• 11072 Citations
  • 51 h-Index
1985 …2024
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Research Output 1985 2020

2020

Biomarkers of Aortopathy in Marfan Syndrome

Iskandar, Z., Mordi, I., Lang, C., Huang, J. & Choy, A., 23 Jan 2020, In : Cardiology in Review. 28, 2, p. 92-97 6 p.

Research output: Contribution to journalArticle

Marfan Syndrome
Biomarkers
Dissection
Patient Care
Cardiovascular System

Distinct Pathological Pathways in Patients with Heart Failure and Diabetes

Tromp, J., Voors, A. A., Sharma, A., Ferreira, J. P., Ouwerkerk, W., Hillege, H. L., Arevalo Gomez, K., Dickstein, K., Anker, S. D., Metra, M., Lang, C., Ng, L. L., van der Harst, P., van Veldhuisen, D. J., van der Meer, P., Lam, C. S. P., Zannad, F. & Sama, I. E., 5 Feb 2020, In : JACC: Heart Failure. 8, 3, p. 234-242 9 p.

Research output: Contribution to journalArticle

Heart Failure
Biomarkers
Epidermal Growth Factor Receptor
Galectin 4
Neutrophils
11 Downloads (Pure)

Genetic Risk and Atrial Fibrillation in Patients with Heart Failure

Kloosterman, M., Santema, B. T., Roselli, C., Nelson, C. P., Koekemoer, A., Romaine, S. P. R., Van Gelder, I. C., Lam, C. S. P., Artola, V. A., Lang, C., Ng, L. L., Metra, M., Anker, S. D., Filippatos, G. S., Dickstein, K., Ponikowski, P., van der Harst, P., Meer, P. V. D., Van Veldhuisen, D. J., Benjamin, E. J. & 3 others, Voors, A. A., Samani, N. J. & Rienstra, M., 9 Jan 2020, In : European Journal of Heart Failure. 9 p.

Research output: Contribution to journalArticle

Open Access
File
Atrial Fibrillation
Heart Failure
Single Nucleotide Polymorphism
Atrial Flutter
Genome-Wide Association Study
22 Downloads (Pure)

Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure

Shah, S., Henry, A., Roselli, C., Lin, H., Sveinbjörnsson, G., Fatemifar, G., Hedman, Å. K., Wilk, J. B., Morley, M. P., Chaffin, M. D., Helgadottir, A., Verweij, N., Dehghan, A., Almgren, P., Andersson, C., Aragam, K. G., Ärnlöv, J., Backman, J. D., Biggs, M. L., Bloom, H. L. & 31 others, Brandimarto, J., Brown, M. R., Buckbinder, L., Carey, D. J., Chasman, D. I., Chen, X., Chen, X., Chung, J., Chutkow, W., Cook, J. P., Delgado, G. E., Denaxas, S., Doney, A. S., Dörr, M., Dudley, S. C., Dunn, M. E., Engström, G., Esko, T., Felix, S. B., Finan, C., Ford, I., Mordi, I. R., Morris, A. D., Morris, A. P., Palmer, C. N. A., Parry, H. M., Smith, N. L., Veluchamy, A., McMurray, J. J. V., Lang, C. C. & Lumbers, R. T., 9 Jan 2020, In : Nature Communications. 11, 1, p. 1-12 12 p., 163.

Research output: Contribution to journalArticle

Open Access
File
Mendelian Randomization Analysis
pathogenesis
genome
Heart Failure
Genes

Genome-wide association study of angioedema induced by angiotensin-converting enzyme inhibitor and angiotensin receptor blocker treatment

Rasmussen, E. R., Hallberg, P., Baranova, E. V., Eriksson, N., Karawajczyk, M., Johansson, C., Cavalli, M., Maroteau, C., Veluchamy, A., Islander, G., Hugosson, S., Terreehorst, I., Asselbergs, F. W., Norling, P., Johansson, H-E., Kohnke, H., Syvänen, A-C., Siddiqui, M. K., Lang, C., Magnusson, P. K. E. & 8 others, Yue, Q-Y., Wadelius, C., von Buchwald, C., Bygum, A., Alfirevic, A., Maitland-van der Zee, A. H., Palmer, C. N. A. & Wadelius, M., 21 Feb 2020, In : Pharmacogenomics Journal. 14 p.

Research output: Contribution to journalArticle

Open Access
File
Angioedema
Angiotensin Receptor Antagonists
Genome-Wide Association Study
Angiotensin-Converting Enzyme Inhibitors
Genome

Geographical differences in heart failure characteristics and treatment across Europe: results from the BIOSTAT-CHF study

Lombardi, C. M., Ferreira, J. P., Carubelli, V., Anker, S. D., Cleland, J. G., Dickstein, K., Filippatos, G., Lang, C. C., Ng, L. L., Ponikowski, P., Samani, N. J., van Veldhuisen, D. J., Zannad, F., Voors, A. & Metra, M., 29 Jan 2020, In : Clinical Research in Cardiology . 11 p.

