• 7564 Citations
  • 43 h-Index
1993 …2022
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Personal profile


I am Professor of Primary Care Medicine at the University of Dundee Medical School where I carry out applied research to translate basic and clinical research into effective and reliable clinical practice. I am additionally an Honorary Consultant in NHS Fife and a General Practitioner in Cardenden in Fife. I was previously a Medical Research Council Health Services Research Fellow at University of Edinburgh, an National Institute for Health Research post-doctoral research fellow at University of Dundee, and a 2006/7 Commonwealth Fund Harkness Fellow in Healthcare Policy at University of California San Francisco where I was also a Visiting Professor in 2010. I regularly review for various grant-making bodies and journals, contribute to undergraduate and postgraduate medical teaching, and supervise and examine MSc and PhD students in Dundee and other universities. As well as conducting research, I serve or have served on a number of National Health Service advisory bodies, including the National Institute for Health and Clinical Excellence (NICE) Quality and Outcomes Framework Indicators Advisory Committee (which recommended which quality indicators should be included in the UK primary care pay for performance programme) where I chaired the Thresholds, Review and Retiral Sub-committee, and the Scottish Government Polypharmacy Working Group. I was the chair of the guideline development group of the NICE Multimorbidity Clinical Guideline published in late 2016. 


My main research interests are the quality and safety of healthcare, particularly in primary care and currently focused on prescribing quality and safety, multimorbidity the organisation of healthcare. I am a mixed methods researcher and collaborate with researchers from a wide range of disciplines and institutions. The methods I use include quantitative analysis of large, routine datasets; cluster randomised trials with mixed methods parallel process evaluations; and qualitative analysis of interview and observational data. My recent and current work includes development and evaluation of interventions to improve polypharmacy, examination of the implications of competing mortality risk for single disease risk prediction, and examination of the applicability of trial evidence to clinical populations. 

Education/Academic qualification

Doctor of Philosophy, University of Edinburgh

Master of Science, University of Edinburgh

Bachelor of Medicine and Bachelor of Surgery, University of Cambridge

Bachelor of Arts, University of Cambridge


  • R Medicine (General)
  • Primary Care Medicine
  • Prescribing Quality and Safety
  • Mixed quantitative and qualitative methods
  • Community based trials
  • Quality of healthcare
  • Organisation of healthcare

Fingerprint Dive into the research topics where Bruce Guthrie is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

Primary Health Care Medicine & Life Sciences
Comorbidity Medicine & Life Sciences
Scotland Medicine & Life Sciences
General Practice Medicine & Life Sciences
Cross-Sectional Studies Medicine & Life Sciences
Population Medicine & Life Sciences
Cohort Studies Medicine & Life Sciences
Quality Improvement Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2012 2022

Research Output 1993 2019

2 Citations (Scopus)
67 Downloads (Pure)

A balanced approach to identifying, prioritising and evaluating all potential consequences of quality improvement: modified Delphi study

Toma, M., Dreischulte, T., Gray, N. M. . & Guthrie, B., 23 Mar 2019, In : BMJ Open. 9, 3, p. 1-11 11 p., e023890.

Research output: Contribution to journalArticle

Open Access
Delphi Technique
Quality Improvement
Delivery of Health Care
59 Downloads (Pure)

A patient-centred intervention to improve the management of multimorbidity in general practice: the 3D RCT

Salisbury, C., Man, M-S., Chaplin, K., Mann, C., Bower, P., Brookes, S., Duncan, P., Fitzpatrick, B., Gardner, C., Gaunt, D. M., Guthrie, B., Hollinghurst, S., Kadir, B., Lee, V., McLeod, J., Mercer, S. W., Moffat, K. R., Moody, E., Rafi, I., Robinson, R. & 2 others, Shaw, A. & Thorn, J., Feb 2019, In : Health Services and Delivery Research. 7, 5, 276 p.

Research output: Contribution to journalArticle

Open Access
General Practice
Patient-Centered Care
Quality of Life
Cost of Illness
18 Downloads (Pure)

Can implementation failure or intervention failure explain the result of the 3D multimorbidity trial in general practice: mixed-methods process evaluation

Mann, C., Shaw, A. R. G., Guthrie, B., Wye, L., Man, M-S., Chaplin, K. & Salisbury, C., 6 Nov 2019, In : BMJ Open. 9, 11, p. 1-12 12 p., e031438.

Research output: Contribution to journalArticle

Open Access
General Practice
Patient Care Planning
Nurse Administrators
36 Downloads (Pure)

Changes in resistance among coliform bacteraemia associated with a primary care antimicrobial stewardship intervention: a population-based interrupted time series study

Hernandez Santiago, V., Davey, P., Nathwani, D., Marwick, C. A. & Guthrie, B., 7 Jun 2019, In : PLoS Medicine. 16, 6, p. 1-19 19 p., e1002825.

Research output: Contribution to journalArticle

Open Access
Primary Health Care
Amoxicillin-Potassium Clavulanate Combination

Correction to: Methods for identifying 30 chronic conditions: application to administrative data

Tonelli, M., Wiebe, N., Fortin, M., Guthrie, B., Hemmelgarn, B. R., James, M. T., Klarenbach, S. W., Lewanczuk, R., Manns, B. J., Ronksley, P., Sargious, P., Straus, S. & Quan, H., 4 Sep 2019, In : BMC Medical Informatics and Decision Making. 19, p. 1-4 4 p., 177.

Research output: Contribution to journalArticle

International Classification of Diseases
Chronic Pain

Press / Media

Better guidelines needed for multimorbidity

Bruce Guthrie & Marion E. T. McMurdo


1 item of Media coverage

Press/Media: Research

Study calls for reviews of psychotropic medication

Colin McCowan, Bruce Guthrie & Stella Clark


1 item of Media coverage

Press/Media: Research

New research on multiple medical conditions

Karen Barnett, Bruce Guthrie & Michael Norbury


1 item of Media coverage

Press/Media: Research

60,000 Scots prescribed 'high risk' drugs

Bruce Guthrie


1 item of Media coverage

Press/Media: Research


Primary care antimicrobial stewardship: Impact on prescribing and resistance

Author: Hernandez Santiago, V., 2019

Supervisor: Guthrie, B. (Supervisor) & Marwick, C. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

Quantifying the Risk of Beta-Blockers and Non-Steroidal Anti-Inflammatory Drugs in Asthma

Author: Morales, D., 2014

Supervisor: Guthrie, B. (Supervisor), Donnan, P. (Supervisor) & Jackson, C. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy


The impact and use of patient feedback in general practice: A realist review

Author: Baldie, D., 2014

Supervisor: Guthrie, B. (Supervisor), Kroll, T. (Supervisor), Entwistle, V. A. (External person) (Supervisor) & Williams, B. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy


Time series analysis for evaluation of antimicrobial stewardship interventions

Author: Patton, A. L., 2019

Supervisor: Marwick, C. (Supervisor) & Guthrie, B. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy