Henderson, Colin

Dr

  • 7006 Citations
  • 40 h-Index
1983 …2021
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Research Output 1983 2019

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38 Citations (Scopus)

1,4-Bis[2-(3,5-dichloropyridyloxy)]benzene, an extremely potent modulator of mouse hepatic cytochrome P-450 gene expression.

Smith, G., Henderson, C. J., WHITE, R., Parker, M. G., Bars, R. G. & Wolf, C. R., 1 Feb 1993, In : Biochemical Journal. 289, 3, p. 807-813 7 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Activation status of the Pregnane X Receptor influences Vemurafenib availability in humanized mouse models

MacLeod, A. K., McLaughlin, L. A., Henderson, C. J. & Wolf, C. R., 1 Nov 2015, In : Cancer Research. 75, 21, p. 4573-4581 10 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP3A
PLX4032
pregnane X receptor
Drug and Narcotic Control
Liver Microsomes
100 Citations (Scopus)

A general strategy for the expression of recombinant human cytochrome P450s in Escherichia coli using bacterial signal peptides: expression of CYP3A4, CYP2A6, and CYP2E1

Pritchard, M. P., Ossetian, R., Li, D. N., Henderson, C. J., Burchell, B., Wolf, C. R. & Friedberg, T., 15 Sep 1997, In : Archives of Biochemistry and Biophysics. 345, 2, p. 342-354 13 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)
144 Downloads (Pure)

Aldo-keto reductases are biomarkers of NRF2 activity and are co-ordinately overexpressed in non-small cell lung cancer

MacLeod, A. K., Acosta-Jimenez, L., Coates, P. J., McMahon, M., Carey, F. A., Honda, T., Henderson, C. J. & Wolf, C. R., 6 Dec 2016, In : British Journal of Cancer. 115, 12, p. 1530-1539 10 p.

Research output: Contribution to journalArticle

Open Access
File
Non-Small Cell Lung Carcinoma
Biomarkers
Squamous Cell Carcinoma
Neoplasms
Cell Line
33 Citations (Scopus)

Alterations in rat hepatic drug metabolism during pregnancy and lactation

Borlakoglu, J. T., Scott, A., Henderson, C. J. & Wolf, C. R., 6 Jul 1993, In : Biochemical Pharmacology. 46, 1, p. 29-36 8 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)
Protein S
Acetaminophen
Glutathione S-Transferase pi
Oxidative Stress
Glutamate-Cysteine Ligase
29 Citations (Scopus)

Analysis of calmodulin acceptor proteins and the influence of calmodulin antagonists on human spermatozoa

Aitken, R. J., Clarkson, J. S., Hulme, M. J. & Henderson, C. J., Sep 1988, In : Gamete Research. 21, 1, p. 93-111 19 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Analysis of the biological properties of antibodies raised against intact and deglycosylated porcine zonae pellucidae

Henderson, C. J., Hulme, M. J. & Aitken, R. J., Apr 1987, In : Gamete Research. 16, 4, p. 323-341 19 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

Analysis of the surface labelling characteristics of human spermatozoa and the interaction with anti-sperm antibodies

Aitken, R. J., Hulme, M. J., Henderson, C. J., Hargreave, T. B. & Ross, A., Jul 1987, In : Journal of Reproduction and Fertility. 80, 2, p. 473-485 13 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

An enhanced in vivo stable isotope labeling by amino acids in cell culture (SILAC) model for quantification of drug metabolism enzymes

MacLeod, A. K., Fallon, P. G., Sharp, S., Henderson, C. J., Wolf, C. R. & Huang, J. T-J., Mar 2015, In : Molecular & Cellular Proteomics. 14, 3, p. 750-760 11 p.

Research output: Contribution to journalArticle

Isotope Labeling
Cell culture
Metabolism
Isotopes
Labeling
34 Downloads (Pure)

An Extensively Humanized Mouse Model to Predict Pathways of Drug Disposition and Drug/Drug Interactions, and to Facilitate Design of Clinical Trials

Henderson, C. J., Kapelyukh, Y., Scheer, N., Rode, A., McLaren, A., MacLeod, K., Lin, D., Wright, J., Stanley, L. A. & Wolf, C. R., Jun 2019, In : Drug Metabolism and Disposition. 47, 6, p. 601-615 15 p.

