Connolly, Christopher

Dr

Accepting PhD Students

  • 2693 Citations
  • 30 h-Index
19952017
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Research Output 1995 2017

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Article

2Bs or not 2Bs: that is the question

Connolly, C. N., 2011, In : Journal of Physiology. 589, 17, p. 4085-4086 2 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
80 Downloads (Pure)

5-hydroxytryptamine (5-HT) cellular sequestration during chronic exposure delays 5-HT3 receptor resensitization due to Its subsequent release

Hothersall, J. D., Alexander, A., Samson, A. J., Moffat, C., Bollan, K. A. & Connolly, C. N., 14 Nov 2014, In : Journal of Biological Chemistry. 289, 46, p. 32020-32029 10 p.

Research output: Contribution to journalArticle

Open Access
File
Serotonin Receptors
Serotonin
Down-Regulation
Ileum
Serotonin Plasma Membrane Transport Proteins
65 Citations (Scopus)

Analysis of GABAA receptor assembly in mammalian cell lines and hippocampal neurons using γ2 subunit green fluorescent protein chimeras

Kittler, J. T., Wang, J., Connolly, C. N., Vicini, S., Smart, T. G. & Moss, S. J., 2000, In : Molecular and Cellular Neuroscience. 16, 4, p. 440-452 13 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

An asymmetric contribution to gamma-aminobutyric type a receptor function of a conserved lysine within TM2-3 of alpha 1, beta 2, and gamma 2 subunits

Hales, T. G., Deeb, T. Z., Tang, H., Bollan, K. A., King, D. P., Johnson, S. J. & Connolly, C. N., 23 Jun 2006, In : Journal of Biological Chemistry. 281, 25, p. 17034-17043 10 p.

Research output: Contribution to journalArticle

64 Citations (Scopus)

An essential role for constitutive endocytosis, but not activity, in the axonal targeting of the CB1 cannabinoid receptor

McDonald, N. A., Henstridge, C. M., Connolly, C. N. & Irving, A. J., 2007, In : Molecular Pharmacology. 71, 4, p. 976-984 9 p.

Research output: Contribution to journalArticle

Cannabinoid Receptor CB1
Endocytosis
Neurons
Axons
Dynamin I
271 Citations (Scopus)

Assembly and cell surface expression of heteromeric and homomeric gamma-aminobutyric acid type A receptors

Connolly, C. N., Krishek, B. J., McDonald, B. J., Smart, T. G. & Moss, S. J., 5 Jan 1996, In : Journal of Biological Chemistry. 271, 1, p. 89-96 8 p.

Research output: Contribution to journalArticle

62 Citations (Scopus)

Assembly and cell surface expression of homomeric and heteromeric 5-HT3 receptors: the role of oligomerization and chaperone proteins

Boyd, G. W., Low, P., Dunlop, J. I., Robertson, L. A., Vardy, A., Lambert, J. J., Peters, J. A. & Connolly, C. N., 2002, In : Molecular and Cellular Neuroscience. 21, 1, p. 38-50 13 p.

Research output: Contribution to journalArticle

Receptors, Serotonin, 5-HT3
Endoplasmic Reticulum
Proteins
Cell Surface Receptors
Serotonin
41 Citations (Scopus)

Cell surface expression of 5-hydroxytryptamine type 3 receptors is controlled by an endoplasmic reticulum retention signal

Boyd, G. W., Doward, A. I., Kirkness, E. F., Millar, N. S. & Connolly, C. N., 25 Jul 2003, In : Journal of Biological Chemistry. 278, 30, p. 27681-27687 7 p.

Research output: Contribution to journalArticle

Receptors, Serotonin, 5-HT3
Endoplasmic Reticulum
Serotonin
COS Cells
51 Citations (Scopus)

Cell surface expression of 5-hydroxytryptamine type 3 receptors is promoted by RIC-3

Cheng, A., McDonald, N. A. & Connolly, C. N., 10 Jun 2005, In : Journal of Biological Chemistry. 280, 23, p. 22502-22507 6 p.

