Henderson, Colin


  • 7101 Citations
  • 40 h-Index
1983 …2023
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Personal profile


My undergrdauate degree from the University of Edinburgh in Biochemistry (1981), was followed by a PhD in the Faculty of Medicine at the same institution. After undertaking a Celltech Training Fellowship at the MRC Reproductive Biology Unit in Edinburgh (1984-1987), I joined the Imperial Cancer Research Fund lab of Professor Roland Wolf, which relocated to the University of Dundee in January 1993. As part of ICRF, later Cancer Research UK, I became a senior, then Chief, Scientifc Officer, and later Associate, and then Staff, Scientist. I was appointed to an honorary lecturer position with the University of Dundee in 1999, formally joining the University in April 2011 as a Senior Lecturer in the School of Medicine, and being appointed Reader in 2018.

I am an enthusiastic advocate for outreach, and believe passionately that it is our duty as academics and scientists to clearly and openly communicate our work to the public. Ihave been extensively involved for >20 years in science communication and public engagement, both internally (Lab Tours, Open Days) and externally (School visits, Race/Relay for Life, charity & fundraising groups). In 2012, I was Ambassador of the Year (Researcher) in the CRUK ‘Flame of Hope’ awards. I was joint recipient of the Ian Stevenson Award for Public Engagement in 2016, and in 2017 I was appointed become Academic Lead for Public Engagement/Wider Impact for the School of Medicine, and represent the School on the University’s Public Engagement Forum.

I chair the Medical School Biological Services management committee, and I am the School of Medicine Representative on the University Welfare and Ethical use of animals committee. I sit on the National Centre for Reduction, Refinement and Replacment (NC3Rs) Studentship Committee.


Trained as a biochemist, I have over 30 years’ experience working across disciplines in the areas of toxicology, drug metabolism and molecular pharmacology, which has made me a leader in these fields, with an international reputation for innovation. For more than two decades I have been at the cutting edge of transgenic model development, culminating in the generation of genetically altered mice designed to closely mirror human drug metabolism. These unique humanised mouse models havethe potential to create a paradigm shift in pre-clinical drug testing and clinical trial design, particularly addressing the increasing use of drug combinations in oncology. 

Over the last 15 years, my sustained research contributions and extensive knowledge of transgenic design and strategies has established me at the forefront of this area and internationally recognised amongst my peers, and I am regularly invited to speak, chair and participate at national/international conferences and symposia. 

I have established many local, national and international collaborations with both academic and industrial partners, resulting in a strong and sustained publication record. As well as several book chapters and reviews, I have published more than 100 peer-reviewed journal articles; my h-factor is 44 (Google Scholar, February 2018http://tinyurl.com/hth7bzq). My expertise in mouse work, and knowledge of transgenics, has led to my involvement in numerous projects, both across the University and nationally/internationally. Since joining the University in 2011, I have been instrumental in securing more than £5M of grant funding, including two MRC Project grants (2017, 2018) worth >£2M. I regularly review manuscripts submitted for publication to a range of journals, and review grant applications for national funding bodies.


Undergraduate: I deliver lectures to science and medical students, mainly in the area of toxicology, drug metabolism and transgenic models. I currently participate in BS50003 MSci Integrated Masters, BS42007 Cancer Biology, BS42027 Cancer Pharmacology, BMSc 40036, BS32029 Biomedical Sciences  and SSC components for Medicine.

Postgraduate: I have been involved in the supervision of a number of graduate students; I am currently primary supervisor to one graduate student. I also participate in, and help run, MRes Cancer Biology

PhD & MSc Examinations:I have been Convenor or Internal Examiner for MSc and PhD theses in the Medical School, and External Examiner at a number of UK academic institutions.

Education/Academic qualification

Doctor of Philosophy, University of Edinburgh

Bachelor of Science, University of Edinburgh


  • RC0254 Neoplasms. Tumors. Oncology (including Cancer)
  • transgenic models
  • toxicology
  • pharmacology

Fingerprint Dive into the research topics where Colin Henderson is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 6 Similar Profiles
Cytochrome P-450 Enzyme System Medicine & Life Sciences
Liver Medicine & Life Sciences
Cytochromes b5 Medicine & Life Sciences
Pharmaceutical Preparations Medicine & Life Sciences
NADPH-Ferrihemoprotein Reductase Medicine & Life Sciences
Metabolism Chemical Compounds
Glutathione Transferase Medicine & Life Sciences
Oxidoreductases Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2013 2023

Research Output 1983 2019

1 Citation (Scopus)
48 Downloads (Pure)

An Extensively Humanized Mouse Model to Predict Pathways of Drug Disposition and Drug/Drug Interactions, and to Facilitate Design of Clinical Trials

Henderson, C. J., Kapelyukh, Y., Scheer, N., Rode, A., McLaren, A., MacLeod, K., Lin, D., Wright, J., Stanley, L. A. & Wolf, C. R., Jun 2019, In : Drug Metabolism and Disposition. 47, 6, p. 601-615 15 p.

Research output: Contribution to journalArticle

Open Access
Drug Interactions
Clinical Trials
Pharmaceutical Preparations
Cytochrome P-450 CYP3A
1 Citation (Scopus)
78 Downloads (Pure)

Application of hepatic cytochrome b5/P450 reductase null (HBRN) mice to study the role of cytochrome b5 in the cytochrome P450-mediated bioactivation of the anticancer drug ellipticine

Reed, L., Indra, R., Mrizova, I., Moserova, M., Schmeiser, H. H., Wolf, C. R., Henderson, C. J., Stiborova, M., Phillips, D. H. & Arlt, V. M., 1 Mar 2019, In : Toxicology and Applied Pharmacology. 366, p. 64-74 11 p.

Research output: Contribution to journalArticle

Open Access
Cytochromes b5
NADPH-Ferrihemoprotein Reductase
Cytochrome P-450 Enzyme System
1 Citation (Scopus)
77 Downloads (Pure)

Constitutive androstane receptor 1 is constitutively bound to chromatin and ‘primed’ for transactivation in hepatocytes

McMahon, M., Ding, S., Acosta-Jimenez, L., Terranova, R., Gerard, M-A., Vitobello, A., Moggs, J. G., Henderson, C. J. & Wolf, C. R., 1 Jan 2019, In : Molecular Pharmacology. 95, 1, p. 97-105 9 p.

Research output: Contribution to journalArticle

Open Access
Transcriptional Activation
constitutive androstane receptor

Correlation between 3-MCPD-induced organ toxicity and oxidative stress response in male mice

Schultrich, K., Henderson, C. J., Braeuning, A. & Buhrke, T., 8 Nov 2019, In : Food and Chemical Toxicology. p. 1-9 9 p., 110957.

Research output: Contribution to journalArticle

Oxidative stress
stress response
Oxidative Stress
2 Citations (Scopus)
Open Access
Cytochrome P-450 CYP1A2
Cytochrome P-450 CYP1A1
Knockout Mice
Pharmaceutical Preparations
Enzyme Inhibitors



Ian Stevenson award for Public Engagement

Colin Henderson (Recipient), 1 Dec 2016

Prize: Prize (including medals and awards)


Activities 2005 2019

Leuchars Primary School (3)

Colin Henderson (Member), Frances Fuller-Pace (Member), Amy Rogers (Member), Li Kang (Member), Jennifer Kennedy (Member)
26 Apr 2019

Activity: Other activity typesSchools engagement

External Examiner - PhD

Colin Henderson (Examiner)
14 May 2019

Activity: Examination typesExamination

Carlogie Primary School

Colin Henderson (Member), Rita Moreno Dorta (Member), Nicola Morrice (Member), Daniella Cavellini (Member)
15 May 2019

Activity: Other activity typesSchools engagement

St Joseph's Primary School

Colin Henderson (Member), Ros Langston (Member), Tania G. Frangova (Member), Chandani Hennayake (Member), Annie Hasib (Member)
10 May 2019

Activity: Other activity typesSchools engagement

Forfar Academy

Colin Henderson (Member), Colin Murdoch (Member), Agathe Lermant (Member)
18 Jun 2019

Activity: Other activity typesSchools engagement

Press / Media

Research could prompt changes in cancer treatment

Colin Henderson


1 item of Media coverage

Press/Media: Research

Dundee takes lead role in supporting cancer drugs development

Colin Henderson


1 item of Media coverage

Press/Media: Research

Cash award for cancer researchers

Colin Henderson


1 item of Media coverage

Press/Media: Research

Painkiller overdose unravelled

Colin Henderson


1 item of Media coverage

Press/Media: Research


Catalytic and non-catalytic mechanisms involved in Glutathione S-transferase Pi mediated cytoprotection

Author: McGarry, D., 2012

Supervisor: Henderson, C. J. (Supervisor) & Wolf, C. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy


Detection of Mouse Hepatitis Virus

Author: Wood, C. S., 2015

Supervisor: Henderson, C. J. (Supervisor) & Newman, E. (Supervisor)

Student thesis: Master's ThesisMaster of Science


Metabolic Factors Determining Outcome in Chemotherapy: Studies with Pazopanib

Author: Sharp, S. L., 2014

Supervisor: Wolf, C. (Supervisor) & Henderson, C. J. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy