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Watts, Colin

Professor

19942018
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Fingerprint Dive into the research topics where Colin Watts is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 4 Similar Profiles
Dendritic Cells Medicine & Life Sciences
Toll-Like Receptors Medicine & Life Sciences
Cystatins Medicine & Life Sciences
Antigen Presentation Medicine & Life Sciences
asparaginylendopeptidase Medicine & Life Sciences
Antigens Medicine & Life Sciences
cathepsin S Medicine & Life Sciences
Endopeptidases Medicine & Life Sciences

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Projects 2013 2018

Improved Control of Foot and Mouth Disease by Development of Virus Like Particle Vaccines (Joint with Institute for Animal Health Pirbright and Universities of Oxford and Reading)

Watts, C.

Wellcome Trust

1/01/14 → 31/12/16

Project: Research

Elucidating the Molecular Mechanism of Intracellular DNA Recognition by the Innate Immune Sensor IFI16 (Career Development Fellowship)

Unterholzner, L. & Watts, C.

Medical Research Council

1/02/13 → 31/01/18

Project: Research

Research Output 1994 2018

3 Citations (Scopus)
78 Downloads (Pure)

Asparaginyl endopeptidase (Legumain) supports human Th1 induction via cathepsin L-mediated intracellular C3 activation

Freeley, S., Cardone, J., Günther, S. C., West, E. E., Reinheckel, T., Watts, C., Kemper, C. & Kolev, M. V., 24 Oct 2018, In : Frontiers in Immunology. 9, p. 1-7 7 p., 2449.

Research output: Contribution to journal › Article

Open Access
File
asparaginylendopeptidase
Cathepsin L
T-Lymphocytes
Thymosin
Complement Receptors
3 Citations (Scopus)
71 Downloads (Pure)

Lysosomal protease deficiency or substrate overload induces an oxidative-stress mediated STAT3-dependent pathway of lysosomal homeostasis

Martinez-Fabregas, J., Prescott, A., van Kasteren, S., Leslie Pedrioli, D., McLean, W., Moles, A., Reinheckel, T., Poli, V. & Watts, C., 17 Dec 2018, In : Nature Communications. 9, 1, p. 1-16 16 p., 5343.

Research output: Contribution to journal › Article

Open Access
File
homeostasis
protease
Oxidative stress
Endopeptidases
Oxidative Stress
13 Citations (Scopus)
22 Downloads (Pure)

PD-1 Inhibitory Receptor Downregulates Asparaginyl Endopeptidase and Maintains Foxp3 Transcription Factor Stability in Induced Regulatory T Cells

Stathopoulou, C., Gangaplara, A., Mallett, G., Flomerfelt, F. A., Liniany, L. P., Knight, D., Samsel, L. A., Berlinguer-Palmini, R., Yim, J. J., Felizardo, T. C., Eckhaus, M. A., Edgington-Mitchell, L., Martinez-Fabregas, J., Zhu, J., Fowler, D. H., van Kasteren, S. I., Laurence, A., Bogyo, M., Watts, C., Shevach, E. M. & 1 others, Amarnath, S., 21 Aug 2018, In : Immunity. 49, 2, p. 247-263.e7 25 p.

Research output: Contribution to journal › Article

Open Access
File
asparaginylendopeptidase
Death Domain Receptors
Regulatory T-Lymphocytes
Transcription Factors
Down-Regulation
19 Citations (Scopus)
110 Downloads (Pure)

Cystatin F Ensures Eosinophil Survival by Regulating Granule Biogenesis

Matthews, S. P., McMillan, S. J., Colbert, J. D., Lawrence, R. A. & Watts, C., 19 Apr 2016, In : Immunity. 44, 4, p. 795-806 12 p.

Research output: Contribution to journal › Article

Open Access
File
Cystatins
Eosinophils
Brugia malayi
Pathology
Nematode Infections
9 Citations (Scopus)
78 Downloads (Pure)

Structural and functional basis for p38-MK2 activated Rsk signalling in Toll-Like receptor-stimulated dendritic cells

Zaru, R., Edgar, A. J., Hanauer, A. & Watts, C., Jan 2015, In : Molecular and Cellular Biology. 35, 1, p. 132-140 9 p.

Research output: Contribution to journal › Article

Open Access
File
Toll-Like Receptors
Dendritic Cells
Phosphotransferases
Interferon Type I
p38 Mitogen-Activated Protein Kinases