• 7946 Citations
  • 44 h-Index
1993 …2022

Research output per year

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Personal profile


I am Professor of Primary Care Medicine at the University of Dundee Medical School where I carry out applied research to translate basic and clinical research into effective and reliable clinical practice. I am additionally an Honorary Consultant in NHS Fife and a General Practitioner in Cardenden in Fife. I was previously a Medical Research Council Health Services Research Fellow at University of Edinburgh, an National Institute for Health Research post-doctoral research fellow at University of Dundee, and a 2006/7 Commonwealth Fund Harkness Fellow in Healthcare Policy at University of California San Francisco where I was also a Visiting Professor in 2010. I regularly review for various grant-making bodies and journals, contribute to undergraduate and postgraduate medical teaching, and supervise and examine MSc and PhD students in Dundee and other universities. As well as conducting research, I serve or have served on a number of National Health Service advisory bodies, including the National Institute for Health and Clinical Excellence (NICE) Quality and Outcomes Framework Indicators Advisory Committee (which recommended which quality indicators should be included in the UK primary care pay for performance programme) where I chaired the Thresholds, Review and Retiral Sub-committee, and the Scottish Government Polypharmacy Working Group. I was the chair of the guideline development group of the NICE Multimorbidity Clinical Guideline published in late 2016. 


My main research interests are the quality and safety of healthcare, particularly in primary care and currently focused on prescribing quality and safety, multimorbidity the organisation of healthcare. I am a mixed methods researcher and collaborate with researchers from a wide range of disciplines and institutions. The methods I use include quantitative analysis of large, routine datasets; cluster randomised trials with mixed methods parallel process evaluations; and qualitative analysis of interview and observational data. My recent and current work includes development and evaluation of interventions to improve polypharmacy, examination of the implications of competing mortality risk for single disease risk prediction, and examination of the applicability of trial evidence to clinical populations. 

Education/Academic qualification

Doctor of Philosophy, University of Edinburgh

Award Date: 1 Jan 2003

Master of Science, University of Edinburgh

Award Date: 1 Jan 1996

Bachelor of Medicine and Bachelor of Surgery, University of Cambridge

Award Date: 1 Jan 1988

Bachelor of Arts, University of Cambridge

Award Date: 1 Jan 1985


  • R Medicine (General)
  • Primary Care Medicine
  • Prescribing Quality and Safety
  • Mixed quantitative and qualitative methods
  • Community based trials
  • Quality of healthcare
  • Organisation of healthcare

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Research Output

A balanced approach to identifying, prioritising and evaluating all potential consequences of quality improvement: modified Delphi study

Toma, M., Dreischulte, T., Gray, N. M. . & Guthrie, B., Feb 2020, In : BMJ Open. 9, 3, p. 1-11 11 p., e023890.

Research output: Contribution to journalArticle

Open Access
  • 2 Citations (Scopus)
    100 Downloads (Pure)

    Cost-effectiveness of a patient-centred approach to managing multimorbidity in primary care: a pragmatic cluster randomised controlled trial

    Thorn, J., Man, M-S., Chaplin, K., Bower, P., Brookes, S., Gaunt, D., Fitzpatrick, B., Gardner, C., Guthrie, B., Hollinghurst, S., Lee, V., Mercer, S. W. & Salisbury, C., 19 Jan 2020, In : BMJ Open. 10, 1, p. 1-10 10 p., e030110.

    Research output: Contribution to journalArticle

    Open Access
  • 25 Downloads (Pure)

    Exclusion rates in randomized controlled trials of treatments for physical conditions: a systematic review

    He, J., Morales, D. R. & Guthrie, B., 26 Feb 2020, In : Trials. 21, p. 1-11 11 p., 228.

    Research output: Contribution to journalReview article

    Open Access
  • 16 Downloads (Pure)

    Pharmacist and Data-driven Quality Improvement in Primary Care (P-DQIP): A qualitative study of anticipated implementation factors informed by the Theoretical Domains Framework

    Tang, J., Toma, M., Gray, N. M., Delvaux, J., Guthrie, B., Grant, A., Duncan, E. M. & Dreischulte, T., 28 Feb 2020, In : BMJ Open. 10, 2, p. 1-16 16 p., e033574.

    Research output: Contribution to journalArticle

    Open Access
  • 10 Downloads (Pure)

    A patient-centred intervention to improve the management of multimorbidity in general practice: the 3D RCT

    Salisbury, C., Man, M-S., Chaplin, K., Mann, C., Bower, P., Brookes, S., Duncan, P., Fitzpatrick, B., Gardner, C., Gaunt, D. M., Guthrie, B., Hollinghurst, S., Kadir, B., Lee, V., McLeod, J., Mercer, S. W., Moffat, K. R., Moody, E., Rafi, I., Robinson, R. & 2 others, Shaw, A. & Thorn, J., Feb 2019, In : Health Services and Delivery Research. 7, 5, 276 p.

    Research output: Contribution to journalArticle

    Open Access
  • 81 Downloads (Pure)

    Press / Media

    Better guidelines needed for multimorbidity

    Bruce Guthrie & Marion E. T. McMurdo


    1 item of Media coverage

    Press/Media: Research

    Study calls for reviews of psychotropic medication

    Colin McCowan, Bruce Guthrie & Stella Clark


    1 item of Media coverage

    Press/Media: Research

    New research on multiple medical conditions

    Karen Barnett, Bruce Guthrie & Michael Norbury


    1 item of Media coverage

    Press/Media: Research

    60,000 Scots prescribed 'high risk' drugs

    Bruce Guthrie


    1 item of Media coverage

    Press/Media: Research


    Primary care antimicrobial stewardship: Impact on prescribing and resistance

    Author: Hernandez Santiago, V., 2019

    Supervisor: Guthrie, B. (Supervisor) & Marwick, C. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy

    Quantifying the Risk of Beta-Blockers and Non-Steroidal Anti-Inflammatory Drugs in Asthma

    Author: Morales, D., 2014

    Supervisor: Guthrie, B. (Supervisor), Donnan, P. (Supervisor) & Jackson, C. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy


    The impact and use of patient feedback in general practice: A realist review

    Author: Baldie, D., 2014

    Supervisor: Guthrie, B. (Supervisor), Kroll, T. (Supervisor), Entwistle, V. A. (External person) (Supervisor) & Williams, B. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy


    Time series analysis for evaluation of antimicrobial stewardship interventions

    Author: Patton, A. L., 2019

    Supervisor: Marwick, C. (Supervisor) & Guthrie, B. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy