• 6436 Citations
  • 38 h-Index
1983 …2019
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Personal profile

Biography

My undergrdauate degree from the University of Edinburgh in Biochemistry (1981), was followed by a PhD in the Faculty of Medicine at the same institution. After undertaking a Celltech Training Fellowship at the MRC Reproductive Biology Unit in Edinburgh (1984-1987), I joined the Imperial Cancer Research Fund lab of Professor Roland Wolf, which relocated to the University of Dundee in January 1993. As part of ICRF, later Cancer Research UK, I became a senior, then Chief, Scientifc Officer, and later Associate, and then Staff, Scientist. I was appointed to an honorary lecturer position with the University of Dundee in 1999, formally joining the University in April 2011 as a Senior Lecturer in the School of Medicine.

I am an enthusiastic advocate for outreach, and believe passionately that it is our duty as academics and scientists to clearly and openly communicate our work to the public. Ihave been extensively involved for >20 years in science communication and public engagement, both internally (Lab Tours, Open Days) and externally (School visits, Race/Relay for Life, charity & fundraising groups). In 2012, I was Ambassador of the Year (Researcher) in the CRUK ‘Flame of Hope’ awards. I was joint recipient of the Ian Stevenson Award for Public Engagement in 2016, and in 2017 I was appointed become Academic Lead for Public Engagement/Wider Impact for the School of Medicine, and represent the School on the University’s Public Engagement Forum.

I chair the Medical School Biological Services management committee, and I am the School of Medicine Representative on the University Welfare and Ethical use of animals committee. I sit on the National Centre for Reduction, Refinement and Replacment (NC3Rs) Studentship Committee.

Research

Trained as a biochemist, I have over 30 years’ experience working across disciplines in the areas of toxicology, drug metabolism and molecular pharmacology, which has made me a leader in these fields, with an international reputation for innovation. For more than two decades I have been at the cutting edge of transgenic model development, culminating in the generation of genetically altered mice designed to closely mirror human drug metabolism. These unique humanised mouse models havethe potential to create a paradigm shift in pre-clinical drug testing and clinical trial design, particularly addressing the increasing use of drug combinations in oncology. 

Over the last 15 years, my sustained research contributions and extensive knowledge of transgenic design and strategies has established me at the forefront of this area and internationally recognised amongst my peers, and I am regularly invited to speak, chair and participate at national/international conferences and symposia. 

I have established many local, national and international collaborations with both academic and industrial partners, resulting in a strong and sustained publication record. As well as several book chapters and reviews, I have published more than 100 peer-reviewed journal articles; my h-factor is 44 (Google Scholar, February 2018http://tinyurl.com/hth7bzq). My expertise in mouse work, and knowledge of transgenics, has led to my involvement in numerous projects, both across the University and nationally/internationally. Since joining the University in 2011, I have been instrumental in securing more than £5M of grant funding, including two MRC Project grants (2017, 2018) worth >£2M. I regularly review manuscripts submitted for publication to a range of journals, and review grant applications for national funding bodies.

Teaching

Undergraduate: I deliver lectures to science and medical students, mainly in the area of toxicology, drug metabolism and transgenic models. I currently participate in BS50003 MSci Integrated Masters, BS42007 Cancer Biology, BS42027 Cancer Pharmacology, BMSc 40036, BS32029 Biomedical Sciences  and SSC components for Medicine.

Postgraduate: I have been involved in the supervision of a number of graduate students; I am currently primary supervisor to one graduate student. I also participate in, and help run, MRes Cancer Biology

PhD & MSc Examinations:I have been Convenor or Internal Examiner for MSc and PhD theses in the Medical School, and External Examiner at a number of UK academic institutions.

Education/Academic qualification

Doctor of Philosophy, University of Edinburgh

Bachelor of Science, University of Edinburgh

Keywords

  • RC0254 Neoplasms. Tumors. Oncology (including Cancer)
  • transgenic models
  • toxicology
  • pharmacology

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

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Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 1983 2019

Constitutive androstane receptor 1 is constitutively bound to chromatin and ‘primed’ for transactivation in hepatocytes

McMahon, M., Ding, S., Acosta-Jimenez, L., Terranova, R., Gerard, M-A., Vitobello, A., Moggs, J. G., Henderson, C. J. & Wolf, C. R., 1 Jan 2019, In : Molecular Pharmacology. 95, 1, p. 97-105 9 p.

Research output: Contribution to journalArticle

Open Access
File
Transcriptional Activation
Chromatin
Hepatocytes
Xenobiotics
constitutive androstane receptor
7 Citations

Cytochrome b5 impacts on cytochrome P450-mediated metabolism of benzo[a]pyrene and its DNA adduct formation: studies in hepatic cytochrome b5 /P450 reductase null (HBRN) mice

Reed, L., Mrizova, I., Barta, F., Indra, R., Moserova, M., Kopka, K., Schmeiser, H. H., Wolf, C. R., Henderson, C. J., Stiborova, M., Phillips, D. H. & Arlt, V. M., 24 Jan 2018, In : Archives of Toxicology. 14 p.

Research output: Contribution to journalArticle

Open Access
File
Cytochromes b5
NADPH-Ferrihemoprotein Reductase
Metabolism
Cytochrome P-450 Enzyme System
Oxidoreductases
1 Citations

Identification of novel pathways of osimertinib disposition and potential implications for the outcome of lung cancer therapy

MacLeod, A. K., Lin, D., Huang, J. T-J., McLaughlin, L. A., Henderson, C. J. & Wolf, C. R., May 2018, In : Clinical Cancer Research. 24, 9, p. 2138-2147 10 p.

Research output: Contribution to journalArticle

Lung Neoplasms
Cytochrome P-450 CYP3A
Therapeutics
Pharmaceutical Preparations
Cytochrome P-450 CYP1A2

Measuring in vivo responses to endogenous and exogenous oxidative stress using a novel Heme Oxygenase 1 reporter mouse

McMahon, M., Ding, S., Acosta-Jimenez, L. P., Frangova, T. G., Henderson, C. J. & Wolf, C. R., 1 Jan 2018, In : Journal of Physiology. 596, 1, p. 105-127 23 p.

Research output: Contribution to journalArticle

Open Access
File
Heme Oxygenase-1
Oxidative Stress
Firefly Luciferases
beta-Galactosidase
Toxicology
2 Citations
Open Access
File
Cytochrome P-450 CYP2D6
Tamoxifen
Drug Interactions
Cytochrome P-450 Enzyme System
Antidepressive Agents

Prizes

diplomat
cancer

Ian Stevenson award for Public Engagement

Colin Henderson (Recipient), 1 Dec 2016

Prize: Prize (including medals and awards)

public

Activities 2005 2018

Mill O’ Mains Primary School

Colin Henderson (Member)
9 Nov 2018

Activity: Other activity typesSchools engagement

NC3Rs Studentship Assessment Committee

Colin Henderson (Member)
10 Oct 2018

Activity: Other activity typesOther

External Examiner, PhD Viva

Colin Henderson (Member)
30 May 2018

Activity: Other activity typesOther

Leuchars Primary School

Colin Henderson (Member), Frances Fuller-Pace (Member), Celine Pourreyron (Member)
2 Nov 2018

Activity: Other activity typesSchools engagement

School of Medicine Open Day

Colin Henderson (Participant), Frances Fuller-Pace (Participant), Gillian Smith (Participant), Francisco Inesta-Vaquera (Participant), Susan Bray (Participant), Norman Pratt (Participant), Rosamund Langston (Participant), Suzanne Duce (Participant), Hugh Nicholson (Participant)
8 Sep 2018

Activity: Participating in or organising an event typesFestival/Exhibition

Press / Media

Dundee takes lead role in supporting cancer drugs development

Colin Henderson

4/05/10

1 item of media coverage

Press/Media: Research

Cash award for cancer researchers

Colin Henderson

9/09/05

1 item of media coverage

Press/Media: Research

New insight into how paracetamol overdoses can damage liver

Colin Henderson

6/11/00

1 item of media coverage

Press/Media: Research

Painkiller overdose unravelled

Colin Henderson

6/11/00

1 item of media coverage

Press/Media: Research

Thesis

Catalytic and non-catalytic mechanisms involved in Glutathione S-transferase Pi mediated cytoprotection

Author: McGarry, D., 2012

Supervisor: Henderson, C. J. (Supervisor) & Wolf, C. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

File

Detection of Mouse Hepatitis Virus

Author: Wood, C. S., 2015

Supervisor: Henderson, C. J. (Supervisor) & Newman, E. (Supervisor)

Student thesis: Master's ThesisMaster of Science

File

Metabolic Factors Determining Outcome in Chemotherapy: Studies with Pazopanib

Author: Sharp, S. L., 2014

Supervisor: Wolf, C. (Supervisor) & Henderson, C. J. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

File