Henstridge, Christopher

Dr

  • 1050 Citations
  • 15 h-Index
20072020
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Personal profile

Research interests

Synaptic alterations feature in many neurological conditions and this has been a central focus throughout my postgraduate research. I spent my first postdoctoral position in the lab or Dr. Istvan Katona in Budapest, assessing the nanoscale distribution of synaptic proteins in a mouse model of Fragile X Syndrome, funded by an EMBO long-term fellowship. With the aim of building upon my technical expertise, I moved to the lab of Dr. Tara Spires-Jones at the University of Edinburgh in 2014 and in 2016 was awarded a 3yr project grant from MND Scotland. The focus of this project is to characterise the synaptic profile of the ALS brain. To do this, I apply high-resolution imaging techniques such as electron microscopy and  array tomography, to examine the structure and function of synapses in human brain. During my time in Edinburgh I helped build the world’s first brain bank of human ALS tissue prepared for the array tomography technique.

In May 2019 I moved to the University of Dundee to establish my own group and continue my research on synaptic pathology in health and disease. My interests are highly interdisciplinary, involving collaboration with local and international colleagues in psychology, neuropathology, neuroimaging, and genetics.

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Projects 2019 2020

Research Output 2007 2019

  • 1050 Citations
  • 15 h-Index
  • 26 Article
  • 3 Review article
13 Citations (Scopus)

Beyond the neuron–cellular interactions early in Alzheimer disease pathogenesis

Henstridge, C., Hyman, B. & Spires-Jones, T., Feb 2019, In : Nature Reviews Neuroscience. 20, 2, p. 94-108 15 p.

Research output: Contribution to journalReview article

Alzheimer Disease
Neurons
Brain
Microglia
Astrocytes
11 Citations (Scopus)
48 Downloads (Pure)

Synapse loss in the prefrontal cortex is associated with cognitive decline in amyotrophic lateral sclerosis

Henstridge, C. M., Sideris, D. I., Carroll, E., Rotariu, S., Salomonsson, S., Tzioras, M., McKenzie, C-A., Smith, C., von Arnim, C. A. F., Ludolph, A. C., Lulé, D., Leighton, D., Warner, J., Cleary, E., Newton, J., Swingler, R., Chandran, S., Gillingwater, T. H., Abrahams, S. & Spires-Jones, T. L., Feb 2018, In : Acta Neuropathologica. 135, 2, p. 213-226 14 p.

Research output: Contribution to journalArticle

Open Access
File
Amyotrophic Lateral Sclerosis
Prefrontal Cortex
Synapses
Nerve Degeneration
Brain
40 Citations (Scopus)
55 Downloads (Pure)

TDP-43 Depletion in Microglia Promotes Amyloid Clearance but Also Induces Synapse Loss

Paolicelli, R. C., Jawaid, A., Henstridge, C. M., Valeri, A., Merlini, M., Robinson, J. L., Lee, E. B., Rose, J., Appel, S., Lee, V. M-Y., Trojanowski, J. Q., Spires-Jones, T., Schulz, P. E. & Rajendran, L., 19 Jul 2017, In : Neuron. 95, 2, p. 297-308.e6 12 p.

Research output: Contribution to journalArticle

Open Access
File
Microglia
Amyloid
Synapses
Alzheimer Disease
Pathology
8 Citations (Scopus)
59 Downloads (Pure)

Region-specific depletion of synaptic mitochondria in the brains of patients with Alzheimer’s disease

Pickett, E., Rose, J., McCrory, C., McKenzie, C-A., King, D., Smith, C., Gillingwater, T., Henstridge, C. & Spires-Jones, T., 6 Sep 2018, In : Acta Neuropathologica. 136, 5, p. 747-757 11 p.

Research output: Contribution to journalArticle

Open Access
File
Alzheimer Disease
Mitochondria
Synapses
Brain
Presynaptic Terminals
1 Citation (Scopus)
49 Downloads (Pure)

Glial contribution to excitatory and inhibitory synapse loss in neurodegeneration

Henstridge, C., Tzioras, M. & Paolicelli, R. C., 26 Feb 2019, In : Frontiers in Cellular Neuroscience. 13, 26 p., 63.

Research output: Contribution to journalReview article

Open Access
File
Neuroglia
Synapses
Microglia
Astrocytes
Neurodegenerative Diseases

Prizes

EMBO Long-Term Fellowship

Christopher Henstridge (Recipient), 2010

Prize: Fellowship awarded competitively

Activities 2015 2018

  • 1 Festival/Exhibition
  • 1 Participation in workshop, seminar, course

Scottish Crucible

Christopher Henstridge (Participant)
May 2018Jun 2018

Activity: Participating in or organising an event typesParticipation in workshop, seminar, course

STEM for Britain

Christopher Henstridge (Participant)
9 Mar 2015

Activity: Participating in or organising an event typesFestival/Exhibition