Research output: Contribution to journalArticle

Heart Failure
Therapeutics
Slovenia
Serbia
Greece
4 Downloads (Pure)

Higher doses of loop diuretics limit uptitration of angiotensin converting enzyme inhibitors in patients with heart failure and reduced ejection fraction

ter Maaten, J. M., Martens, P., Damman, K., Dickstein, K., Ponikowski, P., Lang, C., Ng, L. L., Anker, S. D., Samani, N. J., Filippatos, G. S., Cleland, J. G. F., Zannad, F., Hillege, H. L., van Veldhuisen, D. J., Metra, M., Voors, A. A. & Mullens, W., 30 Jan 2020, In : Clinical Research in Cardiology . 12 p.

Research output: Contribution to journalArticle

Open Access
File
Sodium Potassium Chloride Symporter Inhibitors
Angiotensin-Converting Enzyme Inhibitors
Heart Failure
Mineralocorticoid Receptor Antagonists
Hospitalization

Reply

Gingles, C. R., Symon, R., Gandy, S. J., Struthers, A. D., Houston, G., MacDonald, T. M., Lang, C. C., Donnan, P. T. & George, J., 1 Jan 2020, In : Journal of Hypertension. 38, 1, p. 177-178 2 p.

Research output: Contribution to journalLetter

2019
2 Citations (Scopus)
102 Downloads (Pure)

Allopurinol treatment adversely impacts left ventricular mass regression in patients with well-controlled hypertension

Gingles, C., Symon, R., Gandy, S., Struthers, A., Houston, G., MacDonald, T., Lang, C., Donnan, P. & George, J., Dec 2019, In : Journal of Hypertension. 37, 12, p. 2481-2489 9 p.

Research output: Contribution to journalArticle

Open Access
File
Allopurinol
Hypertension
Placebos
Oxidative Stress
Left Ventricular Hypertrophy
11 Citations (Scopus)
63 Downloads (Pure)

A Randomized Controlled Trial of Metformin on Left Ventricular Hypertrophy in Patients with Coronary Artery Disease without Diabetes: The MET-REMODEL Trial

Mohan, M., Al-Talabany, S., McKinnie, A., Mordi, I., Singh, J., Gandy, S., Baig, F., Hussain, M. S. ., Bhalraam, U., Khan, F., Choy, A., Matthew, S., Houston, G., Struthers, A., George, J. & Lang, C. C., 1 Nov 2019, In : European Heart Journal. 40, 41, p. 3409-3417 9 p.

Research output: Contribution to journalArticle

Open Access
File
Metformin
Left Ventricular Hypertrophy
Coronary Artery Disease
Randomized Controlled Trials
Insulin Resistance
2 Citations (Scopus)

Association of Chromosome 9p21 with Subsequent Coronary Heart Disease events: A GENIUS-CHD study of individual participant data

Schmidt, A. F., Lang, C., Tragante, V., McCubrey, R. O., Holmes, M. V., Howe, L. J., Direk, K., Akerblom, A., Leander, K., Virani, S. S., Kaminski, K. A., Muehischlegel, J. D., Dube, M-P., Allayee, H., Almgren, P., Alver, M., Baranova, E. V., Behlouli, H., Boeckx, B., Braund, P. S. & 30 others, Breitling, L. P., Delgado, G. E., Duarte, N. E., Dufresne, L., Eriksson, N., Foco, L., Gijsberts, C. M., Gong, Y., Hartiala, J., heydarpour, M., Hubacek, J. A., Kleber, M., Kofink, D., Kuukasjarvi, P., Lee, V-V., Leiherer, A., Lenzini, P. A., Levin, D., Lyytikäinen, L-P., Martinelli, N., Mons, U., Nelson, C. P., Nikus, K., Pilbrow, A. P., Ploski, R., Mordi, I. R., Patel, R. S., Muhlestein, J. B., Newton-Cheh, C. & Pitha, J., Apr 2019, In : Circulation: Genomic and Precision Medicine. 12, 4, p. 161-172 12 p.

Research output: Contribution to journalArticle

Open Access
Coronary Disease
Chromosomes
Atherosclerotic Plaques
Disease Progression
Meta-Analysis
5 Citations (Scopus)
104 Downloads (Pure)

Bio-adrenomedullin as a marker of congestion in patients with new-onset and worsening heart failure

ter Maaten, J. M., Kremer, D., Demissei, B., Struck, J., Bergmann, A., Anker, S. D., Ng, L. L., Dickstein, K., Metra, M., Samani, N. J., Romaine, S. P. R., Cleland, J. G. F., Girerd, N., Lang, C., van Veldhuisen, D. J. & Voors, A. A., 20 Jun 2019, In : European Journal of Heart Failure. 21, 6, p. 732-743 12 p.

Research output: Contribution to journalArticle

Open Access
File
Adrenomedullin
Heart Failure
Edema
Venous Pressure
Hepatomegaly
4 Citations (Scopus)
30 Downloads (Pure)

Cardiovascular Effects of Switching from Tobacco Cigarettes to Electronic Cigarettes

George, J., Hussain, M., Vadiveloo, T., Ireland, S., Hopkinson, P., Struthers, A. D., Donnan, P. T., Khan, F. & Lang, C. C., 15 Nov 2019, In : Journal of the American College of Cardiology. 9 p.

