Henstridge, Christopher

Dr

  • 1071 Citations
  • 16 h-Index
20072020
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Research Output 2007 2019

  • 1071 Citations
  • 16 h-Index
  • 27 Article
  • 3 Review article
2019
16 Citations (Scopus)

Beyond the neuron–cellular interactions early in Alzheimer disease pathogenesis

Henstridge, C., Hyman, B. & Spires-Jones, T., Feb 2019, In : Nature Reviews Neuroscience. 20, 2, p. 94-108 15 p.

Research output: Contribution to journalReview article

Alzheimer Disease
Neurons
Brain
Microglia
Astrocytes
5 Downloads (Pure)
Open Access
File
dementia
knowledge
communication
pilot project
expertise
23 Downloads (Pure)

Clusterin accumulates in synapses in Alzheimer’s disease and is increased in Apolipoprotein E4 carriers

Jackson, R. J., Rose, J., Tulloch, J., Henstridge, C., Smith, C. & Spires-Jones, T. L., 24 Jun 2019, In : Brain Communications. p. 1-12 12 p.

Research output: Contribution to journalArticle

Open Access
File
Clusterin
Apolipoprotein E4
Synapses
Alzheimer Disease
Apolipoproteins
3 Citations (Scopus)
65 Downloads (Pure)

Glial contribution to excitatory and inhibitory synapse loss in neurodegeneration

Henstridge, C., Tzioras, M. & Paolicelli, R. C., 26 Feb 2019, In : Frontiers in Cellular Neuroscience. 13, 26 p., 63.

Research output: Contribution to journalReview article

Open Access
File
Neuroglia
Synapses
Microglia
Astrocytes
Neurodegenerative Diseases
24 Downloads (Pure)

Sarm1 deletion suppresses TDP-43-linked motor neuron degeneration and cortical spine loss

White, M. A., Lin, Z., Kim, E., Henstridge, C. M., Pena Altamira, E., Hunt, C. K., Burchill, E., Callaghan, I., Loreto, A., Brown-Wright, H., Mead, R., Simmons, C., Cash, D., Coleman, M. P. & Sreedharan, J., 28 Oct 2019, In : Acta Neuropathologica Communications. 7, 1, p. 1-16 16 p., 166.

Research output: Contribution to journalArticle

Open Access
File
Nerve Degeneration
Motor Neurons
Spine
Amyotrophic Lateral Sclerosis
Wallerian Degeneration
2018
50 Downloads (Pure)
Open Access
File
Dementia
Brain
Research
2 Citations (Scopus)

Modeling Alzheimer’s disease brains in Vitro

Henstridge, C. & Spires-Jones, T., 27 Jun 2018, In : Nature Neuroscience. 21, p. 899-900 2 p.

Research output: Contribution to journalArticle

Lab-On-A-Chip Devices
Alzheimer Disease
Brain
Microglia
Astrocytes
9 Citations (Scopus)
71 Downloads (Pure)

Region-specific depletion of synaptic mitochondria in the brains of patients with Alzheimer’s disease

Pickett, E., Rose, J., McCrory, C., McKenzie, C-A., King, D., Smith, C., Gillingwater, T., Henstridge, C. & Spires-Jones, T., 6 Sep 2018, In : Acta Neuropathologica. 136, 5, p. 747-757 11 p.

Research output: Contribution to journalArticle

Open Access
File
Alzheimer Disease
Mitochondria
Synapses
Brain
Presynaptic Terminals
12 Citations (Scopus)
61 Downloads (Pure)

Synapse loss in the prefrontal cortex is associated with cognitive decline in amyotrophic lateral sclerosis

Henstridge, C. M., Sideris, D. I., Carroll, E., Rotariu, S., Salomonsson, S., Tzioras, M., McKenzie, C-A., Smith, C., von Arnim, C. A. F., Ludolph, A. C., Lulé, D., Leighton, D., Warner, J., Cleary, E., Newton, J., Swingler, R., Chandran, S., Gillingwater, T. H., Abrahams, S. & Spires-Jones, T. L., Feb 2018, In : Acta Neuropathologica. 135, 2, p. 213-226 14 p.

Research output: Contribution to journalArticle

Open Access
File
Amyotrophic Lateral Sclerosis
Prefrontal Cortex
Synapses
Nerve Degeneration
Brain
2017
50 Downloads (Pure)

Assessing amyloid-β, tau, and glial features in Lothian Birth Cohort 1936 participants post-mortem

Tzioras, M., Easter, J., Harris, S., McKenzie, C-A., Smith, C., Deary, I., Henstridge, C. & Spires-Jones, T., 11 Oct 2017, In : Science Matters. p. 1-8 8 p.

Research output: Contribution to journalArticle

Open Access
File
Amyloid
Neuroglia
Parturition
Brain
Cognition
6 Citations (Scopus)
150 Downloads (Pure)

Big conductance calcium-activated potassium channel openers control spasticity without sedation

Baker, D., Pryce, G., Visintin, C., Sisay, S., Bondarenko, A. I., Ho, W. S. V., Jackson, S. J., Williams, T. E., Al-Izki, S., Sevastou, I., Okuyama, M., Graier, W. F., Stevenson, L. A., Tanner, C., Ross, R., Pertwee, R. G., Henstridge, C. M., Irving, A. J., Schulman, J., Powell, K. & 3 others, Baker, M. D., Giovannoni, G. & Selwood, D. L., Aug 2017, In : British Journal of Pharmacology. 174, 16, p. 2662-2681 20 p.

Research output: Contribution to journalArticle

Open Access
File
Calcium-Activated Potassium Channels
Multiple Sclerosis
Cannabinoids
Theoretical Models
Encephalomyelitis
15 Citations (Scopus)
56 Downloads (Pure)

Spread of tau down neural circuits precedes synapse and neuronal loss in the rTgTauEC mouse model of early Alzheimer's disease

Pickett, E., Henstridge, C., Allison, E., Pitstick, R., Pooler, A. M., Wegmann, S., Carlson, G., Hyman, B. T. & Spires-Jones, T., 14 Feb 2017, In : Synapse. 71, 6, 8 p., e21965.

Research output: Contribution to journalArticle

Open Access
File
Synapses
Alzheimer Disease
Presynaptic Terminals
Transgenes
Entorhinal Cortex
26 Citations (Scopus)

Synaptic phosphorylated α-synuclein in dementia with Lewy bodies

Colom-Cadena, M., Pequeroles, J., Herrmann, A., Henstridge, C., Munoz-Llahuna, L., Querol-Vilaseca, M., San Martín-Paniello, C., Luque-Cabecerans, J., Clarimon, J., Belbin, O., Núñez-Llaves, R., Blesa, R., Smith, C., McKenzie, C-A., Frosch, M., Roe, A. D., Fortea, J., Andilla, J., Loza-Alvarez, P., Gelpi, E. & 3 others, Hyman, B., Spires-Jones, T. & Lleo, A., 21 Nov 2017, In : Brain. 140, 12, p. 3204-3214 11 p.

Research output: Contribution to journalArticle

Synucleins
Lewy Body Disease
Synapses
Lewy Bodies
Neurites
42 Citations (Scopus)
67 Downloads (Pure)

TDP-43 Depletion in Microglia Promotes Amyloid Clearance but Also Induces Synapse Loss

Paolicelli, R. C., Jawaid, A., Henstridge, C. M., Valeri, A., Merlini, M., Robinson, J. L., Lee, E. B., Rose, J., Appel, S., Lee, V. M-Y., Trojanowski, J. Q., Spires-Jones, T., Schulz, P. E. & Rajendran, L., 19 Jul 2017, In : Neuron. 95, 2, p. 297-308.e6 12 p.

Research output: Contribution to journalArticle

Open Access
File
Microglia
Amyloid
Synapses
Alzheimer Disease
Pathology
2016
7 Citations (Scopus)

GPR55: metabolic help or hindrance?

Henstridge, C., Brown, A. J. & Waldhoer, M., 21 May 2016, In : Trends in Endocrinology and Metabolism. 27, 9, p. 606-608 3 p.

