Cole, Christian

Personal profile

Biography

Christian Cole is a Principal Investigator at the Leverhulme Research Centre for Forensic Science (LRCFS). His expertise and passion is in Bioinformatics and Data Science gained over his postdoctoral career at UMIST, The University of Manchester and, most recently, within the School of Life Sciences at the University of Dundee. In that time, Chris was the founder member and latterly the co-ordinator of the Data Analysis Group; a team dedicated to collaboration on biological projects requiring computational and statistical direction. At LRCFS Chris will be using his multi-disciplinary computational approaches to challenge existing weaknesses in the analysis and interpretation of several forensic evidence types. Chris has a BSc in Pharmaceutical Chemistry and a PhD in Medicinal Chemistry.

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Projects 2017 2019

1 Active

RSE Cloud Computing Award

Cole, C.

13/11/17 → 12/11/19

Project: Research

Research Output 2008 2019

3229 Citations
18 h-Index
29 Article
3 Letter
2 Other contribution
1 Meeting abstract
1 More
- 1 Software

EMSY expression affects multiple components of the skin barrier with relevance to atopic dermatitis

Elias, M. S., Wright, S. C., Remenyi, J., Abbott, J. C., Bray, S. E., Cole, C., Edwards, S., Gierlinski, M., Glok, M., McGrath, J. A., Nicholson, W. V., Paternoster, L., Prescott, A. R., Have, S. T., Whitfield, P. D., Lamond, A. I. & Brown, S. J., Aug 2019, In : Journal of Allergy and Clinical Immunology. 144, 2, p. 470-481 12 p.

Research output: Contribution to journal › Article

Open Access

Atopic Dermatitis

Skin

Genome-Wide Association Study

Keratinocytes

Skin Diseases

157 Downloads (Pure)

Proteus: an R package for downstream analysis of MaxQuant output

Gierlinski, M., Gastaldello, F., Cole, C. & Barton, G., 20 Sep 2018, In : BioRxiv. 10 p.

Research output: Contribution to journal › Article

Open Access

File

Proteus

Peptides

Mass Spectrometry

Proteins

Reformatter for EMBL's HLA aligner

Cole, C. & Mudie, R., 29 May 2018

Research output: Non-textual form › Software

Polymorphism

Databases

3 Citations (Scopus)

101 Downloads (Pure)

Adenylate cyclase A acting on PKA mediates induction of stalk formation by cyclic diguanylate at the Dictyostelium organizer

Chen, Z-H., Singh, R., Cole, C., Lawal, H. M., Schilde, C., Febrer, M., Barton, G. & Schaap, P., 17 Jan 2017, In : Proceedings of the National Academy of Sciences. 114, 3, p. 516-521 6 p.

Research output: Contribution to journal › Article

Open Access

File

Dictyostelium

Adenylyl Cyclases

Genes

Cell Movement

bis(3',5')-cyclic diguanylic acid

5 Citations (Scopus)

128 Downloads (Pure)

A mechanistic target of rapamycin complex 1/2 (mTORC1)/V-Akt murine thymoma viral oncogene homolog 1 (AKT1)/cathepsin H axis controls filaggrin expression and processing in skin, a novel mechanism for skin barrier disruption in patients with atopic dermatitis

Naeem, A. S., Tommasi, C., Cole, C., Brown, S. J., Zhu, Y., Way, B., Willis Owen, S. A. G., Moffatt, M., Cookson, W. O., Harper, J. I., Di, W. L., Brown, S. J., Reinheckel, T. & O'Shaughnessy, R. F. L., Apr 2017, In : Journal of Allergy and Clinical Immunology. 139, 4, p. 1228-1241 14 p.

Research output: Contribution to journal › Article

Open Access

File

Cathepsin H

Thymoma

Atopic Dermatitis

Oncogenes

Skin