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C. elegans genetics as a model to study basic biological problems

Despite of its simplicity, C. elegans is a multicellular organism that shares many fundamental genetic programs with humans. Thus many results obtained in the C. elegans system are likely to be applicable to mammalian systems. Our studies on C. elegans are facilitated by the simplicity of the organism at the developmental and anatomical level, by the ease of its maintenance, as well as by the power of forward and reverse genetic procedures. Furthermore, we take advantage of the complete genome information and by shared resources of the "worm community".

In response to DNA damage organisms activate checkpoint pathways. In multicellular organisms these pathways lead the activation of DNA repair processes, to a transient cell cycle arrest, or to programmed cell death to eliminate cells that might potentially become harmful for the entire organism.The analysis of the pathways needed for DNA damage sensing, DAN repair and the elucidation of checkpoint responses are currently under intense investigation. We were among the first to use C. elegans to contribute to the understanding of DNA damage dependent apoptosis. Given that genome instability is a major course of human cancers we hope, that in the long run, we might contribute to better tumour-diagnostics and treatment.

Furthermore, we also started to explore C. elegans to uncover molecular mechanisms leading to Parkinson's Disease. Finally we engage in multiple collaborations within the college. Projects include the visualization of key aspects of DNA replication in early C. elegans embryos, and taking full advantage of advanced quantitative mass spectroscopy based approaches.

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  • 8 Similar Profiles
Caenorhabditis elegans Medicine & Life Sciences
DNA Damage Medicine & Life Sciences
Apoptosis Medicine & Life Sciences
Germ Cells Medicine & Life Sciences
Dopaminergic Neurons Medicine & Life Sciences
Genetic Recombination Medicine & Life Sciences
Oxidopamine Medicine & Life Sciences
Genomic Instability Medicine & Life Sciences

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Research Output 1991 2018

6-hydroxydopamine (6-OHDA) Oxidative Stress Assay for Observing Dopaminergic Neuron Loss in Caenorhabditis elegans

Offenburger, S-L. & Gartner, A., 20 Sep 2018, In : Bio-Protocol. 8, 18, 12 p., e3025.

Research output: Contribution to journalArticle

Open Access
Dopaminergic Neurons
Caenorhabditis elegans
Oxidative Stress
Cell Death
1 Citations
Open Access
Caenorhabditis elegans
Oxidative Stress

Biochemical and Structural Properties of Fungal Holliday Junction-Resolving Enzymes

Liu, Y., Freeman, A., Déclais, A-C., Gartner, A. & Lilley, D. M. J., 2018, Mechanisms of DNA Recombination and Genome Rearrangements: Methods to Study Homologous Recombination. Spies, M. & Malkova, A. (eds.). Academic Press, Vol. 600. p. 543-568 26 p. (Methods in Enzymology; vol. 600).

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Cruciform DNA
Structural properties
2 Citations

LEM-3 is a midbody-tethered DNA nuclease that resolves chromatin bridges during late mitosis

Hong, Y., Sonneville, R., Wang, B., Scheidt, V., Meier, B., Woglar, A., Demetriou, S., Labib, K., Jantsch, V. & Gartner, A., 20 Feb 2018, In : Nature Communications. 9, p. 1-11 11 p., 728.

Research output: Contribution to journalArticle

Open Access
Lunar Module
2 Citations

Mutational signatures of DNA mismatch repair deficiency in and human cancers

Meier, B., Volkova, N. V., Hong, Y., Schofield, P., Campbell, P. J., Gerstung, M. & Gartner, A., May 2018, In : Genome Research. 28, 5, p. 666-675 10 p.

Research output: Contribution to journalArticle

Open Access
DNA Repair-Deficiency Disorders
DNA Mismatch Repair


A transthyretin-related gene and a neuroligin-like gene prevent 6-hydroxydopamine-induced dopaminergic neurodegeneration in C. elegans

Author: Offenburger, S., 2016

Supervisor: Gartner, A. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy