Henderson, Colin

Dr

  • 6950 Citations
  • 40 h-Index
1983 …2021
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Research Output 1983 2019

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Article
2019
27 Downloads (Pure)

An Extensively Humanized Mouse Model to Predict Pathways of Drug Disposition and Drug/Drug Interactions, and to Facilitate Design of Clinical Trials

Henderson, C. J., Kapelyukh, Y., Scheer, N., Rode, A., McLaren, A., MacLeod, K., Lin, D., Wright, J., Stanley, L. A. & Wolf, C. R., Jun 2019, In : Drug Metabolism and Disposition. 47, 6, p. 601-615 15 p.

Research output: Contribution to journalArticle

Open Access
File
Drug Interactions
Clinical Trials
Pharmaceutical Preparations
Pharmacokinetics
Cytochrome P-450 CYP3A
53 Downloads (Pure)

Application of hepatic cytochrome b5/P450 reductase null (HBRN) mice to study the role of cytochrome b5 in the cytochrome P450-mediated bioactivation of the anticancer drug ellipticine

Reed, L., Indra, R., Mrizova, I., Moserova, M., Schmeiser, H. H., Wolf, C. R., Henderson, C. J., Stiborova, M., Phillips, D. H. & Arlt, V. M., 1 Mar 2019, In : Toxicology and Applied Pharmacology. 366, p. 64-74 11 p.

Research output: Contribution to journalArticle

Open Access
File
ellipticine
Cytochromes b5
NADPH-Ferrihemoprotein Reductase
Cytochrome P-450 Enzyme System
Oxidoreductases
1 Citation (Scopus)
55 Downloads (Pure)

Constitutive androstane receptor 1 is constitutively bound to chromatin and ‘primed’ for transactivation in hepatocytes

McMahon, M., Ding, S., Acosta-Jimenez, L., Terranova, R., Gerard, M-A., Vitobello, A., Moggs, J. G., Henderson, C. J. & Wolf, C. R., 1 Jan 2019, In : Molecular Pharmacology. 95, 1, p. 97-105 9 p.

Research output: Contribution to journalArticle

Open Access
File
Transcriptional Activation
Chromatin
Hepatocytes
Xenobiotics
constitutive androstane receptor
Open Access
Cytochrome P-450 CYP1A2
Cytochrome P-450 CYP1A1
Knockout Mice
Pharmaceutical Preparations
Enzyme Inhibitors

The pyrrolizidine alkaloid senecionine induces CYP-dependent destruction of sinusoidal endothelial cells and cholestasis in mice

Hessel-Pras, S., Braeuning, A., Guenther, G., Adawy, A., Enge, A-M., Ebmeyer, J., Henderson, C. J., Hengstler, J. G., Lampen, A. & Reif, R., 12 Oct 2019, In : Archives of Toxicology. 11 p.

Research output: Contribution to journalArticle

Pyrrolizidine Alkaloids
Cholestasis
Endothelial cells
Liver
Cytochrome P-450 Enzyme System

Uptake and effects of orally ingested polystyrene microplastic particles in vitro and in vivo

Stock, V., Böhmert, L., Lisicki, E., Block, R., Cara-Carmona, J., Pack, L. K., Selb, R., Lichtenstein, D., Voss, L., Henderson, C. J., Zabinsky, E., Sieg, H., Braeuning, A. & Lampen, A., Jul 2019, In : Archives of Toxicology. 93, 7, p. 1817-1833 17 p.

Research output: Contribution to journalArticle

Macrophages
Polystyrenes
Mammals
Oxidative stress
Health risks
2018
11 Citations (Scopus)
83 Downloads (Pure)

Cytochrome b5 impacts on cytochrome P450-mediated metabolism of benzo[a]pyrene and its DNA adduct formation: studies in hepatic cytochrome b5 /P450 reductase null (HBRN) mice

Reed, L., Mrizova, I., Barta, F., Indra, R., Moserova, M., Kopka, K., Schmeiser, H. H., Wolf, C. R., Henderson, C. J., Stiborova, M., Phillips, D. H. & Arlt, V. M., Apr 2018, In : Archives of Toxicology. 92, 4, p. 1625-1638 14 p.

