Sutherland, Calum

Professor

  • Professor (Teaching and Research) & Professor of Molecular and Cellular Diabetes, Cellular Medicine
  • 6200 Citations
  • 41 h-Index
1989 …2023

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Research Output

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2019

Loss of CRMP2 O-GlcNAcylation leads to reduced novel object recognition performance in mice

Muha, V., Williamson, R., Hills, R., McNeilly, A., McWilliams, T. G., Alonso, J., Schimpl, M., Leney, A. C., Heck, A. J. R., Sutherland, C., Read, K., McCrimmon, R., Brooks, S. P. & van Aalten, D., 27 Nov 2019, In : Open Biology. 9, 11, p. 1-15 15 p.

Research output: Contribution to journalArticle

Open Access
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44 Downloads (Pure)

Recruitment, Retainment, and Biomarkers of Response: A Pilot Trial of Lithium in Humans With Mild Cognitive Impairment

Duthie, A., van Aalten, L., MacDonald, C., McNeilly, A., Gallagher, J., Geddes, J., Lovestone, S. & Sutherland, C., 28 Jun 2019, In : Frontiers in Molecular Neuroscience. 12, p. 1-16 16 p., 163.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
75 Downloads (Pure)
2018

A partnership with the proteasome: the destructive nature of GSK3

Robertson, H., Hayes, J. D. & Sutherland, C., Jan 2018, In : Biochemical Pharmacology. 147, p. 77-92 16 p.

Research output: Contribution to journalArticle

Open Access
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14 Citations (Scopus)
167 Downloads (Pure)
2017

Proinsulin is stable at room temperature for 24 hours in EDTA: A clinical laboratory analysis (adAPT 3)

Davidson, J., McDonald, T. J., Sutherland, C., Mostazir, M., VanAalten, L. & Wilkin, T. J., 20 Apr 2017, In : PLoS ONE. 12, 4, p. 1-6 6 p., e0171716.

Research output: Contribution to journalArticle

Open Access
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2 Citations (Scopus)
147 Downloads (Pure)

Rab-GTPase binding effector protein 2 (RABEP2) is a primed substrate for Glycogen Synthase kinase-3 (GSK3)

Logie, L., Van Aalten, L., Knebel, A., Force, T., Hastie, C. J., MacLauchlan, H., Campbell, D. G., Gourlay, R., Prescott, A., Davidson, J., Fuller, W. & Sutherland, C., 15 Dec 2017, In : Scientific Reports. 7, p. 1-14 14 p., 17682.

Research output: Contribution to journalArticle

Open Access
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2 Citations (Scopus)
158 Downloads (Pure)
2016

Heat Shock Factor 1 is a Substrate for p38 Mitogen-Activated Protein Kinases

Dayalan Naidu, S., Sutherland, C., Zhang, Y., Risco, A., de la Vega, L., Caunt, C. J., Hastie, C. J., Lamont, D. J., Torrente, L., Chowdhry, S., Benjamin, I. J., Keyse, S. M., Cuenda, A. & Dinkova-Kostova, A. T., 15 Sep 2016, In : Molecular and Cellular Biology. 36, 18, p. 2403-2417 15 p.

Research output: Contribution to journalArticle

Open Access
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22 Citations (Scopus)
195 Downloads (Pure)

Investigation of salicylate hepatic responses in comparison with chemical analogues of the drug

Cameron, A., Logie, L., Patel, K., Bacon, S., Forteath, C., Harthill, J., Roberts, A., Sutherland, C., Stewart, D., Viollet, B., Sakamoto, K., McDougall, G., Foretz, M. & Rena, G., Aug 2016, In : Biochimica et Biophysica Acta. Molecular Basis of Disease. 1862, 8, p. 1412-1422 11 p.

Research output: Contribution to journalArticle

Open Access
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5 Citations (Scopus)
1002 Downloads (Pure)

The effect of dietary intervention on the metabolic and behavioural impairments generated by short term high fat feeding in the rat

McNeilly, A. D., Gao, A., Hill, A. Y., Gomersall, T., Balfour, D. J. K., Sutherland, C. & Stewart, C. A., 1 Dec 2016, In : Physiology & Behavior. 167, p. 100-109 10 p.

Research output: Contribution to journalArticle

Open Access
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2 Citations (Scopus)
164 Downloads (Pure)
2015
51 Citations (Scopus)

High fat feeding is associated with stimulation of the hypothalamic-pituitary-adrenal axis and reduced anxiety in the rat

McNeilly, A. D., Stewart, C. A., Sutherland, C. & Balfour, D. J. K., Feb 2015, In : Psychoneuroendocrinology. 52, p. 272-280 9 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Hypertension fails to disrupt white matter integrity in young or aged Fisher (F44) Cyp1a1Ren2 transgenic rats

Holland, P. R., Pannozzo, M. A., Bastin, M. E., McNeilly, A. D., Ferguson, K. J., Caughey, S., Jansen, M. A., Merrifield, G. D., Marshall, I., Mullins, J. J., Wardlaw, J. M., Sutherland, C. & Horsburgh, K., Feb 2015, In : Journal of Cerebral Blood Flow and Metabolism. 35, 2, p. 188-192 5 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Invited commentary on … Lithium treatment and risk for dementia in adults with bipolar disorder

Sutherland, C. & Duthie, A. C., Jul 2015, In : British Journal of Psychiatry. 207, 1, p. 52-54 3 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Phosphorylation of a splice variant of collapsin response mediator protein 2 in the nucleus of tumour cells links cyclin dependent kinase-5 to oncogenesis

Grant, N. J., Coates, P. J., Woods, Y. L., Bray, S. E., Morrice, N. A., Hastie, C. J., Lamont, D. J., Carey, F. A. & Sutherland, C., 10 Nov 2015, In : BMC Cancer. 15, 16 p., 885.

Research output: Contribution to journalArticle

Open Access
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13 Citations (Scopus)
148 Downloads (Pure)

Prolyl isomerase Pin1 regulates axon guidance by stabilizing CRMP2A selectively in distal axons

Balastik, M., Zhou, X. Z., Alberich-Jorda, M., Weissova, R., Žiak, J., Pazyra-Murphy, M. F., Cosker, K. E., Machonova, O., Kozmikova, I., Chen, C-H., Pastorino, L., Asara, J. M., Cole, A., Sutherland, C., Segal, R. A. & Lu, K. P., 27 Oct 2015, In : Cell Reports. 13, 4, p. 812-828 17 p.

Research output: Contribution to journalArticle

Open Access
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18 Citations (Scopus)
128 Downloads (Pure)
2014

Neuronal deletion of GSK3beta increases microtubule speed in the growth cone and enhances axon regeneration via CRMP-2 and independently of MAP1B and CLASP2

Liz, M. A., Mar, F. M., Santos, T. E., Pimentel, H. I., Marques, A. M., Morgado, M. M., Vieira, S., Sousa, V. F., Pemble, H., Wittmann, T., Sutherland, C., Woodgett, J. R. & Sousa, M. M., 12 Jun 2014, In : BMC Biology. 12, 47.

Research output: Contribution to journalArticle

Open Access
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41 Citations (Scopus)
116 Downloads (Pure)

The LKB1-salt-inducible kinase pathway functions as a key gluconeogenic suppressor in the liver

Patel, K., Foretz, M., Marion, A., Campbell, D. G., Gourlay, R., Boudaba, N., Tournier, E., Titchenell, P., Peggie, M., Deak, M., Wan, M., Kaestner, K. H., Göransson, O., Viollet, B., Gray, N. S., Birnbaum, M. J., Sutherland, C. & Sakamoto, K., 4 Aug 2014, In : Nature Communications. 5, 4535.

Research output: Contribution to journalArticle

Open Access
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70 Citations (Scopus)
151 Downloads (Pure)
2013

CNP/cGMP signaling regulates axon branching and growth by modulating microtubule polymerization

Xia, C., Nguyen, M., Garrison, A. K., Zhao, Z., Wang, Z., Sutherland, C. & Ma, L., Sep 2013, In : Developmental Neurobiology. 73, 9, p. 673-687 15 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Obesity-Induced Insulin Resistance in Human Skeletal Muscle Is Characterised by Defective Activation of p42/p44 MAP Kinase

Ruiz-Alcaraz, A. J., Lipina, C., Petrie, J. R., Murphy, M. J., Morris, A. D., Sutherland, C. & Cuthbertson, D. J., 28 Feb 2013, In : PLoS ONE. 8, 2, e56928.

