Hopkins, Andrew

Professor

20022019

Research output per year

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Research Output

2018

Surveying GPCR solubilisation conditions using surface plasmon resonance

Navratilova, I. H., Aristotelous, T., Bird, L. E. & Hopkins, A. L., 1 Sep 2018, In : Analytical Biochemistry. 556, p. 23-34 12 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2016

Discovery of New Bromodomain Scaffolds by Biosensor Fragment Screening

Navratilova, I., Aristotelous, T., Picaud, S., Chaikuad, A., Knapp, S., Filappakopoulos, P. & Hopkins, A. L., 8 Dec 2016, In : ACS Medicinal Chemistry Letters. 7, 12, p. 1213-1218 6 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)
2015

Application of RNAi to genomic drug target validation in schistosomes

Guidi, A., Mansour, N. R., Paveley, R. A., Carruthers, I. M., Besnard, J., Hopkins, A. L., Gilbert, I. H. & Bickle, Q. D., 20 May 2015, In : PLoS Neglected Tropical Diseases. 9, 5, 22 p., e0003801.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Pharmacological space

Hopkins, A. L., 2015, The practice of medicinal chemistry. Wermuth, C., Aldous, D., Raboisson, P. & Rognan, D. (eds.). 4th ed. Academic Press, p. 395-408 14 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Surface plasmon resonance analysis of seven-transmembrane receptors

Aristotelous, T., Hopkins, A. L. & Navratilova, I., 2015, Membrane proteins—production and functional characterization. Shukla, A. K. (ed.). Academic Press, p. 499-525 27 p. (Methods in Enzymology; vol. 556).

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

14 Citations (Scopus)

The Joint European Compound Library: boosting precompetitive research

Besnard, J., Jones, P. S., Hopkins, A. L. & Pannifer, A. D., Feb 2015, In : Drug Discovery Today. 20, 2, p. 181-186 6 p.

Research output: Contribution to journalArticle

Open Access
File
44 Citations (Scopus)
192 Downloads (Pure)
2014

Fragment screening by SPR and advanced application to GPCRs

Shepherd, C. A., Hopkins, A. L. & Navratilova, I., Nov 2014, In : Progress in Biophysics and Molecular Biology. 116, 2-3, p. 113-123 11 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)

The role of ligand efficiency metrics in drug discovery

Hopkins, A. L., Keserü, G. M., Leeson, P. D., Rees, D. C. & Reynolds, C. H., 2014, In : Nature Reviews Drug Discovery. 13, 2, p. 105-121 17 p.

Research output: Contribution to journalArticle

455 Citations (Scopus)

Validity of ligand efficiency metrics

Murray, C. W., Erlanson, D. A., Hopkins, A. L., Keserü, G. M., Leeson, P. D., Rees, D. C., Reynolds, C. H. & Richmond, N. J., 12 Jun 2014, In : ACS Medicinal Chemistry Letters. 5, 6, p. 616-618 3 p.

Research output: Contribution to journalArticle

62 Citations (Scopus)
2013

Discovery of Β2 Adrenergic Receptor Ligands Using Biosensor Fragment Screening of Tagged Wild-Type Receptor

Aristotelous, T., Ahn, S., Shukla, A. K., Gawron, S., Sassano, M. F., Kahsai, A. W., Wingler, L. M., Zhu, X., Tripathi-Shukla, P., Huang, X-P., Riley, J., Besnard, J., Read, K. D., Roth, B. L., Gilbert, I. H., Hopkins, A. L., Lefkowitz, R. J. & Navratilova, I., 2013, In : ACS Medicinal Chemistry Letters. 4, 10, p. 1005-1010 6 p.

Research output: Contribution to journalArticle

43 Citations (Scopus)
2012

Automated design of ligands to polypharmacological profiles

Besnard, J., Ruda, G. F., Setola, V., Abecassis, K., Rodriguiz, R. M., Huang, X-P., Norval, S., Sassano, M. F., Shin, A. I., Webster, L. A., Simeons, F. R. C., Stojanovski, L., Prat, A., Seidah, N. G., Constam, D. B., Bickerton, G. R., Read, K. D., Wetsel, W. C., Gilbert, I. H., Roth, B. L. & 1 others, Hopkins, A. L., 13 Dec 2012, In : Nature. 492, 7428, p. 215-+ 8 p.

