Lipworth, Brian

Professor

  • 8143 Citations
  • 39 h-Index
1989 …2020
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Research Output 1989 2020

1989
11 Citations (Scopus)

Development of persistent late onset asthma following treatment with captopril

Lipworth, B. J., McMurray, J. J., Clark, R. A. & Struthers, A. D., 1989, In : European Respiratory Journal. 2, 6, p. 586-588 3 p.

Research output: Contribution to journalArticle

Bronchial Hyperreactivity
Captopril
Angiotensin-Converting Enzyme Inhibitors
Asthma
Airway Obstruction
34 Citations (Scopus)

Pharmacokinetics, efficacy and adverse effects of sublingual salbutamol in patients with asthma

Lipworth, B. J., Clark, R. A., Dhillon, D. P., Moreland, T. A., Struthers, A. D., Clark, G. A. & McDevitt, D. G., 1989, In : European Journal of Clinical Pharmacology. 37, 6, p. 567-571 5 p.

Research output: Contribution to journalArticle

Albuterol
Metered Dose Inhalers
Tablets
Asthma
Pharmacokinetics
29 Citations (Scopus)
Albuterol
Diuretics
Bendroflumethiazide
Hypokalemia
Drug Combinations
16 Citations (Scopus)
Metered Dose Inhalers
Pyrus
Albuterol
Adrenergic Receptors
Hemodynamics
113 Citations (Scopus)
Tachyphylaxis
Albuterol
Therapeutics
Tremor
Ipratropium
1990
7 Citations (Scopus)
Bendroflumethiazide
Triamterene
Albuterol
Magnesium
Potassium
14 Citations (Scopus)
Triamterene
Spironolactone
Diuretics
Electrocardiography
Bendroflumethiazide
1992
87 Citations (Scopus)

Elevated levels of brain natriuretic peptide in acute hypoxaemic chronic obstructive pulmonary disease

Lang, C. C., Coutie, W. J., Struthers, A. D., Dhillon, D. P., Winter, J. H. & Lipworth, B. J., Nov 1992, In : Clinical Science. 83, 5, p. 529-533 5 p.

Research output: Contribution to journalArticle

Brain Natriuretic Peptide
Chronic Obstructive Pulmonary Disease
Atrial Natriuretic Factor
Partial Pressure
Arterial Pressure
18 Citations (Scopus)

Sex differences in hypokalaemic and electrocardiographic effects of inhaled terbutaline

Rahman, A. R. A., McDevitt, D. G., Struthers, A. D. & Lipworth, B. J., Dec 1992, In : Thorax. 47, 12, p. 1056-1059 4 p.

Research output: Contribution to journalArticle

Terbutaline
Sex Characteristics
Potassium
Heart Rate
Serum
5 Citations (Scopus)

The effects of enalapril and spironolactone on terbutaline-induced hypokalemia

Rahman, A. R. A., McDevitt, D. G., Struthers, A. D. & Lipworth, B. J., 1992, In : Chest. 102, 1, p. 91-5 5 p.

Research output: Contribution to journalArticle

Terbutaline
Spironolactone
Enalapril
Hypokalemia
E 10
1994
40 Citations (Scopus)

C-type natriuretic peptide levels in cor pulmonale and in congestive heart failure

Cargill, R. I., Barr, C. S., Coutie, W. J., Struthers, A. D. & Lipworth, B. J., 1994, In : Thorax. 49, 12, p. 1247-1249 3 p.

Research output: Contribution to journalArticle

C-Type Natriuretic Peptide
Pulmonary Heart Disease
Brain Natriuretic Peptide
Atrial Natriuretic Factor
Heart Failure
77 Citations (Scopus)

Increased plasma levels of brain natriuretic peptide in patients with isolated diastolic dysfunction

Lang, C. C., Prasad, N., McAlpine, H. M., Macleod, C., Lipworth, B. J., MacDonald, T. M. & Struthers, A. D., 1994, In : American Heart Journal. 127, 6, p. 1635-1636 2 p.

Research output: Contribution to journalComment/debate

1995
38 Citations (Scopus)

Abnormal myocardial repolarisation in response to hypoxaemia and fenoterol

Kiely, D. G., Cargill, R. I., Grove, A., Struthers, A. D. & Lipworth, B. J., Oct 1995, In : Thorax. 50, 10, p. 1062-6 5 p.

Research output: Contribution to journalArticle

Fenoterol
Cardiac Arrhythmias
Sudden Death
Hypoxia
16 Citations (Scopus)
Brain Natriuretic Peptide
Atrial Natriuretic Factor
Aldosterone
Angiotensin II
Placebos
14 Citations (Scopus)
Lisinopril
Heart Failure
Placebos
Diastole
Left Ventricular Dysfunction
18 Citations (Scopus)

Human C-type natriuretic peptide: effects on the haemodynamic and endocrine responses to angiotensin II

Cargill, R. I., Struthers, A. D. & Lipworth, B. J., 1995, In : Cardiovascular Research. 29, 1, p. 108-111 4 p.

Research output: Contribution to journalArticle

C-Type Natriuretic Peptide
Natriuretic Agents
Angiotensin II
Hemodynamics
Placebos

Profound vagal reactions to brain natriuretic peptide

Cargill, R. I., Clarkson, P. B. M., MacDonald, T. M. & Lipworth, B. J., Mar 1995, In : Journal of Molecular Medicine. 73, 3, p. 149-150 2 p.

Research output: Contribution to journalLetter

1996
14 Citations (Scopus)
Adrenergic Receptors
Prescriptions
Scotland
Population
Adrenal Cortex Hormones
1997
55 Citations (Scopus)

Cardiopulmonary effects of endothelin-1 in man

Kiely, D. G., Cargill, R. I., Struthers, A. D. & Lipworth, B. J., 1997, In : Cardiovascular Research. 33, 2, p. 378-386 9 p.

Research output: Contribution to journalArticle

Endothelin-1
Lung
Renin-Angiotensin System
Vascular Resistance
Hemodynamics
1998
2 Citations (Scopus)

Inhaled corticosteroid therapy reduces the early morning peak in cortisol and aldosterone

Wilson, A. M., Sims, E. J., Struthers, A. D. & Lipworth, B. J., Oct 1998, In : Clinical Science. 95, 4, p. 513-517 5 p.

Research output: Contribution to journalArticle

Aldosterone
Hydrocortisone
Adrenal Cortex Hormones
Placebos
Circadian Rhythm
11 Citations (Scopus)

Nitric oxide: an important role in the maintenance of systemic and pulmonary vascular tone in man

Kiely, D. G., Lee, A. F. C., Struthers, A. D. & Lipworth, B. J., 1998, In : British Journal of Clinical Pharmacology. 46, 3, p. 263-6 4 p.

Research output: Contribution to journalArticle

Vascular Resistance
Blood Vessels
Nitric Oxide
Maintenance
omega-N-Methylarginine
1999
20 Citations (Scopus)

Differences in lung bioavailability between different propellants for fluticasone propionate

Wilson, A. M., Sims, E. J., Orr, L. C. & Lipworth, B. J., 16 Oct 1999, In : Lancet. 354, 9187, p. 1357-8 2 p.

Research output: Contribution to journalLetter

HFA 134a
Chlorofluorocarbons
Biological Availability
Lung
Fluticasone
2000
89 Citations (Scopus)

Antiasthmatic effects of mediator blockade versus topical corticosteroids in allergic rhinitis and asthma

Wilson, A. M., Orr, L. C., Sims, E. J., Dempsey, O. J. & Lipworth, B. J., 1 Oct 2000, In : American Journal of Respiratory and Critical Care Medicine. 162, 4 , p. 1297-301 5 p.

Research output: Contribution to journalArticle

Anti-Asthmatic Agents
Budesonide
Adrenal Cortex Hormones
Asthma
Placebos
5 Citations (Scopus)

Continuity of prescribing with inhaled corticosteroids and control of asthma

McMahon, A. D., Lipworth, B. J., Davey, P. G., Morris, A. D. & Macdonald, T. M., 2000, In : Pharmacoepidemiology and Drug Safety. 9, 4, p. 293-303 11 p.

Research output: Contribution to journalArticle

Adrenal Cortex Hormones
Asthma
Hospitalization
Compliance
Nuclear Family
2001
25 Citations (Scopus)

Dose-response for adrenal suppression with hydrofluoroalkane formulations of fluticasone propionate and beclomethasone dipropionate

Fowler, S. J., Orr, L., Wilson, A. M., Sims, E. J. & Lipworth, B. J., 2001, In : British Journal of Clinical Pharmacology. 52, 1, p. 93-5 3 p.

Research output: Contribution to journalArticle

HFA 134a
Beclomethasone
Hydrocortisone
Creatinine
Placebos
154 Citations (Scopus)
Mometasone Furoate
Leukotriene Antagonists
Histamine Receptors
Seasonal Allergic Rhinitis
Nose
60 Citations (Scopus)

Effects of topical corticosteroid and combined mediator blockade on domiciliary and laboratory measurements of nasal function in seasonal allergic rhinitis

Wilson, A. M., Sims, E. J., Orr, L. C., Coutie, W. J. R., White, P. S., Gardiner, Q. & Lipworth, B. J., Oct 2001, In : Annals of Allergy, Asthma & Immunology. 87, 4, p. 344-9 6 p.

Research output: Contribution to journalArticle

Seasonal Allergic Rhinitis
Nose
Adrenal Cortex Hormones
2002
51 Citations (Scopus)
fexofenadine
montelukast
Loratadine
Seasonal Allergic Rhinitis
Nose
13 Citations (Scopus)

Airway and systemic effects of hydrofluoroalkane fluticasone and beclomethasone in patients with asthma

Currie, G. P., Fowler, S. J., Wilson, A. M., Sims, E. J., Orr, L. C. & Lipworth, B. J., 2002, In : Thorax. 57, 10, p. 865-8 4 p.

Research output: Contribution to journalArticle

HFA 134a
Beclomethasone
Methacholine Chloride
Creatinine
Asthma
55 Citations (Scopus)
montelukast
Leukotriene Antagonists
Triamcinolone
Adrenal Cortex Hormones
Anti-Inflammatory Agents
37 Citations (Scopus)

Effects of adding either a leukotriene receptor antagonist or low-dose theophylline to a low or medium dose of inhaled corticosteroid in patients with persistent asthma

Dempsey, O. J., Fowler, S. J., Wilson, A., Kennedy, G. & Lipworth, B. J., Jul 2002, In : Chest. 122, 1, p. 151-159 9 p.

Research output: Contribution to journalArticle

Leukotriene Antagonists
Beclomethasone
Theophylline
Adrenal Cortex Hormones
Asthma
40 Citations (Scopus)

Step-down therapy with low-dose fluticasone-salmeterol combination or medium-dose hydrofluoroalkane 134a–beclomethasone alone

Fowler, S. J., Currie, G. P. & Lipworth, B. J., Jun 2002, In : Journal of Allergy and Clinical Immunology. 109, 6, p. 929-935 7 p.

Research output: Contribution to journalArticle

HFA 134a
Beclomethasone
Methacholine Chloride
Adrenal Cortex Hormones
Therapeutics
18 Citations (Scopus)

Therapeutic ratio of hydrofluoroalkane and chlorofluorocarbon formulations of fluticasone propionate

Fowler, S. J., Orr, L. C., Sims, E. J., Wilson, A. M., Currie, G. P., McFarlane, L. & Lipworth, B. J., 2002, In : Chest. 122, 2, p. 618-23 6 p.

Research output: Contribution to journalArticle

HFA 134a
Chlorofluorocarbons
Therapeutics
Fluticasone
2003
17 Citations (Scopus)
Rhinitis, Allergic, Perennial
Adenosine Monophosphate
Nose
Histamine
Adrenal Cortex Hormones
89 Citations (Scopus)

Effects of montelukast on surrogate inflammatory markers in corticosteroid-treated patients with asthma

Currie, G. P., Lee, D. K. C., Haggart, K., Bates, C. E. & Lipworth, B. J., 2003, In : American Journal of Respiratory and Critical Care Medicine. 167, 9, p. 1232-1238 7 p.

Research output: Contribution to journalArticle

montelukast
Adrenal Cortex Hormones
Asthma
Biomarkers
Lung
7 Citations (Scopus)
Adrenal Cortex Hormones
Asthma
Quality of Life
Lung
Methacholine Chloride
2004
81 Citations (Scopus)

Adrenal suppression with dry powder formulations of fluticasone propionate and mometasone furoate

Fardon, T. C., Lee, D. K. C., Haggart, K., McFarlane, L. C. & Lipworth, B. J., Nov 2004, In : American Journal of Respiratory and Critical Care Medicine. 170, 9, p. 960-966 7 p.

Research output: Contribution to journalArticle

Mometasone Furoate
Powders
Hydrocortisone
Creatinine
Biological Availability
2005
22 Citations (Scopus)

Elevated levels of natriuretic peptides in patients with pulmonary thromboembolism

Kiely, D. G., Kennedy, N. S., Pirzada, O., Batchelor, S. A., Struthers, A. D. & Lipworth, B. J., Oct 2005, In : Respiratory Medicine. 99, 10, p. 1286-1291 6 p.

Research output: Contribution to journalArticle

Natriuretic Peptides
Pulmonary Embolism
Hematologic Tests
Uncertainty
Blood Vessels
2006
122 Citations (Scopus)

Arginine-16 β2 adrenoceptor genotype predisposes to exacerbations in young asthmatics taking regular salmeterol

Palmer, C. N. A., Lipworth, B. J., Lee, S., Ismail, T., Macgregor, D. F. & Mukhopadhyay, S., Nov 2006, In : Thorax. 61, 11, p. 940-944 5 p.

