• 95 Citations
  • 3 h-Index
20172018
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Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

  • 11 Similar Profiles
Proteolysis Medicine & Life Sciences
Ubiquitin-Protein Ligases Medicine & Life Sciences
WEB 2086 Medicine & Life Sciences
Ubiquitin-Conjugating Enzymes Medicine & Life Sciences
Small Molecule Libraries Medicine & Life Sciences
Degradation Chemical Compounds
Hydroxyproline Medicine & Life Sciences
Hominidae Medicine & Life Sciences

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Research Output 2017 2018

  • 95 Citations
  • 3 h-Index
  • 6 Article
1 Citations

3-Fluoro-4-hydroxyprolines: Synthesis, conformational analysis and stereoselective recognition by the VHL E3 ubiquitin ligase for targeted protein degradation

Testa, A., Lucas, X., Castro, G., Chan, K. H., Wright, J., Runcie, A., Gadd, M., Harrison, W. T. A., Ko, E. J., Fletcher, D. & Ciulli, A., 25 Jul 2018, In : Journal of the American Chemical Society. 140, 29, p. 9299-9313 15 p.

Research output: Contribution to journalArticle

Open Access
File
Hydroxyproline
Ubiquitin-Protein Ligases
Proteolysis
Proteins
Degradation
18 Citations
Open Access
File
WEB 2086
Proteolysis
Ligands
Ubiquitin-Protein Ligases
Myeloid Cells
3 Citations

Optimization of a “Bump-and-Hole” Approach to Allele-Selective BET Bromodomain Inhibition

Runcie, A., Zengerle, M., Chan, K. H., Testa, A., Van Beurden, L., Baud, M., Epemolu, R., Ellis, L., Read, K., Coulthard, V., Brien, A. & Ciulli, A., 9 Mar 2018, In : Chemical Science. 2018, 9, p. 2387-2634 18 p., 2452.

Research output: Contribution to journalArticle

Open Access
File
Benzodiazepines
Leucine
Proteins
Cell proliferation
Valine
10 Citations

Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation

Maniaci, C., Hughes, S. J., Testa, A., Chen, W., Lamont, D. J., Rocha, S., Alessi, D. R., Romeo, R. & Ciulli, A., 10 Oct 2017, In : Nature Communications. 8, p. 1-14 14 p., 830.

Research output: Contribution to journalArticle

Open Access
File
Proteolysis
Ubiquitin-Protein Ligases
Hominidae
degradation
Degradation
1 Citations

Mind the metal: a fragment library-derived zinc impurity binds the E2 ubiquitin-conjugating enzyme Ube2T and induces structural rearrangements

Morreale, F., Testa, A., Chaugule, V., Bortoluzzi, A., Ciulli, A. & Walden, H., 12 Oct 2017, In : Journal of Medicinal Chemistry. 60, 19, p. 8183-8191 9 p.

Research output: Contribution to journalArticle

Open Access
File
Ubiquitin-Conjugating Enzymes
Small Molecule Libraries
Zinc
Metals
Fanconi Anemia