Hunter, Bill

Professor

  • United Kingdom

1993 …2020

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

Filter
Article
2020
Open Access
File
43 Downloads (Pure)
2019

Amino acid substitutions in the human homomeric β3 GABAA receptor that enable activation by GABA

Gottschald Chiodi, C., Baptista-Hon, D., Hunter, W. & Hales, T., 15 Feb 2019, In : Journal of Biological Chemistry. 294, 7, p. 2375-2385 11 p.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
95 Downloads (Pure)
Open Access
File
156 Downloads (Pure)
1 Citation (Scopus)

Burkholderia pseudomallei D-alanine-D-alanine ligase: detailed characterisation and assessment of a potential antibiotic drug target

Díaz‐Sáez, L., Torrie, L. S., McElroy, S. P., Gray, D. & Hunter, W. M., 18 Nov 2019, In : FEBS Journal. 286, 22, p. 4509-4524 16 p.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
83 Downloads (Pure)

Engineering a surrogate human heteromeric α/β glycine receptor orthosteric site exploiting the structural homology and stability of acetylcholine-binding protein

Dawson, A., Trumper, P., de Souza, J. O., Parker, H., Jones, M. J., Hales, T. G. & Hunter, W. N., 1 Nov 2019, In : IUCrJ. 6, Part 6, p. 1014-1023 10 p.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
88 Downloads (Pure)
Open Access
File
1 Citation (Scopus)
150 Downloads (Pure)
2018

Structure and activity of ChiX, a peptidoglycan hydrolase required for chitinase secretion by Serratia marcescens

Owen, R. A., Fyfe, P. K., Lodge, A., Biboy, J., Vollmer, W., Hunter, W. N. & Sargent, F., 23 Jan 2018, In : Biochemical Journal. 475, 2, p. 415-428 14 p.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
166 Downloads (Pure)
2017

An improved model of the Trypanosoma brucei CTP synthetase glutaminase domain-acivicin complex

de Souza, J. O., Dawson, A. & Hunter, W. N., 20 Apr 2017, In : ChemMedChem. 12, 8, p. 577-579 3 p.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
170 Downloads (Pure)

Exploiting the 2-Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery

Linciano, P., Dawson, A., Pöhner, I., Costa, D. M., Sá, M. S., Cordeiro Da Silva, A., Luciani, R., Gul, S., Witt, G., Ellinger, B., Kuzikov, M., Gribbon, P., Reinshagen, J., Wolf, M., Behrens, B., Hannaert, V., Michels, P. A. M., Nerini, E., Pozzi, C., di Pisa, F. & 19 others, Landi, G., Santarem, N., Ferrari, S., Saxena, P., Lazzari, S., Cannazza, G., Freitas-Junior, L. H., Moraes, C. B., Pascoalino, B. S., Alcântara, L. M., Bertolacini, C. P., Fontana, V., Wittig, U., Müller, W., Wade, R. C., Hunter, W. N., Mangani, S., Costantino, L. & Costi, M. P., 30 Sep 2017, In : ACS Omega. 2, 9, p. 5666-5683 18 p.

Research output: Contribution to journalArticle

Open Access
File
15 Citations (Scopus)
196 Downloads (Pure)

Open and compressed conformations of Francisella tularensis ClpP

Díaz-Sáez, L., Pankov, G. & Hunter, W. N., Jan 2017, In : Proteins: Structure, Function, and Bioinformatics. 85, 1, p. 188-194 7 p.

Research output: Contribution to journalArticle

Open Access
File
5 Citations (Scopus)
94 Downloads (Pure)
2016

EssC: domain structures inform on the elusive translocation channels in the Type VII secretion system.

Zoltner, M., Ng, W. M. A. V., Money, J. J., Fyfe, P. K., Kneuper, H., Palmer, T. & Hunter, W. N., Jul 2016, In : Biochemical Journal. 473, 13, p. 1941-1952 12 p.

Research output: Contribution to journalArticle

Open Access
File
16 Citations (Scopus)
143 Downloads (Pure)

Membrane interactions and self-association of components of the Ess/Type VII secretion system of Staphylococcus aureus

Jager, F., Zoltner, M., Kneuper, H., Hunter, W. N. & Palmer, T., 12 Feb 2016, In : FEBS Letters. 590, 3, p. 349-357 9 p.

Research output: Contribution to journalArticle

Open Access
File
12 Citations (Scopus)
131 Downloads (Pure)

The state-of-the art in macromolecular crystallization: The IYCr series concludes

Weiss, M. S., Hunter, W. N. & Einspahr, H. M., 2016, In : Acta Crystallographica Section F: Structural Biology Communications. 72, p. 1 1 p.

Research output: Contribution to journalArticle

Open Access
2015

Characterization of 2,4-Diamino-6-oxo-1,6-dihydropyrimidin-5-yl Ureido based inhibitors of Trypanosoma brucei FolD and testing for antiparasitic activity

Eadsforth, T. C., Pinto, A., Luciani, R., Tamborini, L., Cullia, G., De Micheli, C., Marinelli, L., Cosconati, S., Novellino, E., Lo Presti, L., Cordeiro Da Silva, A., Conti, P., Hunter, W. N. & Costi, M. P., 22 Oct 2015, In : Journal of Medicinal Chemistry. 58, 20, p. 7938-7948 11 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Crystals on the cover 2015

Einspahr, H., Weiss, M. S. & Hunter, W. N., Jan 2015, In : Acta Crystallographica Section F: Structural Biology Communications. F71, 1, p. 1-2 2 p.

Research output: Contribution to journalArticle

Open Access
File
118 Downloads (Pure)

Crystal structure of the C-terminal domain of tubulin-binding cofactor C from Leishmania major

Barrack, K. L., Fyfe, P. K., Finney, A. J. & Hunter, W. N., May 2015, In : Molecular and Biochemical Parasitology. 201, 1, p. 26-30 5 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
1 Citation (Scopus)
3 Citations (Scopus)
2014

Crystal structures of IspF from Plasmodium falciparum and Burkholderia cenocepacia: comparisons inform antimicrobial drug target assessment

O'Rourke, P. E. F., Kalinowska-Tłuścik, J., Fyfe, P. K., Dawson, A. & Hunter, W. N., 10 Jan 2014, In : BMC Structural Biology. 14, 12 p., 1.

Research output: Contribution to journalArticle

Open Access
12 Citations (Scopus)

Heterogeneity in ess transcriptional organization and variable contribution of the Ess/Type VII protein secretion system to virulence across closely related Staphylocccus aureus strains

Kneuper, H., Cao, Z. P., Twomey, K. B., Zoltner, M., Jäger, F., Cargill, J. S., Chalmers, J., van der Kooi-Pol, M. M., van Dijl, J. M., Ryan, R. P., Hunter, W. N. & Palmer, T., 30 Jul 2014, In : Molecular Microbiology. 93, 5, p. 928-943 15 p.

Research output: Contribution to journalArticle

Open Access
File
35 Citations (Scopus)
149 Downloads (Pure)
Open Access
File
5 Citations (Scopus)
154 Downloads (Pure)

How the structure of the large subunit controls function in an oxygen-tolerant [NiFe]-hydrogenase

Bowman, L., Flanagan, L., Fyfe, P. K., Parkin, A., Hunter, W. N. & Sargent, F., 28 Feb 2014, In : Biochemical Journal. 458, 3, p. 449-458 10 p.

Research output: Contribution to journalArticle

Open Access
File
32 Citations (Scopus)
177 Downloads (Pure)

Structure-based design and synthesis of antiparasitic pyrrolopyrimidines targeting pteridine reductase 1

Khalaf, A. I., Huggan, J. K., Suckling, C. J., Gibson, C. L., Stewart, K., Giordani, F., Barrett, M. P., Wong, P. E., Barrack, K. L. & Hunter, W. N., 14 Aug 2014, In : Journal of Medicinal Chemistry. 57, 15, p. 6479-6494 16 p.

Research output: Contribution to journalArticle

Open Access
File
22 Citations (Scopus)
282 Downloads (Pure)

Structures of bacterial kynurenine formamidase reveal a crowded binuclear zinc catalytic site primed to generate a potent nucleophile

Díaz-Sáez, L., Srikannathasan, V., Zoltner, M. & Hunter, W. N., 15 Sep 2014, In : Biochemical Journal. 462, 3, p. 581-589 9 p.

Research output: Contribution to journalArticle

Open Access
File
8 Citations (Scopus)
144 Downloads (Pure)
2013
12 Citations (Scopus)

Structural basis for type VI secreted peptidoglycan DL-endopeptidase function, specificity and neutralization in Serratia marcescens

Srikannathasan, V., English, G., Bui, N. K., Trunk, K., O'Rourke, P. E. F., Rao, V. A., Vollmer, W., Coulthurst, S. J. & Hunter, W. N., Dec 2013, In : Acta Crystallographica Section D: Biological Crystallography. 69, 12, p. 2468-2482 15 p.

Research output: Contribution to journalArticle

Open Access
File
23 Citations (Scopus)
103 Downloads (Pure)

Structure of Pseudomonas aeruginosa inosine 5-monophosphate dehydrogenase

Rao, V. A., Shepherd, S. M., Owen, R. & Hunter, W. N., 2013, In : Acta Crystallographica F-Structural Biology and Crystallization Communications. 69, 3, p. 243-247 5 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Structure of the SCAN domain of human paternally expressed gene 3 protein

Rimsa, V., Eadsforth, T. C. & Hunter, W. N., 23 Jul 2013, In : PLoS ONE. 8, 7, e69538.

Research output: Contribution to journalArticle

7 Citations (Scopus)

The architecture of EssB, an integral membrane component of the type VII secretion system

Zoltner, M., Norman, D. G., Fyfe, P. K., El Mkami, H., Palmer, T. & Hunter, W. N., 2 Apr 2013, In : Structure. 21, 4, p. 595-603 9 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

The architecture of Trypanosoma brucei tubulin-binding cofactor B and implications for function

Fleming, J. R., Morgan, R. E., Fyfe, P. K., Kelly, S. M. & Hunter, W. N., 2013, In : FEBS Journal. 280, 14, p. 3270-3280 11 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Two high-resolution structures of the human E3 ubiquitin ligase Siah1

Rimsa, V., Eadsforth, T. C. & Hunter, W. N., Dec 2013, In : Acta Crystallographica F-Structural Biology and Crystallization Communications. 69, 12, p. 1339-1343 5 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
2012

Assessment of pseudomonas aeruginosa N-5,N-10-methylenetetrahydrofolate dehydrogenase - cyclohydrolase as a potential antibacterial drug target

Eadsforth, T. C., Gardiner, M., Maluf, F. V., McElroy, S., James, D., Frearson, J., Gray, D. & Hunter, W. N., 2012, In : PLoS ONE. 7, 4, p. - 11 p., e35973.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Conserved signal peptide recognition systems across the prokaryotic domains

Coulthurst, S. J., Dawson, A., Hunter, W. N. & Sargent, F., 28 Feb 2012, In : Biochemistry. 51, 8, p. 1678-1686 9 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

IspE inhibitors identified by a combination of in silico and in vitro high-throughput screening

Tidten-Luksch, N., Grimaldi, R., Torrie, L. S., Frearson, J. A., Hunter, W. N. & Brenk, R., 2012, In : PLoS ONE. 7, 4, p. - 16 p., e35792.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Leishmania TDR1 structure, a unique trimeric glutathione transferase capable of deglutathionylation and antimonial prodrug activation

Fyfe, P. K., Westrop, G. D., Silva, A. M., Coombs, G. H. & Hunter, W. N., 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 29, p. 11693-11698 6 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

New secreted toxins and immunity proteins encoded within the type VI secretion system gene cluster of Serratia marcescens

English, G., Trunk, K., Rao, V. A., Srikannathasan, V., Hunter, W. N. & Coulthurst, S. J., Nov 2012, In : Molecular Microbiology. 86, 4, p. 921-936 16 p.

Research output: Contribution to journalArticle

73 Citations (Scopus)
7 Citations (Scopus)
2011

Crystal structures of Burkholderia cenocepacia dihydropteroate synthase in the apo-form and complexed with the product 7,8-dihydropteroate

Morgan, R. E., Batot, G. O., Dement, J. M., Rao, V. A., Eadsforth, T. C. & Hunter, W. N., 9 May 2011, In : BMC Structural Biology. 11, p. - 9 p., 21.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Crystal structures of penicillin-binding protein 3 from Pseudomonas aeruginosa: comparison of native and antibiotic-bound forms

Sainsbury, S., Bird, L., Rao, V., Shepherd, S. M., Stuart, D. I., Hunter, W. N., Owens, R. J. & Ren, J., 7 Jan 2011, In : Journal of Molecular Biology. 405, 1, p. 173-184 12 p.

Research output: Contribution to journalArticle

47 Citations (Scopus)

Exploiting the high-resolution crystal structure of Staphylococcus aureus MenH to gain insight into enzyme activity

Dawson, A., Fyfe, P. K., Gillet, F. & Hunter, W. N., 22 Apr 2011, In : BMC Structural Biology. 11, p. - 11 p., 19.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Pseudomonas aeruginosa 4-Amino-4-deoxychorismate lyase: spatial conservation of an active site tyrosine and classification of two types of enzyme

O'Rourke, P. E. F., Eadsforth, T. C., Fyfe, P. K., Shepherd, S. M. & Hunter, W. N., 15 Sep 2011, In : PLoS ONE. 6, 9, p. - 8 p., e24158.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Structure of recombinant Leishmania donovani pteridine reductase reveals a disordered active site

Barrack, K. L., Tulloch, L. B., Burke, L-A., Fyfe, P. K. & Hunter, W. N., Jan 2011, In : Acta Crystallographica F-Structural Biology and Crystallization Communications. 67, p. 33-37 5 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Syringyl lignin is unaltered by severe sinapyl alcohol dehydrogenase suppression in tobacco

Barakate, A., Stephens, J., Goldie, A., Hunter, W. N., Marshall, D., Hancock, R. D., Lapierre, C., Morreele, K., Boerjane, W. & Halpin, C., Dec 2011, In : Plant Cell. 23, 12, p. 4492-4506 15 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

The structure of Serratia marcescens Lip, a membrane-bound component of the type VI secretion system

Rao, V. A., Shepherd, S. M., English, G., Coulthurst, S. J. & Hunter, W. N., Dec 2011, In : Acta Crystallographica Section D: Biological Crystallography. 67, p. 1065-1072 8 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)
2010

A triclinic crystal form of Escherichia coli 4-diphosphocytidyl-2C-methyl-D-erythritol kinase and reassessment of the quaternary structure

Kalinowska-Tluscik, J., Miallau, L., Gabrielsen, M., Leonard, G. A., McSweeney, S. M. & Hunter, W. N., Mar 2010, In : Acta Crystallographica F-Structural Biology and Crystallization Communications. 66, p. 237-241 5 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)