Research output: Contribution to journalArticle

12 Citations (Scopus)
2012

A high-fat-diet-induced cognitive deficit in rats that is not prevented by improving insulin sensitivity with metformin

McNeilly, A. D., Williamson, R., Balfour, D. J. K., Stewart, C. A. & Sutherland, C., Nov 2012, In : Diabetologia. 55, 11, p. 3061-3070 10 p.

Research output: Contribution to journalArticle

46 Citations (Scopus)

Insulin resistance in the brain: An old-age or new-age problem?

Williamson, R., McNeilly, A. & Sutherland, C., 15 Sep 2012, In : Biochemical Pharmacology. 84, 6, p. 737-45 9 p.

Research output: Contribution to journalArticle

46 Citations (Scopus)

Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity

Chowdhry, S., Zhang, Y., McMahon, M., Sutherland, C., Cuadrado, A. & Hayes, J. D., 2012, In : Oncogene. 32, p. 3765-3781 17 p.

Research output: Contribution to journalArticle

247 Citations (Scopus)
2011

Bioinformatic Prediction and Confirmation of beta-Adducin as a Novel Substrate of Glycogen Synthase Kinase 3

Farghaian, H., Turnley, A. M., Sutherland, C. & Cole, A. R., 15 Jul 2011, In : Journal of Biological Chemistry. 286, 28, p. 25274-25283 10 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

CRMP2 Hyperphosphorylation is Characteristic of Alzheimer's Disease and not a Feature Common to Other Neurodegenerative Diseases

Williamson, R., van Aalten, L., Mann, D. M. A., Platt, B., Plattner, F., Bedford, L., Mayer, J., Howlett, D., Usardi, A., Sutherland, C. & Cole, A. R., 2011, In : Journal of Alzheimer's Disease. 27, 3, p. 615-625 11 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)

High fat feeding promotes simultaneous decline in insulin sensitivity and cognitive performance in a delayed matching and non-matching to position task

McNeilly, A. D., Williamson, R., Sutherland, C., Balfour, D. J. K. & Stewart, C. A., 2 Feb 2011, In : Behavioural Brain Research. 217, 1, p. 134-141 8 p.

Research output: Contribution to journalArticle

58 Citations (Scopus)

Identification of a Proline-rich Inositol Polyphosphate 5-Phosphatase (PIPP)center dot Collapsin Response Mediator Protein 2 (CRMP2) Complex That Regulates Neurite Elongation

Astle, M. V., Ooms, L. M., Cole, A. R., Binge, L. C., Dyson, J. M., Layton, M. J., Petratos, S., Sutherland, C. & Mitchell, C. A., 1 Jul 2011, In : Journal of Biological Chemistry. 286, 26, p. 23407-23418 12 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Implications of genome wide association studies for the understanding of type 2 diabetes pathophysiology

Petrie, J. R., Pearson, E. R. & Sutherland, C., 15 Feb 2011, In : Biochemical Pharmacology. 81, 4, p. 471-477 7 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)

Models of Dementia: an introductory overview

Graham, L. & Sutherland, C., Aug 2011, In : Biochemical Society Transactions. 39, p. 851-856 6 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

What are the bona fide GSK3 substrates?

Sutherland, C., 2011, In : International Journal of Alzheimer's Disease. 2011, p. 1-23

Research output: Contribution to journalArticle

170 Citations (Scopus)
2010

All tangled up: tau-dependent neurodegeneration

Lyn-Adams, C., Moffat, K., Sutherland, C. & Frenguelli, B. G., 1 Apr 2010, In : Biochemist. 32, 2, p. 10-13 4 p.

Research output: Contribution to journalArticle

Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling

Kickstein, E., Krauss, S., Thornhill, P., Rutschow, D., Zeller, R., Sharkey, J., Williamson, R., Fuchs, M., Koehler, A., Glossmann, H., Schneider, R., Sutherland, C. & Schweiger, S., 14 Dec 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 50, p. 21830-21835 6 p.

Research output: Contribution to journalArticle

217 Citations (Scopus)

Dynamin I phosphorylation by GSK3 controls activity-dependent bulk endocytosis of synaptic vesicles

Clayton, E. L., Sue, N., Smillie, K. J., O'Leary, T., Bache, N., Cheung, G., Cole, A. R., Wyllie, D. J., Sutherland, C., Robinson, P. J. & Cousin, M. A., Jul 2010, In : Nature Neuroscience. 13, 7, p. 845-U85 9 p.