Research output: Contribution to journalArticle

Open Access
File
Cytochromes b5
NADPH-Ferrihemoprotein Reductase
Metabolism
Cytochrome P-450 Enzyme System
Oxidoreductases
7 Citations (Scopus)
58 Downloads (Pure)

Identification of novel pathways of osimertinib disposition and potential implications for the outcome of lung cancer therapy

MacLeod, A. K., Lin, D., Huang, J. T-J., McLaughlin, L. A., Henderson, C. J. & Wolf, C. R., May 2018, In : Clinical Cancer Research. 24, 9, p. 2138-2147 10 p.

Research output: Contribution to journalArticle

Open Access
File
Lung Neoplasms
Cytochrome P-450 CYP3A
Therapeutics
Pharmaceutical Preparations
Cytochrome P-450 CYP1A2
1 Citation (Scopus)
59 Downloads (Pure)

Measuring in vivo responses to endogenous and exogenous oxidative stress using a novel haem oxygenase 1 reporter mouse

McMahon, M., Ding, S., Acosta-Jimenez, L. P., Frangova, T. G., Henderson, C. J. & Wolf, C. R., 1 Jan 2018, In : Journal of Physiology. 596, 1, p. 105-127 23 p.

Research output: Contribution to journalArticle

Open Access
File
Heme Oxygenase (Decyclizing)
Oxidative Stress
Galactosidases
Firefly Luciferases
Toxicology
2017
2 Citations (Scopus)
84 Downloads (Pure)
Open Access
File
Cytochrome P-450 CYP2D6
Tamoxifen
Drug Interactions
Cytochrome P-450 Enzyme System
Antidepressive Agents
13 Citations (Scopus)
132 Downloads (Pure)

Aryl hydrocarbon receptor is required for optimal B-cell proliferation

Villa, M., Gialitakis, M., Tolaini, M., Ahlfors, H., Henderson, C. J., Wolf, C. R., Brink, R. & Stockinger, B., 4 Jan 2017, In : EMBO Journal. 36, 1, p. 116-128 13 p.

Research output: Contribution to journalArticle

Open Access
File
Aryl Hydrocarbon Receptors
Cell proliferation
B-Lymphocytes
Cell Proliferation
Cells
1 Citation (Scopus)

Corrigendum to "Aldo-keto reductases are biomarkers of NRF2 activity and are co-ordinately overexpressed in non-small cell lung cancer"

MacLeod, A. K., Acosta-Jimenez, L., Coates, P. J., McMahon, M., Carey, F. A., Honda, T., Hayes, J. D., Henderson, C. J. & Wolf, C. R., 22 Aug 2017, In : British Journal of Cancer. 117, 1 p., e1.

Research output: Contribution to journalArticle

8 Citations (Scopus)
72 Downloads (Pure)
Open Access
File
Cytochrome P-450 CYP1A1
Poisons
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Glutathione Transferase
Premature Mortality
2 Citations (Scopus)
89 Downloads (Pure)

Xenobiotic CAR activators induce Dlk1-Dio3 locus non-coding RNA expression in mouse liver

Pouché, L., Vitobello, A., Römer, M., Glogovac, M., MacLeod, A. K., Ellinger-Ziegelbauer, H., Westphal, M., Dubost, V., Stiehl, D. P., Dumotier, B., Fekete, A., Moulin, P., Zell, A., Schwarz, M., Moreno, R., Huang, J. T. J., Elcombe, C. R., Henderson, C. J., Wolf, C. R., Moggs, J. G. & 1 others, Terranova, R., Aug 2017, In : Toxicological Sciences. 158, 2, p. 367-378 11 p.

Research output: Contribution to journalArticle

Open Access
File
Untranslated RNA
Xenobiotics
Liver
Carcinogenesis
Biomarkers
2016
15 Citations (Scopus)
140 Downloads (Pure)

Aldo-keto reductases are biomarkers of NRF2 activity and are co-ordinately overexpressed in non-small cell lung cancer

MacLeod, A. K., Acosta-Jimenez, L., Coates, P. J., McMahon, M., Carey, F. A., Honda, T., Henderson, C. J. & Wolf, C. R., 6 Dec 2016, In : British Journal of Cancer. 115, 12, p. 1530-1539 10 p.

Research output: Contribution to journalArticle

Open Access
File
Non-Small Cell Lung Carcinoma
Biomarkers
Squamous Cell Carcinoma
Neoplasms
Cell Line
111 Downloads (Pure)

Attenuation of lung fibrosis in mice with a clinically relevant inhibitor of glutathione-S-transferase π

McMillan, D. H., van der Velden, J. L. J., Lahue, K. G., Quan, X., Schneider, R. W., Iberg, M. S., Nolin, J. D., Abdalla, S., Casey, D. T., Tew, K. D., Townsend, D. M., Henderson, C. J., Wolf, C. R., Butnor, K. J., Taatjes, D. J., Budd, R. C., Irvin, C. G., van der Vliet, A., Flemer, S., Anathy, V. & 1 others, Janssen-Heininger, Y. M. W., 2 Jun 2016, In : JCI Insight. 1, 8, 16 p., e85717.

