Projects per year
Personal profile
Teaching
Biography
Professor Lang is a consultant cardiologist and clinical pharmacologist and Professor of Cardiology at Ninewells Hospital and Medical School, Dundee, United Kingdom. He trained in both cardiology and clinical pharmacology in the United Kingdom and in the United States where he was a Merck International Fellow in Clinical Pharmacology at Vanderbilt University, Nashville and a Fulbright Scholar at Columbia University, New York. He is a Fellow of the Royal Colleges of Physicians of London and Edinburgh and the American College of Cardiology and European Society of Cardiology.
Research
Professor Lang is a translational cardiologist with a track record of research excellence in the area of cardio-metabolic diseases. He has published close to 400 papers in major journals, including NEJM, Lancet, Annals of Internal Medicine, Circulation, European Heart Journal and JACC.
His research takes a multi-disciplinary approach to the understanding of the pathophysiology and pharmacogenetics of cardiovascular diseases and to the development of treatment strategies in patients with cardiovascular diseases.
He leads an integrated cardiovascular research laboratory dedicated and equipped to the study of cardiac and vasomotor regulation. These techniques are applied towards translational research and in the development of biomarkers and novel treatment strategies in patients with cardiovascular diseases.
Prof Lang is WP Co-Lead in the €12.3M IMI2-CARDIATEAM project on diabetic cardiomyopathy and was WP lead in the €11.9M FP-7 BIOSTAT system biology project on heart failure and is the Chief Investigator of the BHF funded MET-REMODEL and RECEDE trials and the EFSD funded REFORM trial and Co-Chief Investigator of the NIHR HTA funded REACH-HFpEF trial.
He is also the lead Applicant of the MRC funded MRC UK-Malaysia Partnership on the Precision medicine for diabetic Individuals: a joint Malaysia-UK Effort (PRIME) project.
He is the UK National Coordinator of the multi-international COMMANDER-HF, ARISE and SELECT trials. A wide range of funding bodies including the British Heart Foundation, MRC, NIHR, Chief Scientist Office, EASD, Chest Heart and Stroke Scotland, Tenovus and the European commission Seventh Framework (FP-7) and Horizon 2020 Programmes funds his research.
Impact of Research:
- In the REF 2014, Dundee put forward two impact cases from Professor Struthers and Professor Lang on their research on BNP (http://impact.ref.ac.uk/CaseStudies/CaseStudy.aspx?Id=35839) and Spironolactone (http://impact.ref.ac.uk/CaseStudies/CaseStudy.aspx?Id=35840). Both impact cases were scored at the highest level of 4-star and helped the University of Dundee to be ranked first in the UK for ‘impact’ in Clinical Medicine.
- Waist-to-Hip Ratio (WTHR) as a cardiovascular risk factor. His research as part of the International Steering Committee, representing Malaysia in the landmark INTERHEART study found that the markers of abdominal obesity and hip size (waist-to-hip-ratio) are far more predictive than body mass index.
- Maintaining serum potassium in drug induced long QT syndrome. Working with Dr AnnaMaria Choy and Professor Dan Roden, their study demonstrated the importance of potassium ion repletion to 4.5 to 5 mmol/L in drug induced long QT syndrome. This work is cited as the supporting evidence in the recommendation of current American Heart Association and the American College of Cardiology on the Prevention of torsade de pointes in hospital settings.
- Use of population-based health informatics research to improve care for patients with cardio-metabolic diseases Using record linkage research of population electronic health records, Professor Lang’s research provided key observational evidence that the use of renin-angiotensin system blockers is safe and associated with better outcome in patients with aortic stenosis and that metformin could be used safely as an anti-glycaemic drug in patients with diabetes and heart failure. Each of these pieces of underpinning research contributed to the development of clinical practice guidelines internationally and helped the Food and Drug Administration in their decision-making and influenced prescribing practice. Rated as internationally excellent in REF 2021 UOA1 for University of Dundee
- Impact on the Department of Health’s guidance on e-cigarettes. Working with Professor Jacob George on the VESUVIUS study, their study provided key data that was used to guide the government’s tobacco control plan for England, Public Health England’s eighth and final report (Nicotine vaping in England: 2022 evidence update - GOV.UK (www.gov.uk). Our data reporting the vascular effects of e-cigarettes provided rigorous, comprehensive and up-to-date piece work that helped demonstrate that nicotine vaping is far less harmful than smoking tobacco. This helped give reassurance to health services and policy makers that encouraging smokers who are unable to stop smoking to switch to these reduced harm products will benefit population health.
