Henstridge, Christopher

Dr

  • 1142 Citations
  • 17 h-Index
20072021

Research output per year

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Personal profile

Research interests

Synaptic alterations feature in many neurological conditions and this has been a central focus throughout my postgraduate research. I spent my first postdoctoral position in the lab or Dr. Istvan Katona in Budapest, assessing the nanoscale distribution of synaptic proteins in a mouse model of Fragile X Syndrome, funded by an EMBO long-term fellowship. With the aim of building upon my technical expertise, I moved to the lab of Dr. Tara Spires-Jones at the University of Edinburgh in 2014 and in 2016 was awarded a 3yr project grant from MND Scotland. The focus of this project is to characterise the synaptic profile of the ALS brain. To do this, I apply high-resolution imaging techniques such as electron microscopy and  array tomography, to examine the structure and function of synapses in human brain. During my time in Edinburgh I helped build the world’s first brain bank of human ALS tissue prepared for the array tomography technique.

In May 2019 I moved to the University of Dundee to establish my own group and continue my research on synaptic pathology in health and disease. My interests are highly interdisciplinary, involving collaboration with local and international colleagues in psychology, neuropathology, neuroimaging, and genetics.

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Projects

Research Output

  • 1142 Citations
  • 17 h-Index
  • 29 Article
  • 3 Review article

Beyond the neuron–cellular interactions early in Alzheimer disease pathogenesis

Henstridge, C., Hyman, B. & Spires-Jones, T., Feb 2019, In : Nature Reviews Neuroscience. 20, 2, p. 94-108 15 p.

Research output: Contribution to journalReview article

  • 22 Citations (Scopus)

    Synapse loss in the prefrontal cortex is associated with cognitive decline in amyotrophic lateral sclerosis

    Henstridge, C. M., Sideris, D. I., Carroll, E., Rotariu, S., Salomonsson, S., Tzioras, M., McKenzie, C-A., Smith, C., von Arnim, C. A. F., Ludolph, A. C., Lulé, D., Leighton, D., Warner, J., Cleary, E., Newton, J., Swingler, R., Chandran, S., Gillingwater, T. H., Abrahams, S. & Spires-Jones, T. L., Feb 2018, In : Acta Neuropathologica. 135, 2, p. 213-226 14 p.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 16 Citations (Scopus)
    96 Downloads (Pure)

    TDP-43 Depletion in Microglia Promotes Amyloid Clearance but Also Induces Synapse Loss

    Paolicelli, R. C., Jawaid, A., Henstridge, C. M., Valeri, A., Merlini, M., Robinson, J. L., Lee, E. B., Rose, J., Appel, S., Lee, V. M-Y., Trojanowski, J. Q., Spires-Jones, T., Schulz, P. E. & Rajendran, L., 19 Jul 2017, In : Neuron. 95, 2, p. 297-308.e6 12 p.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 50 Citations (Scopus)
    102 Downloads (Pure)

    Region-specific depletion of synaptic mitochondria in the brains of patients with Alzheimer’s disease

    Pickett, E., Rose, J., McCrory, C., McKenzie, C-A., King, D., Smith, C., Gillingwater, T., Henstridge, C. & Spires-Jones, T., 6 Sep 2018, In : Acta Neuropathologica. 136, 5, p. 747-757 11 p.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 13 Citations (Scopus)
    108 Downloads (Pure)

    Glial contribution to excitatory and inhibitory synapse loss in neurodegeneration

    Henstridge, C., Tzioras, M. & Paolicelli, R. C., 26 Feb 2019, In : Frontiers in Cellular Neuroscience. 13, 26 p., 63.

    Research output: Contribution to journalReview article

    Open Access
    File
  • 6 Citations (Scopus)
    111 Downloads (Pure)

    Prizes

    EMBO Long-Term Fellowship

    Christopher Henstridge (Recipient), 2010

    Prize: Fellowship awarded competitively

    Activities

    • 2 Festival/Exhibition
    • 1 Participation in workshop, seminar, course

    Doors Open Weekend

    Colin Henderson (Organiser), Gillian Smith (Participant), Hugh Nicholson (Participant), Amber Mcwhirter (Participant), Sharon King (Participant), Susan Bray (Participant), Sally Chalmers (Participant), Daniella Cavellini (Participant), Susan Simpson (Participant), Yvonne Gormley (Participant), Lukas Markwalder (Participant), Agathe Lermant (Participant), Paul O'Mahoney (Participant), Kumara Dissanayake (Participant), Jill Belch (Participant), Amy Rogers (Participant), Suzanne Duce (Participant), Christopher Henstridge (Participant), Ros Langston (Participant), Fiona Hogarth (Participant), Jordan Napier (Participant), Annie Anderson (Participant), Fredrick Comerford (Participant), Frances Fuller-Pace (Participant), Lisa Crozier (Participant), Tania G. Frangova (Participant), Francisco Inesta-Vaquera (Participant), Marilia Henriques Cordeiro (Participant), Rebecca Barr (Participant), Andrea Corno (Participant), Roderick McLeod (Participant), Colin Murdoch (Participant), Susan Storrier (Participant)
    21 Sep 2019

    Activity: Participating in or organising an event typesFestival/Exhibition

    Scottish Crucible

    Christopher Henstridge (Participant)
    May 2018Jun 2018

    Activity: Participating in or organising an event typesParticipation in workshop, seminar, course

    STEM for Britain

    Christopher Henstridge (Participant)
    9 Mar 2015

    Activity: Participating in or organising an event typesFestival/Exhibition