Connolly, Christopher &ndash; Research Outputs

2017

1 Citation (Scopus)

63 Downloads (Pure)

Nerve agents in honey: Analysis of local honey samples shows global landscape contamination by pesticides

Connolly, C., 6 Oct 2017, In : Science. 358, 6359, p. 38-39 2 p.

Research output: Contribution to journal › Article

Open Access

File

Honey

Bees

Pesticides

Ecosystem

Pollination

76 Citations (Scopus)

513 Downloads (Pure)

Subcallosal cingulate deep brain stimulation for treatment-resistant depression: a multi-site, randomized, sham-controlled trial

Holtzheimer, P., Husain, M. M., Lisanby, S. H., Taylor, S. F., Whitworth, L. A., McClintock, S., Slavin, K. V., Berman, J., McKhann, G. M., Patil, P. G., Rittberg, B. R., Abosch, A., Pandurangi, A. K., Holloway, K. L., Lam, R. W., Connolly, C., Neimat, J. S., Henderson, J. M., DeBattista, C., Rothschild, A. J. & 10 others, Pilitsis, J. G., Espinoza, R. T., Petrides, G., Mogilner, A. Y., Matthews, K., Peichel, D., Grosse, R., Hamani, C., Lozano, A. M. & Mayberg, H. S., Nov 2017, In : Lancet Psychiatry. 4, 11, p. 839-849 11 p.

Research output: Contribution to journal › Article

Open Access

File

Treatment-Resistant Depressive Disorder

Deep Brain Stimulation

Randomized Controlled Trials

Medical Futility

Depression

2016

31 Citations (Scopus)

151 Downloads (Pure)

Neonicotinoids target distinct nicotinic acetylcholine receptors and neurons, leading to differential risks to bumblebees

Moffat, C., Buckland, S. T., Samson, A., McArthur, R., Chamosa Pino, V., Bollan, K. A., Huang, J. T-J. & Connolly, C., 28 Apr 2016, In : Scientific Reports. 6, p. 1-10 10 p., 24764.

Research output: Contribution to journal › Article

Open Access

File

Nicotinic Receptors

Bees

Neurons

Aptitude

Food Supply

9 Citations (Scopus)

102 Downloads (Pure)

Neuronal networks provide rapid neuroprotection against spreading toxicity

Samson, A. J., Robertson, G., Zagnoni, M. & Connolly, C. N., 21 Sep 2016, In : Scientific Reports. 6, p. 1-11 11 p., 33746.

Research output: Contribution to journal › Article

Open Access

File

Lab-On-A-Chip Devices

Glutamic Acid

Stroke

Emergency Treatment

Brain

2015

40 Citations (Scopus)

186 Downloads (Pure)

Chronic exposure to neonicotinoids increases neuronal vulnerability to mitochondrial dysfunction in the bumblebee (Bombus terrestris)

Moffat, C., Pacheco, J. G., Sharp, S., Samson, A. J., Bollan, K. A., Huang, J., Buckland, S. T. & Connolly, C. N., May 2015, In : FASEB Journal. 29, 5, p. 2112-2119 8 p.

Research output: Contribution to journal › Article

Open Access

File

Depolarization

Neurons

Brain

Plant Nectar

Bees

2014

2 Citations (Scopus)

71 Downloads (Pure)

5-hydroxytryptamine (5-HT) cellular sequestration during chronic exposure delays 5-HT₃ receptor resensitization due to Its subsequent release

Hothersall, J. D., Alexander, A., Samson, A. J., Moffat, C., Bollan, K. A. & Connolly, C. N., 14 Nov 2014, In : Journal of Biological Chemistry. 289, 46, p. 32020-32029 10 p.

Research output: Contribution to journal › Article

Open Access

File

Serotonin Receptors

Serotonin

Down-Regulation

Ileum

Serotonin Plasma Membrane Transport Proteins

2013

107 Citations (Scopus)

Cholinergic pesticides cause mushroom body neuronal inactivation in honeybees

Palmer, M. J., Moffat, C., Saranzewa, N., Harvey, J., Wright, G. A. & Connolly, C. N., 27 Mar 2013, In : Nature Communications. 4, 1634.