Research output: Contribution to journalArticle

Receptors, Serotonin, 5-HT3
Serotonin
Endoplasmic Reticulum
Serotonin Receptors
Nicotinic Receptors
157 Citations (Scopus)

Cell surface stability of gamma-aminobutyric acid type A receptors: dependence on protein kinase C activity and subunit composition

Connolly, C. N., Kittler, J. T., Thomas, P., Uren, J. M., Brandon, N. J., Smart, T. G. & Moss, S. J., 17 Dec 1999, In : Journal of Biological Chemistry. 274, 51, p. 36565-36572 8 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)

Cellular and subcellular calcium accumulation during glutamate-induced injury in cerebellar granule neurons

Ward, M. W., Kushnareva, Y., Greenwood, S. & Connolly, C. N., 2005, In : Journal of Neurochemistry. 92, 5, p. 1081-1090 10 p.

Research output: Contribution to journalArticle

109 Citations (Scopus)

Cholinergic pesticides cause mushroom body neuronal inactivation in honeybees

Palmer, M. J., Moffat, C., Saranzewa, N., Harvey, J., Wright, G. A. & Connolly, C. N., 27 Mar 2013, In : Nature Communications. 4, 1634.

Research output: Contribution to journalArticle

Open Access
cholinergics
Mushroom Bodies
pesticides
Pesticides
deactivation
42 Citations (Scopus)
195 Downloads (Pure)

Chronic exposure to neonicotinoids increases neuronal vulnerability to mitochondrial dysfunction in the bumblebee (Bombus terrestris)

Moffat, C., Pacheco, J. G., Sharp, S., Samson, A. J., Bollan, K. A., Huang, J., Buckland, S. T. & Connolly, C. N., May 2015, In : FASEB Journal. 29, 5, p. 2112-2119 8 p.

Research output: Contribution to journalArticle

Open Access
File
Depolarization
Neurons
Brain
Plant Nectar
Bees
27 Citations (Scopus)

Differential subcellular localization of RIC-3 Isoforms and their role in determining 5-HT3 receptor composition

Cheng, A., Bollan, K. A., Greenwood, S. M., Irving, A. J. & Connolly, C. N., 7 Sep 2007, In : Journal of Biological Chemistry. 282, 36, p. 26158-26166 9 p.

Research output: Contribution to journalArticle

Receptors, Serotonin, 5-HT3
Protein Isoforms
Endoplasmic Reticulum
Chemical analysis
Agglomeration
38 Citations (Scopus)
155 Downloads (Pure)

Exposure to acetylcholinesterase inhibitors alters the physiology and motor function of honeybees

Williamson, S. M., Moffat, C., Gomersall, M. A. E., Saranzewa, N., Connolly, C. N. & Wright, G. A., 5 Feb 2013, In : Frontiers in Physiology. 4, 13.

Research output: Contribution to journalArticle

Open Access
File
Grooming
Cholinesterase Inhibitors
Coumaphos
Pesticides
Cholinergic Agents
44 Citations (Scopus)

GABAA receptor composition is determined by distinct assembly signals within α and β subunits

Bollan, K., King, D., Robertson, L. A., Brown, K., Taylor, P. M., Moss, S. J. & Connolly, C. N., 2003, In : Journal of Biological Chemistry. 278, 7, p. 4747-4755 9 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Generation and functional characterization of fluorescent, N-terminally tagged CB1 receptor chimeras for live-cell imaging

McDonald, N. A., Henstridge, C. M., Connolly, C. N. & Irving, A. J., Jun 2007, In : Molecular and Cellular Neuroscience. 35, 2, p. 237-248 12 p.

Research output: Contribution to journalArticle

Cannabinoid Receptor CB1
HEK293 Cells
Cell Surface Receptors
Protein Sorting Signals
Fluorescence
191 Citations (Scopus)

GSK-3 phosphorylation of the Alzheimer epitope within collapsin response mediator proteins regulates axon elongation in primary neurons

Cole, A. R., Knebel, A., Morrice, N. A., Robertson, L. A., Irving, A. J., Connolly, C. N. & Sutherland, C., 26 Nov 2004, In : Journal of Biological Chemistry. 279, 48, p. 50176-50180 5 p.

Research output: Contribution to journalArticle

Semaphorin-3A
Glycogen Synthase Kinase 3
Phosphorylation
Neurons
Axons
11 Citations (Scopus)

High-affinity fluorescent ligands for the 5-HT3 receptor

Simonin, J., Vernekar, S. K. V., Thompson, A. J., Hothersall, J. D., Connolly, C. N., Lummis, S. C. R. & Lochner, M., 2012, In : Bioorganic & Medicinal Chemistry Letters. 22, 2, p. 1151-1155 5 p.

Research output: Contribution to journalArticle

92 Citations (Scopus)

Identification of amino acid residues within GABA(A) receptor beta subunits that mediate both homomeric and heteromeric receptor expression

Taylor, P. M., Thomas, P., Gorrie, G. H., Connolly, C. N., Smart, T. G. & Moss, S. J., 1 Aug 1999, In : Journal of Neuroscience. 19, 15, p. 6360-6371 12 p.

Research output: Contribution to journalArticle

64 Citations (Scopus)

Identification of residues within GABAA receptor subunits that mediate specific assembly with receptor β subunits

Taylor, P. M., Connolly, C. N., Kittler, J. T., Gorrie, G. H., Hosie, A., Smart, T. G. & Moss, S. J., 2000, In : Journal of Neuroscience. 20, 4, p. 1297-1306 10 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)

Identifying key knowledge needs for evidence-based conservation of wild insect pollinators: a collaborative cross-sectoral exercise

Dicks, L. V., Abrahams, A., Atkinson, J., Biesmeijer, J., Bourn, N., Brown, C., Brown, M. J. F., Carvell, C., Connolly, C., Cresswell, J. E., Croft, P., Darvill, B., De Zylva, P., Effingham, P., Fountain, M., Goggin, A., Harding, D., Harding, T., Hartfield, C., Heard, M. S. & 30 others, Heathcote, R., Heaver, D., Holland, J., Howe, M., Hughes, B., Huxley, T., Kunin, W. E., Little, J., Mason, C., Memmott, J., Osborne, J., Pankhurst, T., Paxton, R. J., Pocock, M. J. O., Potts, S. G., Power, E. F., Raine, N. E., Ranelagh, E., Roberts, S., Saunders, R., Smith, K., Smith, R. M., Sutton, P., Tilley, L. A. N., Tinsley, A., Tonhasca, A., Vanbergen, A. J., Webster, S., Wilson, A. & Sutherland, W. J., 2012, In : Insect Conservation and Diversity. 6, 3, p. 435-446 12 p.

Research output: Contribution to journalArticle

pollinating insects
pollinator
pollinators
exercise
insect
121 Citations (Scopus)

Leptin promotes rapid dynamic changes in hippocampal dendritic morphology

O'Malley, D., MacDonald, N., Mizielinska, S., Connolly, C. N., Irving, A. J. & Harvey, J., Aug 2007, In : Molecular and Cellular Neuroscience. 35, 4, p. 559-572 14 p.

Research output: Contribution to journalArticle

70 Citations (Scopus)

Leptin Regulates AMPA Receptor Trafficking via PTEN Inhibition

Moult, P. R., Cross, A., Santos, S. D., Carvalho, A-L., Lindsay, Y., Connolly, C. N., Irving, A. J., Leslie, N. R. & Harvey, J., 17 Mar 2010, In : Journal of Neuroscience. 30, 11, p. 4088-4101 14 p.

Research output: Contribution to journalArticle

73 Citations (Scopus)

Mitochondrial dysfunction and dendritic beading during neuronal toxicity

Greenwood, S. M., Mizielinska, S. M., Frenguelli, B. G., Harvey, J. & Connolly, C. N., 7 Sep 2007, In : Journal of Biological Chemistry. 282, 36, p. 26235-26244 10 p.

