Henstridge, Christopher

Dr

  • 1142 Citations
  • 17 h-Index
20072021

Research output per year

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Research Output

  • 1142 Citations
  • 17 h-Index
  • 29 Article
  • 3 Review article
2019

Amyloid Beta and Tau Cooperate to Cause Reversible Behavioral and Transcriptional Deficits in a Model of Alzheimer's Disease

Pickett, E. K., Herrmann, A. G., McQueen, J., Abt, K., Dando, O., Tulloch, J., Jain, P., Dunnett, S., Sohrabi, S., Fjeldstad, M. P., Calkin, W., Murison, L., Jackson, R. J., Tzioras, M., Stevenson, A., d'Orange, M., Hooley, M., Davies, C., Colom-Cadena, M., Anton-Fernandez, A. & 10 others, King, D., Oren, I., Rose, J., McKenzie, C. A., Allison, E., Smith, C., Hardt, O., Henstridge, C. M., Hardingham, G. E. & Spires-Jones, T. L., 10 Dec 2019, In : Cell Reports. 29, 11, p. 3592-3604.e5

Research output: Contribution to journalArticle

Open Access
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36 Downloads (Pure)

Beyond the neuron–cellular interactions early in Alzheimer disease pathogenesis

Henstridge, C., Hyman, B. & Spires-Jones, T., Feb 2019, In : Nature Reviews Neuroscience. 20, 2, p. 94-108 15 p.

Research output: Contribution to journalReview article

22 Citations (Scopus)
Open Access
File
45 Downloads (Pure)

Clusterin accumulates in synapses in Alzheimer’s disease and is increased in Apolipoprotein E4 carriers

Jackson, R. J., Rose, J., Tulloch, J., Henstridge, C., Smith, C. & Spires-Jones, T. L., 24 Jun 2019, In : Brain Communications. 1, 1, p. 1-12 12 p.

Research output: Contribution to journalArticle

Open Access
File
53 Downloads (Pure)

Comparative profiling of the synaptic proteome from Alzheimer’s disease patients with focus on the APOE genotype

Hesse, R., Hurtado, M. L., Jackson, R. J., Eaton, S. L., Herrmann, A. G., Colom-Cadena, M., Tzioras, M., King, D., Rose, J., Tulloch, J., McKenzie, C-A., Smith, C., Henstridge, C., Lamont, D., Wishart, T. M. & Spires-Jones, T. L., 2019, In : Acta Neuropathologica Communications. 7, p. 1-18 18 p., 214.

Research output: Contribution to journalArticle

Open Access
File
40 Downloads (Pure)

Glial contribution to excitatory and inhibitory synapse loss in neurodegeneration

Henstridge, C., Tzioras, M. & Paolicelli, R. C., 26 Feb 2019, In : Frontiers in Cellular Neuroscience. 13, 26 p., 63.

Research output: Contribution to journalReview article

Open Access
File
6 Citations (Scopus)
112 Downloads (Pure)

Sarm1 deletion suppresses TDP-43-linked motor neuron degeneration and cortical spine loss

White, M. A., Lin, Z., Kim, E., Henstridge, C. M., Pena Altamira, E., Hunt, C. K., Burchill, E., Callaghan, I., Loreto, A., Brown-Wright, H., Mead, R., Simmons, C., Cash, D., Coleman, M. P. & Sreedharan, J., 28 Oct 2019, In : Acta Neuropathologica Communications. 7, 1, p. 1-16 16 p., 166.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
58 Downloads (Pure)
2018
Open Access
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86 Downloads (Pure)

Modeling Alzheimer’s disease brains in Vitro

Henstridge, C. & Spires-Jones, T., 27 Jun 2018, In : Nature Neuroscience. 21, p. 899-900 2 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Region-specific depletion of synaptic mitochondria in the brains of patients with Alzheimer’s disease

Pickett, E., Rose, J., McCrory, C., McKenzie, C-A., King, D., Smith, C., Gillingwater, T., Henstridge, C. & Spires-Jones, T., 6 Sep 2018, In : Acta Neuropathologica. 136, 5, p. 747-757 11 p.

Research output: Contribution to journalArticle

Open Access
File
13 Citations (Scopus)
108 Downloads (Pure)

Synapse loss in the prefrontal cortex is associated with cognitive decline in amyotrophic lateral sclerosis

Henstridge, C. M., Sideris, D. I., Carroll, E., Rotariu, S., Salomonsson, S., Tzioras, M., McKenzie, C-A., Smith, C., von Arnim, C. A. F., Ludolph, A. C., Lulé, D., Leighton, D., Warner, J., Cleary, E., Newton, J., Swingler, R., Chandran, S., Gillingwater, T. H., Abrahams, S. & Spires-Jones, T. L., Feb 2018, In : Acta Neuropathologica. 135, 2, p. 213-226 14 p.