Research output: Contribution to journal › Article

Open Access

cholinergics

Mushroom Bodies

pesticides

Pesticides

deactivation

36 Citations (Scopus)

144 Downloads (Pure)

Exposure to acetylcholinesterase inhibitors alters the physiology and motor function of honeybees

Williamson, S. M., Moffat, C., Gomersall, M. A. E., Saranzewa, N., Connolly, C. N. & Wright, G. A., 5 Feb 2013, In : Frontiers in Physiology. 4, 13.

Research output: Contribution to journal › Article

Open Access

File

Grooming

Cholinesterase Inhibitors

Coumaphos

Pesticides

Cholinergic Agents

14 Citations (Scopus)

Prolonged inhibition of 5-HT₃ receptors by palonosetron results from surface receptor inhibition rather than inducing receptor internalization

Hothersall, J. D., Moffat, C. & Connolly, C. N., Jul 2013, In : British Journal of Pharmacology. 169, 6, p. 1252-1262 11 p.

Research output: Contribution to journal › Article

Receptors, Serotonin, 5-HT3

Granisetron

Down-Regulation

Binding Sites

Endocytosis

14 Citations (Scopus)

The microsporidian parasites Nosema ceranae and Nosema apis are widespread in honeybee (Apis mellifera) colonies across Scotland

Bollan, K. A., Hothersall, J. D., Moffat, C., Durkacz, J., Saranzewa, N., Wright, G. A., Raine, N. E., Highet, F. & Connolly, C. N., Feb 2013, In : Parasitology Research. 112, 2, p. 751-759 9 p.

Research output: Contribution to journal › Article

Nosema

Nosema apis

Nosema ceranae

Bees

Microsporidia

The risk of insecticides to pollinating insects

Connolly, C. N., Sep 2013, In : Communicative & Integrative Biology. 6, 5, 3 p., e25074.

Research output: Contribution to journal › Article

neonicotinoid insecticides

pollinating insects

Insecticides

Insects

insecticides

2012

11 Citations (Scopus)

High-affinity fluorescent ligands for the 5-HT3 receptor

Simonin, J., Vernekar, S. K. V., Thompson, A. J., Hothersall, J. D., Connolly, C. N., Lummis, S. C. R. & Lochner, M., 2012, In : Bioorganic & Medicinal Chemistry Letters. 22, 2, p. 1151-1155 5 p.

Research output: Contribution to journal › Article

39 Citations (Scopus)

Identifying key knowledge needs for evidence-based conservation of wild insect pollinators: a collaborative cross-sectoral exercise

Dicks, L. V., Abrahams, A., Atkinson, J., Biesmeijer, J., Bourn, N., Brown, C., Brown, M. J. F., Carvell, C., Connolly, C., Cresswell, J. E., Croft, P., Darvill, B., De Zylva, P., Effingham, P., Fountain, M., Goggin, A., Harding, D., Harding, T., Hartfield, C., Heard, M. S. & 30 others, Heathcote, R., Heaver, D., Holland, J., Howe, M., Hughes, B., Huxley, T., Kunin, W. E., Little, J., Mason, C., Memmott, J., Osborne, J., Pankhurst, T., Paxton, R. J., Pocock, M. J. O., Potts, S. G., Power, E. F., Raine, N. E., Ranelagh, E., Roberts, S., Saunders, R., Smith, K., Smith, R. M., Sutton, P., Tilley, L. A. N., Tinsley, A., Tonhasca, A., Vanbergen, A. J., Webster, S., Wilson, A. & Sutherland, W. J., 2012, In : Insect Conservation and Diversity. 6, 3, p. 435-446 12 p.

Research output: Contribution to journal › Article

pollinating insects

pollinator

pollinators

exercise

insect

2011

2Bs or not 2Bs: that is the question

Connolly, C. N., 2011, In : Journal of Physiology. 589, 17, p. 4085-4086 2 p.

Research output: Contribution to journal › Article

2010

69 Citations (Scopus)

Leptin Regulates AMPA Receptor Trafficking via PTEN Inhibition

Moult, P. R., Cross, A., Santos, S. D., Carvalho, A-L., Lindsay, Y., Connolly, C. N., Irving, A. J., Leslie, N. R. & Harvey, J., 17 Mar 2010, In : Journal of Neuroscience. 30, 11, p. 4088-4101 14 p.

Research output: Contribution to journal › Article

17 Citations (Scopus)

RIC-3 Exclusively Enhances the Surface Expression of Human Homomeric 5-Hydroxytryptamine Type 3A (5-HT(3)A) Receptors Despite Direct Interactions with 5-HT3A, -C, -D, and -E Subunits

Walstab, J., Hammer, C., Lasitschka, F., Möller, D., Connolly, C. N., Rappold, G., Bruess, M., Boenish, H. & Niesler, B., 27 Aug 2010, In : Journal of Biological Chemistry. 285, 35, p. 26956-26965 10 p.

Research output: Contribution to journal › Article

2009

6 Citations (Scopus)

Rapid dendritic and axonal responses to neuronal insults

Mizielinska, S. M., Greenwood, S. M., Tummala, H. & Connolly, C. N., Dec 2009, In : Biochemical Society Transactions. 37, p. 1389-1393 5 p.

Research output: Contribution to journal › Article

2008

27 Citations (Scopus)

The promiscuous role of the epsilon subunit in GABA(A) receptor biogenesis

Bollan, K. A., Baur, R., Hales, T. G., Sigel, E. & Connolly, C. N., Mar 2008, In : Molecular and Cellular Neuroscience. 37, 3, p. 610-621 12 p.

Research output: Contribution to journal › Article

2007

64 Citations (Scopus)

An essential role for constitutive endocytosis, but not activity, in the axonal targeting of the CB1 cannabinoid receptor

McDonald, N. A., Henstridge, C. M., Connolly, C. N. & Irving, A. J., 2007, In : Molecular Pharmacology. 71, 4, p. 976-984 9 p.

Research output: Contribution to journal › Article

Cannabinoid Receptor CB1

Endocytosis

Neurons

Axons

Dynamin I

27 Citations (Scopus)

Differential subcellular localization of RIC-3 Isoforms and their role in determining 5-HT3 receptor composition

Cheng, A., Bollan, K. A., Greenwood, S. M., Irving, A. J. & Connolly, C. N., 7 Sep 2007, In : Journal of Biological Chemistry. 282, 36, p. 26158-26166 9 p.

Research output: Contribution to journal › Article

Receptors, Serotonin, 5-HT3

Protein Isoforms

Endoplasmic Reticulum

Chemical analysis

Agglomeration

22 Citations (Scopus)

Generation and functional characterization of fluorescent, N-terminally tagged CB1 receptor chimeras for live-cell imaging

McDonald, N. A., Henstridge, C. M., Connolly, C. N. & Irving, A. J., Jun 2007, In : Molecular and Cellular Neuroscience. 35, 2, p. 237-248 12 p.

Research output: Contribution to journal › Article

Cannabinoid Receptor CB1

HEK293 Cells

Cell Surface Receptors

Protein Sorting Signals

Fluorescence

119 Citations (Scopus)

Leptin promotes rapid dynamic changes in hippocampal dendritic morphology

O'Malley, D., MacDonald, N., Mizielinska, S., Connolly, C. N., Irving, A. J. & Harvey, J., Aug 2007, In : Molecular and Cellular Neuroscience. 35, 4, p. 559-572 14 p.

Research output: Contribution to journal › Article

72 Citations (Scopus)

Mitochondrial dysfunction and dendritic beading during neuronal toxicity

Greenwood, S. M., Mizielinska, S. M., Frenguelli, B. G., Harvey, J. & Connolly, C. N., 7 Sep 2007, In : Journal of Biological Chemistry. 282, 36, p. 26235-26244 10 p.

Research output: Contribution to journal › Article

32 Citations (Scopus)

Naturally occurring variations in the human 5-HT3A gene profoundly impact 5-HT3 receptor function and expression

Krzywkowski, K., Jensen, A. A., Connolly, C. N. & Brauner-Osborne, H., Apr 2007, In : Pharmacogenetics and Genomics. 17, 4, p. 255-266 12 p.

Research output: Contribution to journal › Article

2006

26 Citations (Scopus)

An asymmetric contribution to gamma-aminobutyric type a receptor function of a conserved lysine within TM2-3 of alpha 1, beta 2, and gamma 2 subunits

Hales, T. G., Deeb, T. Z., Tang, H., Bollan, K. A., King, D. P., Johnson, S. J. & Connolly, C. N., 23 Jun 2006, In : Journal of Biological Chemistry. 281, 25, p. 17034-17043 10 p.

