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Gartner, Anton

Professor

 https://orcid.org/0000-0003-4639-9902
1991 …2020

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Personal profile

Research

C. elegans genetics as a model to study basic biological problems

Despite of its simplicity, C. elegans is a multicellular organism that shares many fundamental genetic programs with humans. Thus many results obtained in the C. elegans system are likely to be applicable to mammalian systems. Our studies on C. elegans are facilitated by the simplicity of the organism at the developmental and anatomical level, by the ease of its maintenance, as well as by the power of forward and reverse genetic procedures. Furthermore, we take advantage of the complete genome information and by shared resources of the "worm community".

In response to DNA damage organisms activate checkpoint pathways. In multicellular organisms these pathways lead the activation of DNA repair processes, to a transient cell cycle arrest, or to programmed cell death to eliminate cells that might potentially become harmful for the entire organism.The analysis of the pathways needed for DNA damage sensing, DAN repair and the elucidation of checkpoint responses are currently under intense investigation. We were among the first to use C. elegans to contribute to the understanding of DNA damage dependent apoptosis. Given that genome instability is a major course of human cancers we hope, that in the long run, we might contribute to better tumour-diagnostics and treatment.

Furthermore, we also started to explore C. elegans to uncover molecular mechanisms leading to Parkinson's Disease. Finally we engage in multiple collaborations within the college. Projects include the visualization of key aspects of DNA replication in early C. elegans embryos, and taking full advantage of advanced quantitative mass spectroscopy based approaches.

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Projects

Processing of Branched DNA Molecules During Cytokinesis, Uncovering New Mechanisms of Genome Maintenance

Gartner, A., Lilley, D. & Rouse, J.

Biotechnology and Biological Sciences Research Council

1/12/18 → 30/11/21

Project: Research

Exploring Fundamental Mechanisms of Mutagenesis Conferred by the Chemotherapeutic DNA Cross Linking Agent Cisplantin Combining Next Generation Sequencing and Genetic Analysis Towards Selective Cancer Killing

Gartner, A.

1/01/18 → 31/08/20

Project: Research

Combined Genetic and Biochemical Approaches to Uncover and Characterize Redundant Factors Involved in Late Stages of Recombinational Repair (Sunset Funding for Senior Fellowship)

Gartner, A.

Project: Research

Molecular Mechanisms of Cell Fate Generation in the Developing Nervous System of Drosophila (Vacation Scholarship)

Gartner, A.

Project: Research

Acquisition of a TriSpim Lightsheet Microscope

Gartner, A., Januschke, J., MacDonald, M., Nathke, I., Storey, K., Swedlow, J., Tanaka, T. & Weijer, K.

Biotechnology and Biological Sciences Research Council

15/08/17 → 14/08/18

Project: Research

Research Output

Mutational signatures are jointly shaped by DNA damage and repair

Volkova, N. V., Meier, B., González-Huici, V., Bertolini, S., Gonzalez, S., Vöhringer, H., Abascal, F., Martincorena, I., Campbell, P. J., Gartner, A. & Gerstung, M., 1 May 2020, In : Nature Communications. 11, p. 1-15 15 p., 2169.

Research output: Contribution to journal › Article

Open Access
File
    • 1 Citation (Scopus)
    11 Downloads (Pure)

    The Balance between Mono- and NEDD8-Chains Controlled by NEDP1 upon DNA Damage Is a Regulatory Module of the HSP70 ATPase Activity

    Bailly, A. P., Perrin, A., Serrano-Macia, M., Maghames, C., Leidecker, O., Trauchessec, H., Martinez-Chantar, M. L., Gartner, A. & Xirodimas, D. P., 1 Oct 2019, In : Cell Reports. 29, 1, p. 212-224.e8 21 p.

    Research output: Contribution to journal › Article

    Open Access
    File
    • 3 Citations (Scopus)
    70 Downloads (Pure)

    6-hydroxydopamine (6-OHDA) Oxidative Stress Assay for Observing Dopaminergic Neuron Loss in Caenorhabditis elegans

    Offenburger, S-L. & Gartner, A., 20 Sep 2018, In : Bio-Protocol. 8, 18, 12 p., e3025.

    Research output: Contribution to journal › Article

    Open Access
    File
    • 170 Downloads (Pure)

    6-OHDA-induced dopaminergic neurodegeneration in Caenorhabditis elegans is promoted by the engulfment pathway and inhibited by the transthyretin-related protein TTR-33

    Offenburger, S-L., Ho, X. Y., Tachie-Menson, T., Coakley, S., Hilliard, M. A. & Gartner, A., 18 Jan 2018, In : PLoS Genetics. 14, 1, p. 1-27 27 p., e1007125.

    Research output: Contribution to journal › Article

    Open Access
    File
    • 4 Citations (Scopus)
    200 Downloads (Pure)

    Biochemical and Structural Properties of Fungal Holliday Junction-Resolving Enzymes

    Liu, Y., Freeman, A., Déclais, A-C., Gartner, A. & Lilley, D. M. J., 2018, Mechanisms of DNA Recombination and Genome Rearrangements: Methods to Study Homologous Recombination. Spies, M. & Malkova, A. (eds.). Academic Press, Vol. 600. p. 543-568 26 p. (Methods in Enzymology; vol. 600).

    Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed)

    • 1 Citation (Scopus)