Projects per year
C. elegans genetics as a model to study basic biological problems
Despite of its simplicity, C. elegans is a multicellular organism that shares many fundamental genetic programs with humans. Thus many results obtained in the C. elegans system are likely to be applicable to mammalian systems. Our studies on C. elegans are facilitated by the simplicity of the organism at the developmental and anatomical level, by the ease of its maintenance, as well as by the power of forward and reverse genetic procedures. Furthermore, we take advantage of the complete genome information and by shared resources of the "worm community".
In response to DNA damage organisms activate checkpoint pathways. In multicellular organisms these pathways lead the activation of DNA repair processes, to a transient cell cycle arrest, or to programmed cell death to eliminate cells that might potentially become harmful for the entire organism.The analysis of the pathways needed for DNA damage sensing, DAN repair and the elucidation of checkpoint responses are currently under intense investigation. We were among the first to use C. elegans to contribute to the understanding of DNA damage dependent apoptosis. Given that genome instability is a major course of human cancers we hope, that in the long run, we might contribute to better tumour-diagnostics and treatment.
Furthermore, we also started to explore C. elegans to uncover molecular mechanisms leading to Parkinson's Disease. Finally we engage in multiple collaborations within the college. Projects include the visualization of key aspects of DNA replication in early C. elegans embryos, and taking full advantage of advanced quantitative mass spectroscopy based approaches.
Meier, B., Volkova, N. V., Gerstung, M. & Gartner, A., Nov 2020, In: DNA Repair. 95, 11 p., 102957.
Research output: Contribution to journal › Article › peer-review
Freeman, A. D. J., Knebel, A., Gartner, A. & Lilley, D. M. J., 2 Oct 2020, In: Journal of Molecular Biology. 432, 21, p. 5825-5834 10 p.
Research output: Contribution to journal › Article › peer-reviewOpen Access
Meier, B., González-Huici, V., Bertolini, S., Gonzalez, S., Vöhringer, H., Abascal, F., Martincorena, I., Campbell, P. J., Gartner, A. & Gerstung, M., 1 May 2020, In: Nature Communications. 11, p. 1-15 15 p., 2169.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile10 Citations (Scopus)33 Downloads (Pure)
The Balance between Mono- and NEDD8-Chains Controlled by NEDP1 upon DNA Damage Is a Regulatory Module of the HSP70 ATPase ActivityBailly, A. P., Perrin, A., Serrano-Macia, M., Maghames, C., Leidecker, O., Trauchessec, H., Martinez-Chantar, M. L., Gartner, A. & Xirodimas, D. P., 1 Oct 2019, In: Cell Reports. 29, 1, p. 212-224.e8 21 p.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile8 Citations (Scopus)89 Downloads (Pure)
6-hydroxydopamine (6-OHDA) Oxidative Stress Assay for Observing Dopaminergic Neuron Loss in Caenorhabditis elegansOffenburger, S-L. & Gartner, A., 20 Sep 2018, In: Bio-Protocol. 8, 18, 12 p., e3025.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile194 Downloads (Pure)