Research output: Contribution to journal › Article

14 Citations (Scopus)

The role of GABA_Areceptor biogenesis, structure and function in epilepsy

Mizielinska, S., Greenwood, S. & Connolly, C. N., 2006, In : Biochemical Society Transactions. 34, 5, p. 863-867 5 p.

Research output: Contribution to journal › Article

2005

51 Citations (Scopus)

Cell surface expression of 5-hydroxytryptamine type 3 receptors is promoted by RIC-3

Cheng, A., McDonald, N. A. & Connolly, C. N., 10 Jun 2005, In : Journal of Biological Chemistry. 280, 23, p. 22502-22507 6 p.

Research output: Contribution to journal › Article

Receptors, Serotonin, 5-HT3

Serotonin

Endoplasmic Reticulum

Serotonin Receptors

Nicotinic Receptors

35 Citations (Scopus)

Cellular and subcellular calcium accumulation during glutamate-induced injury in cerebellar granule neurons

Ward, M. W., Kushnareva, Y., Greenwood, S. & Connolly, C. N., 2005, In : Journal of Neurochemistry. 92, 5, p. 1081-1090 10 p.

Research output: Contribution to journal › Article

51 Citations (Scopus)

The epilepsy mutation, γ2(R43Q) disrupts a highly conserved inter-subunit contact site, perturbing the biogenesis of GABA_Areceptors

Hales, T. G., Tang, H., Bollan, K. A., Johnson, S. J., King, D. P., McDonald, N. A., Cheng, A. & Connolly, C. N., 2005, In : Molecular and Cellular Neuroscience. 29, 1, p. 120-127 8 p.

Research output: Contribution to journal › Article

2004

187 Citations (Scopus)

GSK-3 phosphorylation of the Alzheimer epitope within collapsin response mediator proteins regulates axon elongation in primary neurons

Cole, A. R., Knebel, A., Morrice, N. A., Robertson, L. A., Irving, A. J., Connolly, C. N. & Sutherland, C., 26 Nov 2004, In : Journal of Biological Chemistry. 279, 48, p. 50176-50180 5 p.

Research output: Contribution to journal › Article

Semaphorin-3A

Glycogen Synthase Kinase 3

Phosphorylation

Neurons

Axons

137 Citations (Scopus)

The Cys-loop superfamily of ligand-gated ion channels: the impact of receptor structure on function

Connolly, C. N. & Wafford, K. A., Jun 2004, In : Biochemical Society Transactions. 32, 3, p. 529-534 6 p.

Research output: Contribution to journal › Article

2003

41 Citations (Scopus)

Cell surface expression of 5-hydroxytryptamine type 3 receptors is controlled by an endoplasmic reticulum retention signal

Boyd, G. W., Doward, A. I., Kirkness, E. F., Millar, N. S. & Connolly, C. N., 25 Jul 2003, In : Journal of Biological Chemistry. 278, 30, p. 27681-27687 7 p.

Research output: Contribution to journal › Article

Receptors, Serotonin, 5-HT3

Endoplasmic Reticulum

Serotonin

COS Cells

44 Citations (Scopus)

GABA_A receptor composition is determined by distinct assembly signals within α and β subunits

Bollan, K., King, D., Robertson, L. A., Brown, K., Taylor, P. M., Moss, S. J. & Connolly, C. N., 2003, In : Journal of Biological Chemistry. 278, 7, p. 4747-4755 9 p.

Research output: Contribution to journal › Article

31 Citations (Scopus)

Multiple assembly signals in g-aminobutyric acid (type A) receptor subunits combine to drive receptor construction and composition

Bollan, K., Robertson, L. A., Tang, H. & Connolly, C. N., 2003, In : Biochemical Society Transactions. 31, 4, p. 875-879 5 p.

Research output: Contribution to journal › Article

2002

62 Citations (Scopus)

Assembly and cell surface expression of homomeric and heteromeric 5-HT3 receptors: the role of oligomerization and chaperone proteins

Boyd, G. W., Low, P., Dunlop, J. I., Robertson, L. A., Vardy, A., Lambert, J. J., Peters, J. A. & Connolly, C. N., 2002, In : Molecular and Cellular Neuroscience. 21, 1, p. 38-50 13 p.