Research output: Contribution to journalArticle

Open Access
File
Idiopathic Pulmonary Fibrosis
Glutathione Transferase
Fibrosis
Lung
Protein S
44 Citations (Scopus)
125 Downloads (Pure)

Cyp2c70 is responsible for the species difference in bile acid metabolism between mice and humans

Takahashi, S., Fukami, T., Masuo, Y., Brocker, C. N., Xie, C., Krausz, K. W., Wolf, C. R., Henderson, C. J. & Gonzalez, F. J., Dec 2016, In : Journal of Lipid Research. 57, p. 2130-2037 8 p.

Research output: Contribution to journalArticle

Open Access
File
Chenodeoxycholic Acid
Ursodeoxycholic Acid
Bile Acids and Salts
Metabolism
Taurine
7 Citations (Scopus)
151 Downloads (Pure)

Olaparib, monotherapy or with ionizing radiation, exacerbates DNA damage in normal tissues: insights from a new p21 reporter mouse

McMahon, M., Frangova, T. G., Henderson, C. J. & Wolf, C. R., Dec 2016, In : Molecular Cancer Research. 14, 12, p. 1195-1203 9 p.

Research output: Contribution to journalArticle

Open Access
File
Ionizing Radiation
DNA Damage
Galactosidases
Cisplatin
Firefly Luciferases
18 Citations (Scopus)

The role of protein-protein and protein-membrane Interactions on P450 function

Scott, E. E., Wolf, C. R., Otyepka, M., Humphreys, S. C., Reed, J. R., Henderson, C. J., McLaughlin, L. A., Paloncyova, M., Navratilova, V., Berka, K., Anzenbacher, P., Dahal, U. P., Barnaba, C., Brozik, J. A., Jones, J. P., Estrada, F., Laurence, J. S., Park, J. W. & Backes, W. L., Apr 2016, In : Drug Metabolism and Disposition. 44, 4, p. 576-590 15 p.

Research output: Contribution to journalArticle

Membrane Proteins
NADPH-Ferrihemoprotein Reductase
Membranes
Lyases
Mixed Function Oxygenases
2015
10 Citations (Scopus)

Activation status of the Pregnane X Receptor influences Vemurafenib availability in humanized mouse models

MacLeod, A. K., McLaughlin, L. A., Henderson, C. J. & Wolf, C. R., 1 Nov 2015, In : Cancer Research. 75, 21, p. 4573-4581 10 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP3A
PLX4032
pregnane X receptor
Drug and Narcotic Control
Liver Microsomes
19 Citations (Scopus)
Protein S
Acetaminophen
Glutathione S-Transferase pi
Oxidative Stress
Glutamate-Cysteine Ligase
7 Citations (Scopus)

An enhanced in vivo stable isotope labeling by amino acids in cell culture (SILAC) model for quantification of drug metabolism enzymes

MacLeod, A. K., Fallon, P. G., Sharp, S., Henderson, C. J., Wolf, C. R. & Huang, J. T-J., Mar 2015, In : Molecular & Cellular Proteomics. 14, 3, p. 750-760 11 p.

Research output: Contribution to journalArticle

Isotope Labeling
Cell culture
Metabolism
Isotopes
Labeling
7 Citations (Scopus)
Metabolism
Liver
Biological Availability
Pharmaceutical Preparations
Nelfinavir
20 Citations (Scopus)

Cytochrome b5 is a major determinant of human cytochrome P450 CYP2D6 and CYP3A4 activity in vivo

Henderson, C. J., McLaughlin, L. A., Scheer, N., Stanley, L. A. & Wolf, C. R., Apr 2015, In : Molecular Pharmacology. 87, 4, p. 733-739 7 p.

Research output: Contribution to journalArticle

Cytochromes b5
Cytochrome P-450 CYP3A
Cytochrome P-450 CYP2D6
Cytochrome P-450 Enzyme System
Debrisoquin
13 Citations (Scopus)

Defining human pathways of drug metabolism in vivo through the development of a multiple humanized mouse model

Scheer, N., Kapelyukh, Y., Rode, A., Oswald, S., Busch, D., McLaughlin, L. A., Lin, D., Henderson, C. J. & Wolf, C. R., Nov 2015, In : Drug Metabolism and Disposition. 43, 11, p. 1679-1690 12 p.