Research output: Contribution to journalArticle

Open Access
File
16 Citations (Scopus)
96 Downloads (Pure)
2017

Assessing amyloid-β, tau, and glial features in Lothian Birth Cohort 1936 participants post-mortem

Tzioras, M., Easter, J., Harris, S., McKenzie, C-A., Smith, C., Deary, I., Henstridge, C. & Spires-Jones, T., 11 Oct 2017, In : Science Matters. p. 1-8 8 p.

Research output: Contribution to journalArticle

Open Access
File
69 Downloads (Pure)

Big conductance calcium-activated potassium channel openers control spasticity without sedation

Baker, D., Pryce, G., Visintin, C., Sisay, S., Bondarenko, A. I., Ho, W. S. V., Jackson, S. J., Williams, T. E., Al-Izki, S., Sevastou, I., Okuyama, M., Graier, W. F., Stevenson, L. A., Tanner, C., Ross, R., Pertwee, R. G., Henstridge, C. M., Irving, A. J., Schulman, J., Powell, K. & 3 others, Baker, M. D., Giovannoni, G. & Selwood, D. L., Aug 2017, In : British Journal of Pharmacology. 174, 16, p. 2662-2681 20 p.

Research output: Contribution to journalArticle

Open Access
File
6 Citations (Scopus)
190 Downloads (Pure)

Spread of tau down neural circuits precedes synapse and neuronal loss in the rTgTauEC mouse model of early Alzheimer's disease

Pickett, E., Henstridge, C., Allison, E., Pitstick, R., Pooler, A. M., Wegmann, S., Carlson, G., Hyman, B. T. & Spires-Jones, T., 14 Feb 2017, In : Synapse. 71, 6, 8 p., e21965.

Research output: Contribution to journalArticle

Open Access
File
17 Citations (Scopus)
92 Downloads (Pure)

Synaptic phosphorylated α-synuclein in dementia with Lewy bodies

Colom-Cadena, M., Pequeroles, J., Herrmann, A., Henstridge, C., Munoz-Llahuna, L., Querol-Vilaseca, M., San Martín-Paniello, C., Luque-Cabecerans, J., Clarimon, J., Belbin, O., Núñez-Llaves, R., Blesa, R., Smith, C., McKenzie, C-A., Frosch, M., Roe, A. D., Fortea, J., Andilla, J., Loza-Alvarez, P., Gelpi, E. & 3 others, Hyman, B., Spires-Jones, T. & Lleo, A., 21 Nov 2017, In : Brain. 140, 12, p. 3204-3214 11 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

TDP-43 Depletion in Microglia Promotes Amyloid Clearance but Also Induces Synapse Loss

Paolicelli, R. C., Jawaid, A., Henstridge, C. M., Valeri, A., Merlini, M., Robinson, J. L., Lee, E. B., Rose, J., Appel, S., Lee, V. M-Y., Trojanowski, J. Q., Spires-Jones, T., Schulz, P. E. & Rajendran, L., 19 Jul 2017, In : Neuron. 95, 2, p. 297-308.e6 12 p.

Research output: Contribution to journalArticle

Open Access
File
50 Citations (Scopus)
104 Downloads (Pure)
2016

GPR55: metabolic help or hindrance?

Henstridge, C., Brown, A. J. & Waldhoer, M., 21 May 2016, In : Trends in Endocrinology and Metabolism. 27, 9, p. 606-608 3 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Non-fibrillar oligomeric amyloid-β within synapses

Pickett, E., Koffie, R., Wegmann, S., Henstridge, C., Herrmann, A., Colom-Cadena, M., Lleo, A., Kay, K., Vaught, M., Soberman, R., Walsh, D., Hyman, B. & Spires-Jones, T., 30 May 2016, In : Journal of Alzheimer's Disease. 53, 3, p. 787-800 14 p.

Research output: Contribution to journalArticle

Open Access
File
19 Citations (Scopus)
120 Downloads (Pure)
2015

Cell-specific STORM super-resolution imaging reveals nanoscale organization of cannabinoid signaling

Dudok, B., Barna, L., Ledri, M., Szabó, S. I., Szabadits, E., Pintér, B., Woodhams, S. G., Henstridge, C. M., Balla, G. Y., Nyilas, R., Varga, C., Lee, S-H., Matolcsi, M., Cervenak, J., Kacskovics, I., Watanabe, M., Sagheddu, C., Melis, M., Pistis, M., Soltesz, I. & 1 others, Katona, I., Jan 2015, In : Nature Neuroscience. 18, 1, p. 75-86 12 p.

Research output: Contribution to journalArticle

110 Citations (Scopus)

Functional and structural deficits at accumbens synapses in a mouse model of Fragile X

Neuhofer, D., Henstridge, C. M., Dudok, B., Sepers, M., Lassalle, O., Katona, I. & Manzoni, O. J., 26 Mar 2015, In : Frontiers in Cellular Neuroscience. 9

Research output: Contribution to journalArticle

Open Access
File
18 Citations (Scopus)
90 Downloads (Pure)

Multiple Forms of Endocannabinoid and Endovanilloid Signaling Regulate the Tonic Control of GABA Release

Lee, S-H., Ledri, M., Tóth, B., Marchionni, I., Henstridge, C. M., Dudok, B., Kenesei, K., Barna, L., Szabó, S. I., Renkecz, T., Oberoi, M., Watanabe, M., Limoli, C. L., Horvai, G., Soltesz, I. & Katona, I., 8 Jul 2015, In : Journal of Neuroscience. 35, 27, p. 10039-10057 19 p.