Research interests
Undertaking research on COVID-19 to address the current coronavirus pandemic.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Doctor of Medicine, Neurohormones and sodium homeostasis in Man, University of Dundee
Award Date: 17 Jul 1993
Bachelor of Medicine and Bachelor of Surgery, University of Dundee
Award Date: 1 Jan 1985
Bachelor of Science, University of Dundee
Award Date: 1 Jan 1982
Keywords
- RM Therapeutics. Pharmacology
- Cardiology
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Collaborations and top research areas from the last five years
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Multimorbidity, Frailty And An Ageing Cancer Population – Using Health Data To Improve Decision Making
Baxter, M. (Investigator), Lang, C. (Investigator) & Petty, R. (Investigator)
1/01/25 → 31/12/27
Project: Research
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Sotagliflozin In Patients With Heart Failure Symptoms And Type 1 Diabetes (SOPHIST)
Lang, C. (Investigator), McCrimmon, R. (Investigator), Mordi, I. (Investigator) & Pearson, E. (Investigator)
Juvenile Diabetes Research Foundation
1/09/23 → 31/08/26
Project: Research
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The iDiabetes Platform - Enhanced Phenotyping of Patients With Diabetes For Precision Diagnosis, Prognosis and Treatment (Joint with NHS Education for Scotland and University of Aberdeen)
Bell, S. (Investigator), Croudace, T. (Investigator), Cunningham, S. (Investigator), Dillon, J. (Investigator), Doney, A. (Investigator), Donnan, P. (Investigator), Farre, A. (Investigator), Lang, C. (Investigator), McCrimmon, R. (Investigator), Mordi, I. (Investigator), Palmer, C. (Investigator) & Pearson, E. (Investigator)
1/05/22 → 30/04/26
Project: Research
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CARdiomyopathy in type 2 DIAbetes mellitus (CARDIATEAM) (Joint with the INSERM as lead, CIBER- Network Centre for Biomedical Research, Luxembourg Institute of Health and 17 others)
Doney, A. (Investigator), Houston, G. (Investigator), Lang, C. (Investigator), Mordi, I. (Investigator), Palmer, C. (Investigator), Pearson, E. (Investigator) & Trucco, M. (Investigator)
COMMISSION OF THE EUROPEAN COMMUNITIES
1/03/19 → 28/02/26
Project: Research
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Sonix Touch Echocardiogram:Sir John Fisher
Belch, J. (Investigator), Choy, A.-M. (Investigator), George, J. (Investigator), Houston, G. (Investigator), Khan, F. (Investigator) & Lang, C. (Investigator)
1/07/18 → 31/07/27
Project: Research
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Deep-Learning Prediction of Cardiovascular Outcomes from Routine Retinal Images in Individuals with Type 2 Diabetes
Syed, M. G., Trucco, M., Mookiah, M. R. K., Lang, C., McCrimmon, R., Palmer, C., Pearson, E., Doney, A. & Mordi, I., 2 Jan 2025, In: Cardiovascular Diabetology. 24, 11 p., 3.Research output: Contribution to journal › Article › peer-review
Open AccessFile8 Downloads (Pure) -
Interdisciplinary Perspectives on the Co-Management of Metabolic Dysfunction-Associated Steatotic Liver Disease and Coronary Artery Disease
Gries, J. J., Lazarus, J. V., Brennan, P., Siddiqui, M. S., Targher, G., Lang, C., Virani, S. S., Lavie, C. J., Isaacs, S., Arab, J. P., Cusi, K. & Krittanawong, C. (Lead / Corresponding author), Jan 2025, In: The Lancet Gastroenterology and Hepatology. 10, 1, p. 82-94 13 p.Research output: Contribution to journal › Review article › peer-review
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Accelerated elastin degradation by age-disease interaction: a common feature in age-related diseases
Shek, N., Choy, A.-M., Lang, C. C., Miller, B. E., Tal-Singer, R., Bolton, C. E., Thomson, N. C., Chalmers, J. D., Bown, M. J., Newby, D., Khan, F. & Huang, J. T. J. (Lead / Corresponding author), 27 Feb 2024, In: NPJ Aging and Mechanisms of Disease. 10, 4 p., 15.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)43 Downloads (Pure) -
Artificial intelligence-assisted automated heart failure detection and classification from electronic health records
Oo, M. M. (Lead / Corresponding author), Gao, C., Cole, C., Hummel, Y. M., Guignard-Duff, M., Jefferson, E., Hare, J., Voors, A. A., de Boer, R. A., Lam, C. S. P., Mordi, I., Tromp, J. (Lead / Corresponding author) & Lang, C. (Lead / Corresponding author), Oct 2024, In: ESC Heart Failure. 11, 5, p. 2769-2777 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)67 Downloads (Pure) -