Research output: Contribution to journalArticle

68 Citations (Scopus)

Modulation of neuronal and recombinant GABAA receptors by redox reagents

Amato, A., Connolly, C. N., Moss, S. J. & Smart, T. G., 1999, In : Journal of Physiology. 517, 1, p. 35-50 16 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)

Multiple assembly signals in g-aminobutyric acid (type A) receptor subunits combine to drive receptor construction and composition

Bollan, K., Robertson, L. A., Tang, H. & Connolly, C. N., 2003, In : Biochemical Society Transactions. 31, 4, p. 875-879 5 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)

Naturally occurring variations in the human 5-HT3A gene profoundly impact 5-HT3 receptor function and expression

Krzywkowski, K., Jensen, A. A., Connolly, C. N. & Brauner-Osborne, H., Apr 2007, In : Pharmacogenetics and Genomics. 17, 4, p. 255-266 12 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)
165 Downloads (Pure)

Neonicotinoids target distinct nicotinic acetylcholine receptors and neurons, leading to differential risks to bumblebees

Moffat, C., Buckland, S. T., Samson, A., McArthur, R., Chamosa Pino, V., Bollan, K. A., Huang, J. T-J. & Connolly, C., 28 Apr 2016, In : Scientific Reports. 6, p. 1-10 10 p., 24764.

Research output: Contribution to journalArticle

Open Access
File
Nicotinic Receptors
Bees
Neurons
Aptitude
Food Supply
1 Citation (Scopus)
75 Downloads (Pure)

Nerve agents in honey: Analysis of local honey samples shows global landscape contamination by pesticides

Connolly, C., 6 Oct 2017, In : Science. 358, 6359, p. 38-39 2 p.

Research output: Contribution to journalArticle

Open Access
File
Honey
Bees
Pesticides
Ecosystem
Pollination
9 Citations (Scopus)
109 Downloads (Pure)

Neuronal networks provide rapid neuroprotection against spreading toxicity

Samson, A. J., Robertson, G., Zagnoni, M. & Connolly, C. N., 21 Sep 2016, In : Scientific Reports. 6, p. 1-11 11 p., 33746.

Research output: Contribution to journalArticle

Open Access
File
Lab-On-A-Chip Devices
Glutamic Acid
Stroke
Emergency Treatment
Brain
149 Citations (Scopus)

Newly synthesized transferrin receptors can be detected in the endosome before they appear on the cell surface

Futter, C. E., Connolly, C. N., Cutler, D. F. & Hopkins, C. R., 5 May 1995, In : Journal of Biological Chemistry. 270, 18, p. 10999-11003 5 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Prolonged inhibition of 5-HT3 receptors by palonosetron results from surface receptor inhibition rather than inducing receptor internalization

Hothersall, J. D., Moffat, C. & Connolly, C. N., Jul 2013, In : British Journal of Pharmacology. 169, 6, p. 1252-1262 11 p.

Research output: Contribution to journalArticle

Receptors, Serotonin, 5-HT3
Granisetron
Down-Regulation
Binding Sites
Endocytosis
6 Citations (Scopus)

Rapid dendritic and axonal responses to neuronal insults

Mizielinska, S. M., Greenwood, S. M., Tummala, H. & Connolly, C. N., Dec 2009, In : Biochemical Society Transactions. 37, p. 1389-1393 5 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

RIC-3 Exclusively Enhances the Surface Expression of Human Homomeric 5-Hydroxytryptamine Type 3A (5-HT(3)A) Receptors Despite Direct Interactions with 5-HT3A, -C, -D, and -E Subunits

Walstab, J., Hammer, C., Lasitschka, F., Möller, D., Connolly, C. N., Rappold, G., Bruess, M., Boenish, H. & Niesler, B., 27 Aug 2010, In : Journal of Biological Chemistry. 285, 35, p. 26956-26965 10 p.

