Henderson, Colin

Dr

  • 7015 Citations
  • 40 h-Index
1983 …2021
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Research Output 1983 2019

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2011
10 Citations (Scopus)

Humanizing π-class glutathione S-transferase regulation in a mouse model alters liver toxicity in response to acetaminophen overdose

Vaughn, M. P., Shinohara, D. B., Castagna, N., Hicks, J. L., Netto, G., De Marzo, A. M., Speed, T. J., Reichert, Z. R., Kwabi-Addo, B., Henderson, C. J., Wolf, C. R., Yegnasubramanian, S. & Nelson, W. G., 2011, In : PLoS ONE. 6, 10, p. - 10 p., e25707.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Increased Skin Papilloma Formation in Mice Lacking Glutathione Transferase GSTP

Henderson, C. J., Ritchie, K. J., McLaren, A., Chakravarty, P. & Wolf, C. R., 15 Nov 2011, In : Cancer Research. 71, 22, p. 7048-7060 13 p.

Research output: Contribution to journalArticle

50 Citations (Scopus)

Role of cytochromes P450 1A1/2 in detoxication and activation of carcinogenic aristolochic acid I: studies with the hepatic NADPH:cytochrome P450 reductase null (HRN) mouse model

Levova, K., Moserova, M., Kotrbova, V., Sulc, M., Henderson, C. J., Wolf, C. R., Phillips, D. H., Frei, E., Schmeiser, H. H., Mares, J., Arlt, V. M. & Stiborova, M., May 2011, In : Toxicological Sciences. 121, 1, p. 43-56 14 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

The Imidazoacridinone Antitumor Drug, C-1311, Is Metabolized by Flavin Monooxygenases but Not by Cytochrome P450s

Potega, A., Dabrowska, E., Niemira, M., Kot-Wasik, A., Ronseaux, S., Henderson, C. J., Wolf, C. R. & Mazerska, Z., Aug 2011, In : Drug Metabolism and Disposition. 39, 8, p. 1423-1432 10 p.

Research output: Contribution to journalArticle

2010
54 Citations (Scopus)

Deletion of Microsomal Cytochrome b(5) Profoundly Affects Hepatic and Extrahepatic Drug Metabolism

McLaughlin, L. A., Ronseaux, S., Finn, R. D., Henderson, C. J. & Wolf, C. R., Aug 2010, In : Molecular Pharmacology. 78, 2, p. 269-278 10 p.

Research output: Contribution to journalArticle

105 Citations (Scopus)

Human Constitutive Androstane Receptor (CAR) and Pregnane X Receptor (PXR) Support the Hypertrophic but not the Hyperplastic Response to the Murine Nongenotoxic Hepatocarcinogens Phenobarbital and Chlordane In Vivo

Ross, J., Plummer, S. M., Rode, A., Scheer, N., Bower, C. C., Vogel, O., Henderson, C. J., Wolf, C. R. & Elcombe, C. R., Aug 2010, In : Toxicological Sciences. 116, 2, p. 452-466 15 p.

Research output: Contribution to journalArticle

2009
38 Citations (Scopus)

Cholesterol Metabolism: the Main Pathway Acting Downstream of Cytochrome P450 Oxidoreductase in Skeletal Development of the Limb

Schmidt, K., Hughes, C., Chudek, J. A., Goodyear, S. R., Aspden, R. M., Talbot, R., Gundersen, T. E., Blomhoff, R., Henderson, C., Wolf, C. R. & Tickle, C., 15 May 2009, In : Molecular and Cellular Biology. 29, 10, p. 2716-2729 14 p.

Research output: Contribution to journalArticle

45 Citations (Scopus)

Markedly enhanced colon tumorigenesis in Apc(Min) mice lacking glutathione S-transferase Pi

Ritchie, K. J., Walsh, S., Sansom, O. J., Henderson, C. J. & Wolf, C. R., 8 Dec 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 49, p. 20859-20864 6 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Preclinical toxicokinetic evaluation of Phortress [2-(4-amino-3- methylphenyl)-5-fluorobenzothiazole lysylamide dihydrochloride] in two rodent species

Bradshaw, T. D., Wren, J. E., Bruce, M., Barrett, D. A., Leong, C-O., Gaskell, M., Wright, E. K., Farmer, P. B., Henderson, C. J., Wolf, R. & Stevens, M. F. G., 1 Jan 2009, In : Pharmacology. 83, 2, p. 99-109 11 p.

Research output: Contribution to journalArticle

Rodentia
Cytochrome P-450 CYP1A1
Lung
Maximum Tolerated Dose
DNA Adducts
49 Citations (Scopus)

Unsaturated fatty acid regulation of cytochrome P450 expression via a CAR-dependent pathway

Finn, R. D., Henderson, C. J., Scott, C. L. & Wolf, C. R., 1 Jan 2009, In : Biochemical Journal. 417, 1, p. 43-54 12 p.

Research output: Contribution to journalArticle

2008
67 Citations (Scopus)

Defining the in Vivo Role for Cytochrome b(5) in Cytochrome P450 Function through the Conditional Hepatic Deletion of Microsomal Cytochrome b(5)

Finn, R. D., McLaughlin, L. A., Ronseaux, S., Rosewell, I., Houston, J. B., Henderson, C. J. & Wolf, C. R., 14 Nov 2008, In : Journal of Biological Chemistry. 283, 46, p. 31385-31393 9 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Functional expression and comparative characterization of nine murine cytochromes P450 by fluorescent inhibition screening

McLaughlin, L. A., Dickmann, L. J., Wolf, C. R. & Henderson, C. J., Jul 2008, In : Drug Metabolism and Disposition. 36, 7, p. 1322-1331 10 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Glutathione Transferase P1 An Endogenous Inhibitor of Allergic Responses in a Mouse Model of Asthma

Zhou, J., Wolf, C. R., Henderson, C. J., Cai, Y., Board, P. G., Foster, P. S. & Webb, D. C., 15 Dec 2008, In : American Journal of Respiratory and Critical Care Medicine. 178, 12, p. 1202-1210 9 p.

Research output: Contribution to journalArticle

103 Citations (Scopus)

Metabolic activation of benzo[a]pyrene in vitro by hepatic cytochrome P450 contrasts with detoxification in vivo: experiments with hepatic cytochrome P450 reductase null mice

Arlt, V. M., Stiborova, M., Henderson, C. J., Thiemann, M., Frei, E., Aimova, D., Singh, R., da Costa, G. G., Schmitz, O. J., Farmer, P. B., Wolf, C. R. & Phillips, D. H., Mar 2008, In : Carcinogenesis. 29, 3, p. 656-665 10 p.

Research output: Contribution to journalArticle

52 Citations (Scopus)

Role of hepatic cytochromes P450 in bioactivation of the anticancer drug ellipticine: Studies with the hepatic NADPH: Cytochrome P450 reductase null mouse

Stiborova, M., Arlt, V. M., Henderson, C. J., Wolf, C. R., Kotrbova, V., Moserova, M., Hudecek, J., Phillips, D. H. & Frei, E., 1 Feb 2008, In : Toxicology and Applied Pharmacology. 226, 3, p. 318-327 10 p.

Research output: Contribution to journalArticle

2007
30 Citations (Scopus)
22 Citations (Scopus)

Development of a liquid Chromatography-Electrospray ionization tandem mass spectrometry method for detecting Oxaliplatin-DNA intrastrand cross-links in biological samples

Le Pla, R. C., Ritchie, K. J., Henderson, C. J., Wolf, C. R., Harrington, C. F. & Farmer, P. B., Aug 2007, In : Chemical Research in Toxicology. 20, 8, p. 1177-1182 6 p.

Research output: Contribution to journalArticle

60 Citations (Scopus)

Glutathione transferase π plays a critical role in the development of lung carcinogenesis following exposure to tobacco-related carcinogens and urethane

Ritchie, K. J., Henderson, C. J., Wang, X-J., Vassieva, O., Carrie, D., Farmer, P. B., Gaskell, M., Park, K. & Wolf, C. R., 2007, In : Cancer Research. 67, 19, p. 9248-9257 10 p.

Research output: Contribution to journalArticle

Urethane
Glutathione Transferase
Carcinogens
Tobacco
Carcinogenesis
42 Citations (Scopus)

Rescue of cytochrome P450 oxidoreductase (Por) mouse mutants reveals functions in vasculogenesis, brain and limb patterning linked to retinoic acid homeostasis

Ribes, V., Otto, D. M. E., Dickmann, L., Schmidt, K., Schuhbaur, B., Henderson, C., Blomhoff, R., Wolf, C. R., Tickle, C. & Dollé, P., 1 Mar 2007, In : Developmental Biology. 303, 1, p. 66-81 16 p.

Research output: Contribution to journalArticle

Open Access
Tretinoin
Cytochrome P-450 Enzyme System
Oxidoreductases
Homeostasis
Extremities
18 Citations (Scopus)

The disruption of hepatic cytochrome P450 reductase afters mouse lipid metabolism

Mutch, D. M., Klocke, B., Morrison, P., Murray, C. A., Henderson, C. J., Seifert, M. & Williamson, G., Oct 2007, In : Journal of Proteome Research. 6, 10, p. 3976-3984 9 p.

Research output: Contribution to journalArticle

2006
54 Citations (Scopus)

Bioactivation of 3-aminobenzanthrone, a human metabolite of the environmental pollutant 3-nitrobenzanthrone: evidence for DNA adduct formation mediated by cytochrome P450 enzymes and peroxidases

Arlt, V. M., Henderson, C. J., Wolf, C. R., Schmeiser, H. H., Phillips, D. H. & Stiborova, M., 28 Mar 2006, In : Cancer Letters. 234, 2, p. 220-231 12 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Hepatic cytochrome P-450 reductase-null mice show reduced transcriptional response to quercetin and reveal physiological homeostasis between jejunum and liver

Mutch, D. M., Crespy, V., Clough, J., Henderson, C. J., Lariani, S., Mansourian, R., Moulin, J., Wolf, C. R. & Williamson, G., Jul 2006, In : American Journal of Physiology-Gastrointestinal and Liver Physiology. 291, 1, p. G63-G72 10 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

The hepatic cytochrome P450 reductase null mouse as a tool to identify a successful candidate entity

Henderson, C. J., Pass, G. J. & Wolf, C. R., 15 Mar 2006, In : Toxicology Letters. 162, 1, p. 111-117 7 p.

Research output: Contribution to journalArticle

2005
105 Citations (Scopus)

Environmental pollutant and potent mutagen 3-nitrobenzanthrone forms DNA adducts after reduction by NAD(P)H: quinone oxidoreductase and conjugation by acetyltransferases and sulfotransferases in human hepatic cytosols

Arlt, V. M., Stiborova, M., Henderson, C. J., Osborne, M. R., Bieler, C. A., Frei, E., Martinek, V., Sopko, B., Wolf, C. R., Schmeiser, H. H. & Phillips, D. H., 1 Apr 2005, In : Cancer Research. 65, 7, p. 2644-2652 9 p.

Research output: Contribution to journalArticle

46 Citations (Scopus)

Relationship between hepatic phenotype and changes in gene expression in cytochrome P450 reductase (POR) null mice

Wang, X. J., Chamberlain, M., Vassieva, O., Henderson, C. J. & Wolf, C. R., 15 Jun 2005, In : Biochemical Journal. 388, 3, p. 857-867 11 p.

Research output: Contribution to journalArticle

87 Citations (Scopus)

Role of hepatic cytochrome P450s in the pharmacokinetics and toxicity of cyclophosphamide: studies with the hepatic cytochrome P450 reductase null mouse

Pass, G. J., Carrie, D., Boylan, M., Lorimore, S., Wright, E., Houston, B., Henderson, C. J. & Wolf, C. R., 15 May 2005, In : Cancer Research. 65, 10, p. 4211-4217 7 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

The murine Cyp1a1 gene is expressed in a restricted spatial and temporal pattern during embryonic development

Campbell, S. J., Henderson, C. J., Anthony, D. C., Davidson, D., Clark, A. J. & Wolf, C. R., 18 Feb 2005, In : Journal of Biological Chemistry. 280, 7, p. 5828-5835 8 p.

