Projects per year
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- 19 Similar Profiles
Drug Discovery
Medicine & Life Sciences
Lysosphingolipid Receptors
Medicine & Life Sciences
Trypanosoma brucei brucei
Medicine & Life Sciences
Protein Kinases
Medicine & Life Sciences
Modulators
Chemical Compounds
90-kDa Ribosomal Protein S6 Kinases
Medicine & Life Sciences
Origin Recognition Complex
Medicine & Life Sciences
Pharmaceutical Preparations
Medicine & Life Sciences
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Projects 2014 2020
Topical Soft-Drug Smoothened Inhibitors: Reducing Surgical Burden for Gorlin Syndrome Patients (Pathfinder)
1/08/17 → 31/07/18
Project: Research
De-risking Innovative Drug Discovery Projects through Portfolio Management (Confidence in Concept)
Ferguson, M., Woodland, A. & Wyatt, P.
1/03/14 → 31/08/15
Project: Research
Research Output 2009 2019
Discovery of Soft-Drug Topical Tool Modulators of Sphingosine-1-phosphate Receptor 1 (S1PR1)
Bell, M., Foley, D., Naylor, C., Wood, G., Robinson, C., Riley, J., Epemolu, R., Ellis, L., Scullion, S., Shishikura, Y., Osuna-Cabello, M., Ferguson, L., Pinto, E., Fletcher, D., Katz, E., McLean, W., Wyatt, P., Read, K. & Woodland, C., 14 Mar 2019, In : ACS Medicinal Chemistry Letters. 10, 3, p. 341–347 7 p.Research output: Contribution to journal › Article
Open Access
File
Lysosphingolipid Receptors
Drug Discovery
Modulators
Skin
Pharmaceutical Preparations
3
Citations
(Scopus)
Identification of GSK3186899/DDD853651 as a Preclinical Development Candidate for the Treatment of Visceral Leishmaniasis
Thomas, M. G., De Rycker, M., Ajakane, M., Albrecht, S., Álvarez-Pedraglio, A. I., Boesche, M., Brand, S., Campbell, L., Cantizani-Perez, J., Cleghorn, L. A. T., Copley, R. C. B., Crouch, S. D., Daugan, A., Drewes, G., Ferrer, S., Ghidelli-Disse, S., Gonzalez, S., Gresham, S. L., Hill, A. P., Hindley, S. J. & 32 others, 14 Feb 2019, In : Journal of Medicinal Chemistry. 62, 3, p. 1180-1202 23 p.Research output: Contribution to journal › Article
Visceral Leishmaniasis
Leishmania major
Leishmania donovani
Standard of Care
Solubility
Differential regulation of Toll-like receptor 4-induced interleukin-10 induction in macrophages and B cells reveals a role for p90 ribosomal S6 kinases
Sutavani, R. V., Phair, I. R., Barker, R., McFarlane, A., Shpiro, N., Lang, S., Woodland, A. & Arthur, J. S. C., 16 Feb 2018, In : Journal of Biological Chemistry. 293, 7, p. 2302-2317 16 p.Research output: Contribution to journal › Article
Open Access
File
90-kDa Ribosomal Protein S6 Kinases
Toll-Like Receptor 4
Macrophages
Interleukin-10
B-Lymphocytes
Discovery of super soft-drug modulators of sphingosine-1-phosphate receptor 1
Bell, M., Foley, D., Naylor, C., Robinson, C., Riley, J., Epemolu, R., Scullion, S., Shishikura, Y., Katz, E., McLean, W., Wyatt, P., Read, K. & Woodland, C., 15 Oct 2018, In : Bioorganic & Medicinal Chemistry Letters. 28, 19, p. 3255-3259 5 p.Research output: Contribution to journal › Article
Open Access
File
Lysosphingolipid Receptors
Modulators
Esters
Plasma (human)
Butyrylcholinesterase
Screening a protein kinase inhibitor library against Plasmodium falciparum
Hallyburton, I., Grimaldi, R., Woodland, A., Baragana, B., Luksch, T., Spinks, D., James, D., Leroy, D., Waterson, D., Fairlamb, A. H., Wyatt, P. G., Gilbert, I. H. & Frearson, J. A., 7 Nov 2017, In : Malaria Journal. 16, p. 1-11 11 p., 446.Research output: Contribution to journal › Article
Open Access
File
Plasmodium falciparum
Protein Kinase Inhibitors
Protein Kinases
Malaria
Small Molecule Libraries