of specification strawberries, raspberries and blackberries industrially?
Hooper, M., McNeilly, A. D., Schaschke, C. & Wilkin, J. D., Oct 2022, In: International Journal of Food Science and Technology. 57, 10, p. 6540-6547 8 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Downloads (Pure) -
Cold-induced dishabituation in rodents exposed to recurrent hypoglycaemia
Vickneson, K., Blackburn, J., Gallagher, J. R., Evans, M. L., de Galan, B. E., Pedersen-Bjergaard, U., Thorens, B., McNeilly, A. D. & McCrimmon, R. J., Jun 2021, In: Diabetologia. 64, p. 1436-1441 6 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)49 Downloads (Pure)
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Insulin-induced hypoglycaemia in healthy and streptozotocin-induced diabetic Gottingen Minipigs
Alison McNeilly (Examiner)
13 Jan 2023Activity: Examination types › Examination
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The ECM remodeling and CD44/RHAMM activation drive adipose tissue malfunction in obesity
Alison McNeilly (Examiner)
18 Jan 2023Activity: Examination types › Examination
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Monifieth High School STEM week- Vascular imaging
Colin Murdoch (Member), Alison McNeilly (Member), Calum Forteath (Member) & Hollie Whyte (Member)
24 Jan 2023Activity: Other activity types › Schools engagement
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Frontiers in Cardiovascular Medicine (Journal)
Alison McNeilly (Editorial board member)
31 Dec 2022Activity: Publication peer-review and editorial work types › Publication peer-review
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