Research output: Contribution to journalArticle

Open Access
File
Tobacco Products
Tobacco
Blood Vessels
Nicotine
Dilatation
2 Citations (Scopus)
36 Downloads (Pure)

Clinical correlates and outcome associated with changes in 6-Minute Walking Distance in Patients with Heart Failure: findings from the BIOSTAT-CHF study

Ferreira, J. P., Metra, M., Anker, S. D., Dickstein, K., Lang, C., Ng, L. L., Samani, N. J., Cleland, J. G. F., van Veldhuisen, D. J., Voors, A. A. & Zannad, F., Feb 2019, In : European Journal of Heart Failure. 21, 2, p. 218-226 9 p.

Research output: Contribution to journalArticle

Open Access
File
Walking
Heart Failure
Confidence Intervals
Walk Test
Brain Natriuretic Peptide
2 Citations (Scopus)
34 Downloads (Pure)

Concentric vs. eccentric remodelling in heart failure with reduced ejection fraction: clinical characteristics, pathophysiology and response to treatment

Nauta, J. F., Hummel, Y. M., Tromp, J., Ouwerkerk, W., van der Meer, P., Jin, X., Lam, C. S. P., Bax, J. J., Metra, M., Samani, N. J., Ponikowski, P., Dickstein, K., Anker, S. D., Lang, C., Ng, L. L., Zannad, F., Filippatos, G. S., van Veldhuisen, D. J., van Melle, J. P. & Voors, A. A., 11 Nov 2019, In : European Journal of Heart Failure. 9 p.

Research output: Contribution to journalArticle

Open Access
File
Hypertrophy
Left Ventricular Hypertrophy
Heart Failure
Biomarkers
Angiotensin Receptor Antagonists
1 Citation (Scopus)
49 Downloads (Pure)

Effects of the coronary artery disease associated LPA and 9p21 loci on risk of aortic valve stenosis

Trenkwalder, T., Nelson, C. P., Musameh, M. D., Mordi, I. R., Kessler, T., Pellegrini, C., Debiec, R., Rheude, T., Lazovic, V., Zeng, L., Martinsson, A., Gustav Smith, J., Gådin, J. R., Franco-Cereceda, A., Eriksson, P., Nielsen, J. B., Graham, S. E., Willer, C. J., Hveem, K., Kastrati, A. & 9 others, Braund, P. S., Palmer, C. N. A., Aracil, A., Husser, O., Koenig, W., Schunkert, H., Lang, C. C., Hengstenberg, C. & Samani, N. J., 1 Feb 2019, In : International journal of cardiology. 276, p. 212-217 6 p.

Research output: Contribution to journalArticle

Open Access
File
Aortic Valve Stenosis
Coronary Artery Disease
Alleles
Meta-Analysis
4 Citations (Scopus)

Geographical location affects the levels and association of trimethylamine N-oxide with heart failure mortality in BIOSTAT-CHF: a post-hoc analysis

Yazaki, Y., Salzano, A., Nelson, C. P., Voors, A. A., Anker, S. D., Cleland, J. G., Lang, C. C., Metra, M., Samani, N. J., Ng, L. L. & Suzuki, T., 28 Jul 2019, In : European Journal of Heart Failure. 3 p.

Research output: Contribution to journalLetter

Heart failure etiologies and clinical factors precipitating for worsening heart failure: Findings from BIOSTAT-CHF

Kobayashi, M., Voors, A. A., Girerd, N., Billotte, M., Anker, S. D., Cleland, J. G., Lang, C. C., Ng, L. L., van Veldhuisen, D. J., Dickstein, K., Metra, M., Duarte, K., Rossignol, P., Zannad, F. & Ferreira, J. P., 8 Nov 2019, In : European Journal of Internal Medicine. 8 p.

Research output: Contribution to journalArticle

Precipitating Factors
Heart Failure
Dilated Cardiomyopathy
Renal Insufficiency
Hospitalization
7 Citations (Scopus)
41 Downloads (Pure)

Heart failure in the outpatient versus inpatient setting: findings from the BIOSTAT-CHF study

Ferreira, J. P., Metra, M., Mordi, I., Gregson, J., ter Maaten, J., Tromp, J., Anker, S. D., Dickstein, K., Hillege, H. L., Ng, L. L., van Veldhuisen, D. J., Lang, C. C., Voors, A. A. & Zannad, F., 1 Jan 2019, In : European Journal of Heart Failure. 21, 1, p. 112-120 9 p.

Research output: Contribution to journalArticle

Open Access
File
Inpatients
Outpatients
Heart Failure
Confidence Intervals
Therapeutics
6 Citations (Scopus)
5 Downloads (Pure)

Identifying optimal doses of heart failure medications in men compared with women: a prospective, observational cohort study

Santema, B. T., Ouwerkerk, W., Tromp, J., Sama, I. E., Ravera, A., Regitz-Zagrosek, V., Hillege, H., Samani, N. J., Zannad, F., Dickstein, K., Lang, C., Cleland, J. G., ter Maaten, J. M., Metra, M., Anker, S. D., van der Harst, P., Ng, L. L., Meer, P. V. D., van Veldhuisen, D. J., Meyer, S. & 1 others, Voors, A. A., 5 Oct 2019, In : Lancet. 394, 10205, p. 1254-1263 10 p.

Research output: Contribution to journalArticle

Open Access
File
Observational Studies
Angiotensin Receptor Antagonists
Cohort Studies
Heart Failure
Angiotensin-Converting Enzyme Inhibitors
3 Citations (Scopus)
35 Downloads (Pure)

Iron deficiency in worsening heart failure is associated with reduced estimated protein intake, fluid retention, inflammation and antiplatelet use

van der Wal, H. H., Beverborg, N. G., Dickstein, K., Anker, S. D., Lang, C. C., Ng, L. L., van Veldhuisen, D. J., Voors, A. A. & van der Meer, P., 21 Nov 2019, In : European Heart Journal. 40, 44, p. 3616-3625 10 p., ehz680.

Research output: Contribution to journalArticle

Open Access
File
Iron
Heart Failure
Inflammation
Proteins
Biomarkers
64 Downloads (Pure)

Metformin and its Potential for Heart Failure with Preserved Ejection Fraction

Mohan, P., Iskandar, Z., Mordi, I., Yeow, C., Neaogoie, A., Rena, G., Chew, S. & Lang, C., 26 Aug 2019, In : Journal of Diabetes and Treatment. 4, 2, 4 p.

Research output: Contribution to journalEditorial

Open Access
File

P6505 Urinary desmosine, an elastin-specific degradation product is associated with maximum aortic root size and aortic z-scores in patients with bicuspid aortic valve

Iskandar, Z., Huang, J. T. J., Mordi, I., Miller, L. D., Chin, C., Goudie, D., Mcwilliam, C., Berg, J., Neagoie, A., Lang, C. C. & Choy, A. M., 21 Oct 2019, p. ehz746.1095.

Research output: Contribution to conferenceAbstract

Desmosine
Elastin
Aortic Valve
Marfan Syndrome
Bicuspid Aortic Valve

Plasma desmosine, an elastin degradation product, predicts outcomes in at risk populations

Iskandar, Z., Mordi, I., Huang, J. T. J., Newby, D., Chalmers, J., Bown, M., Lang, C. & Choy, A. M., 12 Mar 2019, In : Journal of the American College of Cardiology. 73, 9, Supplement 1, p. 1805 1 p.

Research output: Contribution to journalArticle

Desmosine
Elastin
Mortality
Rupture
Cardiovascular Diseases
38 Downloads (Pure)

Plasma Desmosine and Abdominal Aortic Aneurysm Disease

Mordi, I., Forsythe, R., Gellatly, C., Iskandar, Z., McBride, O., Saratzis, A., Chalmers, R., Chin, C. W. L., Bown, M. J., Newby, D. E., Lang, C., Huang, J. & Choy, A., 15 Oct 2019, In : Journal of the American Heart Association. 8, 20, p. 1-9 9 p., e013743.

Research output: Contribution to journalArticle

Open Access
File
Desmosine
Aortic Diseases
Abdominal Aortic Aneurysm
Elastin
Cohort Studies
1 Citation (Scopus)
38 Downloads (Pure)

Plasma proteomic approach in patients with heart failure: insights into pathogenesis of disease progression and potential novel treatment targets

Cao, T. H., Jones, D. J. L., Voors, A. A., Quinn, P. A., Sandhu, J. K., Chan, D. C. S., Parry, H., Mohan, P., Mordi, I., Sama, I. E., Anker, S. D., Cleland, J. G. F., Dickstein, K., Filippatos, G. S., Hillege, H. L., Metra, M., Ponikowski, P., Samani, N. J., van Veldhuisen, D. J., Zannad, F. & 2 others, Lang, C. & Ng, L. L., 6 Nov 2019, In : European Journal of Heart Failure. 11 p.

Research output: Contribution to journalArticle

Open Access
File
Proteomics
Disease Progression
Heart Failure
Proteome
Pyruvic Acid
43 Downloads (Pure)

Potential mechanisms for the effects of far-infrared on the cardiovascular system: a review

Shemilt, R., Bagabir, H., Lang, C. & Khan, F., Jul 2019, In : VASA. 48, 4, p. 303-312 10 p.

Research output: Contribution to journalArticle

Open Access
File
Cardiovascular System
Protein Precursors
Nitric Oxide Synthase Type III
Arteriovenous Fistula
Therapeutic Uses
2 Citations (Scopus)
35 Downloads (Pure)

Proenkephalin, an Opioid System Surrogate, as a Novel Comprehensive Renal Marker in Heart Failure

Emmens, J. E., Ter Maaten, J. M., Damman, K., van Veldhuisen, D. J., de Boer, R. A., Struck, J., Bergmann, A., Sama, I. E., Streng, K. W., Anker, S. D., Dickstein, K., Lang, C. C., Metra, M., Samani, N. J., Ng, L. L. & Voors, A. A., 1 May 2019, In : Circulation: Heart Failure. 12, 5, e005544.

