Brown, Andrew

Dr

  • 1773 Citations
  • 15 h-Index
20122022

Research output per year

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Research Output

  • 1773 Citations
  • 15 h-Index
  • 23 Article
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Article
2018

Age-dependent changes in mean and variance of gene expression across tissues in a twin cohort.

Viñuela, A., Brown, A. A., Buil, A., Tsai, P-C., Davies, M. N., Bell, J. T., Dermitzakis, E. T., Spector, T. D. & Small, K. S., 15 Feb 2018, In : Human Molecular Genetics. 27, 4, p. 732-741 10 p.

Research output: Contribution to journalArticle

Open Access
File
19 Citations (Scopus)
96 Downloads (Pure)

Cross-tissue eQTL enrichment of associations in schizophrenia.

Bettella, F., Brown, A. A., Smeland, O. B., Wang, Y., Witoelar, A., Buil Demur, A. A., Thompson, W. K., Zuber, V., Dale, A. M., Djurovic, S. & Andreassen, O. A., 6 Sep 2018, In : PLoS ONE. 13, 9, p. 1-17 17 p., e0202812.

Research output: Contribution to journalArticle

Open Access
File
82 Downloads (Pure)
2017

A complete tool set for molecular QTL discovery and analysis

Delaneau, O., Ongen, H., Brown, A. A., Fort, A., Panousis, N. I. & Dermitzakis, E. T., 18 May 2017, In : Nature Communications. 8, p. 1-7 7 p., 15452.

Research output: Contribution to journalArticle

Open Access
File
23 Citations (Scopus)
96 Downloads (Pure)

Estimating the causal tissues for complex traits and diseases

GTEx Consortium, Ongen, H., Brown, A. A., Delaneau, O., Panousis, N. I., Nica, A. C. & Dermitzakis, E. T., 23 Oct 2017, In : Nature Genetics. 49, 12, p. 1676-1683 8 p.

Research output: Contribution to journalArticle

43 Citations (Scopus)

Genetic effects on gene expression across human tissues

GTEx Consortium, 12 Oct 2017, In : Nature. 550, 7675, p. 204-213 10 p.

Research output: Contribution to journalArticle

Open Access
File
662 Citations (Scopus)
68 Downloads (Pure)

Predicting causal variants affecting expression by using whole-genome sequencing and RNA-seq from multiple human tissues

Brown, A. A., Viñuela, A., Delaneau, O., Spector, T. D., Small, K. S. & Dermitzakis, E. T., Dec 2017, In : Nature Genetics. 49, 12, p. 1747-1751 5 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Quantifying the regulatory effect size of cis-acting genetic variation using allelic fold change

Mohammadi, P., Castel, S. E., Brown, A. A. & Lappalainen, T., Nov 2017, In : Genome Research. 27, 11, p. 1872-1884 13 p.

Research output: Contribution to journalArticle

Open Access
File
15 Citations (Scopus)
95 Downloads (Pure)

Time-dependent genetic effects on gene expression implicate aging processes

Bryois, J., Buil, A., Ferreira, P. G., Panousis, N. I., Brown, A. A., Viñuela, A., Planchon, A., Bielser, D., Small, K., Spector, T. & Dermitzakis, E. T., Apr 2017, In : Genome Research. 27, 4, p. 545-552 8 p.

Research output: Contribution to journalArticle

Open Access
File
7 Citations (Scopus)
82 Downloads (Pure)

veqtl-mapper: variance association mapping for molecular phenotypes

Brown, A. A., 1 Sep 2017, In : Bioinformatics. 33, 17, p. 2772-2773 2 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2016

Fast and efficient QTL mapper for thousands of molecular phenotypes

Ongen, H., Buil, A., Brown, A. A., Dermitzakis, E. T. & Delaneau, O., 15 May 2016, In : Bioinformatics. 32, 10, p. 1479-1485 7 p.

Research output: Contribution to journalArticle

Open Access
File
72 Citations (Scopus)
96 Downloads (Pure)

Genome-wide association analysis identifies TXNRD2, ATXN2 and FOXC1 as susceptibility loci for primary open-angle glaucoma

ANZRAG Consortium, EPIC-Norfolk Eye Study & Brown, A. A., Feb 2016, In : Nature Genetics. 48, 2, p. 189-194 6 p.

Research output: Contribution to journalArticle

99 Citations (Scopus)

Genome-wide association analysis of self-reported events in 6135 individuals and 252 827 controls identifies 8 loci associated with thrombosis

METASTROKE Consortium, INVENT Consortium, Hinds, D. A., Buil, A., Ziemek, D., Martinez-Perez, A., Malik, R., Folkersen, L., Germain, M., Mälarstig, A., Brown, A., Soria, J. M., Dichgans, M., Bing, N., Franco-Cereceda, A., Souto, J. C., Dermitzakis, E. T., Hamsten, A., Worrall, B. B., Tung, J. Y. & 1 others, Sabater-Lleal, M., 1 May 2016, In : Human Molecular Genetics. 25, 9, p. 1867-1874 8 p.