Cardiovascular and Noncardiovascular Prescribing and Mortality After Takotsubo: Comparison With Myocardial Infarction and General Population
Rudd, A. E., Horgan, G., Khan, H., Gamble, D. T., McGowan, J., Sood, A., McGeoch, R., Irving, J., Watt, J., Leslie, S. J., Petrie, M., Lang, C., Mills, N. L., Newby, D. E. & Dawson, D. K. (Lead / Corresponding author), Feb 2024, In: JACC: Advances. 3, 2, 10 p., 100797.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Citations (Scopus)48 Downloads (Pure)
Datasets
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Type 2 Diabetes, Metabolic Traits, and Risk of Heart Failure: A Mendelian Randomization Study
Mordi, I. (Creator), Lumbers, R. T. (Creator), Palmer, C. (Creator), Pearson, E. (Creator), Sattar, N. (Creator), Holmes, M. V. (Creator) & Lang, C. (Creator), figshare, 6 Apr 2021
DOI: 10.2337/figshare.14448480
Dataset
Prizes
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American Federation of Clinical Research Trainee Investigator Award
Lang, C. (Recipient), 1994
Prize: Prize (including medals and awards)
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American Society for Clinical Pharmacology and Therapeutics Presidential Trainee Award
Lang, C. (Recipient), 1995
Prize: Prize (including medals and awards)
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ASEAN Congress of Cardiology Young Investigator Award
Lang, C. (Recipient), 1996
Prize: Prize (including medals and awards)
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British Pharmacological Society's, BrAPP PRIZE and MEDAL.
Lang, C. (Recipient), 1993
Prize: Prize (including medals and awards)
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Dundee Discoveries Past and Present - self-guided walking tours
Jarron, M. (Organiser), Cameron, A. (Organiser), Morrice, N. (Contributor), Lang, C. (Contributor), Lermant, A. (Contributor), Nicholson, C. (Contributor), Henderson, C. (Contributor), Langston, R. (Member), de la Vega, L. (Member), Smith, G. (Contributor), Cavellini, D. (Contributor), Evans, A. (Contributor), Dickson, J. (Contributor), Eccles, J. (Contributor), Epemolu, O. (Contributor), Read, K. (Contributor), Pawlowic, M. (Contributor), Taylor, M. (Contributor), McKim, S. (Contributor), McSorley, H. (Contributor), Mossey, P. (Contributor), Wyllie, S. (Contributor), Nic Daeid, N. (Contributor), McDougall, S. (Contributor), Mackintosh, A. (Contributor), Floyd, A. (Contributor), Goddard, C. (Contributor), Kang, L. (Contributor), Gemmill, J. (Contributor) & Black, R. (Contributor)
Nov 2020Activity: Other activity types › Other
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“Diabetes and Heart failure: Update on research and treatment’
Lang, C. (Speaker)
1 Aug 2014Activity: Talk or presentation types › Invited talk
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‘Blood pressure and heart failure: Some of the complexities of a love hate relationship.
Lang, C. (Speaker)
1 Sept 2014Activity: Talk or presentation types › Invited talk
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Diabetes UK Professional Conference 2013
Lang, C. C. (Participant)
13 Mar 2013 → 15 Mar 2013Activity: Participating in or organising an event types › Participation in conference
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‘Off Target Cardiovascular Effects of Diabetic Therapies’.
Lang, C. (Speaker)
1 Oct 2012Activity: Talk or presentation types › Invited talk
Press/Media
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Blood test raises hopes of tackling 'silent killer'
Huang, J., Choy, A., Lang, C. & Mordi, I.
11/10/19
1 item of Media coverage
Press/Media: Research
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Diabetes drug could help reduce cardiovascular disease
22/08/16
1 Media contribution
Press/Media: Research
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BBC News. Type 2 diabetes drug 'could treat other conditions'
19/08/16
1 Media contribution
Press/Media: Research
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Type 2 diabetes drug 'could treat other conditions'
19/08/16
1 item of Media coverage
Press/Media: Research
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'Super-dose statins can add years to our lives,' says doctors
21/02/14
1 item of Media coverage
Press/Media: Research