Research output: Contribution to journalArticle

Open Access
File
Opioid Analgesics
Heart Failure
Kidney
Glomerular Filtration Rate
Systems Biology
4 Citations (Scopus)
106 Downloads (Pure)

Prognostic Significance of Changes in Heart Rate Following Uptitration of Beta-Blockers in Patients with Sub-Optimally Treated Heart Failure with Reduced Ejection Fraction in Sinus Rhythm versus Atrial Fibrillation

Mordi, I., Santema, B. T., Kloosterman, M., Choy, A-M., Rienstra, M., Van Gelder, I. C., Anker, S. D., Cleland, J. G. F., Dickstein, K., Filippatos, G. S., van der Harst, P., Hillege, H. L., Metra, M., Ng, L. L., Ouwerkerk, W., Ponikowski, P., Samani, N. J., van Veldhuisen, D. J., Zwinderman, A. H., Zannad, F. & 2 others, Voors, A. A. & Lang, C., Jul 2019, In : Clinical Research in Cardiology . 108, 7, p. 797-805 9 p.

Research output: Contribution to journalArticle

Open Access
File
Atrial Fibrillation
Heart Failure
Heart Rate
Hospitalization
Mortality
2 Citations (Scopus)
212 Downloads (Pure)

Proprotein convertase subtilisin/kexin 9 inhibitors in reducing cardiovascular outcomes: A systematic review and meta-analysis

Du, H., Li, X., Su, N., Li, L., Hao, X., Gao, H., Kwong, J. SW., Vandvik, P. O., Yang, X., Nemeth, I., Mordi, I., Li, Q., Zhang, L., Rao, L., Lang, C., Li, J., Tian, H. & Li, S., Aug 2019, In : Heart. 105, 15, p. 1149-1159 11 p.

Research output: Contribution to journalArticle

Open Access
File
Proprotein Convertases
Subtilisin
Meta-Analysis
Stroke
Myocardial Infarction

Scientific Business Abstracts of the 113th Annual Meeting of the Association of Physicians of Great Britain and Ireland

Deciphering Developmental Disorders (DDD) Study, Cacciottolo, T. M., Perikari, A., van der Klaauw, A., Henning, E., Stadler, L. K. J., Keogh, J., Farooqi, I. S., Tenin, G., Keavney, B., Ryan, E., Budd, R., Bewley, M., Coelho, P., Rumsey, W., Sanchez, Y., McCafferty, J., Dockrell, D., Walmsley, S., Whyte, M. & 31 others, Liu, Y., Choy, M-K., Tenin, G., Abraham, S., Black, G., Keavney, B., Watkins, S., Robertson, K., Collison, D., Rush, C., Marshall, J., McGowan, R., Fraser, R., Gandhi, S., Cooper, C., Howden, A., Hukelmann, J. L., Cantrell, D. A., Mordi, I., Forteath, C., Wong, A., Mohan, M., Palmer, C., Doney, A., Rena, G., Lang, C., Gray, E. H., Williams, R., Williams, S., Hughes, J. & Davies, J., 5 Sep 2019, In : QJM : an International Journal of Medicine. 112, 9, p. 724-729 6 p., 9.

Research output: Contribution to journalMeeting abstract

Ireland
Metformin
Blood Pressure
Physicians
Left Ventricular Hypertrophy
23 Downloads (Pure)

Selenium and outcome in heart failure

Bomer, N., Grote Beverborg, N., Hoes, M. F., Streng, K. W., Vermeer, M., Dokter, M. M., IJmker, J., Anker, S. D., Cleland, J. G. F., Hillege, H. L., Lang, C. C., Ng, L. L., Samani, N. J., Tromp, J., van Veldhuisen, D. J., Touw, D. J., Voors, A. A. & van der Meer, P., 6 Dec 2019, In : European Journal of Heart Failure. 9 p.

Research output: Contribution to journalArticle

Open Access
File
Selenium
Heart Failure
Cardiac Myocytes
Mortality
Confidence Intervals
3 Citations (Scopus)
101 Downloads (Pure)

Subsequent Event Risk in Individuals with Established Coronary Heart Disease: Design and Rationale of the GENIUS-CHD Consortium

Patel, R., Tragante, V., Schmidt, A. F., McCubrey, R. O., Holmes, M. V., Howe, L. J., Direk, K., Åkerblom, A., Leander, K., Virani, S. S., Kaminski, K. A., Muehlschlegel, J. D., Allayee, H., Almgren, P., Alver, M., Baranova, E. V., Behlouli, H., Boeckx, B., Braund, P. S., Breitling, L. P. & 161 others, Delgado, G., Duarte, N. E., Dubé, M-P., Dufresne, L., Eriksson, N., Foco, L., Scholz, M., Gijsberts, C. M., Glinge, C., Gong, Y., Hartiala, J., Heydarpour, M., Hubacek, J. A., Kleber, M., Kofink, D., Kotti, S., Kuukasjärvi, P., Lee, V-V., Leiherer, A., Lenzini, P. A., Levin, D., Lyytikäinen, L-P., Martinelli, N., Mons, U., Nelson, C. P., Nikus, K., Pilbrow, A. P., Ploski, R., Sun, Y. V., Tanck, M. W. T., Tang, W. H. W., Trompet, S., van der Laan, S. W., Van Setten, J., Vilmundarson, R. O., Viviani Anselmi, C., Vlachopoulou, E., Al Ali, L., Boerwinkle, E., Briguori, C., Carlquist, J. F., Carruthers, K. F., Casu, G., Deanfield, J., Deloukas, P., Dudbridge, F., Engström, T., Fitzpatrick, N., Fox, K., Gigante, B., James, S., Lokki, M-L., Lotufo, P. A., Marziliano, N., Mordi, I. R., Muhlestein, J. B., Newton-Cheh, C., Pitha, J., Saely, C. H., Samman-Tahhan, A., Sandesara, P. B., Teren, A., Timmis, A., Van de Werf, F., Wauters, E., Wilde, A. A. M., Ford, I., Stott, D. J., Algra, A., Andreassi, M. G., Ardissino, D., Arsenault, B. J., Ballantyne, C. M., Bergmeijer, T. O., Bezzina, C. R., Body, S. C., Boersma, E. H., Bogaty, P., Bots, M., Brenner, H., Brugts, J. J., Burkhardt, R., Carpeggiani, C., Condorelli, G., Cooper-DeHoff, R. M., Cresci, S., Danchin, N., de Faire, U., Doughty, R. N., Drexel, H., Engert, J. C., Fox, K. A. A., Girelli, D., Grobbee, D. E., Hagström, E., Hazen, S. L., Held, C., Hemingway, H., Hoefer, I. E., Hovingh, G. K., Jabbari, R., Johnson, J. A., Jukema, J. W., Kaczor, M. P., Kähönen, M., Kettner, J., Kiliszek, M., Klungel, O. H., Lagerqvist, B., Lambrechts, D., Laurikka, J. O., Lehtimäki, T., Lindholm, D., Mahmoodi, B. K., Maitland-van der Zee, A. H., McPherson, R., Melander, O., Metspalu, A., Niemcunowicz-Janica, A., Olivieri, O., Opolski, G., Palmer, C. N., Pasterkamp, G., Pepine, C. J., Pereira, A. C., Pilote, L., Quyyumi, A. A., Richards, A. M., Sanak, M., Siegbahn, A., Simon, T., Sinisalo, J., Smith, J. G., Spertus, J. A., Stender, S., Stewart, A. F. R., Szczeklik, W., Szpakowicz, A., Tardif, J-C., Ten Berg, J. M., Tfelt-Hansen, J., Thanassoulis, G., Thiery, J., Torp-Pedersen, C., van der Graaf, Y., Visseren, F. L. J., Waltenberger, J., Weeke, P. E., Van der Harst, P., Lang, C. C., Sattar, N., Cameron, V. A., Anderson, J. L., Brophy, J. M., Paré, G., Horne, B. D., März, W., Wallentin, L., Samani, N. J., Hingorani, A. D. & Asselbergs, F. W., Apr 2019, In : Circulation: Genomic and Precision Medicine. 12, 4, p. 145-160 16 p., e002470.

Research output: Contribution to journalArticle

Open Access
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Coronary Disease
Sex Ratio
Acute Coronary Syndrome
Secondary Prevention
Biomarkers
13 Citations (Scopus)
116 Downloads (Pure)

Symptom Onset in Aortic Stenosis - Relation to Sex Differences in Left Ventricular Remodelling

Singh, A., Chan, D. C. S., Greenwood, J. P., Dawson, D. K., Sonecki, P., Hogrefe, K., Kelly, D. J., Dhakshinamurthy, V., Lang, C., Khoo, J. P., Sprigings, D., Steeds, R. P., Zhang, R., Ford, I., Jerosch-Herold, M., Yang, J., Li, Z., Ng, L. L. & McCann, G. P., Jan 2019, In : JACC. Cardiovascular Imaging. 12, 1, p. 96-105 10 p.

Research output: Contribution to journalArticle

Open Access
File
Ventricular Remodeling
Aortic Valve Stenosis
Sex Characteristics
Syndecan-4
Matrix Metalloproteinases
8 Citations (Scopus)
84 Downloads (Pure)

The Clinical Significance of Interleukin-6 in Heart Failure: Results from the BIOSTAT-CHF Study

Markousis-Mavrogeni, G., Tromp, J., Ouwerkerk, W., Devalarja, M., Anker, S. D., Cleland, J. G., Dickstein, K., Filippatos, G. S., van der Harst, P., Lang, C., Metra, M., Ng, L. L., Ponikowski, P., Samani, N. J., Zannad, F., Zwinderman, A. H., Hillege, H. L., van Veldhuisen, D. J., Kakkar, R., Voors, A. & 1 others, Meer, P. V. D., Aug 2019, In : European Journal of Heart Failure. 21, 8, p. 965-973 9 p.