Research output: Contribution to journalArticle

94 Citations (Scopus)

Evidence that glycogen synthase kinase-3 isoforms have distinct substrate preference in the brain

Soutar, M. P. M., Kim, W-Y., Williamson, R., Peggie, M., Hastie, C. J., McLauchlan, H., Snider, W. D., Gordon-Weeks, P. R. & Sutherland, C., Nov 2010, In : Journal of Neurochemistry. 115, 4, p. 974-983 10 p.

Research output: Contribution to journalArticle

73 Citations (Scopus)

Generation, validation and humanisation of a novel insulin resistant cell model

Logie, L., Ruiz-Alcaraz, A. J., Schofield, C. J., Hundal, H. S., Feuerstein, G. Z., Brady, J. D., Crowther, D., Tommasi, A. M., Grierson, C. E., Shepherd, B., Morris, A. D., Hansen, M. K., Pearson, E. & Sutherland, C., 1 Oct 2010, In : Biochemical Pharmacology. 80, 7, p. 1042-1049 8 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

GSK3 beta Regulates Myelin-Dependent Axon Outgrowth Inhibition through CRMP4

Alabed, Y. Z., Pool, M., Tone, S. O., Sutherland, C. & Fournier, A. E., 21 Apr 2010, In : Journal of Neuroscience. 30, 16, p. 5635-5643 9 p.

Research output: Contribution to journalArticle

77 Citations (Scopus)
2009

Blunting of AICAR-induced human skeletal muscle glucose uptake in type 2 diabetes is dependent on age rather than diabetic status

Babraj, J. A., Mustard, K., Sutherland, C., Towler, M. C., Chen, S., Smith, K., Green, K., Leese, G., Hardie, D. G., Rennie, M. J. & Cuthbertson, D. J., May 2009, In : American Journal of Physiology, Endocrinology and Metabolism. 296, 5, p. E1042-E1048 7 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)
12 Citations (Scopus)

Filaggrin in the frontline: role in skin barrier function and disease

Sandilands, A., Sutherland, C., Irvine, A. D. & McLean, W. H. I., 1 May 2009, In : Journal of Cell Science. 122, 9, p. 1285-1294 10 p.

Research output: Contribution to journalArticle

383 Citations (Scopus)

Increased CRMP2 Phosphorylation is Observed in Alzheimer's Disease: Does this Tell us Anything About Disease Development?

Soutar, M. P. M., Thornhill, P., Cole, A. R. & Sutherland, C., Jun 2009, In : Current Alzheimer Research. 6, 3, p. 269-278 10 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)

Insulin resistance in polycystic ovary syndrome is associated with defective regulation of ERK1/2 by insulin in skeletal muscle in vivo

Rajkhowa, M., Brett, S., Cuthbertson, D. J., Lipina, C., Ruiz-Alcaraz, A. J., Thomas, G. E., Logie, L., Petrie, J. R. & Sutherland, C., 15 Mar 2009, In : Biochemical Journal. 418, p. 665-671 7 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Leptin-dependent Phosphorylation of PTEN Mediates Actin Restructuring and Activation of ATP-sensitive K+ Channels

Ning, K., Miller, L. C., Laidlaw, H. A., Watterson, K. R., Gallagher, J., Sutherland, C. & Ashford, M. L. J., 3 Apr 2009, In : Journal of Biological Chemistry. 284, 14, p. 9331-9340 10 p.

Research output: Contribution to journalArticle

Open Access
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30 Citations (Scopus)
307 Downloads (Pure)
2008

Anaesthesia generates neuronal insulin resistance by inducing hypothermia

Holscher, C., van Aalten, L. & Sutherland, C., 9 Oct 2008, In : BMC Neuroscience. 9, p. - 7 p., 100.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Mutation of the PDK1 PH domain inhibits protein kinase B/Akt, leading to small size and insulin resistance

Bayascas, J. R., Wullschleger, S., Sakamoto, K., Garcia-Martinez, J. M., Clacher, C., Komander, D., van Aalten, D. M. F., Boini, K. M., Lan, F., Lipina, C., Logie, L., Sutherland, C., Chudek, J. A., van Diepen, J. A., Voshol, P. J., Lucocq, J. M. & Alessi, D. R., May 2008, In : Molecular and Cellular Biology. 28, 10, p. 3258-3272 15 p.

Research output: Contribution to journalArticle

86 Citations (Scopus)

Novel procedure to investigate the effect of phosphorylation on protein complex formation in vitro and in cells

Rembutsu, M., Soutar, M. P. M., Van Aalten, L., Gourlay, R., Hastie, C. J., McLauchlan, H., Morrice, N. A., Cole, A. R. & Sutherland, C., 19 Feb 2008, In : Biochemistry. 47, 7, p. 2153-2161 9 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Relative resistance of Cdk5-phosphorylated CRMP2 to dephosphorylation

Cole, A. R., Soutar, M. P. M., Rembutsu, M., van Aalten, L., Hastie, C. J., Mclauchlan, H., Peggie, M., Balastik, M., Lu, K. P. & Sutherland, C., 27 Jun 2008, In : Journal of Biological Chemistry. 283, 26, p. 18227-18237 11 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)
2007

5-aminoimidazole-4-carboxamide 1-beta-D-ribofuranoside acutely stimulates skeletal muscle 2-deoxyglucose uptake in healthy men

Cuthbertson, D. J., Babraj, J. A., Mustard, K. J. W., Towler, M. C., Green, K. A., Wackerhage, H., Leese, G. P., Baar, K., Thomason-Hughes, M., Sutherland, C., Hardie, D. G. & Rennie, M. J., 2007, In : Diabetes. 56, 8, p. 2078-2084 7 p.

Research output: Contribution to journalArticle

79 Citations (Scopus)

Characterization of a protein kinase B inhibitor in vitro and in insulin-treated liver cells

Logie, L., Ruiz-Alcaraz, A. J., Keane, M., Woods, Y. L., Bain, J., Marquez, R., Alessi, D. R. & Sutherland, C., Sep 2007, In : Diabetes. 56, 9, p. 2218-2227 10 p.

Research output: Contribution to journalArticle

68 Citations (Scopus)

Collapsin response mediator protein-2 hyperphosphorylation is an early event in Alzheimer's disease progression

Cole, A. R., Noble, W., van Aalten, L., Plattner, F., Meimaridou, R., Hogan, D., Taylor, M., LaFrancois, J., Gunn-Moore, F., Verkhratsky, A., Oddo, S., LaFerla, F., Giese, K. P., Dineley, K. T., Duff, K., Richardson, J. C., Yan, S. D., Hanger, D. P., Allan, S. M. & Sutherland, C., Nov 2007, In : Journal of Neurochemistry. 103, 3, p. 1132-1144 13 p.

Research output: Contribution to journalArticle

118 Citations (Scopus)

Differential proteomics analysis of synaptic proteins identifies potential cellular targets and protein mediators of synaptic neuroprotection conferred by the slow Wallerian degeneration (Wld(s)) gene

Wishart, T. M., Paterson, J. M., Short, D. M., Meredith, S., Robertson, K. A., Sutherland, C., Cousin, M. A., Dutia, M. B. & Gillingwater, T. H., Aug 2007, In : Molecular & Cellular Proteomics. 6, 8, p. 1318-1330 13 p.

Research output: Contribution to journalArticle

72 Citations (Scopus)
2006

A temporal switch in the insulin-signalling pathway that regulates hepatic IGF-binding protein-1 gene expression

Finlay, D., Ruiz-Alcaraz, A. J., Lipina, C., Perrier, S. & Sutherland, C., Oct 2006, In : Journal of Molecular Endocrinology. 37, 2, p. 227-237 11 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Distinct priming kinases contribute to differential regulation of collapsin response mediator proteins by glycogen synthase kinase-3 in vivo

Cole, A. R., Causeret, F., Yadirgi, G., Hastie, C. J., Mclauchlan, H., McManus, E. J., Hernandez, F., Eickholt, B. J., Nikolic, M., Sutherland, C. & Sutherland, C., 16 Jun 2006, In : Journal of Biological Chemistry. 281, 24, p. 16591-16598 8 p.

Research output: Contribution to journalArticle

155 Citations (Scopus)