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Hunter, Bill

Professor

Biological Chemistry and Drug Discovery

https://orcid.org/0000-0002-6019-3102

United Kingdom

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Projects 2012 2024

3 Finished
5 Active

Industrial Collaborative Awards in Science and Engineering (iCASE) Studentships for the University of Dundee

Hunter, W. & MacKintosh, C.

Medical Research Council

3/09/18 → 31/03/23

Project: Research

Industrial Strategy MRC DTP Studentship for the University of Dundee

Hunter, W. & MacKintosh, C.

Medical Research Council

1/09/18 → 28/02/22

Project: Research

University of Dundee NPIF Studentships 2017

Medical Research Council

1/09/17 → 28/02/21

Project: Research

Training the Next Generation of Scientists in Quantitative and Interdisciplinary Approaches to Biomedical Science (Doctoral Training Partnership)

Hunter, W. & MacKintosh, C.

Medical Research Council

5/09/16 → 31/03/24

Project: Research

Lipopolysaccharide Translocation Across the Gram-Negative Inner Membrane: Development and Exploitation of Reagents and Knowledge to Guide Early Stage Drug Discovery(EPSRC-DSTL Industrial CASE Studentship)

Engineering and Physical Sciences Research Council

1/10/15 → 1/10/19

Project: Research

Research Output 1996 2018

86 Article
5 Editorial
2 Letter
2 Review article

Amino acid substitutions in the human homomeric β3 GABAA receptor that enable activation by GABA

Gottschald Chiodi, C., Baptista-Hon, D., Hunter, W. & Hales, T., 13 Dec 2018, In : Journal of Biological Chemistry.

Research output: Contribution to journal › Article

GABA-A Receptors

Amino Acid Substitution

gamma-Aminobutyric Acid

Substitution reactions

Chemical activation

Structure and activity of ChiX, a peptidoglycan hydrolase required for chitinase secretion by Serratia marcescens

Owen, R. A., Fyfe, P. K., Lodge, A., Biboy, J., Vollmer, W., Hunter, W. N. & Sargent, F., 23 Jan 2018, In : Biochemical Journal. 475, 2, p. 415-428 14 p.

Research output: Contribution to journal › Article

Open Access

File

N-Acetylmuramoyl-L-alanine Amidase

Chitinases

Serratia marcescens

Machinery

Peptidoglycan

1 Citations

An improved model of the Trypanosoma brucei CTP synthetase glutaminase domain-acivicin complex

de Souza, J. O., Dawson, A. & Hunter, W. N., 20 Apr 2017, In : ChemMedChem. 12, 8, p. 577-579 3 p.

Research output: Contribution to journal › Article

Open Access

File

CTP synthetase

acivicin

Glutaminase

Trypanosoma brucei brucei

Neglected Diseases

2 Citations

Exploiting the 2-Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery

Linciano, P., Dawson, A., Pöhner, I., Costa, D. M., Sá, M. S., Cordeiro Da Silva, A., Luciani, R., Gul, S., Witt, G., Ellinger, B., Kuzikov, M., Gribbon, P., Reinshagen, J., Wolf, M., Behrens, B., Hannaert, V., Michels, P. A. M., Nerini, E., Pozzi, C., di Pisa, F. & 19 othersLandi, G., Santarem, N., Ferrari, S., Saxena, P., Lazzari, S., Cannazza, G., Freitas-Junior, L. H., Moraes, C. B., Pascoalino, B. S., Alcântara, L. M., Bertolacini, C. P., Fontana, V., Wittig, U., Müller, W., Wade, R. C., Hunter, W. N., Mangani, S., Costantino, L. & Costi, M. P., 30 Sep 2017, In : ACS Omega. 2, 9, p. 5666-5683 18 p.

Research output: Contribution to journal › Article

Open Access

File

2-amino-1,3,4-thiadiazole

Thiadiazoles

Scaffolds

Methotrexate

Folic Acid Antagonists

4 Citations

Mutations in POGLUT1 in Galli-Galli/Dowling Degos-disease

Wilson, N. J., Cole, C., Kroboth, K., Hunter, W. N., Mann, J. A., Irwin McLean, W. H., Kernland Lang, K., Beltraminelli, H., Sabroe, R. A., Tiffin, N., Sobey, G. J., Borradori, L., Simpson, E. & Smith, F. J. D., Jan 2017, In : British Journal of Dermatology. 176, 1, p. 270-274 5 p.

Research output: Contribution to journal › Letter

Open Access

File

Glucosyltransferases

Genetic Databases

Mutation

Proteins

Keratin-5

Thesis

Assessment of potential antibacterial drug targets

Author: Diaz Saez, L., 2016

Supervisor: Hunter, W. (Supervisor)

Student thesis: Doctoral Thesis › Doctor of Philosophy

File

Development of a high throughput ligand screening method and structural studies of pentameric ligand gated ion channels.

Author: Trumper, P., 2014

Supervisor: Hunter, W. (Supervisor) & Hales, T. (Supervisor)

Student thesis: Doctoral Thesis › Doctor of Philosophy

File

Structural characterization of bacterial membrane proteins via molecular dynamics simulations and electrophysiology

Author: Tamburrino, G., 2018

Supervisor: Zachariae, U. (Supervisor) & Hunter, W. (Supervisor)

Student thesis: Doctoral Thesis › Doctor of Philosophy

Structural examination of trypanosomatid tubulin-binding cofactors and pteridine reductase 1 inhibition

Author: Barrack, K. L., 2013

Supervisor: Hunter, W. (Supervisor)

Student thesis: Doctoral Thesis › Doctor of Philosophy

File

Structural studies to inform antimicrobial drug discovery and the basis of immunity against T6 effectors

Author: O'Rourke, P., 2013

Supervisor: Hunter, W. (Supervisor)

Student thesis: Doctoral Thesis › Doctor of Philosophy

File

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