Research output: Contribution to journalArticle

Open Access
File
Interleukin-6
Heart Failure
Stroke Volume
Atrial Fibrillation
Mortality
3 Citations (Scopus)
94 Downloads (Pure)

The cost effectiveness of REACH-HF and home-based cardiac rehabilitation compared with the usual medical care for heart failure with reduced ejection fraction: a decision model-based analysis

on behalf of the REACH-HF investigators, Taylor, R. S. ., Sadler, S., Dalal, H. M., Warren, F. C., Jolly, K., Davis, R., Doherty, P., Miles, J., Greaves, C. J., Wingham, J., Hillsdon, M., Abraham, C., Frost, J., Singh, S., Hayward, C., Eyre, V., Paul, K., Lang, C. & Smith, K., 1 Aug 2019, In : European Journal of Preventive Cardiology. 26, 12, p. 1252-1261 10 p.

Research output: Contribution to journalArticle

Open Access
File
Cost-Benefit Analysis
Rehabilitation
Heart Failure
Quality-Adjusted Life Years
Costs and Cost Analysis
5 Citations (Scopus)
48 Downloads (Pure)

The influence of atrial fibrillation on the levels of NT-proBNP versus GDF-15 in patients with heart failure

Santema, B. T., Chan, M. M. Y., Tromp, J., Dokter, M., van der Wal, H., Emmens, J. E., Takens, J., Samani, N. J., Ng, L. L., Lang, C., van der Meer, P., ter Maaten, J. M., Damman, K., Dickstein, K., Cleland, J. G., Zannad, F., Anker, S. D., Metra, M., van der Harst, P., de Boer, R. A. & 4 others, van Veldhuisen, D. J., Rienstra, M., Lam, C. S. P. & Voors, A. A., 1 Jul 2019, In : Clinical Research in Cardiology . 8 p.

Research output: Contribution to journalArticle

Open Access
File
Growth Differentiation Factor 15
Atrial Fibrillation
Heart Failure
pro-brain natriuretic peptide (1-76)
25 Downloads (Pure)

The Role of Cathepsin D in the Pathophysiology of Heart Failure and its Potentially Beneficial Properties: a translational approach

Hoes, M. F., Tromp, J., Ouwerkerk, W., Bomer, N., Oberdorf-Maas, S. U., Samani, N. J., Ng, L. L., Lang, C., van der Harst, P., Hillege, H. L., Anker, S. D., Metra, M., van Veldhuisen, D. J., Voors, A. A. & van der Meer, P., 3 Dec 2019, In : European Journal of Heart Failure. 10 p.

Research output: Contribution to journalArticle

Open Access
File
Cathepsin D
Heart Failure
Cardiac Myocytes
Troponin T
Stem Cells

Urinary desmosine, a biomarker of elastin degradation is significantly elevated and associated with maximum aortic root size and aortic Z-scores in patients with bicuspid aortic valve

Iskandar, Z., Huang, J., Miller, L., Chin, C., Mordi, I., Mcwilliam, C., Goudie, D., Berg, J., Neagoie, A., Lang, C. & Choy, A-M., 26 May 2019, In : Heart. 105, Supplement 6, p. A103-A104 2 p., 126.

Research output: Contribution to journalMeeting abstract

Desmosine
Elastin
Biomarkers
Bicuspid Aortic Valve
Dilatation
97 Downloads (Pure)

What is the added value of the waist-to-hip ratio on top of the BIOSTAT risk prediction model in patients with heart failure? Reply

Streng, K. W., Lang, C. C. & Voors, A. A., Jan 2019, In : European Journal of Heart Failure. 21, 1, p. 132-133 2 p.

Research output: Contribution to journalLetter

Open Access
File
2018
2 Citations (Scopus)

65 The novel plasma biomarker desmosine, a marker of elastin breakdown, is an independent predictor of abdominal aortic aneurysm events independent of aneurysm size

Mordi, I., Forsythe, R., Bown, M., Lang, C., Newby, D. E., Gellatly, C., Chin, C. W. L., McBride, O., Saratzis, A., Iskandar, Z., Chalmers, R., Huang, J. & Choy, A., Jun 2018, In : Heart. 104, Suppl 6, p. A58-59 2 p.

Research output: Contribution to journalMeeting abstract

Desmosine
Elastin
Abdominal Aortic Aneurysm
Aneurysm
Biomarkers
14 Citations (Scopus)
110 Downloads (Pure)

A Randomised Controlled Trial of a Facilitated Home-Based Rehabilitation Intervention in Patients with Heart Failure with Preserved Ejection Fraction and their Caregivers: The REACH-HFpEF Pilot Study

Lang, C. C., Smith, K., Wingham, J., Eyre, V., Greaves, C. J., Warren, F. C., Green, C., Jolly, K., Davis, R. C., Doherty, P., Miles, J., Britten, N., Abraham, C., Van Lingen, R., Singh, S., Paul, K., Hillsdon, M., Sadler, S., Hayward, C., Dalal Hayes, M. & 2 others, Taylor, R. S. . & REACH-HF, 9 Apr 2018, In : BMJ Open. 8, 4, p. 1-12 12 p., e019649.