Research output: Contribution to journalArticle

Open Access
File
Drug Interactions
Clinical Trials
Pharmaceutical Preparations
Pharmacokinetics
Cytochrome P-450 CYP3A
8 Citations (Scopus)
Metabolism
Liver
Biological Availability
Pharmaceutical Preparations
Nelfinavir
59 Downloads (Pure)

Application of hepatic cytochrome b5/P450 reductase null (HBRN) mice to study the role of cytochrome b5 in the cytochrome P450-mediated bioactivation of the anticancer drug ellipticine

Reed, L., Indra, R., Mrizova, I., Moserova, M., Schmeiser, H. H., Wolf, C. R., Henderson, C. J., Stiborova, M., Phillips, D. H. & Arlt, V. M., 1 Mar 2019, In : Toxicology and Applied Pharmacology. 366, p. 64-74 11 p.

Research output: Contribution to journalArticle

Open Access
File
ellipticine
Cytochromes b5
NADPH-Ferrihemoprotein Reductase
Cytochrome P-450 Enzyme System
Oxidoreductases
2 Citations (Scopus)
84 Downloads (Pure)
Open Access
File
Cytochrome P-450 CYP2D6
Tamoxifen
Drug Interactions
Cytochrome P-450 Enzyme System
Antidepressive Agents
12 Citations (Scopus)

A role for cytochrome b5 in the in vivo disposition of anti-cancer and cytochrome P450 probe drugs in mice

Henderson, C. J., McLaughlin, L. A., Finn, R. D., Ronseaux, S., Kapelyukh, Y. & Wolf, C. R., Jan 2014, In : Drug Metabolism and Disposition. 42, 1, p. 70-77 8 p.

Research output: Contribution to journalArticle

Cytochromes b5
Cytochrome P-450 Enzyme System
Pharmaceutical Preparations
Neoplasms
Cytochromes
14 Citations (Scopus)
140 Downloads (Pure)

Aryl hydrocarbon receptor is required for optimal B-cell proliferation

Villa, M., Gialitakis, M., Tolaini, M., Ahlfors, H., Henderson, C. J., Wolf, C. R., Brink, R. & Stockinger, B., 4 Jan 2017, In : EMBO Journal. 36, 1, p. 116-128 13 p.

Research output: Contribution to journalArticle

Open Access
File
Aryl Hydrocarbon Receptors
Cell proliferation
B-Lymphocytes
Cell Proliferation
Cells
6 Citations (Scopus)
55 Downloads (Pure)

A Targeted in Vivo SILAC Approach for Quantification of Drug Metabolism Enzymes: Regulation by the Constitutive Androstane Receptor

Macleod, A. K., Zang, T., Riches, Z., Henderson, C. J., Wolf, C. R. & Huang, J. T-J., 7 Feb 2014, In : Journal of Proteome Research. 13, 2, p. 866-874 9 p.

Research output: Contribution to journalArticle

Open Access
File
Metabolism
Enzymes
Drug interactions
Pharmaceutical Preparations
Ions
116 Downloads (Pure)

Attenuation of lung fibrosis in mice with a clinically relevant inhibitor of glutathione-S-transferase π

McMillan, D. H., van der Velden, J. L. J., Lahue, K. G., Quan, X., Schneider, R. W., Iberg, M. S., Nolin, J. D., Abdalla, S., Casey, D. T., Tew, K. D., Townsend, D. M., Henderson, C. J., Wolf, C. R., Butnor, K. J., Taatjes, D. J., Budd, R. C., Irvin, C. G., van der Vliet, A., Flemer, S., Anathy, V. & 1 others, Janssen-Heininger, Y. M. W., 2 Jun 2016, In : JCI Insight. 1, 8, 16 p., e85717.