Research output: Contribution to journal › Article

Receptors, Serotonin, 5-HT3

Endoplasmic Reticulum

Proteins

Cell Surface Receptors

Serotonin

2000

65 Citations (Scopus)

Analysis of GABA_Areceptor assembly in mammalian cell lines and hippocampal neurons using γ2 subunit green fluorescent protein chimeras

Kittler, J. T., Wang, J., Connolly, C. N., Vicini, S., Smart, T. G. & Moss, S. J., 2000, In : Molecular and Cellular Neuroscience. 16, 4, p. 440-452 13 p.

Research output: Contribution to journal › Article

63 Citations (Scopus)

Identification of residues within GABA_Areceptor subunits that mediate specific assembly with receptor β subunits

Taylor, P. M., Connolly, C. N., Kittler, J. T., Gorrie, G. H., Hosie, A., Smart, T. G. & Moss, S. J., 2000, In : Journal of Neuroscience. 20, 4, p. 1297-1306 10 p.

Research output: Contribution to journal › Article

1999

156 Citations (Scopus)

Cell surface stability of gamma-aminobutyric acid type A receptors: dependence on protein kinase C activity and subunit composition

Connolly, C. N., Kittler, J. T., Thomas, P., Uren, J. M., Brandon, N. J., Smart, T. G. & Moss, S. J., 17 Dec 1999, In : Journal of Biological Chemistry. 274, 51, p. 36565-36572 8 p.

Research output: Contribution to journal › Article

91 Citations (Scopus)

Identification of amino acid residues within GABA(A) receptor beta subunits that mediate both homomeric and heteromeric receptor expression

Taylor, P. M., Thomas, P., Gorrie, G. H., Connolly, C. N., Smart, T. G. & Moss, S. J., 1 Aug 1999, In : Journal of Neuroscience. 19, 15, p. 6360-6371 12 p.

Research output: Contribution to journal › Article

68 Citations (Scopus)

Modulation of neuronal and recombinant GABA_A receptors by redox reagents

Amato, A., Connolly, C. N., Moss, S. J. & Smart, T. G., 1999, In : Journal of Physiology. 517, 1, p. 35-50 16 p.

Research output: Contribution to journal › Article

67 Citations (Scopus)

Subcellular localization and endocytosis of homomeric γ2 subunit splice variants of γ-aminobutyric acid type A receptors

Connolly, C. N., Uren, J. M., Thomas, P., Gorrie, G. H., Gibson, A., Smart, T. G. & Moss, S. J., 1999, In : Molecular and Cellular Neuroscience. 13, 4, p. 259-271 13 p.

Research output: Contribution to journal › Article

10 Citations (Scopus)

Synaptic targeting and regulation of GABA_Areceptors

Brandon, N. J., Bedford, F. K., Connolly, C. N., Couve, A., Kittler, J. T., Hanley, J. G., Jovanovic, J. N., Uren, J., Taylor, P., Thomas, P., Smart, T. G. & Moss, S. J., 1999, In : Biochemical Society Transactions. 27, 4, p. 527-530 4 p.

Research output: Contribution to journal › Article

1996

269 Citations (Scopus)

Assembly and cell surface expression of heteromeric and homomeric gamma-aminobutyric acid type A receptors

Connolly, C. N., Krishek, B. J., McDonald, B. J., Smart, T. G. & Moss, S. J., 5 Jan 1996, In : Journal of Biological Chemistry. 271, 1, p. 89-96 8 p.

Research output: Contribution to journal › Article

112 Citations (Scopus)

Subcellular localization of γ-aminobutyric acid type A receptors is determined by receptor β subunits

Connolly, C. N., Wooltorton, J. R. A., Smart, T. G. & Moss, S. J., 1996, In : Proceedings of the National Academy of Sciences of the United States of America. 93, 18, p. 9899-9904 6 p.

Research output: Contribution to journal › Article

1995

148 Citations (Scopus)

Newly synthesized transferrin receptors can be detected in the endosome before they appear on the cell surface

Futter, C. E., Connolly, C. N., Cutler, D. F. & Hopkins, C. R., 5 May 1995, In : Journal of Biological Chemistry. 270, 18, p. 10999-11003 5 p.

Research output: Contribution to journal › Article