Keyphrases
Degrader
100%
Universal Reporter
54%
NanoLuc
54%
Bromodomain and Extra-terminal Domain
54%
E3 Ligase
54%
Proteome-wide
54%
Reporter System
54%
Degrons
54%
Protein Degraders
54%
Antitumoral Activity
54%
Target Molecule
54%
Targeted Protein Degraders
54%
Diffuse Large B-cell Lymphoma (DLBCL)
54%
Targeted Protein Degradation
54%
Cell-like
54%
Targeted Degradation
54%
Web Server
54%
Proteolysis Targeting chimera (PROTAC)
49%
Degron
43%
Bromodomain-containing Protein 4 (BRD4)
36%
In Cis
36%
Ligase
36%
E3 Ubiquitin Ligase
33%
Ubiquitination
29%
Mechanism of Action
22%
DCAF16
18%
BRD4 Degradation
18%
Surface Complementarity
18%
Picomolar Potency
18%
Protein Domain
18%
Heterobifunctional Degrader
18%
Proteasomal Degradation
18%
Induced Proximity
18%
Molecular Glue
18%
Ubiquitin-mediated Degradation
18%
Conformational Change
18%
Bifunctional Compounds
18%
Rational Design
18%
BRD2
18%
Genetic Screening
18%
Structural Insights
18%
Reconstitution
18%
Biophysical Characterization
18%
Bromodomain and Extra-terminal Domain Proteins
12%
Lymphoma Cells
12%
Protein Termini
10%
Proteolysis
10%
Unfolded Protein Response
10%
Post-translational Modification
10%
Experimental Validation
10%
Biochemistry, Genetics and Molecular Biology
Proteolysis
66%
Ubiquitination
63%
Protein Catabolism
57%
Necroptosis
54%
Targeting Protein
54%
Bromodomain
54%
Proteome
54%
B Cell
54%
C-Terminus
54%
BRD4
54%
Ubiquitin Ligase
54%
Ubiquitin-Conjugating Enzyme
48%
Ligase
36%
Protein Unfolding
27%
Posttranslational Modification
27%
Short Linear Motif
27%
Prevalence
27%
Protein Tertiary Structure
24%
Conformational Change
18%
Genetic Screening
18%
BRD2
18%
Molecular Glue
18%
IC50
6%
Immunology and Microbiology
B Cell
54%
Carboxy Terminal Sequence
54%
Protein Degradation
49%
Ubiquitins
38%
Ubiquitination
27%
Prevalence
27%
Protein Unfolding
27%
Post-Translational Modification
27%
Diffuse Large B-Cell Lymphoma Cell Line
21%
IC50
21%
Protein Tertiary Structure
21%
Epimer
10%
Cell Proliferation
10%
Transcriptome
10%
Transcription Regulation
10%
Cytotoxicity
10%
Cell Death
10%
Cycline
10%
Upregulation
10%
RNA Sequence
10%
Antineoplastic Activity
10%
Lymphoma Cell Line
10%
Proteasome
10%