Research output: Contribution to journalArticle

Lysophospholipid Receptors
G-Protein-Coupled Receptors
Obesity
17 Citations (Scopus)
64 Downloads (Pure)

Non-fibrillar oligomeric amyloid-β within synapses

Pickett, E., Koffie, R., Wegmann, S., Henstridge, C., Herrmann, A., Colom-Cadena, M., Lleo, A., Kay, K., Vaught, M., Soberman, R., Walsh, D., Hyman, B. & Spires-Jones, T., 30 May 2016, In : Journal of Alzheimer's Disease. 53, 3, p. 787-800 14 p.

Research output: Contribution to journalArticle

Open Access
File
Amyloid
Synapses
Alzheimer Disease
Amyloid Plaques
Tomography
2015
100 Citations (Scopus)

Cell-specific STORM super-resolution imaging reveals nanoscale organization of cannabinoid signaling

Dudok, B., Barna, L., Ledri, M., Szabó, S. I., Szabadits, E., Pintér, B., Woodhams, S. G., Henstridge, C. M., Balla, G. Y., Nyilas, R., Varga, C., Lee, S-H., Matolcsi, M., Cervenak, J., Kacskovics, I., Watanabe, M., Sagheddu, C., Melis, M., Pistis, M., Soltesz, I. & 1 others, Katona, I., Jan 2015, In : Nature Neuroscience. 18, 1, p. 75-86 12 p.

Research output: Contribution to journalArticle

Cannabinoids
Endocannabinoids
Dronabinol
Interneurons
Cannabinoid Receptor CB1
17 Citations (Scopus)
55 Downloads (Pure)

Functional and structural deficits at accumbens synapses in a mouse model of Fragile X

Neuhofer, D., Henstridge, C. M., Dudok, B., Sepers, M., Lassalle, O., Katona, I. & Manzoni, O. J., 26 Mar 2015, In : Frontiers in Cellular Neuroscience. 9

Research output: Contribution to journalArticle

Open Access
File
Synapses
Spine
Long-Term Potentiation
Fragile X Mental Retardation Protein
Nucleus Accumbens
58 Citations (Scopus)

Multiple Forms of Endocannabinoid and Endovanilloid Signaling Regulate the Tonic Control of GABA Release

Lee, S-H., Ledri, M., Tóth, B., Marchionni, I., Henstridge, C. M., Dudok, B., Kenesei, K., Barna, L., Szabó, S. I., Renkecz, T., Oberoi, M., Watanabe, M., Limoli, C. L., Horvai, G., Soltesz, I. & Katona, I., 8 Jul 2015, In : Journal of Neuroscience. 35, 27, p. 10039-10057 19 p.

Research output: Contribution to journalArticle

Endocannabinoids
gamma-Aminobutyric Acid
Cannabinoid Receptor CB1
Synapses
Monoacylglycerol Lipases
9 Citations (Scopus)
55 Downloads (Pure)

Post-mortem brain analyses of the Lothian Birth Cohort 1936: Extending lifetime cognitive and brain phenotyping to the level of the synapse

Henstridge, C., JAckson, R., Kim, J., Herrmann, A., Wright, A. K., Harris, S., Bastin, M., Starr, J., Wardlaw, J., Gillingwater, T., Smith, C., McKenzie, C-A., Cox, S., Deary, I. & Spires-Jones, T., 4 Sep 2015, In : Acta Neuropathologica Communications. 3, 53, 22 p.

Research output: Contribution to journalArticle

Open Access
File
Synapses
Parturition
Brain
Alzheimer Disease
Cognition
2014
12 Citations (Scopus)
49 Downloads (Pure)

Heterogeneous presynaptic distribution of monoacylglycerol lipase, a multipotent regulator of nociceptive circuits in the mouse spinal cord

Horváth, E., Woodhams, S. G., Nyilas, R., Henstridge, C. M., Kano, M., Sakimura, K., Watanabe, M. & Katona, I., 4 Feb 2014, In : European Journal of Neuroscience. 39, 3, p. 419-434 16 p.

Research output: Contribution to journalArticle

Open Access
File
Monoacylglycerol Lipases
Spinal Cord
Endocannabinoids
Staining and Labeling
Knockout Mice
2012
34 Citations (Scopus)

Off-Target Cannabinoid Effects Mediated by GPR55

Henstridge, C. M., 2012, In : Pharmacology. 89, 3-4, p. 179-187 9 p.

