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Baragana, Beatriz

Dr

  • 245 Citations
  • 7 h-Index
20102020
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  • 43 Similar Profiles
Malaria Medicine & Life Sciences
Plasmodium falciparum Medicine & Life Sciences
Antimalarials Medicine & Life Sciences
Drug Discovery Medicine & Life Sciences
Lysine-tRNA Ligase Medicine & Life Sciences
Pharmaceutical Preparations Medicine & Life Sciences
Pharmacokinetics Medicine & Life Sciences
4-Quinolones Chemical Compounds

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Projects 2019 2020

Genetic Validation of a Promising Drug Target for Cryptosporidiosis

Baragana, B., Gilbert, I., Pawlowic, M. & Wyllie, S.

Carnegie Trust for the Universities of Scotland

26/08/19 → 25/08/20

Project: Research

Research Output 2010 2019

  • 245 Citations
  • 7 h-Index
  • 11 Article
  • 1 Review article
  • 1 Patent
1 Citation (Scopus)
83 Downloads (Pure)

Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis

Baragaña, B., Forte, B., Choi, R., Nakazawa Hewitt, S., Bueren-Calabuig, J. A., Pisco, J. P., Peet, C., Dranow, D. M., Robinson, D. A., Jansen, C., Norcross, N. R., Vinayak, S., Anderson, M., Brooks, C. F., Cooper, C. A., Damerow, S., Delves, M., Dowers, K., Duffy, J., Edwards, T. E. & 57 others, Hallyburton, I., Horst, B. G., Hulverson, M. A., Ferguson, L., Jiménez-Díaz, M. B., Jumani, R. S., Lorimer, D. D., Love, M. S., Maher, S., Matthews, H., McNamara, C. W., Miller, P., O'Neill, S., Ojo, K. K., Osuna-Cabello, M., Pinto, E., Post, J., Riley, J., Rottmann, M., Sanz, L. M., Scullion, P., Sharma, A., Shepherd, S. M., Shishikura, Y., Simeons, F. R. C., Stebbins, E. E., Stojanovski, L., Straschil, U., Tamaki, F. K., Tamjar, J., Torrie, L. S., Vantaux, A., Witkowski, B., Wittlin, S., Yogavel, M., Zuccotto, F., Angulo-Barturen, I., Sinden, R., Baum, J., Gamo, F-J., Mäser, P., Kyle, D. E., Winzeler, E. A., Myler, P. J., Wyatt, P. G., Floyd, D., Matthews, D., Sharma, A., Striepen, B., Huston, C. D., Gray, D. W., Fairlamb, A. H., Pisliakov, A. V., Walpole, C., Read, K. D., Van Voorhis, W. C. & Gilbert, I. H., 2 Apr 2019, In : Proceedings of the National Academy of Sciences. 116, 14, p. 7015-7020 6 p.

Research output: Contribution to journal › Article

Open Access
File
Lysine-tRNA Ligase
Cryptosporidiosis
Cryptosporidium parvum
Malaria
Plasmodium falciparum
13 Downloads (Pure)

Substituted Aminoacetamides as Novel Leads for Malaria Treatment

Norcross, N., Wilson, C., Baragana, B., Hallyburton, I., Osuna-Cabello, M., Norval, S., Riley, J., Fletcher, D., Sinden, R., Delves, M. J., Ruecker, A., Duffy, S., Meister, S., Antonova-Koch, Y., Crespo, B., de Cózar, C., Sanz, L., Gamo, F-J., Avery, V. M., Frearson, J. A. & 8 others, Gray, D., Fairlamb, A., Winzeler, E. A., Waterson, D., Campbell, S. F., Willis, P., Read, K. & Gilbert, I., 17 Jul 2019, In : ChemMedChem. 14, 14, p. 1329-1335 7 p.

Research output: Contribution to journal › Article

Pharmacokinetics
Antimalarials
Germ Cells
Scaffolds
Malaria
13 Citations (Scopus)
96 Downloads (Pure)

Challenges and recent progress in drug discovery for tropical diseases

De Rycker, M., Baragaña, B., Duce, S. L. & Gilbert, I. H., 25 Jul 2018, In : Nature. 559, 7715, p. 498-506 9 p.

Research output: Contribution to journal › Review article

Open Access
File
Drug Discovery
Pharmaceutical Preparations
Communicable Diseases
Economics
Morbidity
11 Citations (Scopus)
209 Downloads (Pure)

Biochemical and Structural Characterization of Selective Allosteric Inhibitors of the Plasmodium falciparum Drug Target, Prolyl-tRNA-synthetase

Nakazawa Hewitt, S., Dranow, D. M., Horst, B. G., Abendroth, J. A., Forte, B., Hallyburton, I., Jansen, C., Baragana, B., Choi, R., Rivas, K., Hulverson, M. A., Dumais, M., Edwards, T. E., Lorimer, D. D., Fairlamb, A., Gray, D., Read, K., Lehane, A. M., Kirk, K., Myler, P. J. & 6 others, Wernimont, A., Walpole, C., Stacy, R., Barrett, L., Gilbert, I. H. & Van Voorhis, W. C., 13 Jan 2017, In : ACS Infectious Diseases. 3, 1, p. 34-44 11 p.

Research output: Contribution to journal › Article

Open Access
File
Pharmaceutical Chemistry
Plasmodium falciparum
Malaria
Crystallography
X Ray Crystallography
4 Citations (Scopus)
105 Downloads (Pure)

Screening a protein kinase inhibitor library against Plasmodium falciparum

Hallyburton, I., Grimaldi, R., Woodland, A., Baragana, B., Luksch, T., Spinks, D., James, D., Leroy, D., Waterson, D., Fairlamb, A. H., Wyatt, P. G., Gilbert, I. H. & Frearson, J. A., 7 Nov 2017, In : Malaria Journal. 16, p. 1-11 11 p., 446.

Research output: Contribution to journal › Article

Open Access
File
Plasmodium falciparum
Protein Kinase Inhibitors
Protein Kinases
Malaria
Small Molecule Libraries