Research output: Contribution to journalArticle

Pharmaceutical Preparations
Cytochrome P-450 Enzyme System
Polypharmacy
Oxygenases
Androgen Receptors
4 Citations (Scopus)

Evidence that the capacity of nongenotoxic carcinogens to induce oxidative stress is subject to marked variability

Henderson, C. J., Cameron, A. R., Chatham, L., Stanley, L. A. & Wolf, C. R., May 2015, In : Toxicological Sciences. 145, 1, p. 138-148 11 p.

Research output: Contribution to journalArticle

Oxidative stress
Carcinogens
Oxidative Stress
Liver
Phenobarbital
10 Citations (Scopus)

Glutathione transferases P1/P2 regulate the timing of signaling pathway activations and cell cycle progression during mouse liver regeneration

Pajaud, J., Ribault, C., Ben Mosbah, I., Rauch, C., Henderson, C., Bellaud, P., Aninat, C., Loyer, P., Morel, F. & Corlu, A., 15 Jan 2015, In : Cell Death and Disease. 6, 13 p., e1598.

Research output: Contribution to journalArticle

Liver Regeneration
Glutathione Transferase
Hepatocytes
Cell Cycle
Hepatectomy
7 Citations (Scopus)
73 Downloads (Pure)
Open Access
File
Pharmacodynamics
Pharmacokinetics
Cysteine
Animals
Chemical activation
17 Citations (Scopus)

Proteome-wide identification and quantification of S-glutathionylation targets in mouse liver

McGarry, D. J., Chen, W., Chakravarty, P., Lamont, D. L., Wolf, C. R. & Henderson, C. J., Jun 2015, In : Biochemical Journal. 469, 1, p. 25-32 8 p.

Research output: Contribution to journalArticle

Protein S
Proteome
Liver
Animals
Glutathione S-Transferase pi
9 Citations (Scopus)
Environmental Pollutants
Metabolism
Toxicity
Oxidoreductases
Cytochromes b5
2014
12 Citations (Scopus)

A role for cytochrome b5 in the in vivo disposition of anti-cancer and cytochrome P450 probe drugs in mice

Henderson, C. J., McLaughlin, L. A., Finn, R. D., Ronseaux, S., Kapelyukh, Y. & Wolf, C. R., Jan 2014, In : Drug Metabolism and Disposition. 42, 1, p. 70-77 8 p.

Research output: Contribution to journalArticle

Cytochromes b5
Cytochrome P-450 Enzyme System
Pharmaceutical Preparations
Neoplasms
Cytochromes
5 Citations (Scopus)
50 Downloads (Pure)

A Targeted in Vivo SILAC Approach for Quantification of Drug Metabolism Enzymes: Regulation by the Constitutive Androstane Receptor

Macleod, A. K., Zang, T., Riches, Z., Henderson, C. J., Wolf, C. R. & Huang, J. T-J., 7 Feb 2014, In : Journal of Proteome Research. 13, 2, p. 866-874 9 p.

Research output: Contribution to journalArticle

Open Access
File
Metabolism
Enzymes
Drug interactions
Pharmaceutical Preparations
Ions
32 Citations (Scopus)

Cytochrome b5 and epoxide hydrolase contribute to benzo[a]pyrene-DNA adduct formation catalyzed by cytochrome P450 1A1 under low NADPH:P450 oxidoreductase conditions

Stiborová, M., Moserová, M., Černá, V., Indra, R., Dračínský, M., Šulc, M., Henderson, C. J., Wolf, C. R., Schmeiser, H. H., Phillips, D. H., Frei, E. & Arlt, V. M., 6 Apr 2014, In : Toxicology. 318, 1, p. 1-12 12 p.

Research output: Contribution to journalArticle

Epoxide Hydrolases
Cytochromes b5
NADP
Cytochrome P-450 Enzyme System
Cytochromes b
14 Citations (Scopus)

Deletion of 30 Murine Cytochrome p450 Genes Results In Viable Mice With Compromised Drug Metabolism

Scheer, N., McLaughlin, L. A., Rode, A., MacLeod, A. K., Henderson, C. J. & Wolf, C. R., Jun 2014, In : Drug Metabolism and Disposition. 42, 6, p. 1022-1030 9 p.

Research output: Contribution to journalArticle

Cytochrome P-450 Enzyme System
Pharmaceutical Preparations
Genes
Multigene Family
Liver
8 Citations (Scopus)
97 Downloads (Pure)

HDAC inhibitors increase NRF2-signaling in tumour cells and blunt the efficacy of co-adminstered cytotoxic agents

McMahon, M., Campbell, K. H., MacLeod, A. K., McLaughlin, L. A., Henderson, C. J. & Wolf, C. R., 26 Nov 2014, In : PLoS ONE. 9, 11, e114055.

Research output: Contribution to journalArticle

Open Access
File
Histone Deacetylase Inhibitors
Cytotoxins
Tumors
Cells
drugs
15 Citations (Scopus)

In vivo regulation of human glutathione transferase GSTP by chemopreventive agents

Henderson, C. J., McLaren, A. W. & Wolf, C. R., 15 Aug 2014, In : Cancer Research. 74, 16, p. 4378-4387 10 p.

Research output: Contribution to journalArticle

Glutathione Transferase
Ethoxyquin
Epithelium
Genetic Transcription
Butylated Hydroxyanisole
37 Citations (Scopus)

Phenobarbital induces cell cycle transcriptional responses in mouse liver humanized for constitutive androstane and pregnane X receptors

Luisier, R., Lempiäinen, H., Scherbichler, N., Braeuning, A., Geissler, M., Dubost, V., Müller, A., Scheer, N., Chibout, S-D., Hara, H., Picard, F., Theil, D., Couttet, P., Vitobello, A., Grenet, O., Grasl-Kraupp, B., Ellinger-Ziegelbauer, H., Thomson, J. P., Meehan, R. R., Elcombe, C. R. & 6 others, Henderson, C. J., Wolf, C. R., Schwarz, M., Moulin, P., Terranova, R. & Moggs, J. G., 2014, In : Toxicological Sciences. 139, 2, p. 501-511 11 p.

Research output: Contribution to journalArticle

Phenobarbital
Liver
Cell Cycle
Cells
Untranslated RNA
37 Citations (Scopus)
80 Downloads (Pure)

Phenobarbital-mediated tumor promotion in transgenic mice with humanized CAR and PXR

Braeuning, A., Gavrilov, A., Brown, S., Wolf, C. R., Henderson, C. J. & Schwarz, M., 1 Aug 2014, In : Toxicological Sciences. 140, 2, p. 259-70 12 p.

Research output: Contribution to journalArticle

Open Access
File
Phenobarbital
Transgenic Mice
Tumors
Liver
Neoplasms
2013
35 Citations (Scopus)
Cytochrome Reductases
Cytochromes b5
Cytochrome P-450 Enzyme System
Electrons
Liver
58 Citations (Scopus)

NADPH-cytochrome P450 oxidoreductase: roles in physiology, pharmacology, and toxicology

Riddick, D. S., Ding, X., Wolf, C. R., Porter, T. D., Pandey, A. V., Zhang, Q-Y., Gu, J., Finn, R. D., Ronseaux, S., McLaughlin, L. A., Henderson, C. J., Zou, L. & Flück, C. E., Jan 2013, In : Drug Metabolism and Disposition. 41, 1, p. 12-23 12 p.

Research output: Contribution to journalArticle

NADPH-Ferrihemoprotein Reductase
Cytochromes b5
Toxicology
Oxidoreductases
Pharmacology
17 Citations (Scopus)

Pyrethroid activity-based probes for profiling cytochrome P450 activities associated with insecticide interactions

Ismail, H. M., O'Neill, P. M., Hong, D. W., Finn, R. D., Henderson, C. J., Wright, A. T., Cravatt, B. F., Hemingway, J. & Paine, M. J. I., 3 Dec 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 49, p. 19766-19771 6 p.

Research output: Contribution to journalArticle

Pyrethrins
Insecticides
Cytochrome P-450 Enzyme System
Enzymes
Glucuronosyltransferase
26 Citations (Scopus)

The involvement of mitochondrial amidoxime reducing components 1 and 2 and mitochondrial cytochrome b5 in N-reductive metabolism in human cells

Plitzko, B., Ott, G., Reichmann, D., Henderson, C. J., Wolf, C. R., Mendel, R., Bittner, F., Clement, B. & Havemeyer, A., 2013, In : Journal of Biological Chemistry. 288, 28, p. 20228-20237 10 p.

Research output: Contribution to journalArticle

Cytochromes b5
Metabolism
Cells
Heme
Protein Isoforms
16 Citations (Scopus)

Ubiquitin-proteasome system impairment and MPTP-induced oxidative stress in the brain of C57BL/6 wild-type and GSTP knockout mice

Carvalho, A. N., Marques, C., Rodrigues, E., Henderson, C. J., Wolf, C. R., Pereira, P. & Gama, M. J., Apr 2013, In : Molecular Neurobiology. 47, 2, p. 662-72 11 p.

Research output: Contribution to journalArticle

Glutathione S-Transferase pi
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Proteasome Endopeptidase Complex
Ubiquitin
Knockout Mice
2012
5 Citations (Scopus)

Diminished toxicity of C-1748, 4-methyl-9-hydroxyethylamino-1-nitroacridine, compared with its demethyl analog, C-857, corresponds to its resistance to metabolism in HepG2 cells

Wisniewska, A., Niemira, M., Jagiello, K., Potega, A., Swist, M., Henderson, C., Skwarska, A., Augustin, E., Konopa, J. & Mazerska, Z., 1 Jul 2012, In : Biochemical Pharmacology. 84, 1, p. 30-42 13 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Exposure to benzo[a]pyrene of hepatic cytochrome P450 reductase null (HRN) and P450 reductase conditional null (RCN) mice: detection of benzo[a]pyrene diol epoxide-DNA adducts by immunohistochemistry and P-postlabelling

Arlt, V. M., Poirier, M. C., Sykes, S. E., John, K., Moserova, M., Stiborova, M., Wolf, C. R., Henderson, C. J. & Phillips, D. H., 2012, In : Toxicology Letters. 213, 2, p. 160-166 7 p.

Research output: Contribution to journalArticle

NADPH-Ferrihemoprotein Reductase
DNA Adducts
Benzo(a)pyrene
Epoxy Compounds
Oxidoreductases
25 Citations (Scopus)

Glutathione S-Transferase pi Mediates MPTP-Induced c-Jun N-Terminal Kinase Activation in the Nigrostriatal Pathway

Castro-Caldas, M., Carvalho, A. N., Rodrigues, E., Gama, M. J., Henderson, C. & Wolf, C. R., 1 Jan 2012, In : Molecular Neurobiology. p. 1-12 12 p.

Research output: Contribution to journalArticle

Glutathione S-Transferase pi
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
JNK Mitogen-Activated Protein Kinases
Knockout Mice
Substantia Nigra
53 Citations (Scopus)

Tauroursodeoxycholic acid prevents MPTP-induced dopaminergic cell death in a mouse model of Parkinson's disease

Castro-Caldas, M., Carvalho, A. N., Rodrigues, E., Henderson, C. J., Wolf, C. R., Rodrigues, C. M. P. & Gama, M. J., 2012, In : Molecular Neurobiology. 46, 2, p. 475-486 12 p.

Research output: Contribution to journalArticle

Parkinson Disease
Cell Death
Phosphotransferases
Glutathione S-Transferase pi
Phosphorylation
2011
19 Citations (Scopus)

Cytochrome b (5) null mouse: a new model for studying inherited skin disorders and the role of unsaturated fatty acids in normal homeostasis

Finn, R. D., McLaughlin, L. A., Hughes, C., Song, C., Henderson, C. J. & Wolf, C. R., Jun 2011, In : Transgenic Research. 20, 3, p. 491-502 12 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Effect of hepatic cytochrome P450 (P450) oxidoreductase deficiency on 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-DNA Adduct Formation in P450 reductase conditional null mice

Arlt, V. M., Singh, R., Stiborova, M., da Costa, G. G., Frei, E., Evans, J. D., Farmer, P. B., Wolf, C. R., Henderson, C. J. & Phillips, D. H., Dec 2011, In : Drug Metabolism and Disposition. 39, 12, p. 2169-2173 5 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Humanizing π-class glutathione S-transferase regulation in a mouse model alters liver toxicity in response to acetaminophen overdose

Vaughn, M. P., Shinohara, D. B., Castagna, N., Hicks, J. L., Netto, G., De Marzo, A. M., Speed, T. J., Reichert, Z. R., Kwabi-Addo, B., Henderson, C. J., Wolf, C. R., Yegnasubramanian, S. & Nelson, W. G., 2011, In : PLoS ONE. 6, 10, p. - 10 p., e25707.

Research output: Contribution to journalArticle