Knebel, Axel

Dr

  • Senior investigator Scientist (MRC), MRC PPU
  • United Kingdom

  • 2496 Citations
  • 22 h-Index
20012019
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  • 3 Similar Profiles
Ubiquitin Medicine & Life Sciences
Ubiquitin-Protein Ligases Medicine & Life Sciences
Phosphorylation Chemical Compounds
Cullin Proteins Medicine & Life Sciences
Ligases Medicine & Life Sciences
Polyubiquitin Medicine & Life Sciences
Proteins Chemical Compounds
Serine Medicine & Life Sciences

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Research Output 2001 2019

  • 2496 Citations
  • 22 h-Index
  • 41 Article
16 Downloads (Pure)

Coupled monoubiquitylation of the co-E3 ligase DCNL1 by Ariadne RBR E3 ubiquitin ligases promotes cullin-RING ligase complex remodeling

Kelsall, I. R., Kristariyanto, Y. A., Knebel, A., Wood, N. T., Kulathu, Y. & Alpi, A. F., 22 Feb 2019, In : Journal of Biological Chemistry. 294, 8, p. 2651-2664 14 p.

Research output: Contribution to journalArticle

Open Access
File
Cullin Proteins
Ubiquitin-Protein Ligases
Ligases
Ubiquitin
Ubiquitins
10 Citations (Scopus)
50 Downloads (Pure)

Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity

Pao, K-C., Wood, N. T., Knebel, A., Rafie, K., Stanley, M., Mabbitt, P. D., Sundaramoorthy, R., Hofmann, K., van Aalten, D. M. F. & Virdee, S., 11 Apr 2018, In : Nature. 556, 7701, p. 381-385 5 p.

Research output: Contribution to journalArticle

Open Access
File
Ubiquitin-Protein Ligases
Esterification
Ubiquitin
Genes
Ubiquitination
3 Citations (Scopus)
19 Downloads (Pure)

Phosphorylation of Parkin at Serine65 is essential for its activation in vivo

McWilliams, T. G., Barini, E., Pohjolan-Pirhonen, R., Brooks, S. P., Singh, F., Burel, S., Balk, K., Kumar, A., Montava Garriga, L., Prescott, A., Hassoun, S. M., Mouton-Liger, F., Ball, G., Hills, R., Knebel, A., Ulusoy, A., Di Monte, D. A., Tamjar, J., Antico, O., Fears, K. & 11 othersSmith, L., Brambilla, R., Palin, E., Valori, M., Eerola-Rautio, J., Tienari, P., Corti, O., Dunnett, S. B., Ganley, I., Suomalainen, A. & Muqit, M., 7 Nov 2018, In : Open Biology. 8, 11, p. 1-18 18 p., 181108.

Research output: Contribution to journalArticle

Open Access
File
Phosphorylation
serine
Serine
phosphorylation
Chemical activation
2 Citations (Scopus)
29 Downloads (Pure)

RNF12 X-linked intellectual disability mutations disrupt E3 ligase activity and neural differentiation

Bustos, F., Segarra Fas, A., Chaugule, V. K., Brandenburg, L., Branigan, E., Toth, R., Macartney, T., Knebel, A., Hay, R., Walden, H. & Findlay, G., 8 May 2018, In : Cell Reports. 23, 6, p. 1599-1611 13 p.

Research output: Contribution to journalArticle

Open Access
File
Ubiquitin-Protein Ligases
Stem cells
Intellectual Disability
Mutation
Genes
6 Citations (Scopus)
28 Downloads (Pure)

The MALDI TOF E2/E3 ligase assay as universal tool for drug discovery in the ubiquitin pathway

De Cesare, V., Johnson, C., Barlow, V., Hastie, C., Knebel, A. & Trost, M., 12 Jul 2018, In : Cell Chemical Biology.

Research output: Contribution to journalArticle

Open Access
File
Ubiquitin-Protein Ligases
Drug Discovery
Ubiquitin
Ionization
Assays