Projects per year
Personal profile
Research interests
Synaptic alterations feature in many neurological conditions and this has been a central focus throughout my postgraduate research. I spent my first postdoctoral position in the lab or Dr. Istvan Katona in Budapest, assessing the nanoscale distribution of synaptic proteins in a mouse model of Fragile X Syndrome, funded by an EMBO long-term fellowship. With the aim of building upon my technical expertise, I moved to the lab of Dr. Tara Spires-Jones at the University of Edinburgh in 2014 and in 2016 was awarded a 3yr project grant from MND Scotland. The focus of this project is to characterise the synaptic profile of the ALS brain. To do this, I apply high-resolution imaging techniques such as electron microscopy and array tomography, to examine the structure and function of synapses in human brain. During my time in Edinburgh I helped build the world’s first brain bank of human ALS tissue prepared for the array tomography technique.
In May 2019 I moved to the University of Dundee to establish my own group and continue my research on synaptic pathology in health and disease. My interests are highly interdisciplinary, involving collaboration with local and international colleagues in psychology, neuropathology, neuroimaging, and genetics.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
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Characterising The Synaptic Localisation And Interactome Of TDP-43 In Neurodegenerative Disease
1/07/23 → 30/06/25
Project: Research
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Glial engulfment of human synapses in Amyotrophic Lateral Sclerosis (ALS)
1/02/22 → 31/07/24
Project: Research
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Preclinical Models To Accelerate Drug Discovery In ALS/FTLD
Henstridge, C. & Inesta-Vaquera, F.
1/11/21 → 31/12/23
Project: Research
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Preclinical Models to Accelerate Drug Discovery in ALS/FTLD
Henstridge, C. & Inesta-Vaquera, F.
1/11/21 → 31/12/23
Project: Research
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Beyond the neuron–cellular interactions early in Alzheimer disease pathogenesis
Henstridge, C., Hyman, B. & Spires-Jones, T., Feb 2019, In: Nature Reviews Neuroscience. 20, 2, p. 94-108 15 p.Research output: Contribution to journal › Review article › peer-review
196 Citations (Scopus) -
Synapse loss in the prefrontal cortex is associated with cognitive decline in amyotrophic lateral sclerosis
Henstridge, C. M., Sideris, D. I., Carroll, E., Rotariu, S., Salomonsson, S., Tzioras, M., McKenzie, C-A., Smith, C., von Arnim, C. A. F., Ludolph, A. C., Lulé, D., Leighton, D., Warner, J., Cleary, E., Newton, J., Swingler, R., Chandran, S., Gillingwater, T. H., Abrahams, S. & Spires-Jones, T. L., Feb 2018, In: Acta Neuropathologica. 135, 2, p. 213-226 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile70 Citations (Scopus)211 Downloads (Pure) -
TDP-43 Depletion in Microglia Promotes Amyloid Clearance but Also Induces Synapse Loss
Paolicelli, R. C., Jawaid, A., Henstridge, C. M., Valeri, A., Merlini, M., Robinson, J. L., Lee, E. B., Rose, J., Appel, S., Lee, V. M-Y., Trojanowski, J. Q., Spires-Jones, T., Schulz, P. E. & Rajendran, L., 19 Jul 2017, In: Neuron. 95, 2, p. 297-308.e6 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile141 Citations (Scopus)178 Downloads (Pure) -
Region-specific depletion of synaptic mitochondria in the brains of patients with Alzheimer’s disease
Pickett, E., Rose, J., McCrory, C., McKenzie, C-A., King, D., Smith, C., Gillingwater, T., Henstridge, C. & Spires-Jones, T., 6 Sept 2018, In: Acta Neuropathologica. 136, 5, p. 747-757 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile77 Citations (Scopus)169 Downloads (Pure) -
Glial contribution to excitatory and inhibitory synapse loss in neurodegeneration
Henstridge, C., Tzioras, M. & Paolicelli, R. C., 26 Feb 2019, In: Frontiers in Cellular Neuroscience. 13, 26 p., 63.Research output: Contribution to journal › Review article › peer-review
Open AccessFile67 Citations (Scopus)268 Downloads (Pure)
Prizes
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EMBO Long-Term Fellowship
Henstridge, Christopher (Recipient), 2010