Research output: Contribution to journalArticle

Open Access
File
Idiopathic Pulmonary Fibrosis
Glutathione Transferase
Fibrosis
Lung
Protein S
54 Citations (Scopus)

Bioactivation of 3-aminobenzanthrone, a human metabolite of the environmental pollutant 3-nitrobenzanthrone: evidence for DNA adduct formation mediated by cytochrome P450 enzymes and peroxidases

Arlt, V. M., Henderson, C. J., Wolf, C. R., Schmeiser, H. H., Phillips, D. H. & Stiborova, M., 28 Mar 2006, In : Cancer Letters. 234, 2, p. 220-231 12 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)

Cholesterol Metabolism: the Main Pathway Acting Downstream of Cytochrome P450 Oxidoreductase in Skeletal Development of the Limb

Schmidt, K., Hughes, C., Chudek, J. A., Goodyear, S. R., Aspden, R. M., Talbot, R., Gundersen, T. E., Blomhoff, R., Henderson, C., Wolf, C. R. & Tickle, C., 15 May 2009, In : Molecular and Cellular Biology. 29, 10, p. 2716-2729 14 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)
1 Citation (Scopus)
59 Downloads (Pure)

Constitutive androstane receptor 1 is constitutively bound to chromatin and ‘primed’ for transactivation in hepatocytes

McMahon, M., Ding, S., Acosta-Jimenez, L., Terranova, R., Gerard, M-A., Vitobello, A., Moggs, J. G., Henderson, C. J. & Wolf, C. R., 1 Jan 2019, In : Molecular Pharmacology. 95, 1, p. 97-105 9 p.

Research output: Contribution to journalArticle

Open Access
File
Transcriptional Activation
Chromatin
Hepatocytes
Xenobiotics
constitutive androstane receptor
44 Citations (Scopus)

Contraceptive potential of antibodies to the zona pellucida

Henderson, C. J., Hulme, M. J. & Aitken, R. J., 1 May 1988, In : Journal of Reproduction and Fertility. 83, 1, p. 325-343 19 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Corrigendum to "Aldo-keto reductases are biomarkers of NRF2 activity and are co-ordinately overexpressed in non-small cell lung cancer"

MacLeod, A. K., Acosta-Jimenez, L., Coates, P. J., McMahon, M., Carey, F. A., Honda, T., Hayes, J. D., Henderson, C. J. & Wolf, C. R., 22 Aug 2017, In : British Journal of Cancer. 117, 1 p., e1.

Research output: Contribution to journalArticle

47 Citations (Scopus)
132 Downloads (Pure)

Cyp2c70 is responsible for the species difference in bile acid metabolism between mice and humans

Takahashi, S., Fukami, T., Masuo, Y., Brocker, C. N., Xie, C., Krausz, K. W., Wolf, C. R., Henderson, C. J. & Gonzalez, F. J., Dec 2016, In : Journal of Lipid Research. 57, p. 2130-2037 8 p.

Research output: Contribution to journalArticle

Open Access
File
Chenodeoxycholic Acid
Ursodeoxycholic Acid
Bile Acids and Salts
Metabolism
Taurine
19 Citations (Scopus)

Cytochrome b (5) null mouse: a new model for studying inherited skin disorders and the role of unsaturated fatty acids in normal homeostasis

Finn, R. D., McLaughlin, L. A., Hughes, C., Song, C., Henderson, C. J. & Wolf, C. R., Jun 2011, In : Transgenic Research. 20, 3, p. 491-502 12 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)

Cytochrome b5 and epoxide hydrolase contribute to benzo[a]pyrene-DNA adduct formation catalyzed by cytochrome P450 1A1 under low NADPH:P450 oxidoreductase conditions

Stiborová, M., Moserová, M., Černá, V., Indra, R., Dračínský, M., Šulc, M., Henderson, C. J., Wolf, C. R., Schmeiser, H. H., Phillips, D. H., Frei, E. & Arlt, V. M., 6 Apr 2014, In : Toxicology. 318, 1, p. 1-12 12 p.

Research output: Contribution to journalArticle

Epoxide Hydrolases
Cytochromes b5
NADP
Cytochrome P-450 Enzyme System
Cytochromes b
11 Citations (Scopus)
86 Downloads (Pure)

Cytochrome b5 impacts on cytochrome P450-mediated metabolism of benzo[a]pyrene and its DNA adduct formation: studies in hepatic cytochrome b5 /P450 reductase null (HBRN) mice

Reed, L., Mrizova, I., Barta, F., Indra, R., Moserova, M., Kopka, K., Schmeiser, H. H., Wolf, C. R., Henderson, C. J., Stiborova, M., Phillips, D. H. & Arlt, V. M., Apr 2018, In : Archives of Toxicology. 92, 4, p. 1625-1638 14 p.