Research output: Contribution to journalArticle

Cannabinoids
G-Protein-Coupled Receptors
Physiological Phenomena
Literature
Cannabinoid Receptors
124 Citations (Scopus)
56 Downloads (Pure)

Uncoupling of the endocannabinoid signalling complex in a mouse model of fragile X syndrome

Jung, K-M., Sepers, M., Henstridge, C. M., Lassalle, O., Neuhofer, D., Martin, H., Ginger, M., Frick, A., DiPatrizio, N. V., Mackie, K., Katona, I., Piomelli, D. & Manzoni, O. J., 25 Sep 2012, In : Nature Communications. 3, 11 p.

Research output: Contribution to journalArticle

Open Access
File
Metabotropic Glutamate 5 Receptor
Fragile X Syndrome
Endocannabinoids
Fragile X Mental Retardation Protein
glutamates
2011
86 Citations (Scopus)

Minireview: Recent Developments in the Physiology and Pathology of the Lysophosphatidylinositol-Sensitive Receptor GPR55

Henstridge, C. M., Balenga, N. A. B., Kargl, J., Andradas, C., Brown, A. J., Irving, A., Sanchez, C. & Waldhoer, M., Nov 2011, In : Molecular Endocrinology. 25, 11, p. 1835-1848 14 p.

Research output: Contribution to journalReview article

21 Citations (Scopus)

Pharmacology, signaling and physiological relevance of the G protein-coupled receptor 55

Balenga, N. A. B., Henstridge, C. M., Kargl, J. & Waldhoer, M., 2011, In : Current Vascular Pharmacology. 62, p. 251-277 27 p.

Research output: Contribution to journalArticle

Endocannabinoids
G-Protein-Coupled Receptors
Pharmacology
Physiological Phenomena
Cannabinoid Receptors
2010
60 Citations (Scopus)

Fluorescent ligand binding reveals heterogeneous distribution of adrenoceptors and 'cannabinoid-like' receptors in small arteries

Daly, C. J., Ross, R. A., Whyte, J., Henstridge, C. M., Irving, A. J. & McGrath, J. C., Feb 2010, In : British Journal of Pharmacology. 159, 4, p. 787-796 10 p.

Research output: Contribution to journalArticle

121 Citations (Scopus)

GPR55 ligands promote receptor coupling to multiple signalling pathways

Henstridge, C. M., Balenga, N. A. B., Schroeder, R., Kargl, J. K., Platzer, W., Martini, L., Arthur, S., Penman, J., Whistler, J. L., Kostenis, E., Waldhoer, M. & Irving, A. J., Jun 2010, In : British Journal of Pharmacology. 160, 3, p. 604-614 11 p.

Research output: Contribution to journalArticle

2009
188 Citations (Scopus)

The GPR55 ligand L-alpha-lysophosphatidylinositol promotes RhoA-dependent Ca2+ signaling and NFAT activation

Henstridge, C. M., Balenga, N. A. B., Ford, L. A., Ross, R. A., Waldhoer, M. & Irving, A. J., 2009, In : FASEB Journal. 23, 1, p. 183-193 11 p.

Research output: Contribution to journalArticle

2007
64 Citations (Scopus)

An essential role for constitutive endocytosis, but not activity, in the axonal targeting of the CB1 cannabinoid receptor

McDonald, N. A., Henstridge, C. M., Connolly, C. N. & Irving, A. J., 2007, In : Molecular Pharmacology. 71, 4, p. 976-984 9 p.

Research output: Contribution to journalArticle

Cannabinoid Receptor CB1
Endocytosis
Neurons
Axons
Dynamin I
22 Citations (Scopus)

Generation and functional characterization of fluorescent, N-terminally tagged CB1 receptor chimeras for live-cell imaging

McDonald, N. A., Henstridge, C. M., Connolly, C. N. & Irving, A. J., Jun 2007, In : Molecular and Cellular Neuroscience. 35, 2, p. 237-248 12 p.

Research output: Contribution to journalArticle

Cannabinoid Receptor CB1
HEK293 Cells
Cell Surface Receptors
Protein Sorting Signals
Fluorescence