Knebel, Axel

Dr

  • United Kingdom

  • 2315 Citations
  • 21 h-Index
20012018
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  • 6 Similar Profiles
Ubiquitin Medicine & Life Sciences
Phosphorylation Chemical Compounds
Ubiquitin-Protein Ligases Medicine & Life Sciences
Cullin Proteins Medicine & Life Sciences
Polyubiquitin Medicine & Life Sciences
Proteins Chemical Compounds
Serine Medicine & Life Sciences
Ligases Medicine & Life Sciences

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Research Output 2001 2018

  • 2315 Citations
  • 21 h-Index
  • 40 Article
3 Citations

Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity

Pao, K-C., Wood, N. T., Knebel, A., Rafie, K., Stanley, M., Mabbitt, P. D., Sundaramoorthy, R., Hofmann, K., van Aalten, D. M. F. & Virdee, S., 11 Apr 2018, In : Nature. 556, 7701, p. 381-385 5 p.

Research output: Contribution to journalArticle

Open Access
File
Ubiquitin-Protein Ligases
Esterification
Ubiquitin
Genes
Ubiquitination

Phosphorylation of Parkin at Serine65 is essential for its activation in vivo

McWilliams, T. G., Barini, E., Pohjolan-Pirhonen, R., Brooks, S. P., Singh, F., Burel, S., Balk, K., Kumar, A., Montava Garriga, L., Prescott, A., Hassoun, S. M., Mouton-Liger, F., Ball, G., Hills, R., Knebel, A., Ulusoy, A., Di Monte, D. A., Tamjar, J., Antico, O., Fears, K. & 11 othersSmith, L., Brambilla, R., Palin, E., Valori, M., Eerola-Rautio, J., Tienari, P., Corti, O., Dunnett, S. B., Ganley, I., Suomalainen, A. & Muqit, M., 7 Nov 2018, In : Open Biology. 8, 11, 18 p., 181108.

Research output: Contribution to journalArticle

Open Access
File
Phosphorylation
serine
Serine
phosphorylation
Chemical activation
1 Citations

RNF12 X-linked intellectual disability mutations disrupt E3 ligase activity and neural differentiation

Bustos, F., Segarra Fas, A., Chaugule, V. K., Brandenburg, L., Branigan, E., Toth, R., Macartney, T., Knebel, A., Hay, R., Walden, H. & Findlay, G., 8 May 2018, In : Cell Reports. 23, p. 1599-1611 14 p.

Research output: Contribution to journalArticle

Open Access
File
Ubiquitin-Protein Ligases
Stem cells
Intellectual Disability
Mutation
Genes
1 Citations

The MALDI TOF E2/E3 ligase assay as universal tool for drug discovery in the ubiquitin pathway

De Cesare, V., Johnson, C., Barlow, V., Hastie, C., Knebel, A. & Trost, M., 12 Jul 2018, In : Cell Chemical Biology.

Research output: Contribution to journalArticle

Open Access
File
Ubiquitin-Protein Ligases
Drug Discovery
Ubiquitin
Ionization
Assays
7 Citations

A single MIU motif of MINDY-1 recognizes K48-linked polyubiquitin chains

Kristariyanto, Y., Rehman, S. A. A., Weidlich, S., Knebel, A. & Kulathu, Y., 1 Mar 2017, In : EMBO Reports. 18, 3, p. 392-402 11 p., e201643205.

Research output: Contribution to journalArticle

Open Access
File
Polyubiquitin
Ubiquitin
Tandem Repeat Sequences
Binders
Conformations