Research output: Contribution to journalArticle

Open Access
File
Caregivers
Rehabilitation
Randomized Controlled Trials
Heart Failure
Exercise
11 Citations (Scopus)
40 Downloads (Pure)

Association with outcomes and response to treatment of trimethylamine N-oxide in heart failure (from BIOSTAT-CHF)

Suzuki, T., Yazaki, Y., Voors, A. A., Jones, D. J. L., Chan, D. C. S., Anker, S. D., Cleland, J. G. F., Dickstein, K., Filippatos, G. S., Hillege, H. L., Lang, C., Ponikowski, P., Samani, N. J., van Veldhuisen, D. J., Zannad, F., Zwinderman, A. H., Metra, M. & Ng, L. L., 29 Oct 2018, In : European Journal of Heart Failure. 10 p.

Research output: Contribution to journalArticle

Open Access
File
Heart Failure
Guidelines
Therapeutics
Brain Natriuretic Peptide
Confidence Intervals
14 Citations (Scopus)
201 Downloads (Pure)

Biomarker-Guided Versus Guideline-Based Treatment of Patients With Heart Failure: Results From BIOSTAT-CHF

Ouwerkerk, W., Zwinderman, A. H., Ng, L. L., Demissei, B., Hillege, H. L., Zannad, F., van Veldhuisen, D. J., Samani, N. J., Ponikowski, P., Metra, M., ter Maaten, J. M., Lang, C., van der Harst, P., Filippatos, G. S., Dickstein, K., Cleland, J. G. F., Anker, S. D. & Voors, A. A., 30 Jan 2018, In : Journal of the American College of Cardiology. 71, 4, p. 386-398 13 p.

Research output: Contribution to journalArticle

Open Access
File
Heart Failure
Biomarkers
Guidelines
Angiotensin-Converting Enzyme Inhibitors
Therapeutics
9 Citations (Scopus)
174 Downloads (Pure)

Cohort Profile: Genetics of Diabetes Audit and Research in Tayside Scotland (GoDARTS)

Hébert, H. L., Shepherd, B., Milburn, K., Veluchamy, A., Meng, W., Carr, F., Donnelly, L. A., Tavendale, R., Leese, G., Colhoun, H. M., Dow, E., Morris, A. D., Doney, A. S., Lang, C. C., Pearson, E. R., Smith, B. H. & Palmer, C. N. A., 1 Apr 2018, In : International Journal of Epidemiology. 47, 2, p. 380-381j 12 p.

Research output: Contribution to journalArticle

Open Access
File
12 Citations (Scopus)
32 Downloads (Pure)

Comparing biomarker profiles of patients with heart failure: atrial fibrillation vs. sinus rhythm and reduced vs. preserved ejection fraction

Santema, B. T., Kloosterman, M., Van Gelder, I. C., Mordi, I., Lang, C., Lam, C. S. P., Anker, S. D., Cleland, J. G. F., Dickstein, K., Filippatos, G. S., van der Harst, P., Hillege, H. L., ter Maaten, J. M., Metra, M., Ng, L. L., Ponikowski, P., Samani, N. J., van Veldhuisen, D. J., Zwinderman, A. H., Zannad, F. & 4 others, Damman, K., van der Meer, P., Rienstra, M. & Voors, A. A., 14 Nov 2018, In : European Heart Journal. 39, 43, p. 3867-3875 9 p.

Research output: Contribution to journalArticle

Open Access
File
Atrial Fibrillation
Heart Failure
Biomarkers
Phenotype
Confidence Intervals
5 Citations (Scopus)
279 Downloads (Pure)

Coronary angiography in worsening heart failure: determinants, findings, and prognostic implications

Ferreira, J. P., Rossignol, P., Demissei, B., Sharma, A., Girerd, N., Anker, S. D., Cleland, J. G. F., Dickstein, K., Filippatos, G. S., Hillege, H. L., Lang, C. C., Metra, M., Ng, L., Ponikowski, P., Samani, N. J., van Veldhuisen, D. J., Zwinderman, A. H., Voors, A. A. & Zannad, F., 1 Apr 2018, In : Heart. 104, 7, p. 606-613 8 p.

Research output: Contribution to journalArticle

Open Access
File
Coronary Angiography
Heart Failure
Signs and Symptoms
Troponin I
Systems Biology
4 Citations (Scopus)
118 Downloads (Pure)

Epicardial Adipose Tissue Is Related to Arterial Stiffness and Inflammation in Patients with Cardiovascular Disease and Type 2 Diabetes

Al-Talabany, S., Mordi, I., Houston, J. G., Colhoun, H. M., Weir-McCall, J. R., Matthew, S. Z., Looker, H. C., Levin, D., Belch, J. J. F., Dove, F., Khan, F. & Lang, C. C., 13 Feb 2018, In : BMC Cardiovascular Disorders. 18, p. 1-8 8 p., 31.

Research output: Contribution to journalArticle

Open Access
File
Arteritis
Vascular Stiffness
Type 2 Diabetes Mellitus
Adipose Tissue
Cardiovascular Diseases