Research output: Contribution to journalArticle

Adrenergic Receptors
Arginine
Asthma
Genotype
Young Adult
215 Citations (Scopus)

Respiratory symptoms, pulmonary function, and markers of inflammation among bar workers before and after a legislative ban on smoking in public places

Menzies, D., Nair, A., Williamson, P. A., Schembri, S., Al-Khairalla, M. Z. H., Barnes, M., Fardon, T. C., McFarlane, L., Magee, G. J. & Lipworth, B. J., Oct 2006, In : JAMA: the Journal of the American Medical Association. 296, 14, p. 1742-1748 7 p.

Research output: Contribution to journalArticle

2007
11 Citations (Scopus)

A proof-of-concept study to assess the putative dose response to topical corticosteroid in persistent allergic rhinitis using adenosine monophosphate challenge

Barnes, M. L., Menzies, D., Nair, A. R., Hopkinson, P. J. & Lipworth, B. J., May 2007, In : Clinical and Experimental Allergy. 37, 5, p. 696-703 8 p.

Research output: Contribution to journalArticle

Adenosine Monophosphate
Nose
Adrenal Cortex Hormones
Nitric Oxide
Quality of Life
67 Citations (Scopus)

A proof of concept study to evaluate stepping down the dose of fluticasone in combination with salmeterol and tiotropium in severe persistent asthma

Fardon, T., Haggart, K., Lee, D. K. C. & Lipworth, B. J., Jun 2007, In : Respiratory Medicine. 101, 6, p. 1218-1228 11 p.

Research output: Contribution to journalArticle

Asthma
Placebos
Quality of Life
Plethysmography
Spirometry
2 Citations (Scopus)

Benefits of long-acting beta2-agonists

Lipworth, B. J., 2007, In : Journal of Allergy and Clinical Immunology. 120, 3, p. 725

Research output: Contribution to journalLetter

27 Citations (Scopus)

Combined mediator blockade or topical steroid for treating the unified allergic airway

Barnes, M. L., Menzies, D., Fardon, T. C., Burns, P., Wilson, A. M. & Lipworth, B. J., 2007, In : Allergy. 62, 1, p. 73-80 8 p.

Research output: Contribution to journalArticle

Asthma
Steroids
Allergic Rhinitis
17 Citations (Scopus)

Differential anti-inflammatory effects of large and small particle size inhaled corticosteroids in asthma

Menzies, D., Nair, A., Hopkinson, P., McFarlane, L. & Lipworth, B. J., Jun 2007, In : Allergy. 62, 6, p. 661-667 7 p.

Research output: Contribution to journalArticle

Beclomethasone
HFA 134a
Particle Size
Adrenal Cortex Hormones
Anti-Inflammatory Agents
58 Citations (Scopus)

Effect of inhaled corticosteroids on small airway dysfunction in mild to moderate persistent asthmatics

Menzies, D., Ismail, S., Hopkinson, P., Nair, A. & Lipworth, B., Dec 2007, In : Thorax. 62, Supplement 3, p. A6-A6 1 p.

Research output: Contribution to journalBook/Film/Article review

26 Citations (Scopus)

Long-acting β2-adrenoceptor agonists: a smart choice for asthma?

Lipworth, B. J., Jun 2007, In : Trends in Pharmacological Sciences. 28, 6, p. 257-262 6 p.

Research output: Contribution to journalArticle

Adrenergic Receptors
Asthma
Smooth Muscle
Muscle
Pharmacology
138 Citations (Scopus)

Portable exhaled nitric oxide measurement: Comparison with the "gold standard" technique

Menzies, D., Nair, A. & Lipworth, B. J., Feb 2007, In : Chest. 131, 2, p. 410-4 5 p.

Research output: Contribution to journalArticle

Nitric Oxide
Secondary Care Centers
Asthma
Sweden
Biomarkers

Relationship between asthma symptoms, spirometry, disease severity and exhaled nitric oxide with exacerbation rate in patients attending routine primary care nurse-led clinics

Menzies, D., Jackson, C., Mistry, C. & Lipworth, B., Dec 2007, In : Thorax. 62, Supplement 3, p. A128-A128 1 p., P177.

Research output: Contribution to journalBook/Film/Article review

8 Citations (Scopus)

Removing nasal valve obstruction in peak nasal inspiratory flow measurement

Barnes, M. L. & Lipworth, B. J., 2007, In : Annals of Allergy, Asthma & Immunology. 99, 1, p. 59-60 2 p.

Research output: Contribution to journalArticle

Nasal Obstruction
Nose