Prize: Fellowship awarded competitively
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Life Sciences Work Experience Week 2023
Erin Hardee (Organiser), Senga Robertson-Albertyn (Participant), Davide Bulgarelli (Participant), Alasdair Iredale (Participant), Emily Lyon (Participant), Jonathan Griffin (Participant), Jennifer Gallagher (Participant), Dewar Ritchie (Participant), Michael Porter (Participant), Gillian Stacey (Participant), Alasdair Munro (Participant), Richard Keith (Participant), David Young (Participant), Lawrie K. Brown (Participant), Sharon Matthews (Participant), Adrien Rousseau (Participant), Olga Semenova (Participant), Ifeoluwapo Joshua (Participant), Jens Januschke (Participant), Elizabeth Emslie (Participant), Sowmya Ajay Castro (Participant), Tyrell Cartwright (Participant), Giorgia Kidd (Participant), Louise McGreavey (Participant), Andre Wijaya (Participant), Denzel Gonzales (Participant), Robert Jarvis (Participant), Christopher Henstridge (Participant) & Sharon King (Participant)
24 Jul 2023 → 28 Jul 2023Activity: Other activity types › Schools engagement
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School of Medicine Doors Open Day
Laureano de la Vega (Organiser), Amy Rogers (Organiser), Andrea Corno (Participant), Lisa Crozier (Participant), Aanchal Udaynath Pareri (Participant), Miroslav Novak (Participant), Sharadha Dayalan Naidu (Participant), Boushra Albathish (Participant), Magdalena Sovakova (Participant), Noor Alqurashi (Participant), Julian Parsons (Participant), Vasudha Tandon (Participant), Val Morfin (Participant), Anna Sanchez Avila (Participant), Caitlin Berry (Participant), Shawn Cottrill (Participant), Caitlin Macdonald (Participant), Andrew Todd-Hems (Participant), Kirsty Hamilton (Participant), Ermione Markantoni (Participant), Erica O'Beirne (Participant), Febe Ferro (Participant), Nicola Morrice (Participant), Dot Kisielewski (Participant), Adam Learmonth (Participant), Nicola Liddell (Participant), Shirley Fraser (Participant), Gillian Smith (Participant), Suzanne Zaremba (Participant), Carolyn Tipton (Participant), Susan Krueger (Participant), Sally Chalmers (Participant), Gillian Martin (Participant), Lesley Lindsay (Participant), Christian Cole (Participant), Yvonne Gormley (Participant), Ros Langston (Participant), Suzanne Duce (Participant), Christopher Henstridge (Participant), Karen MacKinnon (Participant), Fiona Hogarth (Participant), Keith Milburn (Participant), Magalie Guignard-Duff (Participant), Chuang Gao (Participant) & Glenn Masson (Participant)
24 Sept 2022Activity: Participating in or organising an event types › Festival/Exhibition
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Studying synaptic change in Amyotrophic Lateral Sclerosis
Christopher Henstridge (Speaker)
8 Jul 2022Activity: Talk or presentation types › Invited talk
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Images of Research Competition 2022
Sandra Oza (Organiser), Nicole Hindley (Recipient), Susie Johnston (Recipient), Omar Alshaibi (Member), Michael Gratzke (Examiner), Anna Notaro (Examiner) & Christopher Henstridge (Examiner)
23 Nov 2022Activity: Other activity types › Other
File -
Frontiers in Molecular Neuroscience (Journal)
Christopher Henstridge (Guest editor)
2021 → 2023Activity: Publication peer-review and editorial work types › Editorial activity
Press/Media
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Agenda: Government U-turn gives much needed hope to those affected by MND
6/12/21
1 Media contribution
Press/Media: Research
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Dr. Henstridge comments on World Alzheimer's Day
21/09/21
1 item of Media coverage
Press/Media: Research
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Dr. Henstridge comments on World Alzheimer's Day
21/09/21
1 item of Media coverage
Press/Media: Research
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New dementia buddy scheme established in Edinburgh by Dr. Chris Henstridge
29/12/18
1 item of Media coverage
Press/Media: Other
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Christopher Henstridge discusses similarities between motor neuron disease and Alzheimer’s
23/12/17
2 items of Media coverage
Press/Media: Research