Research output: Contribution to journalArticle

403 Citations (Scopus)

Introduction: the case for polypharmacology

Hopkins, A. L., 2012, Polypharmacology in drug discovery. Peters, J-U. (ed.). Hoboken: John Wiley & Sons Inc., p. 1-6 6 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)

Quantifying the chemical beauty of drugs

Bickerton, G. R., Paolini, G. V., Besnard, J., Muresan, S. & Hopkins, A. L., Feb 2012, In : Nature Chemistry. 4, 2, p. 90-98 9 p.

Research output: Contribution to journalArticle

360 Citations (Scopus)

Whole organism high-content screening by label-free, image-based Bayesian classification for parasitic diseases

Paveley, R. A., Mansour, N. R., Hallyburton, I., Bleicher, L. S., Benn, A. E., Mikic, I., Guidi, A., Gilbert, I. H., Hopkins, A. L. & Bickle, Q. D., 31 Jul 2012, In : PLoS Neglected Tropical Diseases. 6, 7, 11 p., e1762.

Research output: Contribution to journalArticle

59 Citations (Scopus)
2011

Design of molecules

Hopkins, A. & Besnard, J., 26 May 2011, Patent No. PCT/GB2010/051940

Research output: Patent

Emerging role of surface plasmon resonance in fragment-based drug discovery

Navratilova, I. & Hopkins, A. L., Oct 2011, In : Future Medicinal Chemistry. 3, 14, p. 1809-1820 12 p.

Research output: Contribution to journalReview article

46 Citations (Scopus)

Minimum information about a bioactive entity (MIABE)

Orchard, S., Al-Lazikani, B., Bryant, S., Clark, D., Calder, E., Dix, I., Engkvist, O., Forster, M., Gaulton, A., Gilson, M., Glen, R., Grigorov, M., Hammond-Kosack, K., Harland, L., Hopkins, A., Larminie, C., Lynch, N., Mann, R. K., Murray-Rust, P., Lo Piparo, E. & 6 others, Southan, C., Steinbeck, C., Wishart, D., Hermjakob, H., Overington, J. & Thornton, J., Sep 2011, In : Nature Reviews Drug Discovery. 10, 9, p. 661-669 9 p.

Research output: Contribution to journalReview article

68 Citations (Scopus)

Progress in Neglected Disease Drug Discovery

Hopkins, A. L. & Wyatt, P. G., May 2011, In : Current Topics in Medicinal Chemistry. 11, 10, p. 1215-1215 1 p.

Research output: Contribution to journalEditorial

1 Citation (Scopus)

Rapid Analysis of Pharmacology for Infectious Diseases

Hopkins, A. L., Bickerton, G. R., Carruthers, I. M., Boyer, S. K., Rubin, H. & Overington, J. P., May 2011, In : Current Topics in Medicinal Chemistry. 11, 10, p. 1292-1300 9 p.

Research output: Contribution to journalReview article

15 Citations (Scopus)

Screening for GPCR Ligands Using Surface Plasmon Resonance

Hopkins Navratilova, I., Besnard, J. & Hopkins, A. L., Jul 2011, In : ACS Medicinal Chemistry Letters. 2, 7, p. 549-554 6 p.

Research output: Contribution to journalArticle

59 Citations (Scopus)
2010

An ontology for description of drug discovery investigations

Qi, D., King, R. D., Hopkins, A. L., Bickerton, G. R. J. & Soldatova, L. N., 2010, In : Journal of Integrative Bioinformatics. 7, 3, 13 p., 126.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Fragment Screening by Surface Plasmon Resonance

Hopkins Navratilova, I. & Hopkins, A. L., Apr 2010, In : ACS Medicinal Chemistry Letters. 1, 1, p. 44-48 5 p.