Research output: Contribution to journalArticle

59 Citations (Scopus)

Post-mortem brain analyses of the Lothian Birth Cohort 1936: Extending lifetime cognitive and brain phenotyping to the level of the synapse

Henstridge, C., JAckson, R., Kim, J., Herrmann, A., Wright, A. K., Harris, S., Bastin, M., Starr, J., Wardlaw, J., Gillingwater, T., Smith, C., McKenzie, C-A., Cox, S., Deary, I. & Spires-Jones, T., 4 Sep 2015, In : Acta Neuropathologica Communications. 3, 53, 22 p.

Research output: Contribution to journalArticle

Open Access
File
9 Citations (Scopus)
91 Downloads (Pure)
2014

Heterogeneous presynaptic distribution of monoacylglycerol lipase, a multipotent regulator of nociceptive circuits in the mouse spinal cord

Horváth, E., Woodhams, S. G., Nyilas, R., Henstridge, C. M., Kano, M., Sakimura, K., Watanabe, M. & Katona, I., 4 Feb 2014, In : European Journal of Neuroscience. 39, 3, p. 419-434 16 p.

Research output: Contribution to journalArticle

Open Access
File
12 Citations (Scopus)
85 Downloads (Pure)
2012

Off-Target Cannabinoid Effects Mediated by GPR55

Henstridge, C. M., 2012, In : Pharmacology. 89, 3-4, p. 179-187 9 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

Uncoupling of the endocannabinoid signalling complex in a mouse model of fragile X syndrome

Jung, K-M., Sepers, M., Henstridge, C. M., Lassalle, O., Neuhofer, D., Martin, H., Ginger, M., Frick, A., DiPatrizio, N. V., Mackie, K., Katona, I., Piomelli, D. & Manzoni, O. J., 25 Sep 2012, In : Nature Communications. 3, 11 p.

Research output: Contribution to journalArticle

Open Access
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129 Citations (Scopus)
90 Downloads (Pure)
2011

Minireview: Recent Developments in the Physiology and Pathology of the Lysophosphatidylinositol-Sensitive Receptor GPR55

Henstridge, C. M., Balenga, N. A. B., Kargl, J., Andradas, C., Brown, A. J., Irving, A., Sanchez, C. & Waldhoer, M., Nov 2011, In : Molecular Endocrinology. 25, 11, p. 1835-1848 14 p.

Research output: Contribution to journalReview article

90 Citations (Scopus)

Pharmacology, signaling and physiological relevance of the G protein-coupled receptor 55

Balenga, N. A. B., Henstridge, C. M., Kargl, J. & Waldhoer, M., 2011, In : Current Vascular Pharmacology. 62, p. 251-277 27 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)
2010

Fluorescent ligand binding reveals heterogeneous distribution of adrenoceptors and 'cannabinoid-like' receptors in small arteries

Daly, C. J., Ross, R. A., Whyte, J., Henstridge, C. M., Irving, A. J. & McGrath, J. C., Feb 2010, In : British Journal of Pharmacology. 159, 4, p. 787-796 10 p.

Research output: Contribution to journalArticle

62 Citations (Scopus)

GPR55 ligands promote receptor coupling to multiple signalling pathways

Henstridge, C. M., Balenga, N. A. B., Schroeder, R., Kargl, J. K., Platzer, W., Martini, L., Arthur, S., Penman, J., Whistler, J. L., Kostenis, E., Waldhoer, M. & Irving, A. J., Jun 2010, In : British Journal of Pharmacology. 160, 3, p. 604-614 11 p.

Research output: Contribution to journalArticle

124 Citations (Scopus)
2009

The GPR55 ligand L-alpha-lysophosphatidylinositol promotes RhoA-dependent Ca2+ signaling and NFAT activation

Henstridge, C. M., Balenga, N. A. B., Ford, L. A., Ross, R. A., Waldhoer, M. & Irving, A. J., 2009, In : FASEB Journal. 23, 1, p. 183-193 11 p.

Research output: Contribution to journalArticle

192 Citations (Scopus)
2007

An essential role for constitutive endocytosis, but not activity, in the axonal targeting of the CB1 cannabinoid receptor

McDonald, N. A., Henstridge, C. M., Connolly, C. N. & Irving, A. J., 2007, In : Molecular Pharmacology. 71, 4, p. 976-984 9 p.

Research output: Contribution to journalArticle

64 Citations (Scopus)

Generation and functional characterization of fluorescent, N-terminally tagged CB1 receptor chimeras for live-cell imaging

McDonald, N. A., Henstridge, C. M., Connolly, C. N. & Irving, A. J., Jun 2007, In : Molecular and Cellular Neuroscience. 35, 2, p. 237-248 12 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)