Research output: Contribution to journalArticle

79 Citations (Scopus)
563 Downloads (Pure)

Subcallosal cingulate deep brain stimulation for treatment-resistant depression: a multi-site, randomized, sham-controlled trial

Holtzheimer, P., Husain, M. M., Lisanby, S. H., Taylor, S. F., Whitworth, L. A., McClintock, S., Slavin, K. V., Berman, J., McKhann, G. M., Patil, P. G., Rittberg, B. R., Abosch, A., Pandurangi, A. K., Holloway, K. L., Lam, R. W., Connolly, C., Neimat, J. S., Henderson, J. M., DeBattista, C., Rothschild, A. J. & 10 others, Pilitsis, J. G., Espinoza, R. T., Petrides, G., Mogilner, A. Y., Matthews, K., Peichel, D., Grosse, R., Hamani, C., Lozano, A. M. & Mayberg, H. S., Nov 2017, In : Lancet Psychiatry. 4, 11, p. 839-849 11 p.

Research output: Contribution to journalArticle

Open Access
File
Treatment-Resistant Depressive Disorder
Deep Brain Stimulation
Randomized Controlled Trials
Medical Futility
Depression
67 Citations (Scopus)

Subcellular localization and endocytosis of homomeric γ2 subunit splice variants of γ-aminobutyric acid type A receptors

Connolly, C. N., Uren, J. M., Thomas, P., Gorrie, G. H., Gibson, A., Smart, T. G. & Moss, S. J., 1999, In : Molecular and Cellular Neuroscience. 13, 4, p. 259-271 13 p.

Research output: Contribution to journalArticle

112 Citations (Scopus)

Subcellular localization of γ-aminobutyric acid type A receptors is determined by receptor β subunits

Connolly, C. N., Wooltorton, J. R. A., Smart, T. G. & Moss, S. J., 1996, In : Proceedings of the National Academy of Sciences of the United States of America. 93, 18, p. 9899-9904 6 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Synaptic targeting and regulation of GABAA receptors

Brandon, N. J., Bedford, F. K., Connolly, C. N., Couve, A., Kittler, J. T., Hanley, J. G., Jovanovic, J. N., Uren, J., Taylor, P., Thomas, P., Smart, T. G. & Moss, S. J., 1999, In : Biochemical Society Transactions. 27, 4, p. 527-530 4 p.

Research output: Contribution to journalArticle

138 Citations (Scopus)

The Cys-loop superfamily of ligand-gated ion channels: the impact of receptor structure on function

Connolly, C. N. & Wafford, K. A., Jun 2004, In : Biochemical Society Transactions. 32, 3, p. 529-534 6 p.

Research output: Contribution to journalArticle

51 Citations (Scopus)

The epilepsy mutation, γ2(R43Q) disrupts a highly conserved inter-subunit contact site, perturbing the biogenesis of GABAA receptors

Hales, T. G., Tang, H., Bollan, K. A., Johnson, S. J., King, D. P., McDonald, N. A., Cheng, A. & Connolly, C. N., 2005, In : Molecular and Cellular Neuroscience. 29, 1, p. 120-127 8 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

The microsporidian parasites Nosema ceranae and Nosema apis are widespread in honeybee (Apis mellifera) colonies across Scotland

Bollan, K. A., Hothersall, J. D., Moffat, C., Durkacz, J., Saranzewa, N., Wright, G. A., Raine, N. E., Highet, F. & Connolly, C. N., Feb 2013, In : Parasitology Research. 112, 2, p. 751-759 9 p.

Research output: Contribution to journalArticle

Nosema
Nosema apis
Nosema ceranae
Bees
Microsporidia
27 Citations (Scopus)

The promiscuous role of the epsilon subunit in GABA(A) receptor biogenesis

Bollan, K. A., Baur, R., Hales, T. G., Sigel, E. & Connolly, C. N., Mar 2008, In : Molecular and Cellular Neuroscience. 37, 3, p. 610-621 12 p.

Research output: Contribution to journalArticle

The risk of insecticides to pollinating insects

Connolly, C. N., Sep 2013, In : Communicative & Integrative Biology. 6, 5, 3 p., e25074.

Research output: Contribution to journalArticle

neonicotinoid insecticides
pollinating insects
Insecticides
Insects
insecticides
14 Citations (Scopus)

The role of GABAA receptor biogenesis, structure and function in epilepsy

Mizielinska, S., Greenwood, S. & Connolly, C. N., 2006, In : Biochemical Society Transactions. 34, 5, p. 863-867 5 p.

Research output: Contribution to journalArticle