Research output: Contribution to journalArticle

Open Access
File
37 Citations (Scopus)
82 Downloads (Pure)
2015

Common genetic variants influence human subcortical brain structures

Alzheimer’s Disease Neuroimaging Initiative, The CHARGE Consortium, EPIGEN, IMAGEN, SYS & Brown, A. A., 9 Apr 2015, In : Nature. 520, 7546, p. 224-229 6 p.

Research output: Contribution to journalArticle

363 Citations (Scopus)

Gene-gene and gene-environment interactions detected by transcriptome sequence analysis in twins

Buil, A., Brown, A. A., Lappalainen, T., Viñuela, A., Davies, M. N., Zheng, H-F., Richards, J. B., Glass, D., Small, K. S., Durbin, R., Spector, T. D. & Dermitzakis, E. T., Jan 2015, In : Nature Genetics. 47, 1, p. 88-91 4 p.

Research output: Contribution to journalArticle

81 Citations (Scopus)

Multiple novel prostate cancer susceptibility signals identified by fine-mapping of known risk loci among Europeans

PRACTICAL Consortium, COGS-CRUK GWAS-ELLIPSE (Part of GAME-ON) Initiative, The Australian Prostrate Cancer BioResource, The UK Genetic Prostate Cancer Study Collaborators, The UK ProtecT Study Collaborators & Brown, A. A., 1 Oct 2015, In : Human Molecular Genetics. 24, 19, p. 5589-5602 14 p.

Research output: Contribution to journalArticle

Open Access
File
42 Citations (Scopus)
82 Downloads (Pure)

Pathway-based factor analysis of gene expression data produces highly heritable phenotypes that associate with age

Brown, A. A., Ding, Z., Viñuela, A., Glass, D., Parts, L., Spector, T., Winn, J. & Durbin, R., 1 May 2015, In : G3: Genes, Genomes, Genetics. 5, 5, p. 839-847 9 p.

Research output: Contribution to journalArticle

Open Access
File
5 Citations (Scopus)
57 Downloads (Pure)
2014

Genetic interactions affecting human gene expression identified by variance association mapping

Brown, A. A., Buil, A., Viñuela, A., Lappalainen, T., Zheng, H-F., Richards, J. B., Small, K. S., Spector, T. D., Dermitzakis, E. T. & Durbin, R., 25 Apr 2014, In : eLife. 3, p. 1-16 16 p., e01381.

Research output: Contribution to journalArticle

Open Access
File
57 Citations (Scopus)
89 Downloads (Pure)
2013

CACNA1C risk variant and amygdala activity in bipolar disorder, schizophrenia and healthy controls

Tesli, M., Skatun, K. C., Ousdal, O. T., Brown, A. A., Thoresen, C., Agartz, I., Melle, I., Djurovic, S., Jensen, J. & Andreassen, O. A., 3 Nov 2013, In : PLoS ONE. 8, 2, p. e56970 6 p.

Research output: Contribution to journalArticle

50 Citations (Scopus)

Evaluation of PAX3 genetic variants and nevus number

Ogbah, Z., Badenas, C., Harland, M., Puig-Butille, J. A., Elliot, F., Bonifaci, N., Guino, E., Randerson-Moor, J., Chan, M., Iles, M. M., Glass, D., Brown, A. A., Carrera, C., Kolm, I., Bataille, V., Spector, T. D., Malvehy, J., Newton-Bishop, J., Pujana, M. A., Bishop, T. & 1 others, Puig, S., Sep 2013, In : Pigment Cell and Melanoma Research. 26, 5, p. 666-676 11 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Gene expression changes with age in skin, adipose tissue, blood and brain

King's College London, 26 Jul 2013, In : Genome Biology. 14, 7, p. 1-12 13 p., R75.

Research output: Contribution to journalArticle

128 Citations (Scopus)

Pathway analysis of genetic markers associated with a functional MRI faces paradigm implicates polymorphisms in calcium responsive pathways

Mattingsdal, M., Brown, A. A., Djurovic, S., Sønderby, I. E., Server, A., Melle, I., Agartz, I., Hovig, E., Jensen, J. & Andreassen, O. A., 15 Apr 2013, In : NeuroImage. 70, p. 143-149 7 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

ZNF804A and cortical thickness in schizophrenia and bipolar disorder

Bergmann, O., Haukvik, U. K., Brown, A. A., Rimol, L. M., Hartberg, C. B., Athanasiu, L., Melle, I., Djurovic, S., Andreassen, O. A., Dale, A. M. & Agartz, I., 30 May 2013, In : Psychiatry Research. 212, 2, p. 154-157 4 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)
2012

Effect of DISC1 SNPs on brain structure in healthy controls and patients with a history of psychosis

Kähler, A. K., Rimol, L. M., Brown, A. A., Djurovic, S., Hartberg, C. B., Melle, I., Dale, A. M., Andreassen, O. A. & Agartz, I., Sep 2012, In : American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 159B, 6, p. 722-730 9 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)