Chim Lang

Personal profile

Teaching

Full contribution to teaching in Dundee, especially cardiology and clinical pharmacology. Member of Undergraduate Medical School Assessment Committee. External undergraduate examinerships (National University of Singapore, University of Malaya, International Medical University, Malaysia, National University of Malaysia). Supervisor of 25 MD/PhDs personally. External examiner for MD (Universities of Birmingham, Cardiff, Edinburgh, Glasgow)

Biography

Professor Lang is a consultant cardiologist and clinical pharmacologist and Professor of Cardiology at Ninewells Hospital and Medical School, Dundee, United Kingdom. He trained in both cardiology and clinical pharmacology in the United Kingdom and in the United States where he was a Merck International Fellow in Clinical Pharmacology at Vanderbilt University, Nashville and a Fulbright Scholar at Columbia University, New York. He is a Fellow of the Royal Colleges of Physicians of London and Edinburgh and the American College of Cardiology.

Research

His research takes a multi-disciplinary approach to the understanding of the pathophysiology and pharmacogenetics of cardiovascular diseases and to the development of treatment strategies in patients with cardiovascular diseases. He leads an integrated cardiovascular research laboratory dedicated and equipped to the study of cardiac and vasomotor regulation. These techniques are applied towards translational research and in the development of biomarkers and novel treatment strategies in patients with cardiovascular diseases. Prof Lang is the Work Package Lead for the validation cohort for the FP-7 funded BIOSTAT-CHF study that aims optimize the treatment of heart failure for each individual using information from genomics and proteomics. A wide range of funding bodies including the British Heart Foundation, MRC, Chief Scientist Office, Chest Heart and Stroke Scotland, Tenovus and the European commission Seventh Framework Programme (FP-7) funds his research.

Education/Academic qualification

Doctor of Medicine, University of Dundee

Bachelor of Medicine and Bachelor of Surgery, University of Dundee

Bachelor of Science, University of Dundee

Keywords

RM Therapeutics. Pharmacology
Cardiology

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Projects 2013 2024

1 Not started
9 Active
20 Finished

Immunometabolic Remodelling of Monocyte and Macrophage Responses by Metformin in Non-diabetic CVD

Lang, C. & Rena, G.

British Heart Foundation

1/09/19 → 31/08/22

Project: Research

Targeting Early Extracellular Matrix Abnormalities to Treat Cardiac Insulin Resistance and Associated Dysfunction (Joint with University of Glasgow)

Kang, L. & Lang, C.

British Heart Foundation

6/03/19 → 5/03/22

Project: Research

CARdiomyopathy in type 2 DIAbetes mellitus (CARDIATEAM) (Joint with the INSERM as lead, CIBER- Network Centre for Biomedical Research, Luxembourg Institute of Health and 17 others)

Doney, A., Houston, G., Lang, C., Mordi, I., Palmer, C., Pearson, E. & Trucco, M.

COMMISSION OF THE EUROPEAN COMMUNITIES

1/03/19 → 29/02/24

Project: Research

Cardiovascular Research: From Imaging to Population Health TICR 2018

Anderson, A., Belch, J., Choy, A., George, J., Houston, G., Khan, F. & Lang, C.

The Institute of Cardiovascular Research

12/11/18 → 11/11/22

Project: Research

Nrf2 Antioxidant Gene Expression and Its Role in Combatting Oxidative Stress and Maintaining Vascular Function in Patients with Cardiovascular Disease

Hayes, J., Khan, F. & Lang, C.

3/09/18 → 2/09/21

Project: Research

Research Output 1985 2020

10923 Citations
50 h-Index
245 Article
38 Book/Film/Article review
30 Meeting abstract
15 Letter
35 More

Genetic Risk and Atrial Fibrillation in Patients with Heart Failure

Kloosterman, M., Santema, B. T., Roselli, C., Nelson, C. P., Koekemoer, A., Romaine, S. P. R., Van Gelder, I. C., Lam, C. S. P., Artola, V. A., Lang, C., Ng, L. L., Metra, M., Anker, S. D., Filippatos, G. S., Dickstein, K., Ponikowski, P., van der Harst, P., Meer, P. V. D., Van Veldhuisen, D. J., Benjamin, E. J. & 3 others, Voors, A. A., Samani, N. J. & Rienstra, M., 9 Jan 2020, In : European Journal of Heart Failure. 9 p.

Research output: Contribution to journal › Article

Open Access

File

Atrial Fibrillation

Heart Failure

Single Nucleotide Polymorphism

Atrial Flutter

Genome-Wide Association Study

6 Downloads (Pure)

Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure

Shah, S., Henry, A., Roselli, C., Lin, H., Sveinbjörnsson, G., Fatemifar, G., Hedman, Å. K., Wilk, J. B., Morley, M. P., Chaffin, M. D., Helgadottir, A., Verweij, N., Dehghan, A., Almgren, P., Andersson, C., Aragam, K. G., Ärnlöv, J., Backman, J. D., Biggs, M. L., Bloom, H. L. & 31 others, Brandimarto, J., Brown, M. R., Buckbinder, L., Carey, D. J., Chasman, D. I., Chen, X., Chen, X., Chung, J., Chutkow, W., Cook, J. P., Delgado, G. E., Denaxas, S., Doney, A. S., Dörr, M., Dudley, S. C., Dunn, M. E., Engström, G., Esko, T., Felix, S. B., Finan, C., Ford, I., Mordi, I. R., Morris, A. D., Morris, A. P., Palmer, C. N. A., Parry, H. M., Smith, N. L., Veluchamy, A., McMurray, J. J. V., Lang, C. C. & Lumbers, R. T., 9 Jan 2020, In : Nature Communications. 11, 1, p. 1-12 12 p., 163.

Research output: Contribution to journal › Article

Open Access

File

Mendelian Randomization Analysis

pathogenesis

genome

Heart Failure

Genes

Reply

Gingles, C. R., Symon, R., Gandy, S. J., Struthers, A. D., Houston, G., MacDonald, T. M., Lang, C. C., Donnan, P. T. & George, J., 1 Jan 2020, In : Journal of Hypertension. 38, 1, p. 177-178 2 p.

Research output: Contribution to journal › Letter

2 Citations (Scopus)

84 Downloads (Pure)

Allopurinol treatment adversely impacts left ventricular mass regression in patients with well-controlled hypertension

Gingles, C., Symon, R., Gandy, S., Struthers, A., Houston, G., MacDonald, T., Lang, C., Donnan, P. & George, J., Dec 2019, In : Journal of Hypertension. 37, 12, p. 2481-2489 9 p.

Research output: Contribution to journal › Article

Open Access

File

Allopurinol

Hypertension

Placebos

Oxidative Stress

Left Ventricular Hypertrophy

8 Citations (Scopus)

49 Downloads (Pure)

A Randomized Controlled Trial of Metformin on Left Ventricular Hypertrophy in Patients with Coronary Artery Disease without Diabetes: The MET-REMODEL Trial

Mohan, M., Al-Talabany, S., McKinnie, A., Mordi, I., Singh, J., Gandy, S., Baig, F., Hussain, M. S. ., Bhalraam, U., Khan, F., Choy, A., Matthew, S., Houston, G., Struthers, A., George, J. & Lang, C. C., 1 Nov 2019, In : European Heart Journal. 40, 41, p. 3409-3417 9 p.

Research output: Contribution to journal › Article

Open Access

File

Metformin

Left Ventricular Hypertrophy

Coronary Artery Disease

Randomized Controlled Trials

Insulin Resistance