Personal profile

Research

C. elegans genetics as a model to study basic biological problems

Despite of its simplicity, C. elegans is a multicellular organism that shares many fundamental genetic programs with humans. Thus many results obtained in the C. elegans system are likely to be applicable to mammalian systems. Our studies on C. elegans are facilitated by the simplicity of the organism at the developmental and anatomical level, by the ease of its maintenance, as well as by the power of forward and reverse genetic procedures. Furthermore, we take advantage of the complete genome information and by shared resources of the "worm community".

In response to DNA damage organisms activate checkpoint pathways. In multicellular organisms these pathways lead the activation of DNA repair processes, to a transient cell cycle arrest, or to programmed cell death to eliminate cells that might potentially become harmful for the entire organism.The analysis of the pathways needed for DNA damage sensing, DAN repair and the elucidation of checkpoint responses are currently under intense investigation. We were among the first to use C. elegans to contribute to the understanding of DNA damage dependent apoptosis. Given that genome instability is a major course of human cancers we hope, that in the long run, we might contribute to better tumour-diagnostics and treatment.

Furthermore, we also started to explore C. elegans to uncover molecular mechanisms leading to Parkinson's Disease. Finally we engage in multiple collaborations within the college. Projects include the visualization of key aspects of DNA replication in early C. elegans embryos, and taking full advantage of advanced quantitative mass spectroscopy based approaches.

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

  • 30 Similar Profiles
Caenorhabditis elegans Medicine & Life Sciences
DNA Damage Medicine & Life Sciences
Apoptosis Medicine & Life Sciences
Germ Cells Medicine & Life Sciences
Genetic Recombination Medicine & Life Sciences
Genomic Instability Medicine & Life Sciences
Proteins Medicine & Life Sciences
Cruciform DNA Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 2000 2018

1 Citations
Open Access
File
prealbumin
Prealbumin
Oxidopamine
Caenorhabditis elegans
Oxidative Stress

Biochemical and Structural Properties of Fungal Holliday Junction-Resolving Enzymes

Liu, Y., Freeman, A., Déclais, A-C., Gartner, A. & Lilley, D. M. J. 2018 Mechanisms of DNA Recombination and Genome Rearrangements: Methods to Study Homologous Recombination. Spies, M. & Malkova, A. (eds.). Academic Press, Vol. 600, p. 543-568 24 p. (Methods in Enzymology; vol. 600)

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Cruciform DNA
Structural properties
Enzymes
Chaetomium
DNA

LEM-3 is a midbody-tethered DNA nuclease that resolves chromatin bridges during late mitosis

Hong, Y., Sonneville, R., Wang, B., Scheidt, V., Meier, B., Woglar, A., Demetriou, S., Labib, K., Jantsch, V. & Gartner, A. 20 Feb 2018 In : Nature Communications. 9, p. 1-11 11 p., 728

Research output: Contribution to journalArticle

Open Access
File
Lunar Module
nuclease
mitosis
chromatin
Deoxyribonucleases

Mutational signatures of DNA mismatch repair deficiency in and human cancers

Meier, B., Volkova, N. V., Hong, Y., Schofield, P., Campbell, P. J., Gerstung, M. & Gartner, A. May 2018 In : Genome Research. 28, 5, p. 666-675 10 p.

Research output: Contribution to journalArticle

Open Access
File
DNA Repair-Deficiency Disorders
DNA Mismatch Repair
Neoplasms
Genome
Cytosine
1 Citations
Open Access
File
Oxidopamine
apoptosis
Caenorhabditis elegans
mutation
Dopaminergic Neurons

Thesis

A transthyretin-related gene and a neuroligin-like gene prevent 6-hydroxydopamine-induced dopaminergic neurodegeneration in C. elegans

Author: Offenburger, S., 2016

Supervisor: Gartner, A. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

File