Research output: Contribution to journalArticle

Open Access
File
Cytochromes b5
NADPH-Ferrihemoprotein Reductase
Metabolism
Cytochrome P-450 Enzyme System
Oxidoreductases
20 Citations (Scopus)

Cytochrome b5 is a major determinant of human cytochrome P450 CYP2D6 and CYP3A4 activity in vivo

Henderson, C. J., McLaughlin, L. A., Scheer, N., Stanley, L. A. & Wolf, C. R., Apr 2015, In : Molecular Pharmacology. 87, 4, p. 733-739 7 p.

Research output: Contribution to journalArticle

Cytochromes b5
Cytochrome P-450 CYP3A
Cytochrome P-450 CYP2D6
Cytochrome P-450 Enzyme System
Debrisoquin
14 Citations (Scopus)

Cytochrome P450s and chemoprevention

Henderson, C. J., Sahraouei, A. & Wolf, C. R., Feb 2000, In : Biochemical Society Transactions. 28, 2, p. 42-46 5 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)
14 Citations (Scopus)

Defining human pathways of drug metabolism in vivo through the development of a multiple humanized mouse model

Scheer, N., Kapelyukh, Y., Rode, A., Oswald, S., Busch, D., McLaughlin, L. A., Lin, D., Henderson, C. J. & Wolf, C. R., Nov 2015, In : Drug Metabolism and Disposition. 43, 11, p. 1679-1690 12 p.

Research output: Contribution to journalArticle

Pharmaceutical Preparations
Cytochrome P-450 Enzyme System
Polypharmacy
Oxygenases
Androgen Receptors
1 Citation (Scopus)
Open Access
Cytochrome P-450 CYP1A2
Cytochrome P-450 CYP1A1
Knockout Mice
Pharmaceutical Preparations
Enzyme Inhibitors
67 Citations (Scopus)

Defining the in Vivo Role for Cytochrome b(5) in Cytochrome P450 Function through the Conditional Hepatic Deletion of Microsomal Cytochrome b(5)

Finn, R. D., McLaughlin, L. A., Ronseaux, S., Rosewell, I., Houston, J. B., Henderson, C. J. & Wolf, C. R., 14 Nov 2008, In : Journal of Biological Chemistry. 283, 46, p. 31385-31393 9 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Deletion of 30 Murine Cytochrome p450 Genes Results In Viable Mice With Compromised Drug Metabolism

Scheer, N., McLaughlin, L. A., Rode, A., MacLeod, A. K., Henderson, C. J. & Wolf, C. R., Jun 2014, In : Drug Metabolism and Disposition. 42, 6, p. 1022-1030 9 p.

Research output: Contribution to journalArticle

Cytochrome P-450 Enzyme System
Pharmaceutical Preparations
Genes
Multigene Family
Liver
54 Citations (Scopus)

Deletion of Microsomal Cytochrome b(5) Profoundly Affects Hepatic and Extrahepatic Drug Metabolism

McLaughlin, L. A., Ronseaux, S., Finn, R. D., Henderson, C. J. & Wolf, C. R., Aug 2010, In : Molecular Pharmacology. 78, 2, p. 269-278 10 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Development of a liquid Chromatography-Electrospray ionization tandem mass spectrometry method for detecting Oxaliplatin-DNA intrastrand cross-links in biological samples

Le Pla, R. C., Ritchie, K. J., Henderson, C. J., Wolf, C. R., Harrington, C. F. & Farmer, P. B., Aug 2007, In : Chemical Research in Toxicology. 20, 8, p. 1177-1182 6 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Diminished toxicity of C-1748, 4-methyl-9-hydroxyethylamino-1-nitroacridine, compared with its demethyl analog, C-857, corresponds to its resistance to metabolism in HepG2 cells

Wisniewska, A., Niemira, M., Jagiello, K., Potega, A., Swist, M., Henderson, C., Skwarska, A., Augustin, E., Konopa, J. & Mazerska, Z., 1 Jul 2012, In : Biochemical Pharmacology. 84, 1, p. 30-42 13 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Divergent regulation of cytochrome P450 enzymes by morphine and pethidine: a neuroendocrine mechanism?

Rane, A., Liu, Z., Henderson, C. J. & Wolf, C. R., Jan 1995, In : Molecular Pharmacology. 47, 1, p. 57-64 8 p.

Research output: Contribution to journalArticle

9 Downloads (Pure)

Drug-induced chromatin accessibility changes associate with sensitivity to liver tumor promotion

Vitobello, A., Perner, J., Beil, J., Zhu, J., Del Río-Espínola, A., Morawiec, L., Westphal, M., Dubost, V., Altorfer, M., Naumann, U., Mueller, A., Kapur, K., Borowsky, M., Henderson, C., Wolf, C. R., Schwarz, M., Moggs, J. & Terranova, R., Oct 2019, In : Life Science Alliance. 2, 5, p. 1-18 18 p., e201900461.

Research output: Contribution to journalArticle

Open Access
File
phenobarbital
liver neoplasms
Phenobarbital
tumor
Liver
11 Citations (Scopus)

Effect of hepatic cytochrome P450 (P450) oxidoreductase deficiency on 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-DNA Adduct Formation in P450 reductase conditional null mice

Arlt, V. M., Singh, R., Stiborova, M., da Costa, G. G., Frei, E., Evans, J. D., Farmer, P. B., Wolf, C. R., Henderson, C. J. & Phillips, D. H., Dec 2011, In : Drug Metabolism and Disposition. 39, 12, p. 2169-2173 5 p.

Research output: Contribution to journalArticle

105 Citations (Scopus)

Environmental pollutant and potent mutagen 3-nitrobenzanthrone forms DNA adducts after reduction by NAD(P)H: quinone oxidoreductase and conjugation by acetyltransferases and sulfotransferases in human hepatic cytosols

Arlt, V. M., Stiborova, M., Henderson, C. J., Osborne, M. R., Bieler, C. A., Frei, E., Martinek, V., Sopko, B., Wolf, C. R., Schmeiser, H. H. & Phillips, D. H., 1 Apr 2005, In : Cancer Research. 65, 7, p. 2644-2652 9 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)
Cytochrome Reductases
Cytochromes b5
Cytochrome P-450 Enzyme System
Electrons
Liver
40 Citations (Scopus)
4 Citations (Scopus)

Evidence that the capacity of nongenotoxic carcinogens to induce oxidative stress is subject to marked variability

Henderson, C. J., Cameron, A. R., Chatham, L., Stanley, L. A. & Wolf, C. R., May 2015, In : Toxicological Sciences. 145, 1, p. 138-148 11 p.

Research output: Contribution to journalArticle

Oxidative stress
Carcinogens
Oxidative Stress
Liver
Phenobarbital
29 Citations (Scopus)

Exposure to benzo[a]pyrene of hepatic cytochrome P450 reductase null (HRN) and P450 reductase conditional null (RCN) mice: detection of benzo[a]pyrene diol epoxide-DNA adducts by immunohistochemistry and P-postlabelling

Arlt, V. M., Poirier, M. C., Sykes, S. E., John, K., Moserova, M., Stiborova, M., Wolf, C. R., Henderson, C. J. & Phillips, D. H., 2012, In : Toxicology Letters. 213, 2, p. 160-166 7 p.

Research output: Contribution to journalArticle

NADPH-Ferrihemoprotein Reductase
DNA Adducts
Benzo(a)pyrene
Epoxy Compounds
Oxidoreductases
38 Citations (Scopus)

Expression of P450 isoenzymes during rat-liver organogenesis

Borlakoglu, J. T., Scott, A., Henderson, C. J. & Wolf, C. R., Nov 1993, In : International Journal of Biochemistry & Cell Biology. 25, 11, p. 1659-1668 10 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Functional expression and comparative characterization of nine murine cytochromes P450 by fluorescent inhibition screening

McLaughlin, L. A., Dickmann, L. J., Wolf, C. R. & Henderson, C. J., Jul 2008, In : Drug Metabolism and Disposition. 36, 7, p. 1322-1331 10 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Glutathione S-Transferase pi Mediates MPTP-Induced c-Jun N-Terminal Kinase Activation in the Nigrostriatal Pathway

Castro-Caldas, M., Carvalho, A. N., Rodrigues, E., Gama, M. J., Henderson, C. & Wolf, C. R., 1 Jan 2012, In : Molecular Neurobiology. p. 1-12 12 p.

Research output: Contribution to journalArticle

Glutathione S-Transferase pi
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
JNK Mitogen-Activated Protein Kinases
Knockout Mice
Substantia Nigra