Research output: Contribution to journalArticle

2004
157 Citations (Scopus)

Transcription factor Nrf2 is essential for induction of NAD(P)H:quinone oxidoreductase 1, glutathione S-transferases, and glutamate cysteine ligase by broccoli seeds and isothiocyanates

McWalter, G. K., Higgins, L. G., McLellan, L. I., Henderson, C. J., Song, L., Thornalley, P. J., Itoh, K., Yamamoto, M. & Hayes, J. D., 1 Dec 2004, In : Journal of Nutrition. 134, 12, p. 3499S-3506S

Research output: Contribution to journalArticle

Isothiocyanates
Glutamate-Cysteine Ligase
Brassica
Glutathione Transferase
NAD
2003
145 Citations (Scopus)

Identification of novel roles of the cytochrome P450 system in early embryogenesis: effects on vasculogenesis and retinoic acid homeostasis

Otto, D. M. E., Henderson, C. J., Carrie, D., Davey, M., Gundersen, T. E., Blomhoff, R., Adams, R. H., Tickle, C. & Wolf, C. R., Sep 2003, In : Molecular and Cellular Biology. 23, 17, p. 6103-6116 14 p.

Research output: Contribution to journalArticle

210 Citations (Scopus)

Inactivation of the hepatic cytochrome P450 system by conditional deletion of hepatic cytochrome P450 reductase

Henderson, C. J., Otto, D. M. E., Carrie, D., Magnuson, M. A., McLaren, A. W., Rosewell, I. & Wolf, C. R., 2003, In : Journal of Biological Chemistry. 278, 15, p. 13480-13486 7 p.

Research output: Contribution to journalArticle

NADPH-Ferrihemoprotein Reductase
Cytochrome P-450 Enzyme System
Metabolism
Liver
Steroid hormones
114 Citations (Scopus)

Increased constitutive c-Jun N-terminal kinase signaling in mice lacking glutathione S-transferase Pi

Elsby, R., Kitteringham, N. R., Goldring, C. E., Lovatt, C. A., Chamberlain, M., Henderson, C. J., Wolf, C. R. & Park, B. K., 20 Jun 2003, In : Journal of Biological Chemistry. 278, 25, p. 22243-22249 7 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Knockout mice in xenobiotic metabolism

Henderson, C. J., Otto, D. M. E., McLaren, A. W., Carrie, D. & Wolf, C. R., 2003, In : Drug Metabolism Reviews. 35, 4, p. 385-392 8 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Precision-cut tissue slices from transgenic mice as an in vitro toxicology system

Catania, J. M., Parrish, A. R., Kirkpatrick, D. S., Chitkara, M., Bowden, G. T., Henderson, C. J., Wolf, C. R., Clark, A. J., Brendel, K., Fisher, R. L. & Gandolfi, A. J., 2003, In : Toxicology in Vitro. 17, 2, p. 201-205 5 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Protein expression profiling of glutathione S-transferase pi null mice as a strategy to identify potential markers of resistance to paracetamol-induced toxicity in the liver

Kitteringham, N. R., Powell, H., Hamlett, J., Hamlett, J., Lovatt, C., Elsby, R., Henderson, C. J., Wolf, C. R., Pennington, S. R. & Park, B. K., Feb 2003, In : Proteomics. 3, 2, p. 191-207 17 p.

Research output: Contribution to journalArticle

2002
306 Citations (Scopus)

Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice

Chanas, S. A., Jiang, Q., McMahon, M., McWalter, G. K., McLellan, L. I., Elcombe, C. R., Henderson, C. J., Wolf, C. R., Moffat, G. J., Itoh, K., Yamamoto, M. & Hayes, J. D., 2002, In : Biochemical Journal. 365, Pt 2, p. 405-16 12 p.

Research output: Contribution to journalArticle

Butylated Hydroxyanisole
Glutathione Transferase
Liver
Transcription Factors
Transferases
2001
146 Citations (Scopus)

Pharmacologic or genetic manipulation of glutathione S-transferase P1-1 (GST ∏) influences cell proliferation pathways

Ruscoe, J. E., Rosario, L. A., Wang, T., Gate, L., Arifoglu, P., Wolf, C. R., Henderson, C. J., Ronai, Z. & Tew, K. D., 1 Jul 2001, In : Journal of Pharmacology and Experimental Therapeutics. 298, 1, p. 339-345 7 p.

Research output: Contribution to journalArticle

507 Citations (Scopus)
NF-E2-Related Factor 2
Basic-Leucine Zipper Transcription Factors
Glutathione
Small Intestine
Ethoxyquin
2000
14 Citations (Scopus)

Cytochrome P450s and chemoprevention

Henderson, C. J., Sahraouei, A. & Wolf, C. R., Feb 2000, In : Biochemical Society Transactions. 28, 2, p. 42-46 5 p.

Research output: Contribution to journalArticle

178 Citations (Scopus)

Increased resistance to acetaminophen hepatotoxicity in mice lacking glutathione S-transferase Pi

Henderson, C. J., Wolf, C. R., Kitteringham, N., Powell, H., Otto, D. & Park, B. K., 7 Nov 2000, In : Proceedings of the National Academy of Sciences of the United States of America. 97, 23, p. 12741-12745 5 p.

Research output: Contribution to journalArticle

1999
875 Citations (Scopus)

Regulation of JNK signaling by GSTp

Adler, V., Yin, Z., Fuchs, S. Y., Benezra, M., Rosario, L., Tew, K. D., Pincus, M. R., Sardana, M., Henderson, C. J., Wolf, C. R., Davis, R. J. & Ronai, Z., 1 Mar 1999, In : EMBO Journal. 18, 5, p. 1321-1334 14 p.

Research output: Contribution to journalArticle

1998
333 Citations (Scopus)

Increased skin tumorigenesis in mice lacking pi class glutathione S-transferases

Henderson, C. J., Smith, A. G., Ure, J., Brown, K., Bacon, E. J. & Wolf, C. R., 28 Apr 1998, In : Proceedings of the National Academy of Sciences of the United States of America. 95, 9, p. 5275-5280 6 p.

Research output: Contribution to journalArticle

109 Citations (Scopus)

Pi-class glutathione S-transferase: regulation and function

Henderson, C. J., McLaren, A. W., Moffat, G. J., Bacon, E. J. & Wolf, C. R., 24 Apr 1998, In : Chemico-Biological Interactions. 111-112, p. 69-82 14 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Use of transgenic animals in understanding molecular mechanisms of toxicity

Wolf, C. R. & Henderson, C. J., Jun 1998, In : Journal of Pharmacy and Pharmacology. 50, 6, p. 567-574 8 p.

Research output: Contribution to journalArticle

1997
100 Citations (Scopus)

A general strategy for the expression of recombinant human cytochrome P450s in Escherichia coli using bacterial signal peptides: expression of CYP3A4, CYP2A6, and CYP2E1

Pritchard, M. P., Ossetian, R., Li, D. N., Henderson, C. J., Burchell, B., Wolf, C. R. & Friedberg, T., 15 Sep 1997, In : Archives of Biochemistry and Biophysics. 345, 2, p. 342-354 13 p.

Research output: Contribution to journalArticle

1996
15 Citations (Scopus)

Transfer of PCBs via lactation simultaneously induces the expression of P450 isoenzymes and the protooncogenes c-Ha-ras and c-raf in neonates

Borlak, J. T., Scott, A., Henderson, C. J., Jenke, H. J. & Wolf, C. R., 23 Feb 1996, In : Biochemical Pharmacology. 51, 4, p. 517-529 13 p.

Research output: Contribution to journalArticle

1995
16 Citations (Scopus)

Divergent regulation of cytochrome P450 enzymes by morphine and pethidine: a neuroendocrine mechanism?

Rane, A., Liu, Z., Henderson, C. J. & Wolf, C. R., Jan 1995, In : Molecular Pharmacology. 47, 1, p. 57-64 8 p.

Research output: Contribution to journalArticle