Mackenzie, Claire

Medicinal Chemist, Drug Discovery Unit

United Kingdom

117 Citations
4 h-Index

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45 Similar Profiles

Mycobacterium tuberculosis Medicine & Life Sciences

Pharmaceutical Preparations Medicine & Life Sciences

Indazoles Medicine & Life Sciences

Inosine Monophosphate Medicine & Life Sciences

Trypanosoma brucei brucei Medicine & Life Sciences

Visceral Leishmaniasis Medicine & Life Sciences

Drug Design Medicine & Life Sciences

Sulfonamides Medicine & Life Sciences

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Research Output 2013 2019

117 Citations
4 h-Index
7 Article

2 Citations (Scopus)

120 Downloads (Pure)

Characterising Covalent Warhead Reactivity

Martin, J., Mackenzie, C., Fletcher, D. & Gilbert, I., 15 May 2019, In : Bioorganic & Medicinal Chemistry. 27, 10, p. 2066-2074 9 p.

Research output: Contribution to journal › Article

Open Access

File

Toxicity

Pharmaceutical Preparations

Aptitude

Pharmacokinetics

Threonine

4 Citations (Scopus)

Identification of GSK3186899/DDD853651 as a Preclinical Development Candidate for the Treatment of Visceral Leishmaniasis

Thomas, M. G., De Rycker, M., Ajakane, M., Albrecht, S., Álvarez-Pedraglio, A. I., Boesche, M., Brand, S., Campbell, L., Cantizani-Perez, J., Cleghorn, L. A. T., Copley, R. C. B., Crouch, S. D., Daugan, A., Drewes, G., Ferrer, S., Ghidelli-Disse, S., Gonzalez, S., Gresham, S. L., Hill, A. P., Hindley, S. J. & 32 others, Lowe, R. M., MacKenzie, C. J., MacLean, L., Manthri, S., Martin, F., Miguel-Siles, J., Nguyen, V. L., Norval, S., Osuna-Cabello, M., Woodland, A., Patterson, S., Pena, I., Quesada-Campos, M. T., Reid, I. H., Revill, C., Riley, J., Ruiz-Gomez, J. R., Shishikura, Y., Simeons, F. R. C., Smith, A., Smith, V. C., Spinks, D., Stojanovski, L., Thomas, J., Thompson, S., Underwood, T., Gray, D. W., Fiandor, J. M., Gilbert, I. H., Wyatt, P. G., Read, K. D. & Miles, T. J., 14 Feb 2019, In : Journal of Medicinal Chemistry. 62, 3, p. 1180-1202 23 p.

Research output: Contribution to journal › Article

Visceral Leishmaniasis

Leishmania major

Leishmania donovani

Standard of Care

Solubility

104 Downloads (Pure)

Screening of a novel fragment library with functional complexity against Mycobacterium tuberculosis InhA

Prati, F., Zuccotto, F., Fletcher, D., Convery, M. A., Fernandez-Menendez, R., Bates, R., Encinas, L., Zeng, J., Chung, C-W., De Dios Anton, P., Mendoza-Losana, A., Mackenzie, C., Green, S. R., Huggett, M., Barros, D., Wyatt, P. G. & Ray, P. C., 6 Apr 2018, In : ChemMedChem. 13, 7, p. 672-677 6 p.

Research output: Contribution to journal › Article

Open Access

File

Mycobacterium tuberculosis

Functional groups

Screening

Ligands

Proteins

Correction for Arora et al., "Respiratory Flexibility in Response to Inhibition of Cytochrome c Oxidase in Mycobacterium tuberculosis"

Arora, K., Ochoa-Montaño, B., Tsang, P. S., Blundell, T. L., Dawes, S. S., Mizrahi, V., Bayliss, T., Mackenzie, C. J., Cleghorn, L. A. T., Ray, P. C., Wyatt, P. G., Uh, E., Lee, J., Barry, C. E. & Boshoff, H. I., Sep 2017, In : Antimicrobial Agents and Chemotherapy. 61, 9, 1 p., e01429-17 .

Research output: Contribution to journal › Article

35 Citations (Scopus)

Essential but Not Vulnerable: Indazole Sulfonamides Targeting Inosine Monophosphate Dehydrogenase as Potential Leads against Mycobacterium tuberculosis

Park, Y., Pacitto, A., Bayliss, T., Cleghorn, L. A. T., Wang, Z., Hartman, T., Arora, K., Ioerger, T. R., Sacchettini, J., Rizzi, M., Donini, S., Blundell, T. L., Ascher, D. B., Rhee, K., Breda, A., Zhou, N., Dartois, V., Jonnala, S. R., Via, L. E., Mizrahi, V. & 35 others, Epemolu, O., Stojanovski, L., Simeons, F., Osuna-Cabello, M., Ellis, L., MacKenzie, C. J., Smith, A. R. C., Davis, S. H., Murugesan, D., Buchanan, K. I., Turner, P. A., Huggett, M., Zuccotto, F., Rebollo-Lopez, M. J., Lafuente-Monasterio, M. J., Sanz, O., Diaz, G. S., Lelièvre, J., Ballell, L., Selenski, C., Axtman, M., Ghidelli-Disse, S., Pflaumer, H., Bösche, M., Drewes, G., Freiberg, G. M., Kurnick, M. D., Srikumaran, M., Kempf, D. J., Green, S. R., Ray, P. C., Read, K., Wyatt, P., Barry, C. E. & Boshoff, H. I., 13 Jan 2017, In : ACS Infectious Diseases. 3, 1, p. 18-33 16 p.

Research output: Contribution to journal › Article

Indazoles

Inosine Monophosphate

Sulfonamides

Mycobacterium tuberculosis

Oxidoreductases