Research output: Contribution to journalArticle

101 Citations (Scopus)

Know your chemical space

Hopkins, A. L. & Bickerton, G. R., Jul 2010, In : Nature Chemical Biology. 6, 7, p. 482-483 2 p.

Research output: Contribution to journalComment/debate

16 Citations (Scopus)

The tetrahydrobiopterin pathway and pain

Naylor, A. M., Pojasek, K. R., Hopkins, A. L. & Blagg, J., Jan 2010, In : Current Opinion in Investigational Drugs. 11, 1, p. 19-30 12 p.

Research output: Contribution to journalReview article

10 Citations (Scopus)
2009

A crowdsourcing evaluation of the NIH chemical probes

Oprea, T. I., Bologa, C. G., Boyer, S., Curpan, R. F., Glen, R. C., Hopkins, A. L., Lipinski, C. A., Marshall, G. R., Martin, Y. C., Ostopovici-Halip, L., Rishton, G., Ursu, O., Vaz, R. J., Waller, C., Waldmann, H. & Sklar, L. A., Jul 2009, In : Nature Chemical Biology. 5, 7, p. 441-447 7 p.

Research output: Contribution to journalArticle

89 Citations (Scopus)

Drug discovery Predicting promiscuity

Hopkins, A. L., 12 Nov 2009, In : Nature. 462, 7270, p. 167-168 2 p.

Research output: Contribution to journalEditorial

97 Citations (Scopus)

Genomic-scale prioritization of drug targets: the TDR Targets database

Agüero, F., Al-Lazikani, B., Aslett, M., Berriman, M., Buckner, F. S., Campbell, R. K., Carmona, S., Carruthers, I. M., Chan, A. W. E., Chen, F., Crowther, G. J., Doyle, M. A., Hertz-Fowler, C., Hopkins, A. L., McAllister, G., Nwaka, S., Overington, J. P., Pain, A., Paolini, G. V., Pieper, U. & 8 others, Ralph, S. A., Riechers, A., Roos, D. S., Sali, A., Shanmugam, D., Suzuki, T., Van Voorhis, W. C. & Verlinde, C. L. M. J., 2008, In : Nature Reviews Drug Discovery. 7, 11, p. 900-907 8 p.

Research output: Contribution to journalArticle

213 Citations (Scopus)

Network pharmacology: the next paradigm in drug discovery

Hopkins, A. L., Nov 2008, In : Nature Chemical Biology. 4, 11, p. 682-690 9 p.

Research output: Contribution to journalReview article

1625 Citations (Scopus)

Pharmacological space

Hopkins, A. L., 2008, The practice of medicinal chemistry. Wermuth, C. G. (ed.). 3rd ed. London: Academic Press, p. 521-532 12 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)
2007

Network pharmacology

Hopkins, A. L., Oct 2007, In : Nature Biotechnology. 25, 10, p. 1110-1111 2 p.

Research output: Contribution to journalArticle

354 Citations (Scopus)
2006

Global mapping of pharmacological space

Paolini, G. V., Shapland, R. H. B., Hoorn, W. P. V., Mason, J. S. & Hopkins, A. L., 2006, In : Nature Biotechnology. 24, 7, p. 805-815 11 p.

Research output: Contribution to journalArticle

613 Citations (Scopus)
2004

Design of non-nucleoside inhibitors of HIV-1 reverse transcriptase with improved drug resistance properties. 1

Hopkins, A. L., Ren, J., Milton, J., Hazen, R. J., Chan, J. H., Stuart, D. I. & Stammers, D. K., 2004, In : Journal of Medicinal Chemistry. 47, 24, p. 5912-5922 11 p.

Research output: Contribution to journalArticle

76 Citations (Scopus)

Navigating chemical space for biology and medicine

Lipinski, C. & Hopkins, A., Dec 2004, In : Nature. 432, 7019, p. 855-861 7 p.

Research output: Contribution to journalArticle

671 Citations (Scopus)
2002

The druggable genome

Hopkins, A. L. & Groom, C. R., Sep 2002, In : Nature Reviews Drug Discovery. 1, 9, p. 727-730 4 p.

Research output: Contribution to journalArticle

2274 Citations (Scopus)